ARCH Venture Partners

Aspen Neuroscience develops iPSC-derived autologous cell therapies for neurological diseases, with a lead product (ANPD001) in Phase 1/2a clinical trials for Parkinson's disease. The company is a clinical-stage biotechnology firm focused on personalized neuron replacement therapies.

BiotechDeep TechDigital HealthMedical Devices<UNKNOWN>, US

Andrés Bratt-Leal(Co-Founder and Senior Vice President, Research & Development)Damien McDevitt(President and Chief Executive Officer)

Basking Biosciences develops therapeutics for thrombosis, vascular biology, and ischemic disease. The company focuses on stroke and cardiovascular applications.

BiotechDigital HealthHealthtechMedical Devices

Shahid Nimjee(Co-founder, Chief Scientific Officer and Stroke Clinical Lead)Bruce Sullenger(Co-founder)

Cytrellis develops medical device technologies focused on aesthetic and reconstructive treatments, with expertise spanning dermatology, plastic surgery, and wound healing applications.

BiotechHealthtechMedical Devices

Denise Dajles, PhD(President & CEO)Rox Anderson, MD(Founder, Medical / Technology Advisor)William G. Austen, Jr. MD(Founder, Medical / Technology Advisor)Doug Levinson, PhD(Founder)

Lifordi Immunotherapeutics develops treatments for immunology and rare diseases through discovery, clinical development, and commercialization. The company serves patients with immunological disorders and rare genetic conditions.

BiotechDeep TechHealthtech

Arthur O. Tzianabos, Ph.D.(President and CEO)Naina Bhasin, Ph.D.(Chief Business Officer)

Magnet Biomedicine develops TrueGlue™, a molecular glue discovery platform for designing small molecule therapeutics that induce novel protein-protein interactions to treat cancer and immune disorders. The platform systematically identifies molecular glues capable of targeting historically difficult-to-drug proteins in precision medicine.

AI & Machine LearningBiotechMedical Devices

Benjamin F. Cravatt, PhD(Founder & Advisor)David A. Spiegel, MD, PhD(Founder & Advisor)Michael Rosbash, PhD(Founder & Advisor)Richa Saxena, PhD(Founder & Advisor)

Moleculent develops biological discovery and disease understanding tools for scientists. The company focuses on decoding molecular foundations of biology to advance human health diagnostics and research.

AI & Machine LearningBiotechDeep Tech

Fredrik Roos(CTO & Co-founder)

Paradigm Health operates a platform that increases patient access to clinical trials through a provider-facing infrastructure combined with AI-powered research technology. The company serves patients, healthcare providers, researchers, and study sponsors in the clinical research and life sciences industry.

AI & Machine LearningHealthtechMedical DevicesSaaS

Kent Thoelke(Founder and CEO)Jonathan Hirsch(Chief Strategy and Growth Officer)

Pretzel Therapeutics develops therapeutics targeting bioenergetic dysfunction and mitochondrial disease by addressing defects in mitochondrial DNA function and gene expression. The company leverages expertise in mitochondrial biology and drug discovery to create treatments for diseases associated with mitochondrial dysregulation.

BiotechDeep TechHealthtechMedical Devices<UNKNOWN>

Jay Parrish(Chief Executive Officer & Chairman of the Board)Michal Minczuk(Co-Founder)Gabriel Martinez(Chief Scientific Officer & Co-Founder)Claes Gustafsson(Co-Founder)

RhyGaze develops gene therapies using optogenetic proteins to restore sight in patients with vision loss caused by retinal photoreceptor dysfunction. The company combines optogenetic technology with gene therapy delivery methods to enable light detection in degenerative eye conditions.

BiotechDigital HealthMedical DevicesBasel, CH

Botond Roska(Researcher (M.D., Ph.D.))Bence György(IOB Assistant Professor & Head of Clinical Translation)Katherine High(CEO)

Tenvie is a clinical-stage biopharmaceutical company developing small molecule and biologic therapeutics for neurological and peripheral diseases. The company is led by a team with expertise in biotech and precision medicine, targeting treatments for patients and caregivers affected by neurological conditions.

BiotechMedical Devices

Tony Estrada(President & Chief Executive Officer)

Vizgen develops spatial profiling instruments and reagents for high-throughput analysis of gene expression and protein distribution in tissue samples. The company serves research and diagnostic laboratories in the life sciences and precision oncology fields.

AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, US

George Emanuel(Scientific Cofounder, VP & Portfolio Owner, Instruments)Jiang He(Scientific Cofounder, VP & Portfolio Owner, Reagents & Scientific Affairs)

908 Devices manufactures handheld mass spectrometry and chemical analysis devices for rapid detection in defense, security, and hazardous materials response applications. The company serves customs agencies, law enforcement, first responders, and military organizations requiring real-time chemical identification for explosives, toxic substances, and illicit drugs.

Deep TechDefense TechHardwareMedical DevicesBoston, US

Kevin J. Knopp, PhD(CEO & Co-founder)

Agios is a biopharmaceutical company developing therapies for rare diseases, with a primary focus on hemolytic anemias including pyruvate kinase deficiency, thalassemia, and sickle cell disease. The company's approach is grounded in cellular metabolism research and involves close collaboration with patients and clinical partners.

BiotechHealthtechMedical Devices<UNKNOWN>

Agrivida develops enzyme technology for animal feed and nutrition, improving efficiency in poultry, swine, and other livestock production. The company applies biochemical research to create solutions that enhance sustainable food production.

AgTechBiotechFoodTechMassachusetts, US

Scientists from MIT

RNA editing technology harnessing endogenous enzymes to prevent off-target edits.

Akamis Bio develops oncolytic immunotherapies for colorectal cancer treatment, aiming to offer alternatives to surgery that preserve patient function and quality of life. The company serves patients and clinicians in the oncology market.

BiotechDigital HealthHealthtechMedical Devices

Aledade is an accountable care organization (ACO) partner that works with primary care organizations to improve patient outcomes and healthcare quality. The company operates as a public benefit corporation focused on supporting member primary care organizations and their patients.

Enterprise SoftwareHealthtech<UNKNOWN>

Bijan Salehizadeh(Co-founder)

Alnylam is a biopharmaceutical company that supports investigator-initiated studies in therapeutic areas including transthyretin-mediated amyloidosis, acute hepatic porphyria, and primary hyperoxaluria for medical researchers and healthcare professionals.

BiotechDigital HealthMedical Devices

Altos Labs develops computational and scientific approaches to reverse disease through breakthrough medicines, operating research institutes focused on cell health, computation, and drug discovery.

BiotechDeep TechLongevityBay Area, US

Richard Murray(CEO and Founder)Shinya Yamanaka(Chief Scientific Advisor and Founder)

Areteia Therapeutics was a clinical-stage biotechnology company that is no longer operating.

BiotechChapel Hill, US

Arsenal Biosciences is a clinical-stage company developing programmable cell therapies to treat solid tumors. The company uses computational and engineering approaches to create cancer medicines.

BiotechHealthtechMedical Devices

Beam Therapeutics develops gene-editing medicines, particularly base editors and precision genome editing technologies, to create lifelong cures for patients with serious genetic diseases. The company works across multiple therapeutic areas to advance precision medicine treatments at the molecular level.

BiotechDeep TechMedical DevicesCambridge, US

John Evans(CEO)David R. Liu(Founder and Inventor)J. Keith Joung(Founder and Inventor)Feng Zhang(Founder and Inventor)

bit.bio is a synthetic biology company that engineers human induced pluripotent stem cells into defined cell types for research, drug discovery, and cell therapy applications. The company markets cells and disease models through its ioCells brand for use in biomedical research and therapeutic development.

BiotechDeep TechHealthtechMedical Devices

Dr Mark Kotter(Founder)Przemek Obloj(CEO)

Genetix Biotherapeutics (formerly bluebird bio) develops gene therapies for patients with rare genetic diseases including sickle cell disease, beta-thalassemia, and cerebral adrenoleukodystrophy. The therapies use modified blood stem cells to restore function of affected genes and offer potential cures rather than symptom management.

BiotechLongevityMedical Devices

David Meek(Chief Executive Officer)Brian Riley(President & Chief Technical Officer)Joanne Lager(Chief Medical Officer)Wendy DiCicco(Chief Financial Officer)

Boundless Bio develops precision oncology medicines targeting ecDNA-amplified cancers, specifically creating a new category of ecDNA-directed therapies for patients with oncogenic alterations.

BiotechMedical Devices

City Therapeutics develops RNAi-based medicines targeting rare, specialty, and prevalent diseases using engineered trigger molecules and precision delivery ligands. The company aims to expand RNAi therapeutics beyond liver targeting to additional cell and tissue types.

BiotechMedical DevicesCambridge, US

Mark Keating, MD(Co-founder)Kotaro Nakanishi, PhD(Co-founder)Yukihide Tomari, PhD(Co-founder)Phillip Zamore, PhD(Co-founder)

deCODE analyzes and interprets the human genome to identify genetic risk factors for common diseases including cardiovascular disease and cancer. The company serves pharmaceutical and research organizations through genomic discovery and analysis.

AI & Machine LearningBiotechDeep TechReykjavik, IS

Denali Therapeutics develops therapeutics for neurodegenerative diseases. The company focuses on discovering and developing novel drug candidates targeting specific neurological conditions.

BiotechHealthtechMedical DevicesSan Francisco, US

Dispatch Bio develops a universal immunotherapy treatment for solid tumors, combining engineered immunotherapy with a tumor-specific virus to improve cancer treatment outcomes.

BiotechDeep TechMedical Devices

Sabah Oney(Chief Executive Officer)Lex Johnson(Co-Founder and Chief Platform Officer)Ray Liu(Co-founder and Head of Synthetic Biology)

Elephas develops elive, a live-tissue platform technology that predicts immunotherapy response in cancer patients by measuring real-time immune activity in intact tumor tissue. The company serves oncologists and patients to enable personalized cancer treatment selection.

BiotechDigital HealthHealthtechMedical Devices

Encoded develops gene therapies for neurological disorders through an integrated platform approach. The company focuses on translating discoveries from research through clinical development and commercialization.

Biotech

Countable Labs (formerly Enumerix) develops a digital PCR platform that performs genetic analysis with higher sensitivity, precision, and dynamic range than legacy PCR methods. The technology serves oncology, NIPT (non-invasive prenatal testing), infectious disease, and cell and gene therapy applications.

AI & Machine LearningBiotechDeep TechMedical Devices

Erasca is a clinical-stage oncology company developing therapies targeting RAS- and MAPK pathway-driven cancers using a modality-agnostic approach including small molecules, large molecules, and protein degraders.

BiotechDeep TechDigital HealthMedical DevicesSan Diego, US

Gate Bioscience develops small molecule therapeutics called Molecular Gates for disease treatment. The company operates in the drug discovery and development space.

BiotechDeep TechMedical Devices

Jordi Mata-Fink(Chief Executive Officer, Co-Founder)Raman Talwar(Chief Technology Officer, Co-Founder)Pat Sharp(Scientific Founder)

Gossamer Bio is a clinical-stage biopharmaceutical company developing seralutinib, an investigational drug candidate for treating pulmonary arterial hypertension and pulmonary hypertension associated with interstitial lung disease.

BiotechDigital HealthMedical Devices

GRAIL develops a blood-based multi-cancer early detection test called Galleri that uses next-generation sequencing and machine learning to screen for multiple cancer types before symptoms appear. The company serves healthcare providers, insurers, and patients seeking early cancer detection.

BiotechDigital HealthHealthtechMedical DevicesMenlo Park, US

UNKNOWN

Carrick Therapeutics is a biopharmaceutical company with a leadership team experienced in oncology drug development and commercialization. The company focuses on developing and advancing cancer treatments through clinical development and business development activities.

BiotechDigital HealthHealthtechMedical Devices

Timothy Pearson(CEO)Ash Bahl(CSO)Jenny Horsfield(CBO)Stuart McIntosh(CMO)

HiberCell develops therapeutic candidates targeting the Integrated Stress Response pathway to address treatment-resistant cancers, relapse, and metastasis. The company focuses on cancer patients who have experienced treatment resistance through novel drug development approaches.

BiotechMedical Devices

Julio Aguirre-Ghiso, Ph.D.(Co-Founder)

Homeward provides cash offers for home purchases, allowing buyers to make competitive offers without financing contingencies while enabling real estate agents to maintain full commissions. The service operates in the residential real estate market, primarily serving buyers and agents in the United States.

FintechPropTechAustin, US