Frazier Life Sciences
Crossover fundActively deployingPalo Alto · Seed–Late Stage · 72 people tracked
Also known as FRAZIER LIFE SCIENCES MANAGEMENT, LP
Investment thesis
Frazier Life Sciences is a longstanding biotech-focused investment firm that invests across both venture and public market strategies to support innovation at every stage of company development. Since 2015 it has leveraged an in-house team and infrastructure to back companies developing novel therapeutics, with portfolio activity spanning oncology, orphan diseases, and other major therapeutic areas. The firm emphasizes deep partnership with entrepreneurs and management teams, drawing on seasoned investing experience and a collaborative approach to help build integrated biotechnology companies.
Source: firm website, verified Aug 11, 2026.
Team · 72 people
from the firm's website & public directoriesWhat they invest in
from 80 of 166 portfolio companiesBiotech ×73Healthtech ×34Medical Devices ×26Digital Health ×9Deep Tech ×6AI & Machine Learning ×2EdTech ×1Fintech ×1
HQs:United States×61
Investments · 166 tracked
founders shown can be your intro pathBy year:2025 · 12024 · 12023 · 32022 · 22021 · 42020 · 52019 · 22018 · 42017 · 42016 · 52015 · 102014 · 142 dated
AnaptysBio manages the financial collaborations from Jemperli (with GSK) and imsidolimab (with Vanda), operating a virtual model focused on protecting and returning royalty and milestone value to stockholders.
BiotechSan Diego, US
Robert Hoffman(Executive Officer)Carol Gallagher(Director)Marco Londei(Executive Officer)John Schmid(Director)Nicholas Lydon(Director)Hamza Suria(Executive Officer, Director)
Board seatJames N. Topper· per SEC Form D
BiotechWestlake Village, US
Alexander Asam(Director)Ricky Sun(Director)Jonathan Silverstein(Director)Todd Franklin Watanabe(Executive Officer, Director)
Board seatPatrick HeronDaniel Estes· per SEC Form D · $94.5M raise · filed Oct 2019
BiotechCanton, US
Gino Santini(Director)Eran Nadav(Director)John Freund(Director)Garen Bohlin(Director)David Hirsch(Director)Michael Heffernan(Executive Officer, Director)
Board seatPatrick Heron· per SEC Form D
BiotechCarmel, US
Timothy Knickerbocker(Executive Officer, Director)Richard DiMarchi(Executive Officer, Director)Peter Kent Hawryluk(Executive Officer, Director)
Board seatPatrick Heron· per SEC Form D · $115.2M raise · filed Nov 2022
Rare liver disease treatment company.
San Diego, US
Board seatPatrick HeronPatrick J. HeronPatrick Heron· per SEC Form D · $68.5M raise · filed Jan 2026
Passage Bio is a company focused on developing treatments for central nervous system (CNS) diseases, with an emphasis on neurodegenerative conditions.
BiotechHealthtechPhiladelphia, US
Carl Gordon(Director)Tadataka Yamada(Executive Officer, Director, Promoter)Saqib Islam(Director)Thomas Street Address 1 Woiwode(Director)Stephen Squinto(Executive Officer, Director)
Board seatPatrick Heron· per SEC Form D
BiotechSouth San Francisco, US
Tracy Saxton(Director)Grant E Pickering(Executive Officer, Director, Promoter)Jeff Fairman(Executive Officer)Ashish Khanna(Executive Officer)William Newell(Director)Patrick Enright(Director)
Board seatPatrick Heron· per SEC Form D · $110M raise · filed Apr 2020
Erasca is a clinical-stage oncology company developing therapies targeting RAS- and MAPK pathway-driven cancers using a modality-agnostic approach including small molecules, large molecules, and protein degraders.
BiotechDeep TechDigital HealthMedical DevicesSan Diego, US
Pratik S. Multani, M.D.(Director)Valerie Harding-Start(Director)Jonathan E. Lim, M.D.(President and Executive Chairman)Gary Yeung, CFA(Chief Business Officer)Alexander W. Casdin(Director)James A. Bristol, Ph.D.(Director)
Maze Therapeutics develops precision medicines for kidney disease and other conditions with large unmet medical needs, using a genetic variant-based approach through its Compass platform.
BiotechMedical Devices
Helicons develops a peptide-based therapeutic platform designed to target intracellular proteins previously considered undruggable by combining the specificity of antibodies with the cell-penetrating properties of small molecules.
AI & Machine LearningBiotechDeep TechMedical Devices
Mathai Mammen(CEO, President and Chairman)
BiotechPalo Alto, US
Henry Ji(Executive Officer, Director)Stephen Ma(Executive Officer, Director)Jaisim Shah(Executive Officer, Director)David Lemus(Director)
BoardYue Alexander Wu(Director)Jay Chun(Director)
Trevi Therapeutics is a clinical-stage biopharmaceutical company developing Haduvio (oral nalbuphine ER), an investigational therapy for chronic cough that targets the central and peripheral cough reflex arc.
BiotechHealthtechNew Haven, US
Edward Mathers(Director)Michael Heffernan(Director)Lisa Delfini(Executive Officer)James Cassella(Director)Dominick Colangelo(Director)Jennifer L. Good(Executive Officer, Director)
Vaxcyte develops broad-spectrum vaccines to prevent bacterial infections, using a cell-free protein synthesis platform and synthetic chemistry techniques.
BiotechHealthtech
Enlaza Therapeutics develops covalent protein therapeutics using its War-Lock technology, which incorporates proprietary unnatural amino acids into protein drugs so they form irreversible covalent bonds with disease-related targets.
BiotechDeep TechSan Diego, US
Sergio Duron(Co-Founder & Chief Executive Officer)Sanford Madigan(Co-Founder, President & Chief Business Officer)Analeah Heidt(Chief Scientific Officer)
Board seatJames Topper· per SEC Form D
Eyconis is a clinical-stage biotechnology company developing long-acting ophthalmic therapies for serious eye diseases such as wet age-related macular degeneration and diabetic macular edema using the TransCon technology platform.
BiotechDigital HealthMedical DevicesRedwood City, US
Emmett Cunningham(Executive Officer, Director)Mark Bachleda(Executive Officer, Director)Robert Vitti(Executive Officer)Oliver Stauch(Executive Officer)Oliver Boris Stauch(Executive Officer)Conrad Wang(Director)
Alcresta Therapeutics develops enzyme-based therapeutic products to address nutritional care for enterally fed patients living with rare diseases.
BiotechHealthtechMedical DevicesMassachusetts, US
Daniel Orlando(Chief Executive Officer)Jeremy Lack(Director)Stephen Krauss(Director)Tasos Konidaris(Executive Officer)James Topper(Director)Steve Dubin(Director)
Board seatJames N. Topper· per SEC Form D
BiotechWaltham, US
Chris Pacheco(Director)Carlos Loya(Executive Officer, Director)
Board seatLauren Mifflin· per SEC Form D · $1.2M raise · filed Mar 2022
BiotechNewton, US
Axel Bolte(Director)James Topper(Director)Alexey Margolin(Executive Officer, Director)Gino Santini(Director)Louis Brenner(Executive Officer)Stephen Kraus(Director)
Board seatJames N. Topper· per SEC Form D · $53M raise · filed Dec 2015
South San Francisco, US
Board seatJames TopperJames W. Brush· per SEC Form D
BiotechEvanston, US
Joseph R. Moskal(Chief Scientific Officer)Torsten M. Madsen(Chief Marketing Officer)Liam Ratcliffe(Director)Ashish Khanna(Secretary & Chief Business Officer)Terry P. Gould(Director)Wilbur H. Gantz III(Director)
Board seatJames N. Topper· per SEC Form D
BiotechAnn Arbor, US
Carol Gallagher(Director)Randall Whitcomb(Director)James Topper(Director)Julia C. Owens(Executive Officer, Director)William Harrington(Director)
Board seatJames N. Topper· per SEC Form D · $59.1M raise · filed Dec 2017
HealthtechPhoenix, US
ARASH ARAGHI(Executive Officer, Director)DAVID JACOFSKY(Executive Officer, Director)PETER SLATE(Executive Officer)JOHN BROWN(Director)WARREN COHEN(Director)BRYAN WALL(Executive Officer, Director)
Board seatNathan Every· per SEC Form D · $14M raise · filed Dec 2016
BiotechCleveland, US
Kevin Lalande(Director)Howard Dittrich(Executive Officer)Robert Baltera, Jr.(Executive Officer, Director)Jerel Davis(Director)James Topper(Director)
Board seatJames N. Topper· per SEC Form D · $31.9M raise · filed Feb 2015
Pharmaceutical company developing medicines and vaccines for patient health and treatment.
BiotechHealthtechSan Diego, US
Jeffrey Stein(Executive Officer, Director)Steve Elms(Director)Dan Burgess(Director)Ted Schroeder(Director)Kevin Forrest(Executive Officer)Dirk Thye(Executive Officer)
Board seatPatrick Heron· per SEC Form D
HealthtechLong Beach, US
Keith Arnold(Executive Officer)Richard Whitney(Director)DAVID KOSLOFF(Director)Rob Mahan(Executive Officer)Jim Adams(Executive Officer)Vera Appleyard(Executive Officer)
Board seatNader Naini· per SEC Form D · $14.4M raise · filed Nov 2015
HealthtechSan Carlos, US
Alan Sachs(Director)Laura G. Eichorn(Executive Officer)Dennis Henner(Director)Hugh Y. Rienhoff(Executive Officer, Director)
Board seatPatrick HeronPatrick Heron· per SEC Form D · $80M raise · filed Nov 2020
Iterum Therapeutics develops anti-infective compounds to treat infections caused by multi-drug resistant pathogens.
BiotechDigital HealthHealthtechMedical DevicesDublin, US
Brenton K. Ahrens(Director)Michael W. Dunne(Executive Officer, Promoter)Ronald M. Hunt(Director)Mark Chin(Director)Corey N. Fishman(Executive Officer, Director, Promoter)Robert Hopfner(Director)
Board seatPatrick J. Heron· per SEC Form D · $2.8M raise · filed Jul 2020
BiotechHamilton
Brenton K. Ahrens(Director)James I. Healy(Director)Mark Chin(Director)Patrick J. Heron(Director)Ronald M. Hunt(Director)Shahzad Malik(Director)
Board seatPatrick Heron· per SEC Form D · $51.6M raise · filed Jan 2020
BiotechKing Of Prussia, US
James Topper(Director)Colin Goddard(Director)Markus Goebel(Director)Brian MacDonald(Executive Officer, Director)Remy Sukhija(Executive Officer)Jeffrey Bird(Director)
Board seatJames N. Topper· per SEC Form D · $17.1M raise · filed Apr 2016
Bellevue, US
Kelly Allison(Executive Officer)Scott Svenson(Executive Officer, Director, Promoter)
Board seatNader Naini· per SEC Form D · $35M raise · filed Mar 2016
Menlo Park, US
Yigong Ge(Director)Chen Yu(Director)Brent Ahrens(Director)David Socks(Executive Officer, Director, Promoter)
Board seatPatrick Heron· per SEC Form D · $21.3M raise · filed Jun 2015
Seattle, US
Hendrik Struik(Executive Officer, Director, Promoter)George Willett(Executive Officer, Promoter)Nader Naini(Director, Promoter)Kenneth Hanover(Director, Promoter)Joe Whitters(Director, Promoter)Ben Magnano(Director, Promoter)
Board seatNader Naini· per SEC Form D · $32.3M raise · filed Jul 2017
Belmont, US
Board seatNathan Every· per SEC Form D · $46M raise · filed Jul 2016
South San Francisco, US
Board seatMaria Fardis· per SEC Form D · $89.1M raise · filed Jun 2026
Seattle, US
Gregory R Roer(Executive Officer, Director)
Board seatNader Naini· per SEC Form D · $53M raise · filed Oct 2018
BiotechMenlo Park, US
Yigong Ge(Executive Officer, Director)Michael Savino(Executive Officer)David Socks(Director)
Board seatPatrick Heron· per SEC Form D · $10.7M raise · filed Jul 2018
Early-stage company from the Archer Seed Fund that received follow-on funding in outside-led rounds.
Philadelphia, US
Mark Hefferman(Executive Officer, Director)Tadataka Yamada(Director)Nancy Hong(Director)
BoardCindy Cole(Director)
Board seatPatrick HeronAditya Kohli· per SEC Form D
Seraxis is a regenerative medicine company developing a replacement cell therapy for insulin-dependent (Type 1) diabetes, using engineered islet cells to replace those missing in patients.
BiotechHealthtechGermantown, US
Gi-Hyeok Yang(Director)Carole Welsch(Executive Officer)William L. Rust(Executive Officer, Director, Promoter)Roy Arup(Director)Bernie Treidl(Director)
Board seatJames N. Topper· per SEC Form D · $40M raise · filed Feb 2021
BiotechSan Diego, US
Cam Garner(Treasurer)Theodore R. Schroeder(President and Chief Executive Officer)Cam Gallagher(Secretary)
Board seatPatrick Heron· per SEC Form D · $45.7M raise · filed Apr 2016
BiotechGreenwood Village, US
Frank Segrave(President)Michael Beckloff(Chief Development Officer)Robert Mauro(Chief Operating Officer)Bhaskar Chaundhuri(Director)Nathan Every(Director)Barry Barnard(Chief Financial Officer)
Board seatPatrick HeronNathan Every· per SEC Form D · $4.6M raise · filed Oct 2015
Vernon Hills, US
Robin Selati(Director)Barry Allen(Director)Jonathan Stevens(Executive Officer)Donna Zarcone(Director)Thomas Richards(Executive Officer, Director)Christine Leahy(Executive Officer)
Adverum is a clinical-stage gene therapy company developing Ixo-vec, an investigational single-administration intravitreal treatment for wet age-related macular degeneration and other ocular diseases, based on a proprietary adeno-associated virus (AAV) vector platform.
BiotechDeep TechHealthtech
BiotechRedwood City, US
C. David Nicholson(Director)Linda Rubinstein(Executive Officer)Rabia Gurses Ozden(Director)Setareh Seyedkazemi(Executive Officer)Kishor Peter Soparkar(Executive Officer)Soo Hong(Director)
PartnerDaniel Estes· led
PartnerJames N. Topper· led
Alpha-9 is a clinical-stage radiopharmaceutical company developing a portfolio of targeted molecules to treat cancer cells with precision.
BiotechLongevityMedical Devices
BiotechSeattle, US
Dr. Mitchell H Gold(Executive Officer, Director)Michael Kornacker(Executive Officer, Director)Ryan Swanson(Executive Officer, Director)David Miller(Executive Officer, Director)Jay Venkatesan(Director)James Paul Rickey(Senior Vice President and Chief Financial Officer)
PartnerJames N. Topper· led
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 20
IPOs and acquisitions across the tracked portfolioAnaptysBioNASDAQ: ANABArcutis BiotherapeuticsNASDAQ: ARQTCollegium PharmaceuticalNASDAQ: COLLMBX BiosciencesNASDAQ: MBXMirum PharmaceuticalsNASDAQ: MIRMPassage BioNASDAQ: PASGSutroVaxNASDAQ: PCVXBridgeBio PharmaNASDAQ: BBIODisc MedicineNASDAQ: IRONErascaNASDAQ: ERASMaze TherapeuticsNASDAQ: MAZEPalvella TherapeuticsNASDAQ: PVLAParabilis MedicinesNASDAQ: PBLSScilex HoldingNASDAQ: SCLXTarsus PharmaceuticalsNASDAQ: TARSTrevi TherapeuticsNASDAQ: TRVIVaxcyteNASDAQ: PCVXLumena Pharmaceuticalsacq. by ShireReata Pharmaceuticalsacq. by BiogenTubulis GmbHacq. by Gilead Sciences
Portfolio news
latest coverage across their companiesSidewinderbio · techcrunch.com · Jul 30, 2026
Attovia Therapeutics · medicaldialogues.in · Jul 19, 2026
Braveheart · fb101.com · Jul 19, 2026
Erasca · simplywall.st · Jul 19, 2026
Maze Therapeutics · simplywall.st · Jul 17, 2026
Calliotx · funderintel.com · Jul 16, 2026
Parabilis Medicines · pharmexec.com · Jun 19, 2026
Aspen Neuroscience · longevity.technology · Nov 24, 2025
Public market activity · per SEC filings
what is this? ⓘDisclosed stake · filed Dec 2024
9 insider ownership filings (Forms 3/4/5)
at MBX Biosciences, Inc. (MBX), HilleVax, Inc. (HLVX)
From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.
Frequently asked questions
- What stage does Frazier Life Sciences invest at?
- Frazier Life Sciences invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does Frazier Life Sciences focus on?
- Frazier Life Sciences focuses on Biotech.
- Where is Frazier Life Sciences located?
- Frazier Life Sciences is headquartered in Palo Alto, US.
- Does Frazier Life Sciences lead rounds?
- Yes, Frazier Life Sciences leads investment rounds.
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