S32
Actively deployingPalo Alto Β· Series AβLate Stage Β· 15 people tracked
Investment thesis
S32 operates as a high-conviction venture firm that deliberately limits its portfolio to enable deep engagement with founders. The firm combines experienced investors and operators with execution expertise in critical functional areas including engineering, AI, and go-to-market strategy. By maintaining capital constraints and selective deal-making, S32 aims to provide concentrated support and sustained backing for companies building in artificial intelligence, computational biology, physical AI, infrastructure, cybersecurity, and enterprise sectors.
Source: firm website, verified Jul 20, 2026.
Team Β· 15 people
from the firm's website
Founder and former CEO and Executive Chairman of Verily, Alphabet's healthcare company. With three decades of experience at the intersection of biology, data, and AI, he has held roles across DeepMind, Google Cloud, and Google AI, and previously served as Chief Scientific Officer of LabCorp after co-founding the National Genetics Institute.
CEO and General Partner of S32 with prior executive roles at Alphabet's X and Verily, where he led business development and helped spin out SandboxAQ and Intrinsic. A two-time founder before joining Google with one acquisition and one ongoing venture, he is recognized as a voice on AI in major business publications.
Founder and former CEO of Google Ventures who built the firm into a top-performing corporate venture fund and led private investing for Alphabet. He incubated Waymo, Verily, and Google X, and founded Calico. His portfolio includes partnerships with founders at Uber, Nest, Coinbase, and Crowdstrike, totaling over 500 investments with 30+ IPOs.
Former CEO of Foundation Medicine, which transformed cancer evaluation through genomic analysis and was acquired by Roche. He brings three decades of experience in personalized medicine and previously held leadership roles including President and COO at Clarient, which was acquired by GE Healthcare.
Leads talent strategy at S32 and advises portfolio companies on staffing. She spent a decade at Alphabet as Google's top-producing recruiter, building engineering teams for Waymo, Loon, Glass, Wing, and Verily. She also held principal recruiter roles at Playground Global and Head of Staffing at Essential, resulting in over 1,700 hires throughout her career.
Focused on enterprise software, AI, and deep tech investments. Previously an investor at Norwest Venture Partners where he led investments across applied AI and infrastructure while serving on portfolio boards. He worked as an investment banker at Morgan Stanley on high-profile IPOs including Rivian, Nubank, and HashiCorp.
Focused on enterprise software, AI, and data infrastructure with prior investment experience at CapitalG, Alphabet's late-stage venture arm, working with companies including Stripe, UiPath, Duolingo, and Webflow. He previously advised on capital raises, IPOs, and M&A at Morgan Stanley on transactions involving Slack and ZoomInfo.
Two-time founder with over 20 years leading product and growth initiatives who currently leads AI product work at Airtable. He previously drove Android's product strategy, led Google Maps marketing across EMEA, and was a founding member of Uber Eats, scaling it from zero to over $200 million in annual revenue.
Works with portfolio companies on talent strategy and pipeline development. She started her career at a staffing firm specializing in engineering and design placements and most recently led hiring efforts at Essential across engineering and administrative functions.
Focused on the firm's technology investing with prior experience as an investor at In-Q-Tel, the CIA's venture arm, leading investments across cybersecurity, AI and machine learning, enterprise software, and fintech. He previously scaled partner ecosystems at Google Express and invested with Singapore's GIC.
What they invest in
from 31 of 34 portfolio companiesAI & Machine Learning Γ19Enterprise Software Γ14SaaS Γ8Deep Tech Γ7Biotech Γ6Developer Tools Γ6Cloud Computing Γ4Fintech Γ4
HQs:United StatesΓ16CanadaΓ1GermanyΓ1SwedenΓ1
Investments Β· 34 tracked
founders shown can be your intro pathhumans& is a frontier AI lab focused on building human-centric AI systems that prioritize people and their relationships, emphasizing innovations in reinforcement learning, memory, and user understanding to create AI that strengthens organizations and communities.
AI & Machine LearningEnterprise SoftwareSaaS
Eric Zelikman(Co-founder)
NewLimit develops epigenetic reprogramming medicines to extend healthspan and treat age-related diseases at the intersection of computer science and biotechnology. The company builds therapeutic programs that aim to engineer cell identity and reprogram cell age for human patients.
AI & Machine LearningBiotechLongevity
Jacob(Co-founder, Head of Research, President, and CEO)Brian Armstrong(Co-founder, Board of Directors)
8090 is an AI-native software development platform designed for regulated enterprises in healthcare, financial services, manufacturing, and government that enables teams to build production code from business intent with full audit trails and governance controls.
AI & Machine LearningDeveloper ToolsEnterprise Software
Chamath Palihapitiya(Co-founder and CEO)
Aspen Neuroscience develops iPSC-derived autologous cell therapies for neurological diseases, with a lead product (ANPD001) in Phase 1/2a clinical trials for Parkinson's disease. The company is a clinical-stage biotechnology firm focused on personalized neuron replacement therapies.
BiotechDeep TechDigital HealthMedical Devices<UNKNOWN>, US
AndrΓ©s Bratt-Leal(Co-Founder and Senior Vice President, Research & Development)Damien McDevitt(President and Chief Executive Officer)
AI research lab developing visual intelligence technology including image generation and manipulation models. The company builds foundational infrastructure for visual AI applications used by artists and enterprises.
AI & Machine LearningDeep TechDeveloper ToolsFreiburg, DE
Brightside provides remote mental health care combining personalized psychiatry and therapy through a technology-enabled platform. The service uses data-driven analysis of 100+ personal data points to deliver precision treatment and tracks patient progress through video sessions, messaging, and regular check-ins.
Digital HealthHealthtechMental Health
Chief Medical Officer & Founder
Brightside provides financial wellness services to employees through human Financial Assistants who address personal financial needs including emergency loans, budgeting, credit, and retirement planning. The company serves employers seeking to improve employee financial health and reduce costs associated with financial stress.
Enterprise SoftwareFintechHR TechWellness & Fitness
Shawn Leavitt(Founder)
Endor Labs provides application security tooling to identify, prioritize, and fix vulnerabilities in software development, with particular focus on securing AI-generated code and open-source dependencies.
AI & Machine LearningCybersecurityDeveloper ToolsPalo Alto, US
Varun Badhwar(Founder & Co-founder)Dimitri Stiliadis(Founder & Co-founder)
Cohere builds foundational AI models and enterprise solutions that help businesses automate tasks, accelerate workflows, and enhance decision-making. The company serves enterprise teams seeking to scale productivity and innovation through agentic AI capabilities.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareSaaSToronto, CA
Aidan Gomez(Co-founder and CEO)Ivan Zhang(Co-founder)Nick Frosst(Co-founder)
Coinbase is a cryptocurrency exchange platform that offers trading, custody, and financial services for cryptocurrencies, stocks, derivatives, and prediction markets to consumers, institutions, and developers. The company operates a full-stack infrastructure including secure custody, liquidity services, stablecoin infrastructure, and global settlement rails.
Crypto & Web3FintechLos Angeles, US
Brian Armstrong(Founder/CEO)in
Culture Biosciences provides software and bioreactor hardware solutions for bioprocess development, enabling researchers to design, monitor, and analyze experiments remotely with cloud-native analytics and AI/ML insights.
AI & Machine LearningBiotechCloud ComputingHealthtechSan Francisco, US
Databricks provides a unified platform for data engineering, analytics, and artificial intelligence, enabling organizations to build and deploy data and AI applications on cloud infrastructure.
AI & Machine LearningCloud ComputingData & InfrastructureEnterprise SoftwareSan Francisco, US
Original creators of Apache Spark, Delta Lake, MLflow and Unity Catalog<UNKNOWN>
Deel is a global HR platform that enables businesses to hire, onboard, and manage employees and contractors across borders. The platform handles payroll, compliance, and HR administration for companies managing international workforces.
Enterprise SoftwareFintechFuture of WorkHR TechSaaSSan Francisco, US
Alex Bouaziz(CEO & Co-Founder)inShuo Wang(CRO & Co-Founder)in
EMA is an enterprise platform for building and scaling AI-powered workflows that automatically selects the best combination of models for each task to optimize accuracy, cost, and latency. The platform serves enterprise customers needing to deploy multiple AI workflows across their organization.
AI & Machine LearningEnterprise SoftwareSaaS
CrowdStrike provides cloud-native security software protecting endpoints, cloud workloads, identity systems, and data infrastructure to prevent breaches for enterprise customers.
Cloud ComputingCybersecurityEnterprise Software
Gusto provides payroll processing, employee benefits administration, and HR management tools to businesses, offering integrated software alongside support services for these functions.
Enterprise SoftwareHR TechSan Francisco, US
Josh Reeves(Founder/CEO)inEdward Kim(Founder/Empowering Gusto's Engineering Team)inTomer London(Founder/; Empowering Gusto's Product and Design Teams)in
Inceptive builds foundation models of biological systems for drug discovery, specializing in sequence-based medicines like mRNA and peptides. The company combines deep learning trained on heterogeneous life data with in-house wet lab validation to design novel drug candidates that outperform existing options.
AI & Machine LearningBiotechMedical DevicesPalo Alto, US
<UNKNOWN>
Inductive Bio builds AI and machine learning software to accelerate drug discovery for pharmaceutical and biotech researchers, combining computational chemistry with expertise in translating complex drug programs from preclinical to clinical stages.
AI & Machine LearningBiotechDeep Tech
Josh HaimsoninBen Birnbaum(Ph.D.)inAlexander Taylor(Ph.D.)in
Infleqtion designs and manufactures neutral atom quantum computers, quantum sensors, and software for governments, corporations, and research institutions. The company focuses on quantum computing systems with error correction capabilities and precision sensing products for defense, infrastructure security, and geospatial applications.
Deep TechDefense TechQuantum Computing
Legora builds AI-powered collaboration software for lawyers to automate routine tasks and improve efficiency in legal work. The platform enables lawyers and clients to jointly review, draft, and deliver legal projects.
AI & Machine LearningEnterprise SoftwareLegalTechStockholm, SE
Google Nest manufactures smart home devices including cameras, doorbells, speakers, and thermostats that integrate with Google Home for security, entertainment, and energy management. The products are designed for residential homeowners seeking connected home automation and monitoring capabilities.
ConsumerHardwareIoTMountain View, US
Uber operates a multi-sided platform providing ride-sharing, food delivery, freight logistics, and business fleet management services across various global markets.
Logistics & Supply ChainMarketplacesMobility & TransportationSan Francisco, US
Travis Kalanick(Co-founder & CEO)Garrett Camp(Co-founder)
Ohalo develops agricultural products designed to improve farmer productivity and livelihoods globally. The company focuses on solving farming challenges through innovation.
AgTechBiotech
Phaidra develops an AI control platform that uses reinforcement learning to optimize energy efficiency and operational performance in data centers and AI factories. The platform enables autonomous, self-learning systems to manage complex interconnected infrastructure like cooling systems, power management, and workload distribution.
AI & Machine LearningCloud ComputingDeep TechEnergy
Jim Gao(Chief Executive Officer)Veda Panneershelvam(Chief Technology Officer)Katie Hoffman(President and Chief Operating Officer)
Physical Intelligence develops generalist AI models for robotics that can control any robot to perform various tasks through learning algorithms and multi-robot training. The company is building foundation models for general-purpose physical intelligence to enable widespread robotics applications across different industries.
AI & Machine LearningDeep TechRobotics
Puzzle builds a modern accounting system for startups and small-to-medium businesses, delivering real-time financial intelligence by reconstructing core ledger and data infrastructure. The platform replaces legacy accounting software with AI-era capabilities designed to make financial data trustworthy and actionable.
AI & Machine LearningFintechSaaS
Sasha OrloffJohn Cwikla
SandboxAQ combines artificial intelligence and quantum technology to address complex industrial challenges. The company was spun out from Alphabet in 2022.
AI & Machine LearningDeep TechQuantum Computing
Scale provides high-quality training data, model evaluations, and full-stack AI systems for enterprises and governments to build and deploy AI applications. The company supplies data annotation, RLHF, benchmarking, and red-teaming services for machine learning models.
AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US
Alexandr Wang(Founder/CEO)in
Slack is an AI-powered communication platform that consolidates conversations, applications, and customer interactions in a single workspace for businesses. The platform serves organizations of all sizes across 150+ countries and integrates with 2,500+ apps to automate workflows and enhance workplace productivity.
Enterprise SoftwareFuture of WorkSaaSSan Francisco, US
Sola develops process automation software that uses bots to handle repetitive tasks, allowing teams to focus on higher-value work. The platform serves enterprise teams seeking to automate workflows and improve operational efficiency.
AI & Machine LearningEnterprise SoftwareSaaS
JessicaNeil
Sola develops process automation software that uses AI and bots to handle repetitive tasks for enterprise teams. The platform enables organizations to automate workflows and reclaim employee time for higher-value work.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareSaaSNew York City, US
Board seats Β· per SEC filings Β· 2
what is this? β$8.7M raise Β· filed Feb 2025 Β· via Andrew Conrad, Mike Pellini
$25.7M raise Β· filed Jun 2023 Β· via Mike Pellini
Inferred from directors named on each company's SEC Form D β public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does S32 invest at?
- S32 invests at the Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does S32 focus on?
- S32 focuses on AI & Machine Learning, Biotech, Cybersecurity, Enterprise Software, Robotics.
- Where is S32 located?
- S32 is headquartered in Palo Alto, US.
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