🦊/Investors

RiverVest Venture Partners

Venture capital

St. Louis · Pre-Seed–Late Stage · 22 people tracked

Also known as RiverVest Venture · RIVERVEST VENTURE MANAGEMENT LLC

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Investment thesis

RiverVest focuses on building life sciences companies, aiming to improve patient outcomes by backing innovation in biotechnology, pharmaceuticals, and medical technology. The firm supports entrepreneurs through a combination of scientific insight, strategic guidance, and operational involvement, and seeks to earn the trust of its investors. Its portfolio spans therapeutics areas such as neurodegenerative disease, rare liver diseases, and metabolic conditions like difficult-to-control type 2 diabetes, reflecting a deep-science approach to venture creation.

Source: firm website, verified Sep 15, 2026.

Stage
Pre-Seed–Late Stage
Check
$500K – $3M
HQ
St. Louis, Missouri, US
Leads rounds
Leads
Instruments
Equity
Founded
2000
Last 12 months
1 investment
AUM
$275M
VC funds
5
Tracked investments
76
IPOs
6
Acquisitions
18

Team · 22 people

from the firm's website & public directories
Alessandro Sette· Scientific Advisor; Professor and Member, La Jolla Institute for Immunology
Corrin Short· Executive Assistant
Jared Rutter· Scientific Advisor; Professor of Biochemistry and HHMI Investigator, University of Utah
Jeff Seitz· Senior Analyst
Kelly Cathey· Director of Administration
Peter Tontonoz· Scientific Advisor; Professor of Pathology and Biological Chemistry, UCLA
Poppy Keller· Consultant

What they invest in

from 49 of 76 portfolio companies

Biotech ×37Healthtech ×27Medical Devices ×20Digital Health ×7Enterprise Software ×3AI & Machine Learning ×2Deep Tech ×2Hardware ×2

HQs:United States×38Germany×1Mexico×1Vietnam×1

Who they back

founder profiles across 15 portfolio companies
87%
solo founders
13 of 15 mapped founding teams
~5 yrs
old at investment
median across 12 dated deals

Founding team size:solo founder×132 founders×2

Investments · 76 tracked

founders shown can be your intro path

By year:2026 · 12025 · 52024 · 22023 · 32022 · 12021 · 42020 · 32019 · 12018 · 22017 · 22016 · 32015 · 237 dated

Spruce Biosciencessprucebiosciences.comin𝕏NASDAQ: SPRBAug 2020

Spruce Biosciences develops and commercializes therapies for serious neurological and endocrine disorders with unmet medical need, with a lead investigational enzyme replacement therapy (TA-ERT) for Mucopolysaccharidosis Type IIIB (Sanfilippo Syndrome Type B).

BiotechHealthtechSouth San Francisco, US

Javier Szwarcberg(Executive Officer, Director)inSamir Gharib(Executive Officer)inRICHARD KING(Executive Officer, Director)inJavier Szwarcberg, M.D., M.P.H.(Chief Executive Officer)in

BoardSimpson Camilla(Director)Tiba Aynechi(Director)in

Board seatNiall O'Donnell· per SEC Form D

Co-investorsAisling CapitalHealthCapAbingworthNorwest Venture PartnersNovo HoldingsOmega Funds+1 more

Avalyn Pharma Incavalynpharma.cominNASDAQ: AVLNSep 2023 · $175M

Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.

BiotechHealthtech

Lyn Baranowski(CEO)in

Co-investorsAndera PartnersCatalio Capital Management, LPF-Prime CapitalInVivium CapitalNorwest Venture PartnersSR One Capital Management+9 more

Macrogenics Incmacrogenics.cominNASDAQ: MGNX

MacroGenics is a clinical-stage biopharmaceutical company developing antibody-based therapies for cancer patients.

BiotechHealthtechMedical Devices

Scott Koenig(Director)inEric Risser(President and Chief Executive Officer)in

Co-investorsHavencrest Capital ManagementRidgeback CapitalSanofi VenturesLa CaisseTPG

Mirum Pharmaceuticalsmirumpharma.comin𝕏NASDAQ: MIRMSeries A · Nov 2018 · $120M

Mirum Pharmaceuticals is a biopharmaceutical company that develops and delivers therapies for people living with rare diseases.

BiotechHealthtechSan Diego, US

Chris Peetz(Co-founder & Chief Executive Officer)inEric Bjerkholt(Executive Officer)inPeter Radovich(Executive Officer)in

BoardPatrick Heron(Director)inMichael Grey(Director)Timothy Walbert(Director)

Co-investorsChiesi VenturesFrazier Life SciencesNew Enterprise Associates (NEA)Pappas CapitalFrazier Healthcare PartnersNorwest Venture Partners+1 more

Onkure Therapeutics Inconkuretherapeutics.comin𝕏NASDAQ: OKUR

OnKure Therapeutics is a clinical-stage biopharmaceutical company developing PI3Kα pan-mutant selective inhibitor medicines for the treatment of breast cancer and vascular anomalies.

BiotechDigital HealthHealthtechMedical DevicesBoulder, US

Jason Leverone(Executive Officer)inSamuel Agresta(Executive Officer)inDylan Hartley(Executive Officer)inWendy Johnson(Executive Officer)Nicholas A. Saccomano(President and Chief Executive Officer and Director)

BoardIsaac Manke(Director)in

Co-investorsAccess BiotechnologyBoulder VenturesAbingworthACORN BIOVENTURESNew Enterprise Associates (NEA)Novo Holdings

Xilio Therapeuticsxiliotx.cominNASDAQ: XLO

Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment.

BiotechHealthtechWaltham, US

René Russo(Executive Officer, Director)inJoseph Farmer(Executive Officer)Timothy Clackson(Executive Officer)Christopher Frankenfield(Chief Financial and Operating Officer)inKatarina Luptakova(Chief Medical Officer)inPaul Clancy(Director)

Co-investorsBain Capital Life SciencesBay City CapitalF-Prime CapitalM VenturesMRL Ventures FundRA Capital+9 more

Engrail Therapeuticsengrail.cominSeries B · Mar 2024 · $170M✓ verified

Engrail Therapeutics is a clinical-stage pharmaceutical company developing precision-targeted therapeutics for neupropsychiatric and neurodevelopmental disorders.

BiotechDigital HealthMedical DevicesSan Diego, US

Stephen(Co-founder, EVP Research & Development and Chief Development Officer)Paul Cayer(Chief Financial Officer)inVikram(President and Chief Executive Officer)Kimberly(Chief Scientific Officer)Quentin(Chief Technical Officer)

Co-investorsForesite CapitalLongwood FundNorwest Venture PartnersYsios Capitalabrdn plcEight Roads Ventures+4 more

Alleviant Medical Incalleviantmedical.comin𝕏Jan 2025 · $74M

Alleviant Medical develops an investigational minimally invasive medical device using interatrial shunt therapy to treat heart failure patients, currently in FDA-approved clinical trials (ALLAY-HF and ALLAY-HFrEF).

BiotechHealthtechMedical DevicesAustin, US

Adam Berman(Executive Officer, Director)inJacob Kriegel(Executive Officer, Director)Avni Patel(Executive Officer, Director)Christopher Alex Arevalos(Executive Officer, Director)Albertien Greijdanus(Executive Officer, Director)

BoardGeoff Pardo(Director)in

Board seatJay W. Schmelter· per SEC Form D

Co-investorsBroadview VenturesTMC Venture FundCadence Healthcare VenturesGilde HealthcareGilmartin Capital LLCS3 Ventures+1 more

Bonum Therapeuticsbonumtx.comin𝕏Series A · Apr 2026 · $93M

Bonum Therapeutics develops antibody-controlled protein therapeutics that remain inactive until bound to their target, using a sensor-domain mechanism to deliver regulated, targeted activity.

BiotechHealthtechSeattle, US

John Mulligan(Executive Officer, Director, Promoter)inNeela Patel(Executive Officer)inDiane Hollenbaugh(Executive Officer)in

BoardSamuel Bjork(Director)inMonique Schiersing(Director)in

Board seatJohn McKearn· per SEC Form D

Co-investorsRoche Venture FundVivo Capital3x5 PartnersCodon CapitalDigitalis Ventures

Cardialen Inccardialen.comJul 2021

HealthtechSt. Louis, US

M. Brent Shelton(Executive Officer)Paula Skjefte(Executive Officer, Director)Nick Lanners(Executive Officer)Igor Efimov(Director)

BoardEric A. Gulve(Executive Officer, Director)Warren Watson(Director)

Board seatJay W. Schmelter· per SEC Form D

Co-investorsCultivation Capital

Genoa Pharmaceuticalsgenoa-pharmaceuticals.appspot.comOct 2023

Avalyn Pharma (formerly Genoa Pharmaceuticals) is a biopharma company developing inhaled therapies for idiopathic pulmonary fibrosis (IPF) and other severe respiratory diseases.

BiotechHealthtechSan Diego, US

Mark W. Surber, Ph.D.(Executive Officer, Director)Richard G. Vincent(Executive Officer)

BoardMichael J. Kamdar(Director)Daniel D. Burgess(Director)

Board seatNiall O'Donnell· per SEC Form D

Co-investorsF-Prime CapitalNorwest Venture PartnersSofinnova Ventures

Intervene Incintervene-med.cominSeries A · Mar 2023 · $13M

InterVene, Inc. is a medical device company that has developed a fully integrated mechanical thrombectomy system to treat venous in-stent restenosis and residual thrombotic venous obstructions and occlusions.

BiotechHealthtechMedical DevicesMountain View, US

Fletcher Wilson(Executive Officer, Director)in

BoardThomas Fogarty(Director)Mel Schatz(Director)

Board seatJay W. Schmelter· per SEC Form D

Co-investorsLaunchCapitalTreo Ventures, LlcEmergent Medical Partners, LLP

OncoResponseoncoresponseinc.comMay 2025 · $14M

Clinical-stage immuno-oncology company developing antibodies derived from the immune systems of 'Elite' cancer responders.

BiotechHouston, US

Alice Bexon(Executive Officer)inClifford J. Stocks(Director, Executive Officer)inKamal D. Puri(Executive Officer)inChris Russell(Executive Officer)inRuss Hawkinson(Executive Officer)

BoardSteven Gillis(Director)in

Board seatJohn McKearn· per SEC Form D

Co-investors3B Future Health FundCanaan PartnersGreatPoint VenturesARCH Venture PartnersBering CapitalIntervest+3 more

Smart Wiressmartwires.comMay 2018SEC filingmedium confidence

EnergyOakland, US

James C David(Executive Officer, Director)Woody Gibson(Executive Officer)Stewart Ramsay(Executive Officer, Director)

BoardAnthony Arnerich(Director)Jay Schmelter(Director)inFrederick Buckman(Director)

Board seatJay W. Schmelter· per SEC Form D · $85.8M raise · filed Jan 2020

Co-investorsEnergy Transition Ventures3x5 Partners

Sparrow Pharmasparrowpharma.comin𝕏Jul 2025

Sparrow Pharmaceuticals is a clinical-stage biopharmaceutical company developing targeted therapies for cardiometabolic disease.

BiotechHealthtechMedical DevicesPortland, US

Robert Jacks(Executive Officer, Director)inDavid Aaron Katz(Executive Officer, Director)

BoardJonathan Root(Director)inZach Scheiner(Director)inKlaus Veitinger(Director)in

Board seatNiall O'Donnell· per SEC Form D

Co-investorsOrbiMedRA CapitalUS Venture Partners

Wugenwugen.comJul 2021 · $115M

Allotera (formerly Wugen) develops allogeneic T-cell therapies.

BiotechHealthtechMedical DevicesSt. Louis, US

Ayman Kabakibi(Executive Officer)inCherry Thomas(Executive Officer)inKumar Srinivasan(Executive Officer, Director)inKeith Vendola(Executive Officer)Daniel M Kemp(Executive Officer, Director)Matthew Cooper(Executive Officer)

Board seatNiall O'DonnellJohn McKearn· per SEC Form D

Co-investorsAisling CapitalAlpha Wave GlobalBioGenerator VenturesAbingworthFidelity InvestmentsIntermediate Capital Group+1 more

Allakos Incallakos.comSeries A · Nov 2017 · $25M

Portfolio company that completed a successful 2018 biotech IPO, resulting in a 9x return for RiverVest.

BiotechSan Carlos, US

Nenad Tomasevic(Executive Officer)Christopher Bebbington(Executive Officer, Director)Alejandro Dorenbaum(Executive Officer)

BoardFarah Champsi(Director)inJohn McKearn(Director)inPeter Moldt(Director)

Co-investorsAlta PartnersNew Enterprise Associates (NEA)Samsara BioCapitalRoche Venture Fund

Allotera Therapeuticsalloteratx.comSeries B · Jul 2021 · $170M

St. Louis, US

Co-investorsAisling CapitalLYZZ CapitalAbingworth

Anacorin𝕏Acquired

Pfizer discovers, develops, manufactures, and distributes pharmaceutical medicines and vaccines across therapeutic areas including oncology, cardiology, immunology, and infectious diseases.

BiotechHealthtechMedical DevicesNew York, US

Charles Pfizer

Co-investorsAisling CapitalAndera PartnersRho Capital PartnersRho VenturesVenrockNew Enterprise Associates (NEA)

AnTolRxantolrx.cominSeries A · Sep 2016 · $4M

AnTolRx develops immunotherapy therapeutics based on research in immune tolerance, targeting immune-mediated disorders.

BiotechHealthtechBoston, US

Francisco J. Quintana(Scientific Founder, Member of Board of Directors)Mark Carthy(Founder and CEO, Member of Board of Directors)

BoardSatish Jindal(Director)

Arch Oncology Incarchoncology.comSeries A · Aug 2016 · $86M

Co-investorsAvego BioScience CapitalBioGenerator VenturesPerot JainRoche Venture FundSR One Capital Management

Atalantaatalantatx.comin𝕏Series B · Jan 2025 · $97M

Atalanta is developing treatment options for intractable central nervous system diseases using RNA interference technology.

BiotechDeep TechHealthtechMedical Devices

Co-investorsF-Prime CapitalNovartis Venture FundSanofi Venturesabrdn plcEQT Life Sciences

Biogen Idecbiogen.comin𝕏

Biogen is a biotechnology company founded in 1978 that focuses on breakthroughs in biology.

BiotechMedical Devices

Co-investorsAlpha Wave GlobalAsset Management Company

Biolinqbiolinq.comin

Biolinq develops the Shine sensor, a needle-free glucose monitor that measures glucose along with physical activity and sleep in a single wearable device.

Digital HealthHardwareMedical Devices

Jared Tangney(Founder)inRich Yangin

Co-investorsAble PartnersAlpha Wave GlobalAphelion CapitalAverin CapitalBOLD LongevityFeatures Capital Holdings+3 more

Biolinqbiolinq.mein

Biolinq develops a non-invasive glucose sensor that uses light to display glucose levels in real time, while also tracking activity and sleep to provide personalized health insights via a mobile app.

BiotechDigital HealthHealthtechMedical DevicesSan Diego, US

Jared Tangney(Executive Officer, Director, Promoter)inRichard Yang(Executive Officer, Director)Edward Kliphuis(Director)

BoardDaniel Bradbury(Director)inLana Ghanem(Director)

Co-investorsAlpha Wave GlobalBeyond CapitalBioBritJDRF T1D FundAphelion CapitalHikma Ventures+1 more

Bluejaygetbluejay.aiin𝕏Aug 2022 · $41M

Bluejay develops tools for improving the reliability of generative AI systems in production environments.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US

Rohan Vasishth(Founder)inFaraz Siddiqi(Founder)in

Co-investorsFloodgateHomebrewMoonlanding VenturesY CombinatorZAKA VC

Bluejay TherapeuticsinMay 2024 · $182Macquired by Mirum Pharmaceuticals · Dec 2025 · $620M

Healthcare company acquired by Mirum Pharmaceuticals, a former RiverVest portfolio company.

San Mateo, US

Keting Chu(Executive Officer, Director)inDajun Yang(Director)Nancy Hong(Director)inAlon Lazarus(Director)William J. Rutter(Director)Ting Jia(Director)

Co-investorsFrazier Life SciencesRA CapitalFrazier Healthcare PartnersHBM Healthcare InvestmentsNovo HoldingsT. Rowe Price+1 more

Centerre Healthcare Corporationlifepointhealth.netinAcquired

Lifepoint is a diversified healthcare delivery network operating community hospitals, rehabilitation and behavioral health hospitals, and additional sites of care across the healthcare continuum.

Digital HealthHealthtech

Scott Mercy(Founding Chairman and CEO)

Co-investorsRC Capital

CV Therapeuticsgilead.comin𝕏

Gilead discovers, develops, and delivers innovative therapeutics for people with life-threatening diseases, focusing on virology, oncology, and inflammation across more than 35 countries.

BiotechDigital HealthHealthtechMedical DevicesFoster City, US

Lou Lange(Founder)Michael L. Riordan(Founder)inDaniel O'Dayin

Co-investorsAisling CapitalAsset Management CompanyFrazier Life SciencesKleiner PerkinsLongitude CapitalLumira Ventures+5 more

Cydex Pharmaceuticals Inccaptisol.comin

Captisol is a pharmaceutical-grade sulfobutylether beta-cyclodextrin (SBECD), a derivatized beta cyclodextrin used to solubilize and stabilize difficult-to-deliver molecules across routes such as parenteral, oral, ophthalmic, nasal, and inhalation.

BiotechHealthtechNew Materials

Epix Therapeuticsinacquired by Medtronic · Jan 2019 · $316M

Medtronic designs and develops medical technology for treating complex diseases.

AI & Machine LearningDigital HealthHealthtechMedical Devices

Co-investors8VCCWRU Technology VenturesElevate VenturesMenlo VenturesOak Investment PartnersPfizer Venture Investments+5 more

Flex Vascularflexvascular.comin𝕏

FLEX Vascular develops endovascular devices for treating stenoses in arteriovenous fistulas, grafts, and peripheral vascular conditions.

BiotechHealthtechMedical Devices

John P. Pigott(Founder, Advisor)John P. Pigott, MD(Founder, Advisor)

Gloucester Pharmaceuticalsbms.comin𝕏Acquired

Bristol Myers Squibb is a biopharmaceutical company that develops and delivers medicines across oncology, hematology, neuroscience, immunology, and cardiovascular disease areas.

BiotechHealthtechMedical DevicesNew York, US

Co-investorsKleiner PerkinsNew Enterprise Associates (NEA)Nextech InvestProspect Venture PartnersRho Capital PartnersRho Ventures+2 more

Glycomine www.glycomine.comglycomine.comin𝕏

Glycomine develops therapeutics for rare diseases, many of which currently lack disease-modifying treatment options.

Biotech

Steven Axon(Chief Executive Officer)inHicham Alaoui(Chief Scientific Officer)inRose Marino(Chief Medical Officer)inPeter McWilliams(Chief Business Officer)Geoffrey Hird(Chief Technology Officer)in

Co-investorsAdvent Life SciencesMission Bay CapitalMission BiocapitalRemiges Ventures, Inc.Sanderling VenturesSanofi Ventures

Good Therapeuticsgoodtherapeutics.comin𝕏Series A · Dec 2021 · $11Macquired by Roche

Portfolio company acquired by Roche.

BiotechSeattle, US

John Mulligan(Executive Officer, Director, Promoter)inMitchell Mutz(Director)Nicholas Walrod(Director)

BoardJohn McKearn(Director)inKarl Handelsman(Director)

Co-investorsDigitalis VenturesRoche Venture Fund

Lumena Pharmaceuticalsin𝕏acquired by Shire

Acquired by Shire in 2014 (now part of Takeda).

BiotechMedical Devices

Co-investorsFrazier Life SciencesLongitude CapitalOberland Capital

Maxwell Biomedicalmaxwellbiomedical.comin

Maxwell Biomedical develops a device-based alternative to catheter ablation for atrial fibrillation, using closed-loop adaptive left atrial multisite pacing and Spatial Resynchronization Therapy (SRT) to terminate AF without high-energy shock.

BiotechHardwareHealthtechMedical Devices

Randy Werneth(CEO, President)inTimothy Corvi(Sr. VP, R&D)inDerrick Chou(VP, Science & Technology)

Co-investorsBroadview Ventures

Neuros Medicalneurosmedical.com

Neuros Medical develops the Altius Direct Electrical Nerve Stimulation System, an FDA-approved implantable device that delivers patient-controlled electrical stimulation to treat chronic post-amputation pain in adult lower limb amputees.

BiotechHealthtechMedical DevicesAliso Viejo, US

David Veino(President and CEO)Zach Stassen(Chief Financial Officer)Robert J. Centa(Chief Financial Officer)Jon J. Snyder(Director, President, Secretary and CEO)in

BoardJoyce Erony(Director)inWilliam Harrington(Director)

Co-investorsAmzak HealthAPERTURE Venture PartnersCWRU Technology VenturesiSelect FundJobsOhio VenturesJumpstart Ventures+6 more

Reneoreneo.deinDec 2020 · $95M

Reneo is an asset and investment management platform for decarbonizing residential real estate portfolios in Germany.

Climate TechEnterprise SoftwarePropTechGermany, DE

Lennart Börner(Founder & Co-CEO)inAlexander Graubner-Müller(Founder & Co-CEO)in

Co-investorsFoundamentalAbingworthAisling CapitalAmzak HealthEurazeoLakestar+4 more

Reneo Pharmaceuticalsreneopharma.comDec 2020 · $95M

Xoilac TV is a free online football (soccer) live-streaming platform serving fans in Vietnam, offering Full HD match broadcasts of European, Asian, Vietnamese, and international competitions.

ConsumerMedia & EntertainmentSports Tech

Co-investorsAisling CapitalNew Enterprise Associates (NEA)Pappas CapitalAbingworthAmzak HealthLundbeckfonden Ventures+2 more

Scout Bio Incscoutbio.coin𝕏acquired by Ceva Santé Animale

Scout Bio developed biotechnology therapies for pets, including a pipeline of monoclonal antibodies and gene therapy programs targeting chronic diseases in companion animals.

AgTechBiotechDeep TechHealthtechPhiladelphia, US

Mark Hefferman(Executive Officer, Director)

BoardAditya Kohli(Director)inTadataka Yamada(Director)Patrick Heron(Director)inCindy Cole(Director)inNancy Hong(Director)

Co-investorsCompanion FundCorrelation VenturesDigitalis VenturesFrazier Life Sciences

SeQure Dxsequre-dx.comin

BiotechWaltham, US

Ellen E. Sheets(Executive Officer, Director)in

BoardCarl M. Berke(Director)inNancy Hong(Director)in

Co-investorsBold Capital PartnersDigitalis VenturesKdT Ventures

ShareFilesharefile.comin𝕏

ShareFile provides secure file sharing, document collection, e-signature capabilities, and automated workflow management for teams collaborating with clients, partners, and vendors.

Enterprise SoftwareSaaS

Co-investorsAstellaBlack Diamond VenturesBrightstone Venture CapitalCID CapitalConcord Health PartnersH Venture Partners+1 more

Standard Bariatricsstandardbariatrics.cominAcquired

Standard Bariatrics develops the Titan SGS™ Stapler, a specialized surgical device designed for sleeve gastrectomy procedures that creates consistent and symmetrical gastric pouches using an anatomy-based approach.

Medical Devices

Co-investorsCincyTechEmergent Medical Partners, LLPHatteras Venture PartnersJobsOhio VenturesRC CapitalUS Venture Partners

Statcounterstatcounter.comin𝕏

Statcounter provides website analytics and visitor tracking software that displays traffic data, user behavior, and engagement metrics in a simple interface.

AdTechData & InfrastructureMarketing TechSaaS

Aodhán Cullen(Founder and CEO)

Co-investorsGabriel Venture PartnersHomegrown CapitalHuangpu River CapitalIaso VenturesKumpulan Modal PerdanaNucleation Capital+2 more

ZS Pharmazspharma.comSeries C · Feb 2014 · $46M

BiotechCoppell, US

Alvaro F. Guillem(Executive Officer, Director)Todd Creech(Executive Officer)Donald Jeffrey Keyser(Executive Officer, Director)Cynthia Smith(Executive Officer)Henrick Sandvad Rasmussen(Executive Officer)Robert Alexander(Executive Officer, Director)

Co-investorsSofinnova Ventures

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Curzion Pharmaceuticals IncLyric PharmaceuticalsTryton MedicalVasculoxVentureMed Group555 Bryant StreetAmplyx PharmaceuticalsApnex MedicalArchmont Biopharma IncBridgePoint MedicalCabrellisCameron Health IncCodeable TherapeuticsExcaliard Pharmaceuticals IncGlycomineIdev Technologies IncInterVene MedicalLutonixMpex Pharmaceuticals IncMyonid TherapeuticsOtonomyOutriggerOxalurx IncProspex MedicalSalient SurgicalSecurusSecurus Medical Group IncUhcVelocimed LlcZiarco

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 24

6 IPOs · 18 acquisitions · showing 20

Spruce BiosciencesNASDAQ: SPRBAvalyn Pharma IncNASDAQ: AVLNMacrogenics IncNASDAQ: MGNXMirum PharmaceuticalsNASDAQ: MIRMOnkure Therapeutics IncNASDAQ: OKURXilio TherapeuticsNASDAQ: XLOCurzion Pharmaceuticals Incacq. by Horizon TherapeuticsBluejay Therapeuticsacq. by Mirum PharmaceuticalsCabrellisacq. by PharmionCameron Health Incacq. by Boston ScientificEpix Therapeuticsacq. by MedtronicExcaliard Pharmaceuticals Incacq. by PfizerGood Therapeuticsacq. by RocheIdev Technologies Incacq. by AbbottLumena Pharmaceuticalsacq. by ShireLutonixacq. by C.R. Bard, Inc.Salient Surgicalacq. by MedtronicScout Bio Incacq. by Ceva Santé AnimaleSecurus Medical Group Incacq. by Boston ScientificVelocimed Llcacq. by St. Jude Medical

Portfolio news

latest coverage across their companies

IPO stake values · per SEC filings · 4

Value of this firm's stake in each portfolio company at its IPO price, from the prospectus principal-stockholder table.

CompanyOwnedIPO priceAt IPOStake value
Mirum Pharmaceuticals7.6%$20.00Jan 2020$38.4M
Onkure Therapeutics Inc9.1%$15.00Apr 2021$33.1M
Spruce Biosciences8.5%$15.00Oct 2020$28.5M
Xilio Therapeutics4.5%$16.00Oct 2021$19.1M

Source: SEC S-1 / 424B prospectus filings. Stake value = shares beneficially owned × the initial public offering price, as disclosed — a market value at IPO, not a return multiple (the firm's original cost is not disclosed).

Frequently asked questions

How many investments has RiverVest Venture Partners made?
RiverVest Venture Partners has 76 tracked investments, 24 of which have exited, including 6 dated in the last 24 months.
What stage does RiverVest Venture Partners invest at?
RiverVest Venture Partners invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth, Late Stage stages.
What is RiverVest Venture Partners's typical check size?
RiverVest Venture Partners typically writes checks of $500K – $3M.
What sectors does RiverVest Venture Partners focus on?
RiverVest Venture Partners focuses on Biotech, Digital Health, Healthtech, Medical Devices.
Where is RiverVest Venture Partners located?
RiverVest Venture Partners is headquartered in St. Louis, US.
Does RiverVest Venture Partners lead rounds?
Yes, RiverVest Venture Partners leads investment rounds.
Who does RiverVest Venture Partners co-invest with?
RiverVest Venture Partners most often shares deals with New Enterprise Associates (NEA), Aisling Capital, Frazier Life Sciences, among 111 tracked co-investors.

Media · Podcasts & interviews

featuring the team

Tom Melzer, Managing Director & Co-Founder, RiverVest Venture Partners

InvestMidwest Venture Capital (Forum) · Tom Melzer

Co-investors · 21

New Enterprise Associates (NEA)

New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.

$200K – $40M
Abingworth

Abingworth is a life science venture capital firm that backs early-stage biopharma and biotech companies, helping entrepreneurs translate scientific discoveries into new therapeutics.

$15M – $30M
F-Prime Capital

F-Prime Capital is an early-stage-focused investment firm backing companies across life sciences, technology, healthtech and services, and crypto.

$3M – $10M
Roche Venture Fund

Roche Venture Fund is a corporate venture arm that invests in early-stage biotech and diagnostics companies across more than 10 countries, with a portfolio exceeding 30 portfolio companies. The fund is headquartered in Basel, Switzerland.

$648K – $3.2M
Sanofi Ventures

Sanofi Ventures is the corporate venture capital arm of Sanofi, investing in early-stage biotech and digital health companies focused on improving human health. It serves as Sanofi's entry point into the innovation ecosystem.

$5M
Digitalis Ventures

Digitalis Ventures invests in solutions to unmet needs in biomedicine and health, backing biotechnology and technology-enabled companies across human health and animal health.

$100K – $10M
OrbiMed

OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.

$1M – $75M
OUP (Osage University Partners)

OUP (Osage University Partners) is a venture firm that invests in science-driven startups commercializing deep technology innovations emerging from university and breakthrough research.

Both backed · 2
$1M – $20M
SR One Capital Management

SR One is a biotechnology-focused venture capital firm that partners with founders to develop innovative science into new medicines.

Both backed · 2
Avalyn Pharma IncArch Oncology Inc
S3 Ventures

S3 Ventures is a venture capital firm founded in 2005 that invests in technology companies and medical device/health software startups, backed by a single philanthropic limited partner.

$500K – $15M
Pivotal Life Sciences

Pivotal Life Sciences is an investment platform focused on funding innovative companies developing therapeutic products and technologies aimed at major unmet medical needs.

Frazier Healthcare Partners

Frazier Healthcare Partners is a healthcare-focused private equity firm that partners with profitable, growing healthcare companies to drive scale and long-term value, pairing high-conviction investment themes with experienced executives.

$50M – $400M
9 more co-investors

Advent Life SciencesCanaan PartnersPolaris PartnersForbionDeerfield Management CompanyDomain AssociatesAlta PartnersCodon CapitalUnknown Ventures

Firms observed investing alongside RiverVest Venture Partners, from public investor directories. Shared companies are the overlap with RiverVest Venture Partners's recorded portfolio.

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