Fundraising Fox

The Column Group

Venture capitalActively deploying

San Francisco · Pre-Seed–Late Stage · 21 people tracked

Also known as Column Capital Advisors, Llc · THE COLUMN GROUP MANAGEMENT LP

Fox Verdict
Sign up to see your fit

Investment thesis

TCG pursues a science-driven approach to biotech venture capital, emphasizing company formation while retaining the capital resources to support ventures over the long term across both private and public markets. Its ecosystem comprises multiple complementary funds—TCG Platform funds, TCG Opportunity funds, TCG Labs-Soleil, and TCG Crossover (TCGX)—each with a distinct strategy for deploying capital into technology platforms, single assets, and later-stage programs. The funds collaborate to advance biology, chemistry, and technology innovations from inception through exit, aiming to turn scientific discoveries into successful biotech companies.

Source: firm website, verified Aug 25, 2026.

Stage
Pre-Seed–Late Stage
Check
$30M
HQ
San Francisco, CA, US
Leads rounds
Follows
Instruments
Equity
Founded
2007
Last 12 months
3 investments
AUM
$3.5B
VC funds
15
Tracked investments
59

Team · 21 people

from public directories
Sarah Hymowitz· Partnerin

Founder mafia

2 people who came through The Column Group went on to found or lead other companies.

What they invest in

from 53 of 59 portfolio companies

Biotech ×50Healthtech ×31Deep Tech ×14Medical Devices ×13AI & Machine Learning ×7Digital Health ×5Circular Economy ×1Cleantech ×1

HQs:United States×35New Zealand×1

Who they back

founder profiles across 13 portfolio companies
62%
solo founders
8 of 13 mapped founding teams

Founding team size:solo founder×82 founders×13 founders×24+ founders×2

Investments · 59 tracked

founders shown can be your intro path

By year:2026 · 22025 · 22024 · 62023 · 22022 · 12021 · 32020 · 32017 · 12016 · 12015 · 42014 · 126 dated

Johnson & Johnsonjnj.comin𝕏NYSE: JNJ

Johnson & Johnson develops prescription medicines and medical technology across areas including oncology, immunology, neuroscience, cardiopulmonary, cardiovascular, orthopaedics, surgery, and vision.

BiotechHealthtechMedical DevicesNew Brunswick, US

Joaquin Duatoin

Co-investorsAisling CapitalAtlas VentureNaviMed CapitalPortland Seed FundSPRINGROCK VENTURESvenBio Partners

ORIC Pharmaceuticalsoricpharma.cominNASDAQ: ORIC

ORIC Pharmaceuticals is a clinical-stage oncology company developing therapies aimed at overcoming cancer treatment resistance, including innate, acquired, and bypass resistance.

BiotechHealthtechSouth San Francisco, US

Richard Heyman(Chairman, Founder, Scientific Advisory Board)Charles Sawyers(Founder, Scientific Advisory Board)Scott Lowe(Founder, Scientific Advisory Board)Jacob M. Chacko(Executive Officer, Director)Dominic Piscitelli(Chief Financial Officer)Pratik Multani(Chief Medical Officer)

Co-investorsEcoR1 CapitalNew Enterprise Associates (NEA)Nextech InvestTaiho Ventures, LLC

Tenaya Therapeuticstenayatherapeutics.comin𝕏NASDAQ: TNYA

Tenaya Therapeutics is a clinical-stage biotechnology company developing gene therapies for inherited heart diseases, including TN-201 for MYBPC3-associated hypertrophic cardiomyopathy and TN-401 for PKP2-associated arrhythmogenic right ventricular cardiomyopathy.

BiotechHealthtechSouth San Francisco, US

Deepak Srivastava, M.D.(Scientific Founder)Eric Olson, Ph.D.(Scientific Founder)Bruce R. Conklin, M.D.(Scientific Founder)Sheng Ding, Ph.D.(Scientific Founder)Saptarsi Haldar, M.D.(Scientific Founder)Eric Hyllengren(Chief Financial Officer)

Co-investorsGV (Google Ventures)venBio Partners

Remix Therapeuticsremixtx.comin𝕏Jan 2024✓ verified

Remix Therapeutics develops RNA reprogramming technology to treat various diseases and disorders.

AI & Machine LearningBiotechWatertown, US

Peter Smith, PhD(Co-Founder, President and Chief Executive Officer)Peter Smith(Co-Founder, President and Chief Executive Officer)Robert Gagnon(Executive Officer)Heather Wasserman(Executive Officer)Matthew Patterson(Director)Scott Biller(Director)

Board seatJeff Goater· per SEC Form D

Co-investorsAtlas VentureForesite CapitalARCH Venture PartnersDecheng Capital

Atavistik Bioatavistikbio.comin✓ verified

Atavistik Bio develops selective allosteric therapeutics using a proprietary discovery platform designed to identify functional pockets across multiple protein classes, with an internal focus on rare hematology.

BiotechHealthtechMedical Devices

Bryan E. Stuart(Chief Executive Officer)Marion Dorsch(President and Chief Scientific Officer)

Co-investorsLux CapitalRA CapitalNextech Invest

InduProinduprotx.comin✓ verified

InduPro develops next-generation protein therapeutics by leveraging inherent and induced proximity to modulate disease biology, with a focus on ADCs and T-cell engagers.

BiotechDeep TechMedical DevicesSeattle, US

K. Chris Garcia(Scientific Founder)Prakash Raman(CEO)Amanda J. Redig(Chief Medical Officer)Scott Lesley(President & CSO)Pamela Holland(SVP of Biology)Sally Johnson(Chief People Officer)

Co-investorsMRL Ventures FundVida Ventures

Judo Biojudo.bioin✓ verified

Judo Bio develops oligonucleotide medicines, including ligand-siRNA conjugate drugs, delivered to the kidney for systemic and renal diseases using its STRIKE (Selectively Targeting RNA Into KidnEy) platform.

BiotechHealthtechCambridge, US

Andrew Fraley(Co-founder)Alfica SehgalOMMER CHOHAN(Executive Officer)JAMES JEFFREY GOATER(Executive Officer, Director)Simon Read(CEO)William Ho

Co-investorsAtlas VentureDigitalis VenturesDroia VenturesYK Bioventures

Nura Bionurabio.comJun 2026 · $73.8M✓ verified

Nura Bio develops neuroprotective medicines targeting neurological diseases by translating scientific advances in axonal degeneration and neuroimmune regulation into novel therapeutics.

BiotechDeep TechDigital HealthHealthtechMedical Devices

Co-investorsSamsara BioCapitalSanofi Ventures

Synthekinesynthekine.comin𝕏Jan 2023 · $100M✓ verified

Synthekine is a clinical-stage biotechnology company using protein engineering platforms to develop cytokine-based immunotherapies designed to preserve therapeutic efficacy while avoiding toxicities linked to cytokine pleiotropy.

BiotechHealthtech

K. Christopher Garcia(Founder)Susan Molineaux(CEO)Martin Oft(Chief Scientific Officer)Naiyer Rizvi(Chief Medical Officer)Gregory(Chief Technical Officer)Geoff(Chief Business Officer)

Co-investorsSamsara BioCapitalBain Capital Life SciencesCanaan PartnersRA CapitalTCG CrossoverDeerfield Management Company+2 more

A2 Biotherapeuticsa2biotherapeutics.cominSep 2020 · $80M

A2 Bio develops precision CAR T-cell therapies using its Tmod cell engineering platform, supporting both autologous and allogeneic applications.

BiotechHealthtechAgoura Hills, US

C. Alexander Kamb(Director)inScott Foraker(Executive Officer, Director)Madhavan Balachandran(Director)Michael Gallo(Director)

BoardSrini Akkaraju(Director)in

Board seatDavid Goeddel· per SEC Form D

Co-investorsNextech InvestVida VenturesSamsara BioCapital

Carmot Therapeutics Inc.Oct 2020SEC filinghigh confidence

Berkeley, US

Board seatPeter SvennilsonTim KutzkeyLarry Lasky· per SEC Form D · $46.9M raise · filed Oct 2020

Co-investorsColumn

Circle Pharmacirclepharma.comJun 2021

Circle Pharma develops cancer treatments using macrocycle therapies designed to reduce side effects compared to conventional therapies.

BiotechDigital HealthHealthtechMedical DevicesSouth San Francisco, US

Matthew P. Jacobson(Co-founder)Scott R. Lokey(Director)Matthew Jacobson(Director)David J. Earp(President & CEO)Paul Park(Executive Officer)

BoardThilo Schroeder(Director)in

Board seatJohn JoseyJames EvangelistaPeter Svennilson· per SEC Form D

Co-investorsBerkeley CatalystLifeforce CapitalMission Bay CapitalMission BiocapitalNextech InvestPandect Bioventures+1 more

Constellation Pharmaconstellationpharma.comin𝕏Dec 2015acquired by NovartisSEC filingmedium confidence

BiotechHealthtechCambridge, US

Michael R. Cooper(Executive Officer)James E. Audia(Executive Officer)Keith Dionne(Executive Officer, Director)Matthias Jaffe(Executive Officer)Mark A. Goldsmith(Director)Tom Maniatis(Director)

Board seatPeter SvennilsonDavid Goeddel· per SEC Form D · $100M raise · filed Apr 2018

Co-investorsAvoro Capital AdvisorsBain Capital Life SciencesVenrockThird Rock Ventures

Day One Biopharmaceuticalsdayonebio.comin𝕏Feb 2021SEC filingmedium confidence

Day One is a biopharmaceutical company that develops first- or best-in-class targeted medicines for children and adults with life-threatening diseases, with a focus on cancers such as pediatric brain tumors.

BiotechHealthtechSouth San Francisco, US

Jeremy Bender(Executive Officer, Director)

BoardMichael Gladstone(Director)inDerek DiRocco(Director)inJulie Papanek Grant(Director)inDaniel Becker(Director)

Board seatJohn Josey· per SEC Form D · $130M raise · filed Feb 2021

Co-investorsAccess BiotechnologyAtlas VentureCanaan PartnersRA Capital

Exonics TherapeuticsNov 2017SEC filinghigh confidence

BiotechWatertown, US

John Ripple(Executive Officer, Director)Jesper Gromada(Executive Officer)H. James Magee(Executive Officer)Roger Perlmutter(Director)

Board seatDavid GoeddelJeenJoo Kang· per SEC Form D · $42M raise · filed Nov 2018

FLX BioApr 2016SEC filingmedium confidence

BiotechSouth San Francisco, US

Rekha Hemrajani(Executive Officer)Brian Wong(Executive Officer, Director)

BoardBeth Seidenberg(Director)inWilliam J. Rieflin(Director)Linda Kozick(Director)

Board seatDavid Goeddel· per SEC Form D · $67.1M raise · filed Jun 2019

Co-investorsKleiner Perkins

Hexagon Biohexagonbio.cominJun 2021

Hexagon Bio develops novel payload mechanisms for antibody-drug conjugates (ADCs) aimed at overcoming resistance to current cancer treatments and expanding ADC indications.

BiotechDeep TechHealthtechMenlo Park, US

Colin James Bell Harvey(Director)Brian T. Naughton(Director)Maureen E. Hillenmeyer(Executive Officer, Director)Maureen Hillenmeyer(CEO & Co-Founder)in

BoardAlex Kolich(Director)

Board seatDavid Goeddel· per SEC Form D

Co-investorsB3 HoldingNextech InvestSoftBank Vision Fund8VCCasdin CapitalTwo Sigma Ventures

Igenica BiotherapeuticsJan 2015SEC filingmedium confidence

BiotechBurlingame, US

John Celebi(Executive Officer)Mary Haak-Frendscho(Executive Officer, Director)

BoardJohn Diekman(Director)inCarl Gordon(Director)inRobert Schreiber(Director)

Board seatDavid Goeddel· per SEC Form D · $6.3M raise · filed Jan 2015

Co-investors5AM VenturesOrbiMed

Kallyopekallyope.cominSep 2015

Kallyope is a biotechnology company founded by neuroscientists that discovers and develops novel therapeutics targeting neural networks, with a lead candidate in pivotal studies for acute migraine treatment and metabolism programs approaching clinical studies.

BiotechHealthtechNew York City, US

Tom Maniatis(Director)Nancy Thornberry(Executive Officer, Director)Kenneth Clark(Executive Officer)

BoardTerry McGuire(Director)inJoshua Wolfe(Director)in

Board seatTim Kutzkey· per SEC Form D

Co-investorsDns CapitalIllumina VenturesLux CapitalPolaris Partners

Neurona Therapeuticsneuronatherapeutics.cominApr 2025 · $102M

Neurona is a clinical-stage biotherapeutics company developing allogeneic, off-the-shelf regenerative neural cell therapies that integrate into neural circuits to treat chronic neurological disorders.

BiotechHealthtechSouth San Francisco, US

Cory Nicholas(Executive Officer, Director, Promoter)inJames Stutz(Executive Officer)Arnold Kriegstein(Director)

BoardRay Kelleher(Director)

Board seatPeter SvennilsonTim KutzkeyDavid Goeddel· per SEC Form D

Co-investorsBerkeley FrontierIaso VenturesYsios CapitalAlexandriaFidelity InvestmentsLYFE Capital+7 more

NGM Biongmbio.cominMar 2026

NGM Bio is a biopharmaceutical company developing NGM120, a GDF15/GFRAL antagonist antibody, to treat conditions rooted in overactivation of the GDF15 pathway.

BiotechHealthtechSouth San Francisco, US

Diana Peng Bockus(Executive Officer, Director)

BoardRoger M. Perlmutter(Director)

Board seatPeter SvennilsonTim Kutzkey· per SEC Form D

Co-investorsRho Ventures

Ngm BiopharmaceuticalsOct 2014SEC filinghigh confidence

BiotechSouth San Francisco, US

Jin-Long Chen(Executive Officer, Director)William J. Rieflin(Executive Officer, Director)David V. Goeddel(Director)

BoardMark Leschly(Director)David Schnell(Director)

Board seatDavid GoeddelPeter Svennilson· per SEC Form D · $60M raise · filed Feb 2015

Co-investorsForesite CapitalProspect Venture Partners

Nurix Therapeuticsnurixtx.comin𝕏Sep 2015

Nurix Therapeutics develops protein degrader-based medicines using proprietary DEL-AI discovery technology to address cancer and autoimmune diseases.

AI & Machine LearningBiotechDeep TechMedical DevicesSan Francisco, US

Arthur T. Sands(Executive Officer, Director)Gwenn M. Hansen(Chief Scientific Officer)Timothy Kutzkey(Executive Officer, Director)

BoardMark Goldsmith(Director)

Board seatDavid Goeddel· per SEC Form D

Co-investorsBain Capital Life SciencesEcoR1 CapitalForesite CapitalSofinnova Ventures

Ribon TherapeuticsinDec 2022SEC filingmedium confidence

BiotechLexington, US

Victoria M. Richon(Executive Officer, Director)

BoardCameron Wheeler(Director)Jonathan Root(Director)Laurence Lasky(Director)

Board seatJeff Goater· per SEC Form D · $25M raise · filed Dec 2022

Co-investorsAvego BioScience CapitalOUP (Osage University Partners)Peregrine VenturesAbbVieNovartis Venture Fund

RYNE Biotechnology Inc.Feb 2024SEC filingmedium confidence

BiotechCambridge, US

Peter Fuhrken(Director)Howard Federoff(Executive Officer, Director)Nick Manusos(Executive Officer, Director)Martin Ostrowski(Executive Officer)Jonathan Yeh(Director)

Board seatJeff Goater· per SEC Form D · $81.8M raise · filed Mar 2024

Co-investorsCure Ventures

Site Tx, Inc.Apr 2024SEC filingmedium confidence

HealthtechSan Francisco, US

Alexander Marson(Director)

BoardAadit Shah(Executive Officer)

Board seatTim Kutzkey· per SEC Form D · $15M raise · filed Apr 2024

SurrozenJun 2020SEC filinghigh confidence

BiotechSouth San Francisco, US

Anna Berkenblit(Director)Harold Varmus(Director)

BoardCraig Parker(Executive Officer, Director)

Board seatDavid GoeddelTim Kutzkey· per SEC Form D · $50M raise · filed Jun 2020

Co-investors5AM Ventures

A2 Biotherapeuticsa2bio.comin

A2 Biotherapeutics develops cell therapy technology using the Tmod platform, which applies quantitative drug discovery methods to treat cancer patients.

BiotechDeep TechDigital HealthHealthtechMedical Devices

Jim Robinson(CEO)

Co-investorsSamsara BioCapital

Accent Therapeuticsaccenttx.comin𝕏Jan 2024

Accent Therapeutics is a biotechnology company focused on discovering and developing small molecule drugs to improve health outcomes for cancer patients.

BiotechHealthtechLongevity

Co-investorsAtlas VentureDroia VenturesEcoR1 CapitalGV (Google Ventures)JJDCJohnson & Johnson Innovation – JJDC+1 more

Arcus Biosciencesarcusbio.comin𝕏

Arcus Biosciences develops combination cancer therapies, producing small molecules and antibodies designed to be combined and advanced from Phase 1 studies through commercialization.

Biotech

Juan Jaen(Founder)in

Co-investorsAisling CapitalDecheng CapitalDroia VenturesEcoR1 CapitalForesite CapitalSLVC+2 more

Cajalcaj.alin𝕏

Tau provides formal verification of compiled binaries by generating mathematical proofs of correctness or identifying bugs, addressing risks from AI-assisted code generation and complex software systems.

AI & Machine LearningCybersecurityDeveloper ToolsEnterprise SoftwareSan Francisco, US

Pedro Nobre(Founder)inLuke Johnston(Founder)in

Co-investorsY CombinatorLux Capital

Cajal Therapeuticscajal-tx.comin

Cajal Therapeutics develops novel therapies through translating scientific advances into treatments for patients.

AI & Machine LearningBiotechMedical DevicesSeattle, US

Andrew Dervan(Co-Founder and Co-Chief Executive Officer)inIan Peikon(Co-Founder and Co-Chief Executive Officer)inRob Hershberg(Co-Founder and Executive Chairman)

Gloucester Pharmaceuticalsbms.comin𝕏Acquired

Bristol Myers Squibb is a biopharmaceutical company that develops and delivers medicines across oncology, hematology, neuroscience, immunology, and cardiovascular disease areas.

BiotechHealthtechMedical DevicesNew York, US

Co-investorsKleiner PerkinsNew Enterprise Associates (NEA)Nextech InvestProspect Venture PartnersRho Capital PartnersRho Ventures+2 more

Kenaitxkenaitx.comin

Kenai Therapeutics develops iPSC-derived cell therapies and gene-modified medicines for neurodegenerative diseases, particularly Parkinson's disease, leveraging induced pluripotent stem cell technology to replace damaged neurons and restore neural function.

BiotechDeep TechHealthtechMedical Devices

Howard Federoff(Scientific Co-Founder, Chief Medical Officer and Executive Vice President of Corporate Medicine and Science)

Co-investorsCure Ventures

Kimiakimiatx.com

Kimia develops a drug discovery platform called ATLAS that combines active learning, automated chemical synthesis, high-throughput screening, and machine learning to design and optimize novel drug molecules.

AI & Machine LearningBiotechDeep Tech

Stig Hansen(Founder)in

Co-investorsHorizons VenturesAirTree VenturesBlackbird VenturesDIMENSIONDimension CapitalSkip Capital

Lyterian Therapeuticslyterian.comin

Lyterian Therapeutics develops pharmaceutical treatments by leveraging protein homeostatic mechanisms to target genetically-validated disease drivers.

BiotechDeep TechHealthtechSouth San Francisco, US

Nilonilo.worldin

NILO develops technology to upcycle hard-to-recycle plastic waste, primarily polyethylene (PE) and polypropylene (PP), into materials for use in circular systems and safer products.

Circular EconomyCleantechNew Materials

Co-investorsArc AngelsIcehouse VenturesDCVC BioLux Capital

Nilo TherapeuticsJul 2024

BiotechNew York, US

Jeff Goater(Executive Officer, Director)

BoardTim Kutzkey(Executive Officer, Director, Promoter)

Co-investorsDCVC (Data Collective)DCVC BioLux Capital

Nilo Therapeuticsnilotx.comOct 2025

Nilo Therapeutics develops immunomodulation therapies that target brain-body neural circuits controlling systemic inflammation, aiming to treat autoimmune and inflammatory diseases.

BiotechDeep TechHealthtech

Co-investorsDCVC BioLux Capital

Peloton Therapeuticspelotontherapeutics.com

Peloton Therapeutics is a clinical-stage pharmaceutical company developing first-in-class small molecule medicines targeting HIF-2α for cancer and other life-threatening conditions, with initial focus on kidney cancer and VHL disease.

BiotechDigital HealthMedical Devices

Co-investorsNextech InvestVida Ventures

Plexiumplexium.comin

Plexium is a targeted protein degradation company developing small molecule therapeutics for treating diseases with high unmet medical needs using their proprietary DELTA Discovery platform.

AI & Machine LearningBiotechDeep TechSan Diego, US

Michael Martin, Ph.D.(Chief Executive Officer, President)Jorge F. DiMartinoMichael Martin(President, Chief Executive Officer)Stephen Mullennix(Executive Officer)

BoardSerge Messerlian(Director)inCariad Chester(Director)in

Co-investorsCRV (Charles River Ventures)DCVC (Data Collective)M VenturesNeotribe VenturesSoftBank Vision FundTCG Crossover+1 more

RAPT Therapeuticsrapt.comin

RAPT Therapeutics is a clinical-stage biopharmaceutical company developing therapeutics that target the immune system to treat inflammatory and immunologic diseases.

BiotechHealthtech

Co-investorsFrazier Life SciencesKleiner PerkinsSolasta VenturesOrbiMed

Small MoleculesFeb 2023 · $77.3M

Santa Monica, US

Michael Einziger(Executive Officer, Director)Edna Coryell(Executive Officer, Director)Katherine Power(Director)Jessica Goldin(Executive Officer, Director)

BoardAnn Marie Simpson(Director)

Co-investors8VCDroia VenturesFrazier Life SciencesNovartis Venture FundRTW Investments L.P.Thuja Capital+1 more

Thumbnail for Carmot Therapeuticscarmot.usin

Carmot Therapeutics is a clinical-stage biopharmaceutical company developing drug candidates for obesity and type 2 diabetes, including injectable GLP-1/GIP receptor agonists (CT-388, CT-868) and an oral small molecule GLP-1 receptor agonist (CT-996).

BiotechDeep TechDigital Health

Co-investorsHorizons VenturesTCG Crossover

Thumbnail for Constellation Pharmaceuticalsin𝕏

BiotechHealthtech

Co-investorsClal Biotechnology IndustriesExSight VenturesLongitude CapitalTachyon Ventures

Thumbnail for Eikon Therapeuticseikontx.comin

Co-investorsEcoR1 CapitalHorizons VenturesLux CapitalTCG CrossoverInnovation Endeavors

Thumbnail for Escient Pharmaceuticalsescientpharma.com

BiotechSan Diego, US

Alain Baron(Executive Officer, Director)JeenJoo Kang(Director)Robert Tjian(Director)Marcus Boehm(Executive Officer)

BoardAndrew Schwab(Director)in

Co-investors5AM VenturesAvego BioScience CapitalNew Enterprise Associates (NEA)OUP (Osage University Partners)Sanofi VenturesAbingworth+3 more

Thumbnail for Exonics Therapeuticsvrtx.com

Co-investorsArtis VenturesRidgeback Capital

Thumbnail for Gritstone Biogritstonebio.comin

Nexoplex Bio develops immunotherapies designed to target tumors through recognition of HLA-peptide complexes using multi-specific antibodies, aimed at cancers including certain lung, gastric, esophageal, head and neck, and cervical cancers.

BiotechHealthtechSan Carlos, US

Wayne(CEO)Rachel(VP of Operations)

Co-investorsFrazier Life SciencesGV (Google Ventures)

Thumbnail for Immune Designin𝕏Acquired

Merck is a pharmaceutical company focused on developing medicines and vaccines for patients globally, guided by a science-led innovation strategy.

BiotechHealthtechMedical DevicesRahway, US

Co-investorsAisling CapitalAtlas VentureHM Venture PartnersSanderling VenturesSPRINGROCK VENTURES

Thumbnail for Monimoi Therapeuticsmonimoitx.comin

Monimoit develops cancer therapeutics by combining chemical proteomics, covalent-based molecular technologies, and patient-derived translational insights to target difficult-to-drug cancer-promoting proteins and overcome resistance to existing treatments.

BiotechDeep Tech

Thumbnail for Revolution Medicinesrevmed.comin

Revolution Medicines is a clinical-stage oncology company developing targeted cancer therapies based on its tri-complex platform and RAS(ON) inhibitor biology.

BiotechHealthtech

Co-investorsGen CapitalIllinois VenturesNextech Invest

Thumbnail for Seragon Pharmaceuticalsgene.comin

Co-investorsAisling CapitalKleiner PerkinsNew Enterprise Associates (NEA)

Thumbnail for Surrozensurrozen.comin

Surrozen develops multifunctional antibody therapeutics that modulate the Wnt signaling pathway and other disease drivers, using a proprietary antibody-engineering platform.

BiotechHealthtech

Co-investorsAccess Biotechnology

Thumbnail for SyntheXsynthexlabs.comin𝕏

SyntheX develops the ToRFLEx platform, a first-in-class drug discovery technology that enables screening for compounds that modulate protein-protein interactions and targeted protein degradation for previously inaccessible drug targets identified by geneticists.

AI & Machine LearningBiotechDeep Tech

Maria Soloveychik(PhD)

Co-investorsNorth South VenturesOMX Ventures8VC

Thumbnail for Tortugas Neurosciencetortugasneuro.comin

Tortugas Neuro is a neuroscience drug development company focused on the neurology and neuropsychiatry space, working to advance clinical-stage therapies for brain health.

BiotechHealthtech

Co-investorsAN Venture PartnersCure Ventures

Topo Therapeuticstopo-tx.com

Topo Therapeutics is a drug discovery company developing treatments targeting ion channels and transmembrane proteins for conditions such as pain, epilepsy, and CNS, pulmonary, and renal diseases.

BiotechHealthtechCambridge, US

Hui Tian(Executive Officer, Director)Madgalene Moran(Executive Officer, Director)Magdalene Moran(Chief Executive Officer)

BoardKarin Kleinhans(Director)Bruce Bean(Director)James Jeffrey Goater, Jr.(Director)

Co-investorsSR One Capital ManagementMRL Ventures Fund

Tr1X Biotr1x.bioJan 2024

Tr1X is a biopharmaceutical company developing cell and gene therapies to cure autoimmune and inflammatory diseases with high unmet medical need.

BiotechDeep TechHealthtechMedical Devices

David(Co-Founder)Maria Grazia Roncarolo(Co-Founder, President and Head of R&D)

Co-investorsNeva Sgr.

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 4

IPOs and acquisitions across the tracked portfolio

Johnson & JohnsonNYSE: JNJORIC PharmaceuticalsNASDAQ: ORICTenaya TherapeuticsNASDAQ: TNYAConstellation Pharmaacq. by Novartis

Portfolio news

latest coverage across their companies

Fund performance · per public LP disclosures · 6

as of Nov 2025
FundVintageCommittedNet IRRTVPIDPI
The Column Group Fund Opportunity Fund IIILPs: Employees' Retirement System of Rhode Island, Carnegie Corporation of New York20220.2%1.01x0.34x
The Column Group Fund VLPs: Employees' Retirement System of Rhode Island, Carnegie Corporation of New York2022-19.1%0.77x0.00x
Column Group IVLPs: The Regents of the University of California2019-1.8%0.95x0.07x
Column Group IIILPs: The Regents of the University of California20167.7%1.25x0.78x
Column Group IILPs: The Regents of the University of California20147.8%2.40x1.88x
The Column Group, L.P.LPs: The Regents of the University of California200523.4%2.10x0.79x

Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).

Frequently asked questions

How many investments has The Column Group made?
The Column Group has 42 tracked investments, including 4 dated in the last 24 months.
What stage does The Column Group invest at?
The Column Group invests at the Pre-Seed, Seed, Series A, Series B, Growth, Late Stage stages.
What is The Column Group's typical check size?
The Column Group typically writes checks of $30M.
What sectors does The Column Group focus on?
The Column Group focuses on Biotech, Deep Tech.
Where is The Column Group located?
The Column Group is headquartered in San Francisco, US.
Does The Column Group lead rounds?
The Column Group typically participates in rounds rather than leading them.
Who does The Column Group co-invest with?
The Column Group most often shares deals with Nextech Invest, Atlas Venture, EcoR1 Capital, among 71 tracked co-investors.

Images

The Column Group photoThe Column Group photo

Co-investors · 38

Nextech Invest

Nextech Invest is a Zurich-based investment firm focused on emerging biotechnology companies, backing transformative cancer medicines and precision medicine advances worldwide.

$648K – $3.2M
Lux Capital

Lux Capital is a venture capital firm that backs founders building transformative deep technologies, having been among the first investors in category-defining companies across AI, robotics, biotech, defense, and infrastructure.

Both backed · 7
Atavistik BioCajalKallyopeNiloNilo TherapeuticsBE BiopharmaThumbnail for Eikon Therapeutics
$100K – $100M
Atlas Venture

Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.

$500K – $1M
New Enterprise Associates (NEA)

New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.

$200K – $40M
Kleiner Perkins

Kleiner Perkins is a venture capital firm that backs founders across technology and life sciences, from early stage through growth.

Both backed · 4
FLX BioGloucester PharmaceuticalsRAPT TherapeuticsThumbnail for Seragon Pharmaceuticals
$500K – $15M
Aisling Capital

Aisling Capital is an investment firm focused on companies developing and commercializing innovative healthcare products, services, and technologies.

Both backed · 4
Johnson & JohnsonArcus BiosciencesThumbnail for Immune DesignThumbnail for Seragon Pharmaceuticals
Foresite Capital

Foresite Capital is a healthcare-focused investment firm backing companies at the intersection of technology and biotechnology to personalize healthcare and accelerate medical innovation.

Samsara BioCapital

Samsara BioCapital is an investment firm backing the development of transformative therapeutics for patients, bringing together scientists, physicians, drug developers, and business leaders to support next-generation therapeutic breakthroughs.

Both backed · 4
GV (Google Ventures)

GV (Google Ventures) is a venture capital firm that has invested in artificial intelligence and machine learning since its early days, building a global portfolio of more than 100 AI companies across infrastructure, life sciences, and applications.

$250K – $50M
8VC

8VC is a venture capital firm investing across logistics, life sciences, healthcare, IT infrastructure, and government/defense, guided by its Smart Enterprise thesis focused on data integration and platform network effects.

$100K – $50M
RA Capital

RA Capital is a multi-stage investment firm focused on healthcare, life sciences, and planetary health, investing across public and private markets and creating new companies through its Raven incubation platform.

5AM Ventures

5AM Ventures is a life science venture capital firm founded in 2002 that invests primarily in private therapeutic companies, with a focus on biopharmaceuticals, drug delivery technologies, and life science instruments.

$100K – $4M
26 more co-investors

Vida VenturesCure VenturesDCVC (Data Collective)Canaan PartnersTwo Sigma VenturesARCH Venture PartnersOrbiMedOUP (Osage University Partners)Sanofi VenturesInnovation EndeavorsDimension CapitalSR One Capital ManagementThird Rock VenturesPivotal Life SciencesLeaps by BayerGeneral CatalystFounders FundUS Venture PartnersGeneral AtlanticM12 (Microsoft's Venture Fund)Versant VenturesMPM BioImpactPfizer Venture InvestmentsOmega FundsLightstone VenturesAstellas Venture Management LLC

Firms observed investing alongside The Column Group, from public investor directories. Shared companies are the overlap with The Column Group's recorded portfolio.

Similar investors

Featured in lists