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Rock Springs Capital

Venture capital

Baltimore · Late Stage · 12 people tracked

Also known as ROCK SPRINGS CAPITAL MANAGEMENT LP

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Investment thesis

Rock Springs Capital pursues research-driven investing across healthcare sectors, combining deep scientific and clinical insight with a rigorous, fundamental approach. Founded by physician-scientists, the firm brings together sector specialists whose senior team has collaborated for over two decades. Its methodology leverages the full resources of the firm to identify healthcare innovations believed to be positioned for long-term value, emphasizing companies that address critical unmet medical needs. The firm stresses experience, continuity, shared investment discipline, and a reputation for integrity.

Source: firm website, verified Aug 25, 2026.

Stage
Late Stage
HQ
Baltimore, US
Instruments
Equity
Founded
2013
Last 12 months
2 investments
AUM
$2.4B
Tracked investments
9

Team · 12 people

from the firm's website

What they invest in

from 9 of 9 portfolio companies

Biotech ×9Healthtech ×5Medical Devices ×2AI & Machine Learning ×1

HQs:United States×5United Kingdom×2

Investments · 9 tracked

founders shown can be your intro path

By year:2026 · 12025 · 12024 · 12023 · 25 dated

Avalyn Pharma Incavalynpharma.cominNASDAQ: AVLNSep 2023 · $175M

Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.

BiotechHealthtech

Lyn Baranowski(CEO)in

Co-investorsAndera PartnersCatalio Capital Management, LPF-Prime CapitalInVivium CapitalNorwest Venture PartnersRiverVest Venture Partners+7 more

Xilio Therapeuticsxiliotx.cominNASDAQ: XLO

Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment.

BiotechHealthtechWaltham, US

Rene Russo(Executive Officer, Director)inJoseph Farmer(Executive Officer)Timothy Clackson(Executive Officer)Paul Clancy(Director)Daniel Curran(Director)Nancy Hong(Director)

Co-investorsBain Capital Life SciencesBay City CapitalF-Prime CapitalM VenturesMRL Ventures FundRA Capital+4 more

Apollo Therapeuticsapollotherapeutics.comin✓ verified

Apollo Therapeutics is a portfolio biopharmaceutical company that translates academic biology and medical research into new medicines, operating over 20 therapeutic programs including six in clinical development.

BiotechHealthtechCambridge, GB

Co-investorsPatient Square CapitalAlbionVCUCL Technology Fund

Apollo Therapeuticsapollotx.cominSep 2023 · $226.5M✓ verified

Apollo Therapeutics is a biopharmaceutical company that translates academic biology and medical research into new medicines, operating a portfolio of over 20 therapeutic programs with several in clinical development.

BiotechCambridge, GB

Co-investorsPatient Square CapitalAlbionVC

Abcuroabcuro.comAug 2026

Abcuro develops therapies that target highly cytotoxic T cells for autoimmune diseases, including its lead candidate ulviprubart for inclusion body myositis.

BiotechHealthtechNewton, US

Steven A. Greenberg(Chief Scientific Advisor & Co-Founder)Steven A. Greenberg, MD(Chief Scientific Advisor & Co-Founder)John Alexander Martin(Executive Officer, Director)Stefano Gulla(Executive Officer)Evan Thompson(Executive Officer)David de Graaf(Executive Officer, Director)

Co-investorsBain Capital Life SciencesNew Enterprise Associates (NEA)RA CapitalSamsara BioCapitalSanofi VenturesMass General Brigham Ventures+8 more

City Therapeuticscitytx.comin𝕏Oct 2024

City Therapeutics develops RNAi-based medicines targeting rare, specialty, and prevalent diseases using engineered trigger molecules and precision delivery ligands.

BiotechMedical DevicesCambridge, US

Mark Keating, MD(Co-founder)Kotaro Nakanishi, PhD(Co-founder)Yukihide Tomari, PhD(Co-founder)Phillip Zamore, PhD(Co-founder)

Co-investorsAN Venture PartnersARCH Venture PartnersSofinnova VenturesCasdin CapitalFidelity InvestmentsInvus

Homology Medicineshomologymedicines.com

Clinical-stage genetic medicines company using human-derived AAV vectors and nuclease-free gene editing for rare diseases.

BiotechBedford, US

Siyamak Rasty(Executive Officer)Albert Seymour(Executive Officer)

BoardSteven Gillis(Director)Arthur Tzianabos(Executive Officer, Director)Kush Parmar(Director)inRichard Gregory(Director)

Co-investors5AM VenturesARCH Venture PartnersOUP (Osage University Partners)AlexandriaDeerfield Management CompanyHBM Healthcare Investments+4 more

Synthekinesynthekine.comin𝕏

Synthekine is a clinical-stage biotechnology company using protein engineering platforms to develop cytokine-based immunotherapies designed to preserve therapeutic efficacy while avoiding toxicities linked to cytokine pleiotropy.

BiotechHealthtech

K. Christopher Garcia(Founder)Susan Molineaux(CEO)Martin Oft(Chief Scientific Officer)Naiyer Rizvi(Chief Medical Officer)Gregory(Chief Technical Officer)Geoff(Chief Business Officer)

Co-investorsSamsara BioCapitalThe Column GroupBain Capital Life SciencesCanaan PartnersRA CapitalTCG Crossover+2 more

Treeline Biosciencestreeline.bioSep 2025

Treeline develops therapeutics focused on oncology, leveraging insights from clinical practice and laboratory research.

AI & Machine LearningBiotechMedical DevicesWatertown, US

Joshua H. Bilenker(Executive Officer, Director, Promoter)Jeffrey Engelman(Executive Officer, Director, Promoter)inJosh Bilenker(Founder)in

BoardKristina Burow(Director)inAli Satvat(Director)David Schenkein(Director)in

Co-investorsAisling CapitalARCH Venture PartnersOrbiMedCasdin CapitalFidelity InvestmentsGV (Google Ventures)+1 more

Exits · 2

IPOs and acquisitions across the tracked portfolio

Avalyn Pharma IncNASDAQ: AVLNXilio TherapeuticsNASDAQ: XLO

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Rock Springs Capital invest at?
Rock Springs Capital invests at the Late Stage stage.
What sectors does Rock Springs Capital focus on?
Rock Springs Capital focuses on Biotech, Digital Health, Healthtech, Medical Devices.
Where is Rock Springs Capital located?
Rock Springs Capital is headquartered in Baltimore, US.

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