🦊/Investors

Rock Springs Capital

Venture capital

Baltimore · Late Stage · 13 people tracked

Also known as ROCK SPRINGS CAPITAL MANAGEMENT LP

Find your way into Rock Springs Capital

544 people in our graph share verified history with the Rock Springs Capital team — schools, employers, funds. One of them is your warm intro.

Nino Marakovicunlockedknows Mark Bussard · together at Williams College (overlapped)
×3knows the team · via Duke University
×7knows the team · via Williams College
knows the team · via Loyola University Maryland
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Investment thesis

Rock Springs Capital pursues research-driven investing across healthcare sectors, combining deep scientific and clinical insight with a rigorous, fundamental approach. Founded by physician-scientists, the firm brings together sector specialists whose senior team has collaborated for over two decades. Its methodology leverages the full resources of the firm to identify healthcare innovations believed to be positioned for long-term value, emphasizing companies that address critical unmet medical needs. The firm stresses experience, continuity, shared investment discipline, and a reputation for integrity.

Source: firm website, verified Sep 15, 2026.

Stage
Late Stage
HQ
Baltimore, US
Instruments
Equity
Founded
2013
Last 12 months
1 investment
AUM
$2.4B
Tracked investments
25
IPOs
7

Team · 13 people

from the firm's website & public directories
Gordon Margraff (Mark) Bussard· Executive Officer

What they invest in

from 25 of 25 portfolio companies

Biotech ×20Healthtech ×12Medical Devices ×6AI & Machine Learning ×3Enterprise Software ×2SaaS ×2Advanced Manufacturing ×1Climate Tech ×1

HQs:United States×16United Kingdom×2Germany×1Vietnam×1

Investments · 25 tracked

founders shown can be your intro path

By year:2026 · 12025 · 12024 · 22023 · 22022 · 22021 · 42020 · 22017 · 115 dated

Avalyn Pharma Incavalynpharma.cominNASDAQ: AVLNSep 2023 · $175M

Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.

BiotechHealthtech

Lyn Baranowski(CEO)in

Co-investorsAndera PartnersCatalio Capital Management, LPF-Prime CapitalInVivium CapitalNorwest Venture PartnersRiverVest Venture Partners+9 more

Bolt Biotherapeuticsboltbio.comin𝕏NASDAQ: BOLT

Bolt Biotherapeutics is a clinical-stage biotech company developing novel immunotherapies that leverage innate immune system mechanisms to treat cancer.

BiotechHealthtechMedical DevicesSan Francisco, US

Dr. Edgar G. Engleman(Founder)

Co-investorsPfizer Venture InvestmentsRA CapitalSamsara BioCapitalSofinnova VenturesVivo CapitalNan Fung Life Sciences+3 more

Disc Medicinediscmedicine.comin𝕏NASDAQ: IRONSep 2021 · $90M

Disc Medicine is a biopharmaceutical company developing therapies from discovery through clinical development for patients in need.

BiotechHealthtech

John Quisel(Chief Executive Officer)inJean Franchi(Chief Financial Officer)inJonathan Yu(Chief Operating Officer)inWill Savage(Chief Medical Officer)inPamela Stephenson(Chief Commercial Officer)inSteve Caffé(Chief Regulatory Officer)in

Co-investorsAccess BiotechnologyAtlas VentureBain Capital Life SciencesForesite CapitalFrazier Life SciencesOrbiMed+6 more

Immuneeringimmuneering.comin𝕏NASDAQ: IMRX

Immuneering develops Deep Cyclic Inhibitors, a class of oncology medicines designed to pulse dosing faster than cancer's adaptive mechanisms to limit resistance and reduce side effects.

BiotechHealthtechCambridge, US

Benjamin J. Zeskind(Executive Officer, Director)Harold E. Brakewood(Chief Business Officer)inBrett Hall(Chief Scientific Officer)inMichael D. Bookman(Chief Legal Officer, Secretary)inIgor Matushansky(Chief Medical Officer)Mallory Morales(SVP Finance, Chief Accounting Officer, Treasurer)in

Co-investorsT. Rowe Price

Korro Biokorrobio.comin𝕏NASDAQ: KRROApr 2024 · $70M

Korro Bio is a biotechnology company developing a new class of RNA-editing therapies guided by human genetics and disease biology.

BiotechHealthtechCambridge, US

Nessan Bermingham(Mr. Bermingham is the Executive Chair of the Issuer.)inJean-François Formela(Director)inOmmer Chohan(Mr. Chohan is the Secretary and Treasurer of the Issuer.)inRam Aiyar(Chief Executive Officer, President and Director)inTodd Chappell(Chief Operating Officer)in

BoardJean-Francois Formela(Director)in

Co-investorsAtlas VentureMC Healthcare VenturesNew Enterprise Associates (NEA)AlexandriaQiming Venture Partners USATaiwania Capital+1 more

Xilio Therapeuticsxiliotx.cominNASDAQ: XLO

Xilio Therapeutics is a clinical-stage biotechnology company developing masked immuno-oncology therapies that use protein engineering to remain inactive until activated by tumor-specific proteases within the tumor microenvironment.

BiotechHealthtechWaltham, US

René Russo(Executive Officer, Director)inJoseph Farmer(Executive Officer)Timothy Clackson(Executive Officer)Christopher Frankenfield(Chief Financial and Operating Officer)inKatarina Luptakova(Chief Medical Officer)inPaul Clancy(Director)

Co-investorsBain Capital Life SciencesBay City CapitalF-Prime CapitalM VenturesMRL Ventures FundRA Capital+9 more

Apollo Therapeuticsapollotherapeutics.comin✓ verified

A portfolio biopharmaceutical company that translates breakthroughs in biology and basic medical research from top universities into novel therapeutics.

BiotechHealthtechCambridge, GB

Co-investorsPatient Square CapitalAlbionVCUCL Technology Fund

Apollo Therapeuticsapollotx.cominSep 2023 · $226.5M✓ verified

A portfolio biopharmaceutical company translating basic medical research breakthroughs from leading universities into novel therapeutic medicines.

BiotechDeep TechMedical DevicesCambridge, GB

Richard Butt(Chief Scientific Officer)inSanjay Aggarwal(Chief Medical Officer)in

Co-investorsPatient Square CapitalAlbionVC

Abcuroabcuro.comAug 2026

Abcuro develops therapies that target highly cytotoxic T cells for autoimmune diseases, including its lead candidate ulviprubart for inclusion body myositis.

BiotechHealthtechNewton, US

Steven A. Greenberg(Chief Scientific Advisor & Co-Founder)Steven A. Greenberg, MD(Chief Scientific Advisor & Co-Founder)John Alexander Martin(Executive Officer, Director)Stefano Gulla(Executive Officer)Evan Thompson(Executive Officer)David de Graaf(Executive Officer, Director)

Co-investorsBain Capital Life SciencesNew Enterprise Associates (NEA)RA CapitalSamsara BioCapitalSanofi VenturesMass General Brigham Ventures+9 more

Affinivaxaffinivax.comin𝕏

Affinivax was a clinical-stage biopharmaceutical company that developed next-generation pneumococcal vaccines using its proprietary Multiple Antigen Presenting System (MAPS) platform technology.

BiotechMedical DevicesCambridge, US

Richard Malley(Director)inKamran Tavangar(Executive Officer)Steven Brugger(Executive Officer, Director)in

BoardRobert More(Director)Frances Heller(Director)George Siber(Director)

Co-investorsBain Capital Life SciencesEcoR1 CapitalForesite CapitalBain CapitalT. Rowe Price

Aptinyxaptinyx.com

BiotechEvanston, US

Joseph R. Moskal(Chief Scientific Officer)Torsten M. Madsen(Chief Marketing Officer)Ashish Khanna(Secretary & Chief Business Officer)Norbert G. Riedel(Chief Executive Officer)

BoardLiam Ratcliffe(Director)Terry P. Gould(Director)

Co-investorsBain Capital Life SciencesFrazier Life SciencesLatterell Venture PartnersLongitude CapitalOUP (Osage University Partners)Agent Capital+2 more

City Therapeuticscitytx.comin𝕏Oct 2024

City Therapeutics develops RNAi-based medicines targeting rare, specialty, and prevalent diseases using engineered trigger molecules and precision delivery ligands.

BiotechMedical DevicesCambridge, US

Mark Keating, MD(Co-founder)Kotaro Nakanishi, PhD(Co-founder)Yukihide Tomari, PhD(Co-founder)Phillip Zamore, PhD(Co-founder)

Co-investorsAN Venture PartnersARCH Venture PartnersSofinnova VenturesCasdin CapitalFidelity InvestmentsInvus

Homology Medicineshomologymedicines.cominJul 2017

Clinical-stage genetic medicines company using human-derived AAV vectors and nuclease-free gene editing for rare diseases.

BiotechBedford, US

Siyamak Rasty(Executive Officer)Albert Seymour(Executive Officer)

BoardSteven Gillis(Director)Arthur Tzianabos(Executive Officer, Director)Kush Parmar(Director)inRichard Gregory(Director)

Co-investors5AM VenturesARCH Venture PartnersOUP (Osage University Partners)AlexandriaDeerfield Management CompanyHBM Healthcare Investments+4 more

Imperativeimperative.comin𝕏Jul 2021 · $260M

Chronus is a platform that connects employees for guided, AI-assisted conversations focused on career development, mentoring, community building, and change adoption in enterprise organizations.

AI & Machine LearningEnterprise SoftwareFuture of WorkHR TechSaaSNew York, US

Aaron Hurst(Founder)in

Co-investorsVoyager CapitalAlly Bridge GroupAmed VenturesAscension VenturesBain Capital Life SciencesCatalio Capital Management+2 more

MOMA Therapeuticsmomatx.comin𝕏May 2022 · $150M

A drug discovery company staffed by scientists and industry specialists focused on developing pharmaceutical candidates.

Biotech

Timur Yusufzai(Founder)inAsit Parikh(Chief Executive Officer)in

Co-investorsNextech InvestThird Rock VenturesAlexandriaCasdin CapitalCreacion VenturesGoldman Sachs+3 more

Reneoreneo.deinDec 2020 · $95M

Reneo is an asset and investment management platform for decarbonizing residential real estate portfolios in Germany.

Climate TechEnterprise SoftwarePropTechGermany, DE

Lennart Börner(Founder & Co-CEO)inAlexander Graubner-Müller(Founder & Co-CEO)in

Co-investorsFoundamentalAbingworthAisling CapitalAmzak HealthEurazeoLakestar+4 more

Reneo Pharmaceuticalsreneopharma.comDec 2020 · $95M

Xoilac TV is a free online football (soccer) live-streaming platform serving fans in Vietnam, offering Full HD match broadcasts of European, Asian, Vietnamese, and international competitions.

ConsumerMedia & EntertainmentSports Tech

Co-investorsAisling CapitalNew Enterprise Associates (NEA)Pappas CapitalRiverVest Venture PartnersAbingworthAmzak Health+2 more

Simcha Therapeuticssimchatx.cominJan 2022 · $40M

Simcha is a biotechnology company developing new cancer medicines based on immune biology research.

BiotechHealthtechNew Haven, US

Aaron Ring(Executive Officer, Director)inBeatrice McQueen(Chief Operating Officer)inSanuj Ravindran(Chief Executive Officer)Jeremy Barton(Chief Medical Director)Hirdesh Uppal(Senior Vice President Translational Research and Development Sciences)Joseph Catino(Executive Officer)

Co-investorsConnecticut InnovationsPfizer Venture InvestmentsSR One Capital ManagementAxial VCBiotechnology Value FundSamsara BioCapital

Synthekinesynthekine.comin𝕏

Synthekine is a clinical-stage biotechnology company using protein engineering platforms to develop cytokine-based immunotherapies designed to preserve therapeutic efficacy while avoiding toxicities linked to cytokine pleiotropy.

BiotechHealthtech

K. Christopher Garcia(Founder)Susan Molineaux(CEO)inMartin Oft(Chief Scientific Officer)inNaiyer Rizvi(Chief Medical Officer)inGregory(Chief Technical Officer)Geoff(Chief Business Officer)

Co-investorsSamsara BioCapitalThe Column GroupBain Capital Life SciencesCanaan PartnersRA CapitalTCG Crossover+2 more

Theseustheseus.usinApr 2021

Theseus builds robotic situational awareness software using visual positioning for drones that operate in GPS-denied environments.

Advanced ManufacturingAI & Machine LearningDefense TechHardwareRoboticsSan Francisco, US

Ian Laffey(Founder)inSacha Lévy(Founder)in

Co-investorsY CombinatorAntlerFirst Round CapitalForesite CapitalLongitude CapitalLux Capital+4 more

Theseus Pharmaceuticalstheseusrx.comApr 2021

BiotechCambridge, US

William C. Shakespeare(Director)in

BoardIain Dukes(Executive Officer, Director)inMichael Rome(Director)inCarl Gordon(Director)in

Co-investorsForesite CapitalLongitude CapitalNextech InvestNexTech VenturesOrbiMedPontifax Venture Capital+1 more

Treeline Biosciencestreeline.bioSep 2025

Treeline develops therapeutics focused on oncology, leveraging insights from clinical practice and laboratory research.

AI & Machine LearningBiotechMedical DevicesWatertown, US

Joshua H. Bilenker(Executive Officer, Director, Promoter)Jeffrey Engelman(Executive Officer, Director, Promoter)inJosh Bilenker(Founder)in

BoardKristina Burow(Director)inAli Satvat(Director)David Schenkein(Director)in

Co-investorsAisling CapitalARCH Venture PartnersOrbiMedCasdin CapitalFidelity InvestmentsGV (Google Ventures)+1 more

Vets First Choicevetsfirstchoice.comin

Covetrus provides software and pharmacy solutions for veterinary practices, including an integrated platform that manages prescription workflows, online pharmacy storefronts with home delivery, and compounded medication services.

HealthtechMedical DevicesSaaS

Co-investorsHarbor Light Capital PartnersMountain Group CapitalBorealis VenturesClayton Dubilier & RiceHLM Venture PartnersSequoia Heritage+1 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

EIP PharmaFlame Biosciences

Exits · 7

7 IPOs · showing 6

Avalyn Pharma IncNASDAQ: AVLNBolt BiotherapeuticsNASDAQ: BOLTDisc MedicineNASDAQ: IRONImmuneeringNASDAQ: IMRXKorro BioNASDAQ: KRROXilio TherapeuticsNASDAQ: XLO

Portfolio news

latest coverage across their companies

IPO stake values · per SEC filings · 2

Value of this firm's stake in each portfolio company at its IPO price, from the prospectus principal-stockholder table.

CompanyOwnedIPO priceAt IPOStake value
Bolt Biotherapeutics6.4%$20.00Feb 2021$44.1M
Immuneering4.4%$15.00Jul 2021$16.3M

Source: SEC S-1 / 424B prospectus filings. Stake value = shares beneficially owned × the initial public offering price, as disclosed — a market value at IPO, not a return multiple (the firm's original cost is not disclosed).

Frequently asked questions

How many investments has Rock Springs Capital made?
Rock Springs Capital has 25 tracked investments, 7 of which have exited, including 3 dated in the last 24 months.
What stage does Rock Springs Capital invest at?
Rock Springs Capital invests at the Late Stage stage.
What sectors does Rock Springs Capital focus on?
Rock Springs Capital focuses on Biotech, Digital Health, Healthtech, Medical Devices.
Where is Rock Springs Capital located?
Rock Springs Capital is headquartered in Baltimore, US.

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