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TCG Crossover

Crossover fundActively deploying

Palo Alto · Seed–Late Stage · 25 people tracked

Also known as TCG CROSSOVER MANAGEMENT, LLC

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Investment thesis

TCG Crossover is a science-driven crossover investment firm dedicated to advancing disruptive medicines. It focuses on companies developing innovative therapeutics and life-science breakthroughs.

Invests inBiotechHealthtechChinaEuropeNorth AmericaPalo AltoUnited States

Source: firm website, verified Aug 3, 2026.

Stage
Seed–Late Stage
HQ
Palo Alto, California, US
Instruments
Equity
Founded
2021
AUM
$5.1B
Tracked investments
30

Team · 25 people

from the firm's website & public directories

What they invest in

from 13 of 30 portfolio companies

Biotech ×12Medical Devices ×9Digital Health ×6Healthtech ×6AI & Machine Learning ×2Deep Tech ×2Consumer ×1

HQs:United States×11

Investments · 30 tracked

founders shown can be your intro path
Lbpharmalbpharma.usNASDAQ: LBRXSEC filingmedium confidence

LB Pharma develops novel therapies for neuropsychiatric disorders, with a lead product candidate called LB-102, an oral small molecule benzamide antipsychotic targeting schizophrenia, bipolar depression, and other neuropsychiatric diseases.

BiotechDigital Health

Zachary Prensky(Executive Officer, Director)Edmund Sullivan(Director)Vincent Grattan(Director)Lauren Stipp(Executive Officer)Mark Panoff(Executive Officer)

Board seatChen Yu· per SEC Form D · $110.7M raise · filed Jan 2024

Aktis Oncologyaktisoncology.cominNASDAQ: AKTS

Aktis Oncology discovers and develops targeted radiopharmaceuticals for treating solid tumors.

BiotechHealthtechMedical DevicesBoston, US

Todd Foley(Co-founder and Chairman)Patrick Baeuerle(Co-founder & Advisor)Shulamit Ron-Bigger(Executive Officer)

BoardHelen S. Kim(Director)Oleg Nodelman(Director)Andrew Levin(Director)

CG Oncologycgoncology.comin𝕏NASDAQ: CGON
Entrada Therapeutics, Inc.entradatx.cominNASDAQ: TRDA

Entrada Therapeutics develops intracellular therapeutics using its EEV Platform to target previously inaccessible disease-causing targets within cells, with a pipeline spanning retinal, neuromuscular, and metabolic diseases including Duchenne muscular dystrophy.

BiotechHealthtechMedical DevicesBoston, US

Carole Nuechterlein(Director)Natarajan Sethuraman(Executive Officer)Kush M. Parmar(Director)inTodd Foley(Director)Peter Kim(Director)Nerissa Kreher(Executive Officer)

Upstream Bioupstreambio.comin𝕏NASDAQ: UPB
ADARx Pharmaceuticals, Inc.SEC filingmedium confidence

San Diego, US

Board seatChen Yu· per SEC Form D · $200M raise · filed Aug 2023

Ollin Biosciences, Inc.SEC filingmedium confidence

Austin, US

Board seatCariad Chester· per SEC Form D · $330M raise · filed Jun 2026

Plexiumplexium.comin

Plexium is a targeted protein degradation company developing small molecule therapeutics for treating diseases with high unmet medical needs using their proprietary DELTA Discovery platform.

AI & Machine LearningBiotechDeep TechSan Diego, US

Michael Martin, Ph.D.(Chief Executive Officer, President)Jorge F. DiMartinoMichael Martin(President, Chief Executive Officer)

BoardMike Grey(Executive Chairman)in

Board seatCariad Chester· per SEC Form D

Adarxadarx.comin
Adcendoadcendo.com

Adcendo develops antibody-drug conjugates (ADCs) targeting cancers with high unmet medical need.

BiotechMedical Devices

Affinia Therapeuticsaffiniatx.comin

Affinia Therapeutics develops genetically engineered adeno-associated virus (AAV) therapies for treating genetic diseases, focusing initially on cardiovascular and central nervous system conditions.

AI & Machine LearningBiotechDeep TechWaltham, US

Carole Faig(Director)Rami Daoud(Executive Officer)Diana Brainard(Director)Rick Modi(Executive Officer, Director)Luc Vandenberghe(Director)Elliott Sigal(Director)

Alkeuspharmaalkeuspharma.comin𝕏

Alkeus Pharma develops therapies for retinal diseases, including inherited and neovascular conditions.

BiotechDigital HealthHealthtechMedical DevicesCambridge, US

Carlos Quezada-Ruiz(Chief Medical Officer)

Arbor Biotechnologiesarbor.bioin𝕏

Arbor develops programmable DNA editors for genetic medicine, aiming to enable functional cures for patients by addressing genetic diseases through bespoke gene editing approaches.

BiotechDigital HealthMedical DevicesCambridge, US

KEITH CRANDELL(Director)DAVID ARTHUR SCOTT(Executive Officer)WINSTON XIA YAN(Executive Officer)ANNIE HAZLEHURST(Director)FENG ZHANG(Director)

BoardDAVID R. WALT(Director)

Beacontxbeacontx.comin𝕏

Beacon Therapeutics is a clinical-stage biotechnology company developing gene therapies for rare and prevalent ocular diseases, including X-linked retinitis pigmentosa.

BiotechDigital HealthMedical Devices

Daniel Chung(Chief Medical Officer)

Candid Therapeuticscandidrx.comin

CandidRx develops T-cell engager antibodies to treat autoimmune diseases by redirecting T-cells to eliminate autoreactive B-cells.

BiotechHealthtechSan Diego, US

Ken Song(Chairman, President and CEO)Kenneth Song, M.D.(Executive Officer, Director)Arvind Kush(Executive Officer)Timothy Lu, M.D.(Executive Officer)Bernie Huyghe, Ph.D.(Executive Officer)

BoardJeffrey Tong, Ph.D.(Director)

CandidProcandidco.comin

Candid develops clear aligner technology and offers remote monitoring services for dental professionals to deliver orthodontic treatment.

ConsumerDigital HealthHealthtechMedical Devices

Damoratxdamoratx.comin

Damora Therapeutics develops targeted monoclonal antibody therapies for rare blood disorders, specifically Essential Thrombocythemia and Myelofibrosis driven by mutant calreticulin mutations.

BiotechDigital HealthMedical Devices

Jennifer Jarrett(Chief Executive Officer & Board Director)Sherwin Sattarzadeh(Chief Operating Officer)Becker Hewes(Chief Medical Officer)

Korsanakorsana.comin
Obsidiantxobsidiantx.comin𝕏
Ollin Bioollin.bio
Pheontxpheontx.comin
Rayze Biorayzebio.comin

RayzeBio develops radiopharmaceutical therapies for cancer treatment.

BiotechHealthtechMedical DevicesSan Diego, US

Ben Hickey(President)Abhi Bhat, PhD(Senior Vice President, Research & Development)Deborah Charych(Executive Officer)Jerel Davis(Director)Ken Song(Executive Officer, Director)Bong Koh(Director)

Shoutipharmashoutipharma.com
Tourmaline Biotourmalinebio.com
Versanisbioversanisbio.com
Vicebiovicebio.comin𝕏

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Fund performance · per public LP disclosures

as of Nov 2025
FundVintageCommittedNet IRRTVPIDPI
TCG Crossover FundLPs: Employees' Retirement System of Rhode Island202116.4%1.42x0.71x

Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).

Public market activity · per SEC filings

what is this? ⓘ

6 insider ownership filings (Forms 3/4/5)

at Vor Biopharma Inc. (VOR), Surrozen, Inc./DE (SRZN)

From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.

Frequently asked questions

What stage does TCG Crossover invest at?
TCG Crossover invests at the Seed, Series A, Series B, Series C, Late Stage stages.
What sectors does TCG Crossover focus on?
TCG Crossover focuses on Biotech, Healthtech.
Where is TCG Crossover located?
TCG Crossover is headquartered in Palo Alto, US.

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