TCG Crossover
Crossover fundActively deployingPalo Alto · Seed–Late Stage · 25 people tracked
Also known as TCG CROSSOVER MANAGEMENT, LLC
Investment thesis
TCG Crossover is a science-driven crossover investment firm dedicated to advancing disruptive medicines. It focuses on companies developing innovative therapeutics and life-science breakthroughs.
Source: firm website, verified Aug 3, 2026.
Team · 25 people
from the firm's website & public directoriesWhat they invest in
from 13 of 30 portfolio companiesBiotech ×12Medical Devices ×9Digital Health ×6Healthtech ×6AI & Machine Learning ×2Deep Tech ×2Consumer ×1
HQs:United States×11
Investments · 30 tracked
founders shown can be your intro pathLB Pharma develops novel therapies for neuropsychiatric disorders, with a lead product candidate called LB-102, an oral small molecule benzamide antipsychotic targeting schizophrenia, bipolar depression, and other neuropsychiatric diseases.
BiotechDigital Health
Zachary Prensky(Executive Officer, Director)Edmund Sullivan(Director)Vincent Grattan(Director)Lauren Stipp(Executive Officer)Mark Panoff(Executive Officer)
Board seatChen Yu· per SEC Form D · $110.7M raise · filed Jan 2024
Aktis Oncology discovers and develops targeted radiopharmaceuticals for treating solid tumors.
BiotechHealthtechMedical DevicesBoston, US
Todd Foley(Co-founder and Chairman)Patrick Baeuerle(Co-founder & Advisor)Shulamit Ron-Bigger(Executive Officer)
BoardHelen S. Kim(Director)Oleg Nodelman(Director)Andrew Levin(Director)
Entrada Therapeutics develops intracellular therapeutics using its EEV Platform to target previously inaccessible disease-causing targets within cells, with a pipeline spanning retinal, neuromuscular, and metabolic diseases including Duchenne muscular dystrophy.
BiotechHealthtechMedical DevicesBoston, US
Carole Nuechterlein(Director)Natarajan Sethuraman(Executive Officer)Kush M. Parmar(Director)inTodd Foley(Director)Peter Kim(Director)Nerissa Kreher(Executive Officer)
San Diego, US
Board seatChen Yu· per SEC Form D · $200M raise · filed Aug 2023
Austin, US
Board seatCariad Chester· per SEC Form D · $330M raise · filed Jun 2026
Plexium is a targeted protein degradation company developing small molecule therapeutics for treating diseases with high unmet medical needs using their proprietary DELTA Discovery platform.
AI & Machine LearningBiotechDeep TechSan Diego, US
Michael Martin, Ph.D.(Chief Executive Officer, President)Jorge F. DiMartinoMichael Martin(President, Chief Executive Officer)
BoardMike Grey(Executive Chairman)in
Board seatCariad Chester· per SEC Form D
Adcendo develops antibody-drug conjugates (ADCs) targeting cancers with high unmet medical need.
BiotechMedical Devices
Affinia Therapeutics develops genetically engineered adeno-associated virus (AAV) therapies for treating genetic diseases, focusing initially on cardiovascular and central nervous system conditions.
AI & Machine LearningBiotechDeep TechWaltham, US
Carole Faig(Director)Rami Daoud(Executive Officer)Diana Brainard(Director)Rick Modi(Executive Officer, Director)Luc Vandenberghe(Director)Elliott Sigal(Director)
Alkeus Pharma develops therapies for retinal diseases, including inherited and neovascular conditions.
BiotechDigital HealthHealthtechMedical DevicesCambridge, US
Carlos Quezada-Ruiz(Chief Medical Officer)
Arbor develops programmable DNA editors for genetic medicine, aiming to enable functional cures for patients by addressing genetic diseases through bespoke gene editing approaches.
BiotechDigital HealthMedical DevicesCambridge, US
KEITH CRANDELL(Director)DAVID ARTHUR SCOTT(Executive Officer)WINSTON XIA YAN(Executive Officer)ANNIE HAZLEHURST(Director)FENG ZHANG(Director)
BoardDAVID R. WALT(Director)
CandidRx develops T-cell engager antibodies to treat autoimmune diseases by redirecting T-cells to eliminate autoreactive B-cells.
BiotechHealthtechSan Diego, US
Ken Song(Chairman, President and CEO)Kenneth Song, M.D.(Executive Officer, Director)Arvind Kush(Executive Officer)Timothy Lu, M.D.(Executive Officer)Bernie Huyghe, Ph.D.(Executive Officer)
BoardJeffrey Tong, Ph.D.(Director)
Damora Therapeutics develops targeted monoclonal antibody therapies for rare blood disorders, specifically Essential Thrombocythemia and Myelofibrosis driven by mutant calreticulin mutations.
BiotechDigital HealthMedical Devices
Jennifer Jarrett(Chief Executive Officer & Board Director)Sherwin Sattarzadeh(Chief Operating Officer)Becker Hewes(Chief Medical Officer)
RayzeBio develops radiopharmaceutical therapies for cancer treatment.
BiotechHealthtechMedical DevicesSan Diego, US
Ben Hickey(President)Abhi Bhat, PhD(Senior Vice President, Research & Development)Deborah Charych(Executive Officer)Jerel Davis(Director)Ken Song(Executive Officer, Director)Bong Koh(Director)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Fund performance · per public LP disclosures
as of Nov 2025| Fund | Vintage | Committed | Net IRR | TVPI | DPI |
|---|---|---|---|---|---|
| TCG Crossover FundLPs: Employees' Retirement System of Rhode Island | 2021 | — | 16.4% | 1.42x | 0.71x |
Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).
Public market activity · per SEC filings
what is this? ⓘ6 insider ownership filings (Forms 3/4/5)
at Vor Biopharma Inc. (VOR), Surrozen, Inc./DE (SRZN)
From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.
Frequently asked questions
- What stage does TCG Crossover invest at?
- TCG Crossover invests at the Seed, Series A, Series B, Series C, Late Stage stages.
- What sectors does TCG Crossover focus on?
- TCG Crossover focuses on Biotech, Healthtech.
- Where is TCG Crossover located?
- TCG Crossover is headquartered in Palo Alto, US.
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