Fundraising Fox

MPM BioImpact

Venture capital

Boston · Pre-Seed–Series C · 40 people tracked

Also known as MPM ASSET MANAGEMENT LLC

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Investment thesis

MPM BioImpact invests in biotechnology companies working to transform the lives and outcomes of patients suffering from disease. The firm's BioImpact Fund approach spans both private and public equity, combining MPM Capital's 30+ year biotech venture track record with BioImpact's 10+ years of public investing and dedication to impact. Entrepreneur Partners bring deep domain expertise across the entire drug development process and regulatory landscape, informing every investment decision across all development phases. The firm is committed to Global Standards for managing impact investments.

Invests inBiotechHealthtechImpact & Social GoodLongevityMental HealthAsia-PacificBostonGlobalNorth America

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Series C
Check
$1M – $15M
HQ
Boston, Massachusetts, US
Instruments
Equity
Founded
1992
AUM
$3.6B
Tracked investments
32

Team · 40 people

from the firm's website & public directories
Chris Bardon· Managing Partner

Managing Partner at MPM BioImpact who led the firm's early public investment in argenx.

Chris Bardon, M.D.· Managing Partner
Michael Ehlers, M.D.· Board Member

What they invest in

from 25 of 32 portfolio companies

Biotech ×25Medical Devices ×14Healthtech ×9Digital Health ×5AI & Machine Learning ×3Deep Tech ×1FemTech ×1Mental Health ×1

HQs:United States×18

Investments · 32 tracked

founders shown can be your intro path
Aktis Oncologyaktisoncology.cominNASDAQ: AKTS

Aktis Oncology discovers and develops targeted radiopharmaceuticals for treating solid tumors.

BiotechHealthtechMedical DevicesBoston, US

Todd Foley(Co-founder and Chairman)Patrick Baeuerle(Co-founder & Advisor)Shulamit Ron-Bigger(Executive Officer)

BoardHelen S. Kim(Director)Oleg Nodelman(Director)Andrew Levin(Director)

Board seatTodd Foley· per SEC Form D

Entrada Therapeutics, Inc.entradatx.cominNASDAQ: TRDA

Entrada Therapeutics develops intracellular therapeutics using its EEV Platform to target previously inaccessible disease-causing targets within cells, with a pipeline spanning retinal, neuromuscular, and metabolic diseases including Duchenne muscular dystrophy.

BiotechHealthtechMedical DevicesBoston, US

Carole Nuechterlein(Director)Natarajan Sethuraman(Executive Officer)Kush M. Parmar(Director)inTodd Foley(Director)Peter Kim(Director)Nerissa Kreher(Executive Officer)

Board seatTodd Foley· per SEC Form D

Dyne Therapeuticsdyne-tx.comin𝕏NASDAQ: DYN

Dyne Therapeutics develops targeted therapies for genetically driven neuromuscular diseases using its proprietary FORCE platform.

BiotechMedical DevicesWaltham, US

Lawrence Klein, Ph.D.(Director)Richard Scalzo(Executive Officer)Joshua Brumm(Executive Officer, Director)David Lubner(Director)Edward Hurwitz(Director)Dirk Kersten(Director)

ChiasmaSEC filinghigh confidence

BiotechNewton Centre, US

Scott Minick(Director)John A. Scarlett(Director)Chaime Orlev(Executive Officer)Todd T. Foley(Director)Vincent Miles(Director)Ansbert K. Gadicke(Director)

Board seatAnsbert K. Gadicke· per SEC Form D · $87.2M raise · filed Mar 2015

Clinical inkin𝕏SEC filingmedium confidence

Digital data collection and clinical trial technology platform offering Direct Data Capture, eCOA, eConsent, and digital biomarkers.

Winston-Salem, US

Ansbert Gadicke(Director)Matt King(Director)Joe Schmidt(Executive Officer)Brad Geesaman(Director)Robert Kniejski(Director)Todd Foley(Director)

Board seatTony RosenbergTodd Foley· per SEC Form D · $2.5M raise · filed Dec 2017

Crossbow Therapeuticscrossbowtx.comin

Crossbow Therapeutics develops TCR-mimetic antibody therapies designed to target cancer antigens by mimicking T-cell receptors, with a focus on treating solid tumors and hematologic malignancies.

AI & Machine LearningBiotechMedical DevicesCambridge, US

Alexander Nolte(Executive Officer)inAlexandra Cantley(Director)inDmitri Wiederschain(Executive Officer)inSakae Asanuma(Director)inCharles Baum(Director)inIrena Melnikova(Director)in

Board seatTodd Foley· per SEC Form D

Firefly Bio, Inc.SEC filingmedium confidence

South San Francisco, US

Board seatTodd Foley· per SEC Form D · $72M raise · filed Mar 2024

HotKnot Therapeutics, Inc.SEC filingmedium confidence

BiotechCambridge, US

Brian Goodman(Executive Officer)Todd Foley(Director)Lloyd M. Segal(Director)Matthew Roden(Executive Officer, Director)

Board seatTodd Foley· per SEC Form D · $72M raise · filed Feb 2021

Moat BiotechnologySEC filingmedium confidence

BiotechOklahoma City, US

Russell P. Rother(Executive Officer, Director, Promoter)Michael Moradi-Araghi(Director)Scott A. Rollins(Executive Officer, Director, Promoter)Todd Foley(Director)Phillip Jones(Director)Philip Jones(Director)

Board seatTodd Foley· per SEC Form D · $15.6M raise · filed Oct 2025

NextPoint Therapeuticsnextpointtx.comin𝕏

NextPoint is developing precision cancer therapeutics based on the B7-H7/HHLA2 axis, including T-cell engagers, antibody-drug conjugates, and checkpoint inhibitors for cancer patients.

BiotechDigital HealthMedical DevicesAustin, US

Detlev Biniszkiewicz(Director)Ivan Cheung(Executive Officer, Director)Axel Hoos(Director)R. Jacob Vogelstein(Director)Brian Shuster(Director)Paulina Hill(Director)

Board seatDetlev Biniszkiewicz· per SEC Form D

Reunion Neurosciencereunionneuro.comin𝕏

Reunion develops serotonergic psychedelic therapies for mental health conditions, targeting postpartum depression, adjustment disorder, and generalized anxiety disorder.

BiotechDigital HealthMental HealthMorristown, US

Sahil V. Kirpekar(President and CEO)Gregory Mayes(Executive Officer, Director)Michael Ehlers(Director)Ansbert Gadicke(Director)Natalie Sacks(Director)Ellen Lubman(Director)

Board seatAnsbert K. Gadicke· per SEC Form D

Tetherex Pharmaceuticals CorpSEC filingmedium confidence

BiotechOklahoma City, US

David Facloner(Executive Officer)Richard Alvarez(Executive Officer)Rodger McEver, M.D.(Director)David Keiser(Director)Scott Rollins, Ph.D.(Executive Officer, Director)Russell Rother(Executive Officer)

Board seatTodd Foley· per SEC Form D · filed Dec 2020

0 2 AstronauTxastronautx.bioin
Aktis

Transforming the radiopharmaceutical field to deliver significant patient impact potential.

Antiva Biosciencesantivabio.comin

Antiva Biosciences develops a topical therapeutic for women with high-risk HPV infection and pre-cancerous cervical lesions, utilizing antiviral prodrug chemistry.

BiotechFemTechHealthtechMedical DevicesRedwood City, US

Gail Maderis(Director)Kristine Ball(Executive Officer, Director)Elaine Chien(Executive Officer)Sarah Walter(Executive Officer)Raju Gadiraju(Executive Officer)Steven James(Director)

Argenxargenx.com

argenx is an immunology company that operates an antibody innovation ecosystem where scientists and antibody engineers develop novel targets, disease pathways, and therapeutic antibodies.

BiotechHealthtech

Arialysarialysrx.comin𝕏

Arialys Therapeutics develops precision medicines targeting pathogenic autoantibodies in the brain to treat neuropsychiatric disorders driven by autoimmune disease.

BiotechDigital HealthMedical DevicesLa Jolla, US

Jay Lichter, Ph.D.(Director)Peter Flynn, Ph.D.(Executive Officer, Director)Brian Slingsby, M.D., Ph.D., M.P.H.(Director)Ed Hurwitz(Director)Ashish Xavier, Ph.D.(Director)Tighe Reardon(Executive Officer)

AshiBioashibio.comin

āshibio is a clinical-stage biotech developing therapies for bone and connective tissue disorders, with clinical programs targeting heterotopic ossification conditions (including fibrodysplasia ossificans progressiva) and autosomal dominant osteopetrosis type 2.

BiotechHealthtechBurlingame, US

Cullinan Oncologycullinanoncology.comin𝕏

Cullinan Therapeutics develops clinical-stage T cell engager therapies targeting autoimmune diseases and cancer, leveraging immune modulation expertise to advance high-impact therapeutic candidates.

BiotechDigital Health

elevatebioelevate.bioin𝕏

ElevateBio is a contract development and manufacturing organization (CDMO) that provides end-to-end services for cell and gene therapies, from discovery and process development through clinical and commercial-scale manufacturing.

BiotechDeep TechMedical Devices

Mike Paglia(Chief Technology Officer)

Fablefabletherapeutics.com

Fable Therapeutics develops biologics for metabolic disease treatment, specifically targeting the ActR2 pathway to address obesity and related comorbidities through protein engineering.

BiotechHealthtechMedical Devices

Fireflyfireflybiologics.comin

Firefly Bio develops Degrader Antibody Conjugates (DACs), a technology that combines antibody drug conjugates with selective protein degraders to deliver degraders to target tissue.

BiotechMedical Devices

Frontier Medicinesfrontiermeds.comin𝕏

Frontier Meds develops small-molecule drugs targeting previously undruggable protein targets using a proprietary approach to identify and exploit novel binding sites across the human proteome.

BiotechSouth San Francisco, US

Jim Winkler(Executive Officer)Janwillem Naesens(Director)Johannes Hermann, Ph.D.(Executive Officer)Kevin Webster(Executive Officer)Cameron Wheeler(Director)Luke Evnin(Director)

Ornaornatx.comin

Orna Therapeutics develops RNA and lipid nanoparticle (LNP) based therapies for treating diseases including oncology and cell therapy applications.

AI & Machine LearningBiotechMedical Devices

Joe Bolen(Chief Executive Officer)Joe Bolen, Ph.D.(Chief Executive Officer)Hope D'Oyley-Gay, JD(Chief Legal Officer)Ciaran Lawlor, Ph.D.(Chief Operating Officer)Frank Neumann, M.D., Ph.D.(Chief Medical Officer)Siva Sakhamuri(Chief Technology Officer)

Protegoprotegobiopharma.com
Recodetxrecodetx.comin

ReCode develops mRNA and gene correction therapeutics for genetic diseases, using proprietary lipid nanoparticle technology to deliver treatments to specific organs.

AI & Machine LearningBiotechMedical Devices

Dr. Daniel J. Siegwart

Reunion

Pioneering a new treatment paradigm for severe mental health disorders with rapid-acting and well-tolerated therapeutic options.

Tizona Therapeutics, Inc.tizonatx.com

Tizona Therapeutics develops first-in-class immunotherapies for the treatment of cancer, translating scientific research into novel drug candidates.

BiotechHealthtech

Trishula Therapeutics, Inc.trishulatx.comin

Trishula Therapeutics develops cancer treatments that target immune evasion mechanisms in the tumor microenvironment.

BiotechHealthtech

Umoja Biopharma, Inc.umoja-biopharma.comin𝕏

Umoja Biopharma develops in vivo CAR T cell therapies for cancer treatment using its VivoVec platform, which generates CAR T cells directly in patients' bodies.

BiotechDigital HealthMedical DevicesSeattle, US

Philip S. Low(Director)Irena Melnikova(Executive Officer)Anna French(Director)Robert Glassman(Director)John Hamer(Director)Luke Evnin(Director)

Werewolf Therapeuticswerewolftx.com

Werewolf Therapeutics is a biotechnology company developing immunotherapy treatments for cancer.

BiotechHealthtechMedical DevicesWatertown, US

Daniel J. Hicklin(Founder, President, Chief Executive Officer, and Board member)Luke Evnin(Co-founder, Board member (Chairman))Daniel Hicklin(Executive Officer, Director)Alon Lazarus(Director)David Cordo(Executive Officer)Christoph Westphal(Director)

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Frequently asked questions

What stage does MPM BioImpact invest at?
MPM BioImpact invests at the Pre-Seed, Seed, Series A, Series B, Series C stages.
What is MPM BioImpact's typical check size?
MPM BioImpact typically writes checks of $1M – $15M.
What sectors does MPM BioImpact focus on?
MPM BioImpact focuses on Biotech, Healthtech, Impact & Social Good, Longevity, Mental Health.
Where is MPM BioImpact located?
MPM BioImpact is headquartered in Boston, US.

Co-investors · 18

Agent Capital

Agent Capital is a healthcare venture capital firm that invests in novel, differentiated therapeutics and treatments addressing unmet patient needs across all stages of development.

Andreessen Horowitz

Andreessen Horowitz's Strategic Partnerships page describes collaborations that connect its portfolio companies with established institutions to help scale and deploy their technology.

Both backed · 1
$500K – $50M
8VC

8VC is a technology investment firm that builds and invests in ambitious companies across sectors including life sciences, healthcare, manufacturing, enterprise, logistics, and defense.

Both backed · 1
Photys Therapeutics, Inc.
$100K – $50M
Polaris Partners

Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.

Both backed · 1
$500K – $5M
GV (Google Ventures)

GV (formerly Google Ventures) is a venture investment firm that backs founders across many industries, aiming to build long-term relationships and support companies across multiple stages and milestones.

$250K – $50M
ARCH Venture Partners

ARCH Venture Partners is a venture capital firm that backs and helps build transformational companies, with a strong focus on the life sciences and biotech sector.

$50K – $250M
Third Point Ventures

Third Point Ventures is the venture capital arm that invests in and supports technology companies, guiding, coaching, and connecting founders from early to late stage.

Earlybird Venture Capital

Earlybird Venture Capital is a European venture capital firm that backs early-stage technology founders with capital, strategic support, and access to an international network.

$540K – $13M
Versant Ventures

Versant Ventures operates in-house Discovery Engines staffed by multidisciplinary scientists in dedicated laboratory facilities to help launch new biotechnology companies alongside academic founders.

$250K – $5M
Digitalis Ventures

Digitalis Ventures invests in solutions to unmet needs in biomedicine and health, backing biotechnology and technology-enabled companies across human health and animal health.

$100K – $10M
6 more co-investors

Frazier Healthcare PartnersVivo CapitalQiming Venture PartnersTencent HoldingsCofounders CapitalMedical Excellence Capital

Firms observed investing alongside MPM BioImpact, from public investor directories. Shared companies are the overlap with MPM BioImpact's recorded portfolio.

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