Cambridge · Seed–Series A · 5 people tracked
Also known as Flagship Pioneering Special · FLAGSHIP PIONEERING, LLC · Flagship Ventures Management, Inc.
Investment thesis
Flagship Pioneering has spent over 25 years pursuing breakthroughs at the frontiers of science, aiming to make the seemingly impossible possible for the benefit of people and the planet. The firm emphasizes a culture of fearless exploration and discovery, building companies and pioneering advances that push the boundaries of knowledge. Its work is centered on both scientific breakthroughs and the people who drive them.
Source: firm website, verified Aug 25, 2026.
Team · 5 people
from the firm's website & public directories
Founder mafia
The Flagship Pioneering mafia →14 people who came through Flagship Pioneering went on to found or lead other companies.
+ 2 more
What they invest in
from 42 of 55 portfolio companiesBiotech ×31AI & Machine Learning ×21Deep Tech ×15Healthtech ×9Medical Devices ×8Developer Tools ×4Digital Health ×4Enterprise Software ×4
HQs:United States×19Germany×1Rwanda×1Sweden×1
Who they back
founder profiles across 8 portfolio companiesFounding team size:solo founder×63 founders×2
Investments · 55 tracked
founders shown can be your intro pathBy year:2026 · 12025 · 42024 · 22018 · 22017 · 22015 · 32014 · 216 dated
Generate:Biomedicines develops protein-based therapeutics using artificial intelligence and machine learning in a field it calls Generative Biology, combining computational protein design with biological engineering.
AI & Machine LearningBiotechDeep TechSomerville, US
Gevorg Grigoryan(Co-Founder & Chief Technology Officer)in
Co-investorsARCH Venture PartnersMarch Capital PartnersNVentures
Seres Therapeutics is a clinical-stage biotechnology company developing therapies composed of rationally selected live bacterial consortia to treat serious diseases through modulation of the human microbiome.
BiotechDigital HealthHealthtechMedical DevicesCambridge, US
Matthew Henn(President and Chief Scientific Officer)
Co-investorsRA CapitalSofinnova Ventures
BiotechCambridge, US
John Aunins(Executive Officer)Eric D. Shaff(Executive Officer)David Cook(Executive Officer)Roger J. Pomerantz(Executive Officer, Director)Roger Pomerantz(Executive Officer, Director)
Board seatDavid BerryNoubar Afeyan· per SEC Form D · $65M raise · filed Jan 2015
CIBO provides a software platform for designing, deploying, and measuring regenerative agriculture and conservation programs, including workflow automation, scientific modeling, impact reporting, and a network of advisors managing grower engagement.
AgTechAI & Machine LearningClimate TechSaaSCambridge, US
Bruno Basso(Co-Founder and Special Advisor)David Worn(Executive Officer, Director)Barry Martin(Executive Officer)Ryan Richt(Executive Officer)Dale Sorensen(Executive Officer)Sunand Menon(Executive Chairman & CEO)
Board seatIgnacio MartinezStephen BerensonNoubar Afeyan· per SEC Form D
Co-investorsGeneration Investment ManagementStage 1 Ventures
Abiologics uses computational design tools to create protein-inspired molecules called Synteins, engineered to avoid the vulnerabilities of natural protein medicines while retaining biological function.
AI & Machine LearningBiotechDeep Tech
Avak Kahvejian(Chairman (Founder / founding CEO))Maria-Chiara Magnone(Chief Scientific Officer)Mike(Chief Innovation Officer & Co-Founder)Jaclyn Dunphy(Co-Founder & Senior Director of Strategy and Research Operations)
Alltrna develops engineered, chemically modified tRNA oligonucleotides as programmable medicines, using proprietary machine learning tools to design tRNA molecules with desired pharmacologic properties.
AI & Machine LearningBiotechDeep TechHealthtech
Michelle Werner(CEO)Lovisa Afzelius(Executive Chair & Founding CEO)Joanne Protano(President & Chief Financial Officer)Dave Hava(Chief Scientific Officer)Nerissa Kreher(Chief Medical Officer)Caroline Köhrer(SVP, Discovery Platform)
Apriori Bio applies AI/ML combined with biological insights to predict how viruses evolve and to design vaccines, assessing their expected performance before clinical trials.
AI & Machine LearningBiotechDeep TechHealthtech
Cloud ComputingData & InfrastructureEnterprise SoftwareAustin, US
Jonathan Ring(Executive Officer, Director)Paul Carpentier(Director)George Teixeira(Chairman of the Board, Co-founder)inJohn Bocskor(Former DataCore Vice President, Product Development and Co-founder)Dave Zabrowski(Chief Executive Officer)inKevin Thimble(Chief Financial Officer)in
Co-investorsInsight PartnersNew Science Ventures
Etiome develops stage-specific medicines by applying single-cell omics and artificial intelligence to map disease progression and identify disease-modifying targets at early biological inflection points for preemptive intervention.
AI & Machine LearningBiotechLongevity
Katharine von Herrmann(Co-founder)Avak Kahvejian(Founding Team; Founding CEO)Noubar Afeyan(Founding Team)Scott Lipnick(Founding Team)Torben Straight Nissen(Founding Team; Board Director)Yann Echelard(Founding Team; Chief Operating Officer)
Inari applies artificial intelligence and gene editing to accelerate plant breeding, delivering crop improvement solutions for farmers focused on soybeans, corn, and wheat across broadacre agriculture.
AgTechAI & Machine LearningBiotechCambridge, US
Lisa Safarian(CEO)Stuart Brown(Chief Financial Officer)Pierre-Etienne Boin(Secretary and General Counsel)Ponsi Trivisvavet(President and Chief Executive Officer)
BoardRobert Berendes, Ph.D.(Director)Ignacio Martinez(Director)in
Co-investorsAcre Venture PartnersCongruent VenturesG Squared
Metaphore develops a platform that measures biological activity inside cells at scale to design antibody medicines with novel mechanisms of action.
AI & Machine LearningBiotechDeep TechMedical Devices
Co-investorsGlobal Brain
Montai is a drug discovery company that combines human biology, chemistry, computational biology, and machine learning to identify connections between chemistry and disease pathways and develop new therapies.
AI & Machine LearningBiotechDeep TechHealthtech
Quotient is a biotechnology company applying somatic genetics research to R&D, developing its work through a proprietary platform.
AI & Machine LearningBiotechDeep Tech
Sail Biomedicines develops programmable RNA medicines using circular RNA technology (Endless RNA/eRNA) and targeted nanoparticles for delivery, applying generative AI to design therapies.
AI & Machine LearningBiotechDeep Tech
Co-investorsNextech InvestQuan Capital
Terrana Biosciences is an agricultural biotech company applying RNA technology to plant health, developing a platform that gives crops new traits such as drought tolerance and shorter ripening times.
AgTechAI & Machine LearningBiotechDeep Tech
Noubar Afeyan(Founder)Ignacio Martinez(Founder)Ryan Rapp(Founder & CEO)
Vesalius Therapeutics develops a computational platform that identifies distinct disease subtypes within common diseases like heart failure, diabetes, and Alzheimer's by analyzing patient data and gene circuits, then uses proprietary cell-based models to discover targeted drug candidates.
AI & Machine LearningBiotechDeep TechCambridge, US
Yasir Al-Wakeel(CEO)in
Co-investorsARCH Venture Partners
BG Medicine develops the BGM Galectin-3 test, a diagnostic blood test marker used in the assessment of cardiac fibrosis.
BiotechHealthtechMedical DevicesWaltham, US
Stephen Hall(Executive Officer)Paul Sohmer(Executive Officer, Director)Aram Adourian(Executive Officer)Harry Wilcox(Director)
BoardTimothy Harris(Director)
Board seatNoubar Afeyan· per SEC Form D · $2.5M raise · filed May 2015
Cambridge, MA clinical-stage biotech developing engineered exosome therapeutics; IPO'd on NASDAQ in 2020, later restructured.
BiotechSeattle, US
Doug Williams(Executive Officer, Director)
BoardSteven Gillis(Director)Eric Lander(Director)
Board seatNoubar Afeyan· per SEC Form D · filed Nov 2015
Co-investorsARCH Venture PartnersEcoR1 Capital
Moderna develops mRNA-based medicines for infectious and serious diseases using its proprietary mRNA platform and design technology.
BiotechDeep TechMedical DevicesCambridge, US
Robert Langer(Director)Lorence Kim(Executive Officer)James R. Kasinger(Executive Officer)Stephen Hoge(Executive Officer)Theo Melas-Kyriazi(Director)Robert Carpenter(Director)
Board seatNoubar Afeyan· per SEC Form D
Co-investorsAglae VenturesBlackstone Life SciencesFPVKhosla VenturesPremji InvestRA Capital
BiotechCambridge, US
Robert Connelly(Executive Officer, Director)Garry Menzel(Executive Officer)Jeff Moore(Executive Officer)
BoardJohn Mendlein(Director)
Board seatDavid BerryNoubar Afeyan· per SEC Form D · filed Feb 2016
BiotechCambridge, US
Torben Straight Nissen(Executive Officer, Director)Joanne Protano(Executive Officer)David Epstein(Director)Harvey F. Lodish(Director)Michael Rosenblatt(Director)Roger Pomerantz(Director)
Board seatNoubar Afeyan· per SEC Form D · $120M raise · filed Jun 2017
Co-investorsKendall Capital Partners
Sana is a biotech company developing engineered cell medicines, including gene therapies for gene modification and delivery, cell replacement therapies using stem cell biology, and manufacturing solutions to improve patient access to these treatments.
BiotechHealthtechMedical DevicesSeattle, US
Steve Harr(President and Chief Executive Officer)
Board seatGeoffrey von Maltzahn· per SEC Form D
Co-investorsAmerican Family VenturesARCH Venture PartnersF-Prime CapitalInnovating CapitalJDRF T1D FundManta Ray Ventures+1 more
Ampersand provides a declarative integration framework for building bi-directional, customer-configurable product integrations with third-party applications.
Developer ToolsEnterprise SoftwareSaaS
Lauren Long(Founder)in
Co-investors2.12 AngelsMatrixFlex Capital Partners
Ampersand is a cash management platform that places large business deposits across a network of FDIC- and NCUA-insured banks and credit unions, extending deposit insurance coverage and providing competitive yields on idle cash.
Enterprise SoftwareFintechSaaS
Co-investorsFINTOP CapitalPatriot Financial Partners
Ampersand builds electric motorcycles, battery packs, swap stations, and AmperOps fleet management software for motorcycle taxi (boda) drivers in Africa, operating a battery-swapping network for commercial e-motos.
CleantechEnergyMobility & Transportation
Co-investorsBeyond CapitalBeyond Capital VenturesEcosystem Integrity FundFactor[e] Ventures
MIT is an educational and research institution in Cambridge, Massachusetts, pursuing teaching, research, and innovation across science, engineering, and other fields.
BiotechEdTechCambridge, US
Co-investorsBeyond Earth VenturesFoundersX VenturesJIMCOLair East LabsMassChallenge MexicoSelvedge Venture
Cellarity develops therapeutics using AI-powered multi-omics analysis to identify and correct dysfunctional cellular states, treating complex diseases by regulating genetic pathways rather than targeting single genes.
AI & Machine LearningBiotechMedical Devices
Co-investorsAhren Innovation CapitalManta Ray Ventures
Cloudflare provides a global cloud network platform delivering security, performance, and development services through sixty-plus integrated services including SASE, application security, and full-stack development infrastructure.
Cloud ComputingCybersecurityDeveloper ToolsSan Francisco, US
Matthew Prince(Founder)inDane Knechtin
Co-investorsApposite CapitalEQT VenturesIcon VenturesKhosla VenturesLocalGlobeLSP (Life Sciences Partners)+7 more
BiotechCambridge, US
Jennifer Glennon(Executive Officer)Balkrishan (Simba) Gill, Ph.D.(Executive Officer, Director)Duncan McHale(Executive Officer)William DeVaul(Executive Officer)Mark Bodmer, Ph.D.(Executive Officer)
BoardNoubar B. Afeyan, Ph.D.(Director)
Co-investorsSV Health InvestorsKaiser Permanente Ventures
Harbinger Health develops early cancer detection technology through its Harbinger HX platform, which embeds developmental biology into biomarker discovery, assay design, and model training to detect faint biological signals of early cancer in real-world samples.
AI & Machine LearningBiotechDigital HealthHealthtech
Inari analyzes customer feedback, support tickets, and CRM data to identify product opportunities and customer insights, automatically surfacing relevant information and linking findings to backlog items.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US
Frank Lee(Founder)inEric Kim(Founder)in
Co-investorsY Combinator
Co-investorsInvestX
Co-investorsKickstart InnovationStage 1 Ventures
Korrus develops circadian lighting technology based on research into light and human biology, holding over 500 patents.
ConsumerHardwareIoTWellness & Fitness
Co-investorsEastward Capital PartnersRichmond Global Ventures
KSQ Therapeutics develops eTIL therapies—engineered tumor-infiltrating lymphocyte treatments for solid tumors—using its proprietary CRISPRomics platform to identify and target novel therapeutic candidates through genome-wide CRISPR/Cas9 functional genomic screens.
AI & Machine LearningBiotechMedical DevicesCambridge, US
Tim Wang(Cofounder)JOHN TRZUPEK, PH.D.(TREASURER, SECRETARY & CHIEF FINANCIAL OFFICER)DAVID P. MEEKER, M.D.(PRESIDENT AND CHIEF EXECUTIVE OFFICER)FRANK STEGMEIER, PH.D.(CHIEF SCIENTIFIC OFFICER)JAMES GILBERT(Director)
BoardALAN L. CRANE(Director)
Co-investorsAlpha Wave GlobalARCH Venture PartnersLAVLilly Asia VenturesBaillie GiffordPolaris Partners
LILA Sciences builds AI systems for autonomous scientific research and discovery across medicine, materials, energy, and defense sectors.
AI & Machine LearningBiotechDeep TechSaaS
Co-investorsCatalio Capital Management, LPDauntless VenturesMarch Capital PartnersModi VenturesCollective GlobalIn-Q-Tel+1 more
Nobelprize.org provides open data about the Nobel Prizes and Nobel Laureates to developers through a REST API and as Linked Data (RDF/SPARQL).
Data & InfrastructureDeveloper ToolsEdTechImpact & Social GoodMedia & EntertainmentStockholm, SE
ProFound Therapeutics identifies previously undiscovered proteins encoded by the human genome and characterizes their biological functions to find new drug targets and therapeutic proteins.
BiotechDeep Tech
Co-investorsModi Ventures
Repertoire's Decode platform focuses on mapping the immune synapse — the interactions between T cell receptors, epitopes, and HLA molecules — to support the development of medicines targeting cancer and other diseases.
AI & Machine LearningBiotechDeep TechDigital HealthHealthtech
Torben Straight Nissen(Chief Executive Officer)Anthony Coyle(President, Research and Development)Robert Andtbacka(Chief Medical Officer)John Delyani(Chief Business Officer)Jan Kisielow(Chief Scientific Officer, Repertoire Immune Medicines (Switzerland) Ltd.)
Co-investorsSoftBank Vision FundJDRF T1D Fund
Ring provides video doorbells and security cameras that allow homeowners to monitor their property and enhance security across indoor and outdoor spaces.
HardwareIoT
Jamie Siminoff(Founder)in
Co-investorsAmerican Family VenturesCRV (Charles River Ventures)Energy Impact PartnersFelicis VenturesGreen Meadow VenturesGrishin Robotics+8 more
Google is a technology company that provides tools and products designed with privacy, security, and responsible AI practices as foundational principles.
AI & Machine LearningCloud ComputingCybersecurity
Co-investors82VSAdvantage Capital PartnersBain Capital VenturesDCVC (Data Collective)EQT VenturesHeartcore Capital+9 more
Serif Biomedicines develops technology to write DNA in different forms so that DNA can be used as a medicine, aiming to create a new category of genetic medicines to treat and prevent disease.
BiotechDeep Tech
Co-investorsModi Ventures
Audio distribution and music-sharing platform for artists and creators.
Berlin, DE
Eric Quidenus-Wahlforss(Founder)in
Co-investorsAtlanticAtlantic LabsBirk VentureEdge Case Capital PartnersGerman Startups GroupIVP (Institutional Venture Partners)+6 more
Tessera Therapeutics develops Gene Writing, a genome engineering technology platform designed to make permanent alterations to the human genome for treating diseases.
BiotechDigital HealthMedical Devices
Co-investorsArtis VenturesMarch Capital PartnersOMX VenturesSoftBank Vision FundSolari CapitalToba Capital+4 more
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 5
IPOs and acquisitions across the tracked portfolioGenerate BiomedicinesNASDAQ: GENBSeres TherapeuticsNASDAQ: MCRBSeres HealthNASDAQ: MCRBFoghorn TherapeuticsNASDAQ: FHTXCaringoacq. by DataCore
Portfolio news
latest coverage across their companies
Valo · startbase.com · Aug 18, 2026
Generate Biomedicines · stocktitan.net · Aug 6, 2026
Moderna · forbes.com · Jul 19, 2026
Cloudflare Turnstile · marketbeat.com · Jul 18, 2026
Inari · theedgemalaysia.com · Jul 13, 2026
Inari · theedgemalaysia.com · Jul 13, 2026
Tessera · erp.today · Jun 26, 2026
Public market activity · per SEC filings
what is this? ⓘ51 insider ownership filings (Forms 3/4/5)
at Generate Biomedicines, Inc. (GENB), Foghorn Therapeutics Inc. (FHTX), Sana Biotechnology, Inc. (SANA), Sigilon Therapeutics, Inc. (SGTX), Evelo Biosciences, Inc. (EVLO), Omega Therapeutics, Inc. (OMGA), Axcella Health Inc. (AXLA), Seres Therapeutics, Inc. (MCRB)
Files 13F institutional holdings reports · latest Aug 2026
From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.
Frequently asked questions
- How many investments has Flagship Pioneering made?
- Flagship Pioneering has 37 tracked investments, 1 of which have exited via acquisition or IPO, including 2 dated in the last 24 months.
- What stage does Flagship Pioneering invest at?
- Flagship Pioneering invests at the Seed, Series A stages.
- What is Flagship Pioneering's typical check size?
- Flagship Pioneering typically writes checks of $500K – $10M.
- What sectors does Flagship Pioneering focus on?
- Flagship Pioneering focuses on AI & Machine Learning, Biotech, Deep Tech, Healthtech, Longevity, Sector Agnostic.
- Where is Flagship Pioneering located?
- Flagship Pioneering is headquartered in Cambridge, US.
- Does Flagship Pioneering lead rounds?
- Flagship Pioneering typically participates in rounds rather than leading them.
- Who does Flagship Pioneering co-invest with?
- Flagship Pioneering most often shares deals with March Capital Partners, Modi Ventures, EQT Ventures, among 79 tracked co-investors.
Media · Podcasts & interviews
featuring the teamAvak Kahvejian of Flagship Pioneering at HLTH USA 2025
New York Stock Exchange · Avak Kahvejian
Flagship Pioneering's Noubar Afeyan speaks to new citizens at the JFK Library
John F. Kennedy Library Foundation · Noubar Afeyan
Fireside Chat with Noubar Afeyan, Founder & CEO of Flagship Pioneering
Boston Globe Events · Noubar Afeyan
No Priors Ep. 104 | With Flagship Pioneering CEO and Co-Founder Noubar Afeyan
No Priors: AI, Machine Learning, Tech, & Startups · Noubar Afeyan
Noubar Afeyan: Moderna, AI, Flagship Pioneering, Biotech, Armenia, Lebanon | Episode #007
MIT New Colossus Project · Noubar Afeyan
Founder Stories: Noubar Afeyan, Flagship Pioneering
Axial · Noubar Afeyan
Images
Co-investors · 28
ARCH Venture Partners is a venture capital firm that backs and helps build transformational companies, with a strong focus on the life sciences and biotech sector.
Khosla Ventures is a venture capital firm that invests in early-stage companies focused on technology, mobile, and clean energy sectors, including biotechnology applications. The firm provides capital and strategic support to entrepreneurs developing breakthrough technologies across multiple markets.
F-Prime Capital is an early-stage-focused investment firm backing companies across life sciences, technology, healthtech and services, and crypto.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
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General Catalyst is a venture capital firm operating as a partnership focused on company building and accelerating the growth of the businesses it backs.
GV (Google Ventures) is a venture capital firm that has invested in artificial intelligence and machine learning since its early days, building a global portfolio of more than 100 AI companies across infrastructure, life sciences, and applications.
Lightspeed is a global venture capital firm that has spent over two decades backing innovative companies as an early and first investor.
Alumni Ventures (AV) is a venture firm that gives accredited individual investors access to professionally managed, diversified venture portfolios by co-investing alongside leading lead VC firms. It offers annual funds, syndicate deal-by-deal investing, and various investor clubs.
Sapphire Ventures partners with expansion-stage enterprise software companies aiming to become category leaders.
SOSV is a deep tech venture capital firm that makes first-check pre-seed investments and follow-on rounds in startups focused on human and planetary health, providing lab space and hands-on support at its US locations.
Venrock is a venture capital firm investing across technology and healthcare, backing companies in fintech, developer infrastructure, life sciences, therapeutics, semiconductors, and consumer products.
23andMe Research Institute is a genetic research organization that unites a community of 11 million members to advance health discoveries and deepen understanding of human DNA through collaborative research. The institute operates a cycle where members contribute genetic data that fuels research, which produces insights and breakthroughs that flow back to members and society.
▶16 more co-investors
Tribeca Venture PartnersOrbiMedFlare Capital PartnersNational Grid PartnersTA VenturesJohnson & Johnson Innovation – JJDCCambridge Innovation CapitalThird Rock VenturesAisling CapitalSamsara BioCapital1955 Capital+ND CapitalVensana CapitalBorealis VenturesACORN BIOVENTURESPetri
Firms observed investing alongside Flagship Pioneering, from public investor directories. Shared companies are the overlap with Flagship Pioneering's recorded portfolio.
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