Flagship Pioneering
Venture studioCambridge · Seed–Series A · 9 people tracked
Also known as Flagship Pioneering Special · FLAGSHIP PIONEERING, LLC · Flagship Ventures Management, Inc.
Investment thesis
Flagship Pioneering has spent over 25 years pursuing breakthroughs at the frontiers of science, aiming to make the seemingly impossible possible for the benefit of people and the planet. The firm emphasizes a culture of fearless exploration and discovery, building companies and pioneering advances that push the boundaries of knowledge. Its work is centered on both scientific breakthroughs and the people who drive them.
Source: firm website, verified Aug 3, 2026.
Team · 9 people
from the firm's website & public directories
What they invest in
from 17 of 50 portfolio companiesBiotech ×15AI & Machine Learning ×7Deep Tech ×5Medical Devices ×5IoT ×2AgTech ×1Consumer ×1Digital Health ×1
HQs:United States×14
Investments · 50 tracked
founders shown can be your intro pathGenerate:Biomedicines develops protein-based therapeutics using artificial intelligence and machine learning in a field it calls Generative Biology, combining computational protein design with biological engineering.
AI & Machine LearningBiotechDeep TechSomerville, US
Gevorg Grigoryan(Co-Founder & Chief Technology Officer)
Seres Therapeutics is a clinical-stage biotechnology company developing therapies composed of rationally selected live bacterial consortia to treat serious diseases through modulation of the human microbiome.
BiotechDigital HealthHealthtechMedical DevicesCambridge, US
Matthew Henn(President and Chief Scientific Officer)
BiotechCambridge, US
Lorence Kim(Executive Officer)Stephane Bancel(Executive Officer, Director)Robert Langer(Director)Peter Hutt(Director)John Mendlein(Director)James R. Kasinger(Executive Officer)
Board seatNoubar Afeyan· per SEC Form D · $600M raise · filed Aug 2016
BiotechCambridge, US
Peter Barton Hutt(Director)Richard Kender(Director)David Berry(Director)Werner Cautreels(Director)Noubar Afeyan(Director)John Aunins(Executive Officer)
Board seatDavid BerryNoubar Afeyan· per SEC Form D · $65M raise · filed Jan 2015
In March 2024, BXLS announced a collaboration providing up to $750M to advance Moderna's influenza mRNA vaccine program.
Inari applies artificial intelligence and gene editing to accelerate plant breeding, delivering crop improvement solutions for farmers focused on soybeans, corn, and wheat across broadacre agriculture.
AgTechAI & Machine LearningBiotechCambridge, US
Lisa Safarian(CEO)Robert Berendes, Ph.D.(Director)Robert Rosiello(Director)Sophie V. Vandebroek(Director)Michael Mack(Chairman of the Board)Ignacio Martinez(Director)
Metaphore develops a platform that measures biological activity inside cells at scale to design antibody medicines with novel mechanisms of action.
AI & Machine LearningBiotechDeep TechMedical Devices
Vesalius Therapeutics develops a computational platform that identifies distinct disease subtypes within common diseases like heart failure, diabetes, and Alzheimer's by analyzing patient data and gene circuits, then uses proprietary cell-based models to discover targeted drug candidates.
AI & Machine LearningBiotechDeep TechCambridge, US
Yasir Al-Wakeel(CEO)in
BiotechWaltham, US
Timothy Harris(Director)Stephen Hall(Executive Officer)Paul Sohmer(Executive Officer, Director)Noubar Afeyan(Director)Stelios Papadopoulos(Director)Aram Adourian(Executive Officer)
Board seatNoubar Afeyan· per SEC Form D · $2.5M raise · filed May 2015
Cambridge, US
Lila Preston(Director)David Worn(Executive Officer, Director)Barry Martin(Executive Officer)Martin Taylor(Director)Robert Berendes(Director)Ryan Richt(Executive Officer)
Board seatIgnacio MartinezStephen BerensonNoubar Afeyan· per SEC Form D · $15M raise · filed Jan 2020
BiotechSeattle, US
Noubar Afeyan(Director)Eric Lander(Director)Steven Gillis(Director)Doug Williams(Executive Officer, Director)
Board seatNoubar Afeyan· per SEC Form D · filed Nov 2015
Cambridge, US
Board seatNoubar Afeyan· per SEC Form D · $502.2M raise · filed Jan 2015
BiotechCambridge, US
Robert Connelly(Executive Officer, Director)Garry Menzel(Executive Officer)John Mendlein(Director)Peter Barton Hutt(Director)David Berry(Director)Jeff Moore(Executive Officer)
Board seatNoubar Afeyan· per SEC Form D · filed Feb 2016
BiotechCambridge, US
Peter Barton Hutt(Director)David Epstein(Director)Harvey F. Lodish(Director)Michael Rosenblatt(Director)Roger Pomerantz(Director)Robert S. Langer(Director)
Board seatNoubar Afeyan· per SEC Form D · $120M raise · filed Jun 2017
KSQ Therapeutics develops eTIL therapies—engineered tumor-infiltrating lymphocyte treatments for solid tumors—using its proprietary CRISPRomics platform to identify and target novel therapeutic candidates through genome-wide CRISPR/Cas9 functional genomic screens.
AI & Machine LearningBiotechMedical DevicesCambridge, US
GEORGE GOLUMBESKI(Director)RICHARD A. MOSCICKI, PH.D.(Director)ALAN L. CRANE(Director)JAMES GILBERT(Director)JOHN TRZUPEK, PH.D.(TREASURER, SECRETARY & CHIEF FINANCIAL OFFICER)DAVID P. MEEKER, M.D.(PRESIDENT AND CHIEF EXECUTIVE OFFICER)
LILA Sciences builds AI systems for autonomous scientific research and discovery across medicine, materials, energy, and defense sectors.
AI & Machine LearningBiotechDeep TechSaaS
Ring provides video doorbells and security cameras that allow homeowners to monitor their property and enhance security across indoor and outdoor spaces.
HardwareIoT
Jamie Siminoff(Founder)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Public market activity · per SEC filings
what is this? ⓘ51 insider ownership filings (Forms 3/4/5)
at Generate Biomedicines, Inc. (GENB), Foghorn Therapeutics Inc. (FHTX), Sana Biotechnology, Inc. (SANA), Sigilon Therapeutics, Inc. (SGTX), Evelo Biosciences, Inc. (EVLO), Omega Therapeutics, Inc. (OMGA), Axcella Health Inc. (AXLA), Seres Therapeutics, Inc. (MCRB)
Files 13F institutional holdings reports · latest May 2026
From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.
Frequently asked questions
- What stage does Flagship Pioneering invest at?
- Flagship Pioneering invests at the Seed, Series A stages.
- What is Flagship Pioneering's typical check size?
- Flagship Pioneering typically writes checks of $500K – $10M.
- What sectors does Flagship Pioneering focus on?
- Flagship Pioneering focuses on AI & Machine Learning, Biotech, Deep Tech, Healthtech, Longevity, Sector Agnostic.
- Where is Flagship Pioneering located?
- Flagship Pioneering is headquartered in Cambridge, US.
- Does Flagship Pioneering lead rounds?
- Flagship Pioneering typically participates in rounds rather than leading them.
Media · Podcasts & interviews
featuring the teamFlagship Pioneering's Noubar Afeyan speaks to new citizens at the JFK Library - YouTube
John F. Kennedy Library Foundation · Noubar Afeyan
Fireside Chat with Noubar Afeyan, Founder & CEO of Flagship Pioneering - YouTube
Boston Globe Events · Noubar Afeyan
No Priors Ep. 104 | With Flagship Pioneering CEO and Co-Founder Noubar Afeyan - YouTube
No Priors: AI, Machine Learning, Tech, & Startups · Noubar Afeyan
Noubar Afeyan: Moderna, AI, Flagship Pioneering, Biotech, Armenia, Lebanon | Episode #007 - YouTube
MIT New Colossus Project · Noubar Afeyan
Founder Stories: Noubar Afeyan, Flagship Pioneering - YouTube
Axial · Noubar Afeyan
Interview with Geoffrey von Maltzahn, General Partner, Flagship Pioneering - YouTube
The Montgomery Summit · Geoffrey von Maltzahn
Images
Co-investors · 28
General Catalyst is a venture capital and investment firm that backs founders across industries, with a strong focus on AI-driven transformation, fintech, healthcare, and other sectors.
Google Ventures is a venture capital investor that backs innovative founders across multiple industries, focusing on long-term partnerships and providing value across multiple funding stages and company milestones.
Lightspeed Venture Partners is a global venture capital firm known for backing AI and technology founders, emphasizing deep, hands-on partnerships with the companies it funds.
Khosla Ventures is a venture capital firm known for backing bold, contrarian bets in world-class teams that can reshape entire industries.
Alumni Ventures (AV) is a venture firm that gives accredited individual investors access to professionally managed, diversified venture portfolios by co-investing alongside leading lead VC firms. It offers annual funds, syndicate deal-by-deal investing, and various investor clubs.
Sapphire Ventures is a venture capital firm founded in 2011 that backs technology companies, offering operating support such as executive talent and customer introductions to its portfolio.
SOSV is a deep tech venture capital firm that makes first-check pre-seed investments and follow-on rounds in startups focused on human and planetary health, providing lab space and hands-on support at its US locations.
F-Prime Capital Partners is a venture capital firm whose team of scientists, engineers, physicians, operators, and investors supports companies in scaling and accelerating growth.
Venrock is a venture capital firm investing across technology and healthcare, backing companies in fintech, developer infrastructure, life sciences, therapeutics, semiconductors, and consumer products.
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
23andMe Research Institute is a genetic research organization that unites a community of 11 million members to advance health discoveries and deepen understanding of human DNA through collaborative research. The institute operates a cycle where members contribute genetic data that fuels research, which produces insights and breakthroughs that flow back to members and society.
Tribeca Venture Partners is a New York-based venture capital firm that backs early-stage founders using emerging technologies to build category-defining companies.
▶16 more co-investors
ARCH Venture PartnersOrbiMedFlare Capital PartnersNational Grid PartnersTA VenturesJohnson & Johnson Innovation – JJDCCambridge Innovation CapitalThird Rock VenturesAisling CapitalSamsara BioCapital1955 Capital+ND CapitalVensana CapitalBorealis VenturesACORN BIOVENTURESPetri
Firms observed investing alongside Flagship Pioneering, from public investor directories.
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