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HEALTHCARE ROYALTY PARTNERS

Venture debt

New York · 29 people tracked

Also known as HEALTHCARE ROYALTY MANAGEMENT, LLC

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Investment thesis

HCRx focuses on advancing biopharmaceutical innovation through creative capital solutions, principally royalty monetization and corporate financing arrangements for life sciences and biopharma companies. Since inception the firm has committed more than $7 billion across over 110 biopharma products, supporting companies that develop and commercialize approved and near-approval therapeutics. Its financing model provides non-dilutive capital tied to product revenues and royalty streams rather than traditional early-stage venture equity.

Source: firm website, verified Sep 29, 2026.

HQ
New York, US
Instruments
Debt
Founded
2016
AUM
$3.8B
Tracked investments
81
Unicorns
3
IPOs
9
Acquisitions
4

Team · 29 people

from the firm's website & public directories
Joshua C. House· Managing Director
Aaron B. Simon· Associatein
Amy J. Zacharias· Senior Vice President and Controller
Hayden C.B. Futch· Associate
Jeffrey Jung· Chief Legal Officer
Lauren C. Dunn· Executive Assistant
Rosa I. Mercado· Finance Clerk
Ryan P. Delaney· Associate
Stephanie A. Gilbey· Executive Assistant

What they invest in

from 43 of 81 portfolio companies

Biotech ×41Healthtech ×34Medical Devices ×21Digital Health ×7Deep Tech ×1Fintech ×1

HQs:United States×23France×1Netherlands×1

Who they back

founder profiles across 9 portfolio companies
78%
solo founders
7 of 9 mapped founding teams

Founding team size:solo founder×72 founders×2

Investments · 81 tracked

founders shown can be your intro path

By year:2025 · 12022 · 12017 · 12016 · 12014 · 26 dated

ADC Therapeutics SAadctherapeutics.cominNYSE: ADCT

ADC Therapeutics is a biopharmaceutical company that develops antibody drug conjugates and other therapies focused on hematology and oncology.

BiotechHealthtechMedical Devices

Ameet Mallik(Chief Executive Officer)inJose Carmona(Chief Financial Officer)Mohamed Zaki(Chief Medical Officer)inKristen Harrington-Smith(Chief Commercial Officer)inDavid Ege(Chief Technical Officer)inPeter Graham(Chief Legal Officer)in

Co-investorsETCapitalScientia Ventures

Agenusagenusbio.comNASDAQ: AGEN

Agenus is a biotechnology company developing cancer immunotherapies, including its lead investigational combination of botensilimab (an anti-CTLA-4 antibody) and balstilimab (a PD-1 inhibitor), known as BOT+BAL.

BiotechHealthtechLexington, US

Garo Armen(Chairman & CEO, Co-founder)Ozer Baysal(Executive Officer)Robert Stein(Executive Officer)Christine Klaskin(Executive Officer)inKaren Valentine(Executive Officer)Steven O'Day(Chief Medical Officer)in

Co-investorsAdvent Life SciencesGrazia Equity GmbHOberland CapitalCommodore CapitalInvusLigand Pharmaceuticals+1 more

Apnimedapnimed.comin𝕏NASDAQ: APMD

Apnimed develops investigational oral pharmaceutical therapies for obstructive sleep apnea (OSA), including its lead clinical candidate AD109, a neuromuscular approach intended to treat undertreated and untreated OSA patients.

BiotechDigital HealthHealthtechCambridge, US

Lawrence G. Miller(Executive Officer, Director)inDennis Molnar(Executive Officer)inBarry Wohl(Chief Business Officer)inKetan Mehta(Head of Product and Engineering, Connected Wearables)Ron Farquhar(Director)Gerald Chan(Director)

Co-investorsAlpha Wave GlobalMorningside GroupSectoral Asset Management

Aptevo Therapeuticsaptevotherapeutics.comNASDAQ: APVOApr 2025

Aptevo Therapeutics is a clinical-stage biotechnology company developing bispecific and trispecific immunotherapies to treat cancer.

BiotechHealthtechSeattle, US

Marvin L. White(Executive Officer, Director)inDaphne Taylor(Executive Officer)Jeffrey G. Lamothe(Executive Vice President and Chief Operating Officer)

BoardJohn E Niederhuber(Director)Daniel J Abdun-Nabi(Director)Grady Grant III(Director)

Co-investorsYorkville Advisors

Atara Biotherapeuticsatarabio.comin𝕏NASDAQ: ATRA

Atara Biotherapeutics develops allogeneic T-cell immunotherapies using its proprietary EBV T-cell platform to harness the immune system for treating disease.

BiotechHealthtechMedical DevicesThousand Oaks, US

AnhCo Nguyen(President and Chief Executive Officer)

Co-investorsDag VenturesEcoR1 CapitalKleiner PerkinsDomain AssociatesFidelity Investments

Coherus Biosciencescoherus.comin𝕏NASDAQ: CHRS

Coherus Oncology develops and commercializes immuno-oncology therapies, including the approved LOQTORZI, to treat patients with cancer.

BiotechHealthtechMedical DevicesRedwood City, US

Dennis M. Lanfear(Executive Officer, Director)Denny Lanfear(Founder)inAlan C. Herman(Executive Officer)inJean-Frederic Viret, Ph.D.(Executive Officer)Peter K. Watler, Ph.D.(Executive Officer)Barbara K Finck, M.D.(Executive Officer)

Co-investorsF-Prime CapitalSofinnova VenturesVenrock

Nektar Therapeuticsnektar.cominNASDAQ: NKTR

Nektar develops therapies that modulate the immune system to treat autoimmune diseases and inflammatory conditions, targeting the root causes of immune dysfunction.

BiotechHealthtechSan Francisco, US

Howard W. Robin(Executive Officer, Director)Gil M. Labrucherie(Executive Officer)inManinder Hora(Executive Officer)inStephen K. Doberstein(Executive Officer)John Nicholson(Executive Officer)Jillian B. Thomsen(Executive Officer)

Co-investorsNew Enterprise Associates (NEA)

RedHill Biopharma Ltdredhillbio.comNASDAQ: RDHL

BiotechTel Aviv

Shmuel Cabilly(Director)June Almenoff(Executive Officer)Ofer Tsimchi(Director)Rick D Scruggs(Executive Officer, Director)Nicolas Weinstein(Director)Alla Felder(Director)

Co-investorsLifeSci Venture Partners

Spero Therapeuticssperotherapeutics.cominNASDAQ: SPRO

Spero Therapeutics is a clinical-stage biopharmaceutical company developing medicines for immune-mediated diseases, led by SP001, a third-generation anti-CD40L antibody targeting IgG4-related disease.

BiotechCambridge, US

Ankit Mahadevia(Executive Officer, Director)inStephen Garbacz(Executive Officer)inEsther Rajavelu(Director, President, Chief Executive Officer, Chief Financial Officer, Chief Business Officer and Treasurer)in

BoardJean-Francois Formela(Director)inReza Halse(Director)Casper Breum(Director)

Co-investorsGV (Google Ventures)MRL Ventures FundOUP (Osage University Partners)RA CapitalAlphabetAtlas Venture+1 more

AcuFocus, Inc.acufocus.com

BiotechIrvine, US

Alan Waterhouse(President and Chief Operating Officer)Jason Tester(Chief Financial Officer and Secretary)James V. Mazzo(President, Chief Executive Officer and Chairman of the Board)

BoardArjun Arora(Director)Richard L. Lindstrom, M.D.(Director)William J. Link(Director)

Co-investorsEvidity Health CapitalFlying L PartnersRevelation PartnersSV Life SciencesVersant Venture AIV HoldingsVersant Ventures

Adynovateadynovate.com

The site presents ADYNOVATE, a PEGylated recombinant antihemophilic Factor VIII injectable used to treat and control bleeding in adults and children with hemophilia A.

BiotechHealthtech

Albireo Pharmaalbireopharma.comin𝕏

A biopharmaceutical company (Ipsen, following its acquisition of Albireo Pharma) developing and commercializing medicines in oncology, rare diseases, and neuroscience for patients with high unmet medical needs.

BiotechHealthtech

Co-investorsDecheng Capital

Ardelyxardelyx.com𝕏

Ardelyx is a biopharmaceutical company that develops first-in-class medicines for patients with unmet medical needs.

BiotechFremont, US

Mark Kaufmann(Executive Officer)Elizabeth Grammer(Executive Officer)inDavid Rosenbaum(Executive Officer)inJeremy Caldwell(Executive Officer)Mike Raab(Executive Officer, Director)in

BoardDavid Mott(Director)

Co-investorsForesite CapitalNew Enterprise Associates (NEA)

Bridgebiobridgebio.comin𝕏

BridgeBio develops treatments for genetic conditions and cancers using a decentralized hub-and-spoke model, where autonomous teams focus on specific diseases or drug candidates while a central hub provides clinical, regulatory, and commercial support.

BiotechHealthtech

Co-investorsAisling CapitalAmzak HealthEcoR1 CapitalFrazier Life SciencesLongwood FundSequoia Capital+2 more

Chiasmachiasmapharma.com

BiotechNewton Centre, US

Chaime Orlev(Executive Officer)Roni Mamluk(Executive Officer, Director)

BoardScott Minick(Director)inTodd T. Foley(Director)inVincent Miles(Director)Ansbert K. Gadicke(Director)in

Co-investorsSofinnova VenturesAbingworthARCH Venture PartnersMPM BioImpact

Clearside Biomedicalclearsidebio.comin

Clearside Biomedical is an intellectual property holding, investment, and commercialization company focused on its suprachoroidal space (SCS) ocular drug-delivery platform and microinjector technology.

BiotechHealthtechMedical DevicesAlpharetta, US

Mark Prausnitz(Director)inCharles Deignan(Executive Officer)Glenn Noronha(Executive Officer)inDaniel H. White(Executive Officer, Director)in

BoardEvgeny Zaytsev(Director)Derek Yoon(Director)in

Co-investorsMountain Group CapitalSolasta VenturesHatterasHatteras Venture Partners

Curis Inccuris.comin𝕏

Curis is a biopharmaceutical company focused on drug development and clinical advancement.

BiotechHealthtech

James Dentzer(Chief Executive Officer)

Ebvalloebvallo-ebv.com

EBVALLO is an on-demand allogeneic T-cell immunotherapy for treating relapsed or refractory EBV-positive post-transplant lymphoproliferative disease.

BiotechDigital HealthMedical Devices

Eligardeligard.com

ELIGARD is a GnRH agonist medication in injectable form used to treat prostate cancer by reducing testosterone production.

BiotechHealthtechMedical Devices

Invuityinvuity.comMar 2014 · $36M

Sophisticated optics for illumination and enhanced visualization in surgical procedures.

HealthtechSan Francisco, US

Kenneth Trauner(Executive Officer, Director)Alex Vayser(Executive Officer)Philip Sawyer(Executive Officer, Director)inTheresa Brandner-Allen(Executive Officer)Brett Robertson(Executive Officer)Doug Rimer(Executive Officer)

Co-investorsAlpine MeridianWindham Capital PartnersAvedro, Inc.Kleiner PerkinsValence Advantage Life SciencesWellington Management

Iqirvoiqirvo.com

IQIRVO is a prescription medicine for treating primary biliary cholangitis (PBC) in adults, used either in combination with ursodeoxycholic acid or as a standalone treatment for patients unable to tolerate standard therapy.

BiotechHealthtechMedical Devices

Karyopharm Therapeuticskaryopharm.comin𝕏Dec 2022

Karyopharm is a pharmaceutical company developing drugs based on its SINE (Selective Inhibitor of Nuclear Export) technology, with medicines targeting cancers including multiple myeloma and diffuse large B-cell lymphoma.

BiotechHealthtechNewton, US

Stuart Poulton(Executive Officer)inMichael Mano(Executive Officer)inReshma Rangwala(Executive Officer)inRichard Paulson(CEO)inStephen Mitchener(Executive Officer)inMichael Mason(Executive Officer)in

Co-investorsAvoro Capital AdvisorsForesite CapitalRA Capital

Korsuvakorsuva.com

KORSUVA is a prescription medicine that treats moderate-to-severe itching associated with chronic kidney disease in adults undergoing hemodialysis.

BiotechDigital HealthHealthtechMedical Devices

Lantheuslantheus.comin𝕏

Lantheus is a radiopharmaceutical company that develops, manufactures, and commercializes radiodiagnostics and radiotherapeutics for cancer detection, treatment and monitoring, as well as precision diagnostics for non-oncologic diseases.

BiotechHealthtechMedical DevicesNorth Billerica, US

Lyricalyrica.com

Lyrica is a pharmaceutical product used to manage fibromyalgia, a chronic condition characterized by widespread pain and fatigue.

BiotechHealthtechMedical Devices

Nanobiotixnanobiotix.comin𝕏

Nanobiotix develops physics-based nanotherapeutics for cancer treatment, applying nanotechnology to expand therapeutic options for oncology patients.

BiotechDeep TechMedical Devices

Co-investorsKaristaSeventure PartnersJefferies

Opkoopko.com

OPKO Health is a fully integrated healthcare company developing multispecific therapies for serious diseases including cancers and infectious diseases, and operates BioReference Laboratories, a clinical reference laboratory serving approximately 11 million patients annually in the U.S.

BiotechDigital HealthHealthtechMedical DevicesMiami, US

Gary Nabelin

Orenitramorenitram.com

Orenitram is a prescription oral medication containing treprostinil, indicated to treat pulmonary arterial hypertension (PAH) by slowing disease progression and improving exercise capacity in adults.

BiotechHealthtech

Regenx Biosciencesregenxbio.comin𝕏

REGENXBIO is a gene therapy company developing treatments for rare and retinal diseases using its NAV Technology Platform of viral vectors, which it also licenses to other pharmaceutical and biotech companies.

BiotechHealthtechRockville, US

Kenneth T. Mills(Executive Officer, Director)

BoardJohn Daniel Kiser(Director)Allan M. Fox(Director)Benjamin Auspitz(Director)Donald J. Hayden, Jr.(Director)

Co-investorsF-Prime CapitalFoothill VenturesVenrock

Relistorrelistor.com

RELISTOR is a prescription medication containing methylnaltrexone bromide that treats opioid-induced constipation in adults with chronic pain or advanced illness.

BiotechDigital HealthHealthtechMedical Devices

Rhythm Pharmaceuticalsrhythmtx.comin𝕏Jan 2017

Rhythm Therapeutics develops precision medicines for rare neuroendocrine diseases, particularly those affecting the melanocortin-4 receptor pathway.

BiotechDigital HealthHealthtechMedical DevicesBoston, US

Keith Gottesdiener(Executive Officer, Director)inBart Henderson(Mr. Henderson is the President and Treasurer of the Issuer.)inDavid Meeker(President and Chief Executive Officer)in

BoardEdward T. Mathers(Director)inJonathan Silverstein(Director)inNeil Exter(Director)in

Co-investorsForesite CapitalNew Enterprise Associates (NEA)Pfizer Venture InvestmentsWellington ManagementOrbiMedThird Rock Ventures

Seysaraseysara.com

SEYSARA is a prescription medication with a patient co-pay assistance program (Almirall Advantage) that offers savings on retail and network pharmacy purchases.

BiotechHealthtech

Sperosperotx.comin

Spero Therapeutics is a clinical-stage biopharmaceutical company developing next-generation immunology and inflammation medicines, particularly targeting patients with serious diseases and major treatment gaps.

BiotechHealthtechCambridge, US

Co-investorsAtlas VentureThe Kraft Group

Suneva Medicalsunevamedical.cominJan 2014 · $35M

A company offering regenerative and aesthetic medical products for facial, breast, and body treatments across all stages of life.

HealthtechMedical DevicesSan Diego, US

Nicholas L. Teti, Jr.(Executive Officer, Director)Joseph A. Newcomb(Executive Officer)Stewart M. Brown(Executive Officer)in

BoardClarke B. Futch(Director)Paul J. Hadden(Director)Todd C. Davis(Director)

Co-investorsBioBritEssex Woodlands Healthcare PartnersPolaris Partners

Tenapanoribsrela.com

IBSRELA is a prescription medication containing tenapanor designed to treat irritable bowel syndrome with constipation (IBS-C) in adults by reducing constipation and abdominal pain.

BiotechHealthtechMedical Devices

Tg Therapeuticstgtherapeutics.comin𝕏

TG Therapeutics is a biopharmaceutical company focused on developing treatments for cancer patients.

BiotechHealthtechMedical Devices

Michael S. Weiss(CEO)

Theravance Biopharmatheravance.com

Theravance Biopharma develops FDA-approved pharmaceutical treatments, including YUPELRI for chronic obstructive pulmonary disease (COPD) maintenance treatment.

BiotechHealthtechMedical Devices

Rick E Winningham(Chief Executive Officer)inRhonda F. Farnum(Senior Vice President, Commercial and Medical Affairs and Chief Business Officer)inBrett A. Grimaud(Senior Vice President, General Counsel and Secretary)inStuart Knight(Senior Vice President, IT&I and Chief Information Officer)Aine Miller(Senior Vice President, Development and Head of Ireland Office)Stacy Pryce(Senior Vice President and Chief Strategy Officer)in

Trelegy Elliptatrelegy.com

TRELEGY is a once-daily prescription inhaler used long-term to treat COPD (including chronic bronchitis and emphysema) and asthma in adults.

Biotech

Uniqureuniqure.comin𝕏

uniQure is a biotech company developing gene therapies for serious genetic diseases.

BiotechHealthtechMedical Devices

Matthew Kapustain

Co-investorsAdvent Life SciencesALS Investment FundForesite CapitalRidgeback CapitalForbion

Vafseovafseo.com

Vafseo (vadadustat) is a once-daily oral prescription medicine that treats anemia caused by chronic kidney disease in adults who have been on dialysis for at least three months.

BiotechHealthtech

XOMAxoma.cominacquired by Ligand · Jul 2026 · $739M

XOMA Royalty is a biotech royalty aggregator that acquires the economic rights to future milestone and royalty payments tied to partnered pre-commercial clinical candidates, providing sellers with non-dilutive, non-recourse funding.

BiotechFintech

Owen Hughes(Chief Executive Officer)inJeffrey Trigilio(Chief Financial Officer)inBrad Sitko(Chief Investment Officer)inMaricel Montano(Chief Legal Officer)

Co-investorsLigand PharmaceuticalsSanderling Ventures

Zevrazevra.comin𝕏

Zevra Therapeutics develops and commercializes rare disease treatments, including therapies for Niemann-Pick disease type C and urea cycle disorders.

BiotechHealthtechMedical Devices

Neil McFarlanein

Zolgensmazolgensma.com

ZOLGENSMA is a gene replacement therapy that delivers a working SMN gene to treat spinal muscular atrophy (SMA), a rare genetic disease affecting motor nerve cells.

BiotechDigital HealthHealthtechMedical Devices

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Acorda Therapeutics IncAdamas PharmaceuticalsAkebiaBexacatBeyonttraCara TherapeuticsCetrotideCopiktratmDyaxElobixibatErivedgeEsperionFampyraGenfitHeidelbergHemgenixInavirJnj 1900 Nbtxr3La Jolla Pharmaceutical CompanyLexivaLiquidiaLumifyModeysoMovantikOraceaPortolaProgenics PharmaceuticalsQs 21 Adjuvant Including ShingrixRaptorRelypsaRezurockRuxienceTearScienceTheracosTlx250 CdxTrumenbaVimpatXipere Et Al

Exits · 13

9 IPOs · 4 acquisitions · showing 12

ADC Therapeutics SANYSE: ADCTAgenusNASDAQ: AGENApnimedNASDAQ: APMDAptevo TherapeuticsNASDAQ: APVOAtara BiotherapeuticsNASDAQ: ATRACoherus BiosciencesNASDAQ: CHRSNektar TherapeuticsNASDAQ: NKTRRedHill Biopharma LtdNASDAQ: RDHLSpero TherapeuticsNASDAQ: SPROProgenics Pharmaceuticalsacq. by Lantheus HoldingsRelypsaacq. by Galenica (Vifor Pharma)XOMAacq. by Ligand

Portfolio news

latest coverage across their companies

Fund performance · per public LP disclosures

as of Jun 2024
FundVintageCommittedNet IRRTVPIDPI
HealthCare Royalty Partners III, L.P.LPs: Florida State Board of Administration2007—9.1%1.27x1.27x

Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).

Frequently asked questions

How many investments has HEALTHCARE ROYALTY PARTNERS made?
HEALTHCARE ROYALTY PARTNERS has 81 tracked investments, 13 of which have exited, including 1 dated in the last 24 months.
What sectors does HEALTHCARE ROYALTY PARTNERS focus on?
HEALTHCARE ROYALTY PARTNERS focuses on Biotech, Healthtech.
Where is HEALTHCARE ROYALTY PARTNERS located?
HEALTHCARE ROYALTY PARTNERS is headquartered in New York, US.
Who does HEALTHCARE ROYALTY PARTNERS co-invest with?
HEALTHCARE ROYALTY PARTNERS most often shares deals with Foresite Capital, New Enterprise Associates (NEA), Ridgeback Capital, among 44 tracked co-investors.

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