Fundraising Fox

Pivotal Life Sciences

Crossover fund

San Francisco · Seed–Late Stage · 11 people tracked

Also known as Pivotal bioVenture Partners · Pivotal bioVenture Partners CNS · Pivotal bioVenture Partners CNS SLP · PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC · Pivotal bioVenture Partners SLP

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Investment thesis

Pivotal Life Sciences invests across all company stages, with a primary emphasis on 'high impact' therapeutics. The firm targets solutions that address growing unmet medical needs and offer near-curative or otherwise transformative disease-management potential. Its name reflects both its investment approach and the pivotal role it aims to play in the companies it backs.

Source: firm website, verified Aug 25, 2026.

Stage
Seed–Late Stage
HQ
San Francisco, California, US
Leads rounds
Follows
Instruments
Equity
Founded
2017
Last 12 months
1 investment
AUM
$2B
VC funds
2
Tracked investments
10

Team · 11 people

from the firm's website & public directories
Benjamin Li· Vice Presidentin

What they invest in

from 10 of 10 portfolio companies

Biotech ×9Healthtech ×5Medical Devices ×2AI & Machine Learning ×1Deep Tech ×1Digital Health ×1Enterprise Software ×1Fintech ×1

HQs:United States×7

Investments · 10 tracked

founders shown can be your intro path

By year:2025 · 22023 · 12020 · 14 dated

SutroVaxNASDAQ: PCVXMar 2020SEC filingmedium confidence

BiotechSouth San Francisco, US

Grant E Pickering(Executive Officer, Director, Promoter)Ashish Khanna(Executive Officer)Jeff Fairman(Executive Officer)

BoardTracy Saxton(Director)William Newell(Director)Kurt von Emster(Director)in

Board seatRob Hopfner· per SEC Form D · $110M raise · filed Apr 2020

Co-investorsAbingworthFrazier Life SciencesMedicxiRed Tree Venture

Avalyn Pharma Incavalynpharma.cominNASDAQ: AVLNSep 2023 · $175M

Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.

BiotechHealthtech

Lyn Baranowski(CEO)in

Co-investorsAndera PartnersCatalio Capital Management, LPF-Prime CapitalInVivium CapitalNorwest Venture PartnersRiverVest Venture Partners+7 more

Bolt Biotherapeuticsboltbio.comin𝕏NASDAQ: BOLT

Bolt Biotherapeutics is a clinical-stage biotech company developing novel immunotherapies that leverage innate immune system mechanisms to treat cancer.

BiotechHealthtechMedical DevicesSan Francisco, US

Dr. Edgar G. Engleman(Founder)

Co-investorsPfizer Venture InvestmentsRA CapitalSamsara BioCapitalSofinnova VenturesVivo CapitalNan Fung Life Sciences+1 more

Engrail Therapeuticsengrail.comin✓ verified

Engrail Therapeutics is a clinical-stage pharmaceutical company developing precision-targeted therapeutics for neupropsychiatric and neurodevelopmental disorders.

BiotechDigital HealthMedical DevicesSan Diego, US

Stephen(Co-founder, EVP Research & Development and Chief Development Officer)Paul Cayer(Chief Financial Officer)Vikram(President and Chief Executive Officer)Kimberly(Chief Scientific Officer)Quentin(Chief Technical Officer)

Co-investorsForesite CapitalLongwood FundNorwest Venture PartnersRiverVest Venture PartnersYsios Capitalabrdn plc+4 more

Plexiumplexium.cominJul 2025SEC filingmedium confidence

Plexium is a targeted protein degradation company developing small molecule therapeutics for treating diseases with high unmet medical needs using their proprietary DELTA Discovery platform.

AI & Machine LearningBiotechDeep TechSan Diego, US

Michael Martin, Ph.D.(Chief Executive Officer, President)Jorge F. DiMartinoMichael Martin(President, Chief Executive Officer)Stephen Mullennix(Executive Officer)

BoardSerge Messerlian(Director)inCariad Chester(Director)in

Board seatRob Hopfner· per SEC Form D · $60.1M raise · filed Aug 2025

Co-investorsCRV (Charles River Ventures)DCVC (Data Collective)M VenturesNeotribe VenturesSoftBank Vision FundTCG Crossover+1 more

Addition Therapeuticsadditiontx.cominDec 2025

Addition Therapeutics is a biotechnology company developing therapeutics, led by a scientific and clinical team.

BiotechHealthtechSouth San Francisco, US

Kathleen Collins(Director)Matthew Patterson(Director)Lawrence Kong(Executive Officer)Jennifer Lee(Director)Ronald Park(Executive Officer, Director)Ron Park(President & CEO)

Co-investorsSR One Capital ManagementAbingworthOsage University Partners

Akouosakouos.comin

Akouos is a precision genetic medicine company developing therapies for the inner ear to restore, improve, and preserve hearing.

BiotechHealthtechBrookline, US

Emmanuel Simons(Executive Officer, Director)william sewell(Founder)in

BoardEd Mathers(Director)inKush Parmar(Director)in

Co-investors5AM VenturesEcoR1 CapitalNew Enterprise Associates (NEA)RA CapitalSofinnova VenturesCowen Healthcare Investments+1 more

Ark PESarkpes.com

Ark provides a customizable digital platform for venture capital and private equity firms to manage investor communications, performance reporting, and document sharing with their limited partners.

Enterprise SoftwareFintechSaaS

Co-investorsAcies InvestmentsAloft VCAlta PartnersAmity VenturesArtis VenturesAsymmetric Capital Partners+21 more

Inozyme Pharmainozyme.com

BiotechBoston, US

Axel Bolte(Executive Officer, Director)inReinaldo Diaz(Director)Joseph Schlessinger(Executive Officer, Director)

BoardEdward Mathers(Director)Rob Hopfner(Director)Martin Edwards(Director)

Co-investorsLongitude CapitalNew Enterprise Associates (NEA)Sanofi VenturesSofinnova Ventures

Windward Biowindwardbio.comin

Windward Bio is a clinical-stage biotechnology company developing long-acting monoclonal and bispecific antibodies for serious immunological conditions such as asthma, COPD, and dermatological diseases.

BiotechHealthtech

Co-investorsOrbiMedQuan CapitalRA CapitalSanofi VenturesSR One Capital ManagementJanus Henderson Investors+3 more

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 3

IPOs and acquisitions across the tracked portfolio

SutroVaxNASDAQ: PCVXAvalyn Pharma IncNASDAQ: AVLNBolt BiotherapeuticsNASDAQ: BOLT

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Pivotal Life Sciences invest at?
Pivotal Life Sciences invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
What sectors does Pivotal Life Sciences focus on?
Pivotal Life Sciences focuses on Biotech, Digital Health, Healthtech, Medical Devices.
Where is Pivotal Life Sciences located?
Pivotal Life Sciences is headquartered in San Francisco, US.
Does Pivotal Life Sciences lead rounds?
Pivotal Life Sciences typically participates in rounds rather than leading them.
Who does Pivotal Life Sciences co-invest with?
Pivotal Life Sciences most often shares deals with Amity Ventures, Artis Ventures, At One Ventures, among 27 tracked co-investors.

Images

Pivotal Life Sciences photoPivotal Life Sciences photoPivotal Life Sciences photoPivotal Life Sciences photoPivotal Life Sciences photoPivotal Life Sciences photo

Co-investors · 31

RA Capital

RA Capital is a multi-stage investment firm focused on healthcare, life sciences, and planetary health, investing across public and private markets and creating new companies through its Raven incubation platform.

SR One Capital Management

SR One is a biotechnology-focused venture capital firm that partners with founders to develop innovative science into new medicines.

Sofinnova Ventures

Sofinnova is an investment firm focused on the life sciences and biotechnology sector, partnering with companies from inception through drug development, regulatory approval, company building, and IPO.

$100K – $15M
Norwest Venture Partners

Norwest Venture Partners is an investment firm whose growth equity team backs private, profitable, fast-growing companies, providing capital and hands-on support through its 'invited guest' approach.

$10M – $30M
F-Prime Capital

F-Prime Capital is an early-stage-focused investment firm backing companies across life sciences, technology, healthtech and services, and crypto.

$3M – $10M
Abingworth

Abingworth is a life science venture capital firm that backs early-stage biopharma and biotech companies, helping entrepreneurs translate scientific discoveries into new therapeutics.

$15M – $30M
RiverVest Venture Partners

RiverVest Venture Partners is a life sciences venture capital firm that invests in biotechnology and medical companies, working with entrepreneurs to advance therapeutic and medical innovations.

$500K – $3M
DCVC (Data Collective)

DCVC (Data Collective) is a deep tech venture capital firm that backs entrepreneurs using computational approaches to solve large-scale real-world problems across many industries.

Both backed · 1
$5M – $25M
OrbiMed

OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.

Both backed · 1
$1M – $75M
Forbion

Forbion is a global venture capital firm focused on advancing biotech innovations and sustainable solutions aimed at improving human and planetary health.

Both backed · 1
The Column Group

The Column Group (TCG) is a venture capital firm focused on building and backing biotechnology companies, applying an edge-to-edge investment model centered on company formation with capacity for long-term private and public capital support.

Both backed · 1
$30M
Longitude Capital

Longitude Capital is a healthcare venture capital firm that invests in biotechnology, medical technology, and health solutions companies. The firm focuses on companies working to improve clinical outcomes, quality of life, and healthcare delivery efficiency.

Both backed · 1
$10M – $30M
19 more co-investors

SV AngelCanaan PartnersRevolutionMaveronOperator LPAtlas Ventureboldstart venturesEarlybird Venture CapitalScalar CapitalEQT Life SciencesDimension CapitalOUP (Osage University Partners)Sofinnova PartnersJohnson & Johnson Innovation – JJDCDomain AssociatesSV Health InvestorsInkefJMI EquityBVCF

Firms observed investing alongside Pivotal Life Sciences, from public investor directories. Shared companies are the overlap with Pivotal Life Sciences's recorded portfolio.

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