Pivotal Life Sciences
Crossover fundSan Francisco · Seed–Late Stage · 11 people tracked
Also known as Pivotal bioVenture Partners · Pivotal bioVenture Partners CNS · Pivotal bioVenture Partners CNS SLP · PIVOTAL BIOVENTURE PARTNERS INVESTMENT ADVISOR LLC · Pivotal bioVenture Partners SLP
Investment thesis
Pivotal Life Sciences invests across all company stages, with a primary emphasis on 'high impact' therapeutics. The firm targets solutions that address growing unmet medical needs and offer near-curative or otherwise transformative disease-management potential. Its name reflects both its investment approach and the pivotal role it aims to play in the companies it backs.
Source: firm website, verified Aug 25, 2026.
Team · 11 people
from the firm's website & public directoriesWhat they invest in
from 10 of 10 portfolio companiesBiotech ×9Healthtech ×5Medical Devices ×2AI & Machine Learning ×1Deep Tech ×1Digital Health ×1Enterprise Software ×1Fintech ×1
HQs:United States×7
Investments · 10 tracked
founders shown can be your intro pathBy year:2025 · 22023 · 12020 · 14 dated
BiotechSouth San Francisco, US
Grant E Pickering(Executive Officer, Director, Promoter)Ashish Khanna(Executive Officer)Jeff Fairman(Executive Officer)
BoardTracy Saxton(Director)William Newell(Director)Kurt von Emster(Director)in
Board seatRob Hopfner· per SEC Form D · $110M raise · filed Apr 2020
Co-investorsAbingworthFrazier Life SciencesMedicxiRed Tree Venture
Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.
BiotechHealthtech
Lyn Baranowski(CEO)in
Co-investorsAndera PartnersCatalio Capital Management, LPF-Prime CapitalInVivium CapitalNorwest Venture PartnersRiverVest Venture Partners+7 more
Bolt Biotherapeutics is a clinical-stage biotech company developing novel immunotherapies that leverage innate immune system mechanisms to treat cancer.
BiotechHealthtechMedical DevicesSan Francisco, US
Dr. Edgar G. Engleman(Founder)
Co-investorsPfizer Venture InvestmentsRA CapitalSamsara BioCapitalSofinnova VenturesVivo CapitalNan Fung Life Sciences+1 more
Engrail Therapeutics is a clinical-stage pharmaceutical company developing precision-targeted therapeutics for neupropsychiatric and neurodevelopmental disorders.
BiotechDigital HealthMedical DevicesSan Diego, US
Stephen(Co-founder, EVP Research & Development and Chief Development Officer)Paul Cayer(Chief Financial Officer)Vikram(President and Chief Executive Officer)Kimberly(Chief Scientific Officer)Quentin(Chief Technical Officer)
Co-investorsForesite CapitalLongwood FundNorwest Venture PartnersRiverVest Venture PartnersYsios Capitalabrdn plc+4 more
Plexium is a targeted protein degradation company developing small molecule therapeutics for treating diseases with high unmet medical needs using their proprietary DELTA Discovery platform.
AI & Machine LearningBiotechDeep TechSan Diego, US
Michael Martin, Ph.D.(Chief Executive Officer, President)Jorge F. DiMartinoMichael Martin(President, Chief Executive Officer)Stephen Mullennix(Executive Officer)
BoardSerge Messerlian(Director)inCariad Chester(Director)in
Board seatRob Hopfner· per SEC Form D · $60.1M raise · filed Aug 2025
Co-investorsCRV (Charles River Ventures)DCVC (Data Collective)M VenturesNeotribe VenturesSoftBank Vision FundTCG Crossover+1 more
Addition Therapeutics is a biotechnology company developing therapeutics, led by a scientific and clinical team.
BiotechHealthtechSouth San Francisco, US
Kathleen Collins(Director)Matthew Patterson(Director)Lawrence Kong(Executive Officer)Jennifer Lee(Director)Ronald Park(Executive Officer, Director)Ron Park(President & CEO)
Co-investorsSR One Capital ManagementAbingworthOsage University Partners
Akouos is a precision genetic medicine company developing therapies for the inner ear to restore, improve, and preserve hearing.
BiotechHealthtechBrookline, US
Emmanuel Simons(Executive Officer, Director)william sewell(Founder)in
BoardEd Mathers(Director)inKush Parmar(Director)in
Co-investors5AM VenturesEcoR1 CapitalNew Enterprise Associates (NEA)RA CapitalSofinnova VenturesCowen Healthcare Investments+1 more
Ark provides a customizable digital platform for venture capital and private equity firms to manage investor communications, performance reporting, and document sharing with their limited partners.
Enterprise SoftwareFintechSaaS
Co-investorsAcies InvestmentsAloft VCAlta PartnersAmity VenturesArtis VenturesAsymmetric Capital Partners+21 more
BiotechBoston, US
Axel Bolte(Executive Officer, Director)inReinaldo Diaz(Director)Joseph Schlessinger(Executive Officer, Director)
BoardEdward Mathers(Director)Rob Hopfner(Director)Martin Edwards(Director)
Co-investorsLongitude CapitalNew Enterprise Associates (NEA)Sanofi VenturesSofinnova Ventures
Windward Bio is a clinical-stage biotechnology company developing long-acting monoclonal and bispecific antibodies for serious immunological conditions such as asthma, COPD, and dermatological diseases.
BiotechHealthtech
Co-investorsOrbiMedQuan CapitalRA CapitalSanofi VenturesSR One Capital ManagementJanus Henderson Investors+3 more
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 3
IPOs and acquisitions across the tracked portfolioSutroVaxNASDAQ: PCVXAvalyn Pharma IncNASDAQ: AVLNBolt BiotherapeuticsNASDAQ: BOLT
Portfolio news
latest coverage across their companiesWindward Bio · xtalks.com · May 15, 2026
Avalyn Pharma Inc · investing.com · May 1, 2026
Frequently asked questions
- What stage does Pivotal Life Sciences invest at?
- Pivotal Life Sciences invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does Pivotal Life Sciences focus on?
- Pivotal Life Sciences focuses on Biotech, Digital Health, Healthtech, Medical Devices.
- Where is Pivotal Life Sciences located?
- Pivotal Life Sciences is headquartered in San Francisco, US.
- Does Pivotal Life Sciences lead rounds?
- Pivotal Life Sciences typically participates in rounds rather than leading them.
- Who does Pivotal Life Sciences co-invest with?
- Pivotal Life Sciences most often shares deals with Amity Ventures, Artis Ventures, At One Ventures, among 27 tracked co-investors.
Images
Co-investors · 31
RA Capital is a multi-stage investment firm focused on healthcare, life sciences, and planetary health, investing across public and private markets and creating new companies through its Raven incubation platform.
SR One is a biotechnology-focused venture capital firm that partners with founders to develop innovative science into new medicines.
Sofinnova is an investment firm focused on the life sciences and biotechnology sector, partnering with companies from inception through drug development, regulatory approval, company building, and IPO.
Norwest Venture Partners is an investment firm whose growth equity team backs private, profitable, fast-growing companies, providing capital and hands-on support through its 'invited guest' approach.
F-Prime Capital is an early-stage-focused investment firm backing companies across life sciences, technology, healthtech and services, and crypto.
Abingworth is a life science venture capital firm that backs early-stage biopharma and biotech companies, helping entrepreneurs translate scientific discoveries into new therapeutics.
RiverVest Venture Partners is a life sciences venture capital firm that invests in biotechnology and medical companies, working with entrepreneurs to advance therapeutic and medical innovations.
DCVC (Data Collective) is a deep tech venture capital firm that backs entrepreneurs using computational approaches to solve large-scale real-world problems across many industries.
OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.
Forbion is a global venture capital firm focused on advancing biotech innovations and sustainable solutions aimed at improving human and planetary health.
The Column Group (TCG) is a venture capital firm focused on building and backing biotechnology companies, applying an edge-to-edge investment model centered on company formation with capacity for long-term private and public capital support.
Longitude Capital is a healthcare venture capital firm that invests in biotechnology, medical technology, and health solutions companies. The firm focuses on companies working to improve clinical outcomes, quality of life, and healthcare delivery efficiency.
▶19 more co-investors
SV AngelCanaan PartnersRevolutionMaveronOperator LPAtlas Ventureboldstart venturesEarlybird Venture CapitalScalar CapitalEQT Life SciencesDimension CapitalOUP (Osage University Partners)Sofinnova PartnersJohnson & Johnson Innovation – JJDCDomain AssociatesSV Health InvestorsInkefJMI EquityBVCF
Firms observed investing alongside Pivotal Life Sciences, from public investor directories. Shared companies are the overlap with Pivotal Life Sciences's recorded portfolio.
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