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Catalio Capital Management, LP

Crossover fund

New York · Seed–Late Stage · 39 people tracked

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Investment thesis

Catalio invests in innovative healthcare companies at all stages and sizes, spanning the full capital structure across private, public, and credit markets. The firm leverages a network of 45+ venture partners — world-renowned scientist-entrepreneurs — who provide proprietary deal flow, serve as an expert network for due diligence, advise on emerging and disruptive life sciences trends, and offer early exposure to breakthrough technologies. These partners contribute specialized scientific, technological, and clinical expertise and bring a track record of building companies that have generated significant enterprise value.

Invests inBiotechDigital HealthHealthtechLongevityMedical DevicesFranceGlobalNew YorkNew York CityUnited KingdomUnited States

Source: firm website, verified Aug 11, 2026.

Stage
Seed–Late Stage
HQ
New York, New York, US
Leads rounds
Follows
Instruments
Equity · Debt
Founded
2020
Last 12 months
2 investments
AUM
$2.2B
Tracked investments
106

Team · 39 people

from public directories
Henry Brem· Venture Partnerin
Jeffrey M. Friedman· Venture Partner
Solomon H. Snyder· Venture Partnerin
Thomas C. Südhof· Venture Partner𝕏
Jenna Glatzer· Analyst
Josh Samuelson· Advisorin
Maria Sirenko· Analystin𝕏
Nathan Livingston· Analystin

What they invest in

from 52 of 106 portfolio companies

Biotech ×37Healthtech ×28Medical Devices ×23AI & Machine Learning ×11Deep Tech ×9Digital Health ×8Longevity ×2Mental Health ×2

HQs:United States×40

Investments · 106 tracked

founders shown can be your intro path

By year:2026 · 12025 · 12023 · 12022 · 22021 · 12020 · 12018 · 12016 · 12015 · 110 dated

ArriVent BioPharmaNASDAQ: AVBPDec 2022

Clinical-stage biopharmaceutical company focused on identifying, developing and commercializing differentiated medicines for cancer patients.

BiotechMedical DevicesNewtown Square, US

Brent Rice(Chief Commercial Officer)Jason Zhang(Director)Cong Xu(Director)Zhengbin (Bing) Yao(Executive Officer, Director)Stuart Lutzker(Director)

AtaiBeckleyatai.lifeNASDAQ: ATAI

AtaiBeckley develops rapid-acting mental health treatments and therapies for patients with difficult-to-treat mental health conditions.

BiotechDeep TechDigital HealthMedical DevicesMental Health

Srinivas Rao(Co-Founder and Chief Executive Officer)Christian Angermayer(Founder and Chairman of the Board)

Avalyn Pharma Incavalynpharma.cominNASDAQ: AVLN

Avalyn Pharma develops a nebulized inhalation treatment for pulmonary fibrosis designed to improve tolerability compared to existing oral therapies by directly delivering the drug to the lungs.

BiotechMedical Devices

Lyn Baranowski(CEO)in

Compass Pathwayscompasspathways.comin𝕏NASDAQ: CMPS
Fractylfractyl.comin𝕏NASDAQ: GUTS

Fractyl develops therapies for obesity and type 2 diabetes, focusing on non-drug-based approaches rooted in understanding metabolic disease mechanisms.

BiotechHealthtechMedical DevicesLexington, US

ALLAN WILL(Director)STANLEY LAPIDUS(Director)NIMESH SHAH(Director)CHRISTOPHER GABRIELI(Director)HARITH RAJAGOPALAN(Executive Officer, Director)JAY CAPLAN(Executive Officer, Director)

Freenomefreenome.cominNASDAQ: FRNMOct 2015

Freenome develops early-stage cancer detection technology using blood tests to identify cancer in its earliest, most treatable phases.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesLondon

Riley Ennis(Co-Founder and Chief Product Officer)Stuart Lawson(Director)Charles Roberts(Director)Gabriel Otte(Director)

Kardigankardigan.bioinNASDAQ: KARD

Kardigan develops targeted cardiovascular treatments through a discovery and translational research platform, with a pipeline of late-stage drug candidates aimed at functional cures for cardiovascular disease.

AI & Machine LearningBiotechHealthtechMedical Devices

Neumora Therapeuticsneumoratx.comin𝕏NASDAQ: NMRASep 2020

Neumora is a clinical research company developing investigational medications, with a focus on conducting clinical trials to obtain regulatory approval and make treatments available to patients.

BiotechDeep TechDigital HealthMedical DevicesWatertown, US

Matthew Fust(Director)Kari Stefansson(Director)Joshua Pinto(Executive Officer)Maykin Ho(Director)Alaa Halawa(Director)Tamara Tompkins(Executive Officer)

Parabilis Medicinesparabilismed.cominNASDAQ: PBLS

Helicons develops a peptide-based therapeutic platform designed to target intracellular proteins previously considered undruggable by combining the specificity of antibodies with the cell-penetrating properties of small molecules.

AI & Machine LearningBiotechDeep TechMedical Devices

Mathai Mammen(CEO, President and Chairman)

Protara TherapeuticsNASDAQ: TARA
9am Healthjoin9am.com
Abridgeabridge.comin𝕏

Abridge builds AI software that converts clinical conversations into structured insights for healthcare providers.

AI & Machine LearningDigital HealthHealthtechPhiladelphia, US

Shiv Rao(Founder & CEO)Julia Chapin(Executive Officer)Sagar Sanghvi(Executive Officer)

BoardAndy Weissman(Director)Sebastian Duesterhoeft(Director)Will Reed(Director)

AdvanCelladvancell.com.auinJun 2026

AdvanCell develops radioisotope-based therapies, using Th-228 sourced through the U.S.

BiotechHealthtechMedical DevicesCambridge, US

Philina Lee(Executive Officer, Director)Aaron Pickett(Executive Officer)Wing Cheong Lam(Director)Nik Economopoulos(Director)Anthony Aiudi(Director)Jamil Beg(Director)

Alentis Therapeutics
Amalgamamalgamrx.comin

Amalgam develops a modular, AI-powered software-as-a-medical-device (SaMD) platform and EHR-integrated solutions for healthcare providers, health plans, and life sciences companies.

AI & Machine LearningDigital HealthHealthtechMedical DevicesWilmington, US

RYAN A. SYSKO(Executive Officer, Director)

BoardSONNY VU(Director)JEFFREY P. COURTNEY(Director)

Ashvattha Therapeutics

BiotechRedwood City, US

Jeffrey Cleland(Manager of Company)Kannan Rangaramanujam(Manager of Company)Sujatha Kannan(Manager of Company)

BoardJustin Hanes(Manager of Company)

ATAIatai.com

ATAI is developing rapid-acting, durable mental health treatments to address unmet needs in psychiatric conditions affecting over one billion people globally.

BiotechHealthtechMental Health

Audicusaudicus.com

HealthtechNew York, US

Patrick Freuler(Executive Officer, Director)Andre Sequin(Executive Officer)

Automata
AVAVA
Aviceda Therapeutics

BiotechCambridge, US

Mohamed Genead(Executive Officer, Director)Michael Tolentino(Executive Officer, Director)David Callanan(Executive Officer)Tarek Hassan(Executive Officer)Derek Kunimoto(Executive Officer)

BoardDavid Guyer(Director)

Axena Health

HealthtechAuburndale, US

Samantha Pulliam(Executive Officer, Director)Vincent Ricci(Executive Officer)Jim O'Connor(Executive Officer)Shacey Petrovic(Executive Officer, Director)Eileen Maus(Executive Officer, Director)

BoardJonathan Dean(Director)

B Well
Bayesian Healthbayesianhealth.comin𝕏

Bayesian Health develops clinical artificial intelligence for real-time patient monitoring and clinical decision support.

AI & Machine LearningDigital HealthHealthtechMedical Devices

Dr. Suchi Saria

Beacon Biosignals

Boston, US

Jacob A. Donoghue, M.D., Ph.D.(Executive Officer, Director)Jarrett Revels(Executive Officer)Jacob A. Donoghue(Executive Officer, Director, Promoter)

BoardCaitlin Donovan(Director)Pavel Raifeld(Director)Naveen Rao(Director)

Blackrock Neurotechblackrockneurotech.comin𝕏

Blackrock Neurotech develops a neurotechnology platform, including brain-computer interface systems, aimed at improving patient lives and treating neurological conditions.

BiotechDeep TechMedical Devices

Florian Solzbacher(Co-Founder & CSO)Marcus Gerhardt(Co-Founder & CEO)Thomas Thiele(CFO)Christian Angermayer(Co-Chairman)Tim Sievers(Co-Chairman)

Cage Pharmaceuticals

HealthtechBaltimore, US

Jason Rifkin(Executive Officer)

Cambrian Biocambrianbio.comin𝕏

Cambrian Bio is a clinical-stage biopharmaceutical company developing precision therapeutics targeting metabolic pathways associated with aging, including AMPK and mTOR.

BiotechLongevityMedical DevicesNew York, US

James G. Peyer(Executive Officer, Director)Juliette Han(Executive Officer, Director)Mark Nuttall(Executive Officer)Ruth Thieroff-Ekerdt(Executive Officer)William DeVaul(Executive Officer)Christian Angermeyer(Director)

Carbon Health
Cartography
Celsius Therapeuticscelsiustx.comacquired by AbbVie

Combines single-cell RNA analysis technology from the Broad Institute with AI/ML models and large-scale clinical sample collection for novel drug discovery and precision medicine.

HealthtechCambridge, US

Michael Boretti(Executive Officer)Tariq Kassum(Executive Officer, Director)Christoph Lengauer(Executive Officer, Director)

Centenara Labscentenara.comin𝕏

Centenara Labs is a longevity-focused drug discovery company that translates research on the biology of aging into therapies intended to improve healthy aging and extend lifespan.

BiotechHealthtechLongevity

Christian Angermayer(Founder)

Centrexioncentrexion.comin𝕏

Centrexion is a pharmaceutical company developing drugs in two therapeutic areas: non-opioid pain relief and immunology.

BiotechBaltimore, US

Sol Barer(Director)Kerrie L. Brady(Executive Officer)James N. Campbell(Executive Officer, Director)Shengda Zan(Director)Gregg Beloff(Executive Officer)Arnold L. Oronsky(Director)

Character Biosciences

BiotechJersey City, US

Cheng Zhang(Executive Officer, Director)

BoardVivek Garipalli(Director)Nick Olsen(Director)Peter DiLaura(Director)

Claris Bio
Compass
Cresiloncresilon.comin𝕏

Cresilon is a Brooklyn-based medical device company that develops plant-based hydrogel hemostatic products to rapidly stop bleeding.

BiotechHealthtechMedical DevicesBrooklyn, US

Isaac Miller(Co-founder)Joseph Landolina(Executive Officer, Director)Scott Levine(Executive Officer)Joe Landolina(Co-founder)

Dianthus
DNA Script
eGenesisegenesis.com

BiotechBrookline, US

Luhan Yang(President, Secretary and Treasurer)Geoff MacKay(Chief Executive Officer)

BoardGeorge M. Church(Director)

Elektrofi
eNeura
Ensomaensoma.com

Boston, US

Envedaenvedabio.com
Erisyon
Fogpharmafogpharma.comin

FogPharma develops ultra-tunable Helicon peptide therapeutics designed to reach historically undruggable targets, aiming to treat cancer and other serious diseases.

BiotechBoston, US

Gregory L Verdine(Executive Officer, Director)Mathai Mammen(CEO, President and Chairman)

Georgiamunegeorgiamune.com

Georgiamune develops targeted immunomodulator drugs designed to regulate immune signaling pathways for treating cancer and autoimmune diseases.

BiotechHealthtech

GlycoEraglycoera.comin𝕏

GlycoEra develops glycan-based therapeutics, applying glycoengineering technology to create biologic drugs.

BiotechHealthtechNewton, US

Ganesh V. Kaundinya(President & CEO)

Haystack Oncology
Hippocratic AIhippocraticai.comin𝕏

Hippocratic AI develops generative AI agents designed for healthcare delivery, working with hospital systems, health plans, and life sciences companies to support clinical decision-making and patient care.

AI & Machine LearningDigital HealthHealthtech

Munjal Shah(Chief Executive Officer, Co-founder)inDr. Meenesh Bhimani(Chief Medical Officer, co-founder)inVishal Parikh(Chief Product Officer, Co-founder)inSubho Mukherjee(Chief Science Officer, Co-founder)in

Iambiciambic.aiin

iambic.ai develops an AI-driven platform for drug discovery that uses multimodal transformer and co-folding technologies to design novel molecules and optimize compounds for diseases.

AI & Machine LearningBiotechDeep Tech

Imbria
Immunaiimmunai.comin𝕏

Immunai develops AMICA, a data platform for decoding the immune system to accelerate drug discovery and development.

AI & Machine LearningBiotechData & InfrastructureNew York City, US

Imperative Care
Insightecinsightec.comin𝕏

HealthtechTirat Carmel

Brett Chugg(Director)Sim Mann(Director)Ron Hadassi(Director)Jeremy Blank(Director)Roni Karie(Vice President - Finance)Shirel Aroshase(Vice President - Human Resources)

Kailerakailera.comin𝕏
Lassen Therapeuticslassentherapeutics.comin
Leo Cancer Careleocancercare.comin𝕏

Leo Cancer Care develops upright radiotherapy systems, including patient positioning, imaging, and treatment solutions for photon and particle (proton) therapy.

HardwareHealthtechMedical Devices

Lifesproutbiolifesproutbio.comFeb 2018

LifeSprout develops tissue-engineering products for aesthetic and regenerative medicine, designed to restore soft tissue losses caused by aging, cancer, and metabolic disease.

BiotechHealthtechMedical DevicesBaltimore, US

Hai-Quan Mao(Executive Officer, Promoter)Sashank Reddy(Executive Officer, Director, Promoter)Gregory Sieczkiewicz(Executive Officer, Director, Promoter)

Exits · 11

IPOs and acquisitions across the tracked portfolio

ArriVent BioPharmaNASDAQ: AVBPAtaiBeckleyNASDAQ: ATAIAvalyn Pharma IncNASDAQ: AVLNCompass PathwaysNASDAQ: CMPSFractylNASDAQ: GUTSFreenomeNASDAQ: FRNMKardiganNASDAQ: KARDNeumora TherapeuticsNASDAQ: NMRAParabilis MedicinesNASDAQ: PBLSProtara TherapeuticsNASDAQ: TARACelsius Therapeuticsacq. by AbbVie

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Catalio Capital Management, LP invest at?
Catalio Capital Management, LP invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
What sectors does Catalio Capital Management, LP focus on?
Catalio Capital Management, LP focuses on Biotech, Digital Health, Healthtech, Longevity, Medical Devices.
Where is Catalio Capital Management, LP located?
Catalio Capital Management, LP is headquartered in New York, US.
Does Catalio Capital Management, LP lead rounds?
Catalio Capital Management, LP typically participates in rounds rather than leading them.

Images

Catalio Capital Management, LP photoCatalio Capital Management, LP photoCatalio Capital Management, LP photoCatalio Capital Management, LP photoCatalio Capital Management, LP photoCatalio Capital Management, LP photo

Co-investors · 12

ARCH Venture Partners

ARCH Venture Partners is a venture capital firm that backs and helps build transformational companies, with a strong focus on the life sciences and biotech sector.

$50K – $250M
Andreessen Horowitz

Andreessen Horowitz's Strategic Partnerships page describes collaborations that connect its portfolio companies with established institutions to help scale and deploy their technology.

$500K – $50M
Vivo Capital

Vivo Capital is a global healthcare-focused investment firm operating a multi-strategy platform spanning venture capital, private equity, and public equity. It aims to expand healthcare access and drive innovation through its 'Ecosystem Strategy.'

Both backed · 2
Compass PathwaysClasp Therapeutics
$10M – $50M
Sequoia Capital

Sequoia Capital is a venture capital firm that partners with founders to build technology companies, with a strong current focus on artificial intelligence.

Both backed · 1
OpenEvidence
$4.4M – $214M
Alumni Ventures

Alumni Ventures (AV) is a venture firm that gives accredited individual investors access to professionally managed, diversified venture portfolios by co-investing alongside leading lead VC firms. It offers annual funds, syndicate deal-by-deal investing, and various investor clubs.

Both backed · 1
$100K – $10M
Polaris Partners

Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.

Both backed · 1
$500K – $5M
MPM BioImpact

MPM BioImpact combines 30+ years of biotech venture capital expertise with impact investing and public market experience, managing early-stage venture funds, private/public impact funds, and a public equities fund focused on transforming patient outcomes.

Both backed · 1
$1M – $15M
Third Rock Ventures

Third Rock Ventures is a venture capital firm that discovers, launches, and builds life sciences and biotechnology companies developing novel medicines and therapies.

Both backed · 1
$100K – $5M
Abingworth

Abingworth is a life science venture capital firm that backs early-stage biopharma and biotech companies, helping entrepreneurs translate scientific discoveries into new therapeutics.

Both backed · 1
$15M – $30M
Hatteras Venture Partners

Hatteras Venture Partners is a venture capital firm focused on early-stage life sciences and healthcare companies, backing therapeutics, diagnostics, and businesses aiming to transform healthcare delivery and innovation.

Both backed · 1
$500K – $4M
Nexus Venture Partners

Nexus Venture Partners invests in early and early growth stage companies operating in India and the United States across multiple sectors. The firm was founded by entrepreneurs with experience building companies.

$500K – $10M
Catalio Capital Management

Catalio is a software platform that uses AI to automatically extract and document business logic from legacy and modern systems, creating living specifications that stay current as software evolves.

Firms observed investing alongside Catalio Capital Management, LP, from public investor directories. Shared companies are the overlap with Catalio Capital Management, LP's recorded portfolio.

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