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Matrix Capital Management

Venture capital

Portsmouth · 4 people tracked

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HQ
Portsmouth, US
AUM
$2.3B
Tracked investments
11
Unicorns
1
IPOs
1
Acquisitions
2

Team · 4 people

from public directories
Dmitry Alpatkin· Managing Directorin

What they invest in

from 10 of 11 portfolio companies

Biotech ×8AI & Machine Learning ×4Digital Health ×4Healthtech ×4Deep Tech ×2Enterprise Software ×2Medical Devices ×2Crypto & Web3 ×1

HQs:United States×10

Investments · 11 tracked

founders shown can be your intro path

By year:2025 · 12024 · 12021 · 32020 · 22015 · 29 dated

Maze Therapeuticsmazetx.comin𝕏NASDAQ: MAZEDec 2024

Maze Therapeutics develops precision medicines for common diseases with high unmet need, using its Compass platform based on human genetics and variant functionalization.

AI & Machine LearningBiotechSouth San Francisco, US

Charles Homcy(Director)Jason Coloma(Chief Executive Officer)in

Co-investorsAndreessen HorowitzARCH Venture PartnersForesite CapitalFrazier Life SciencesGV (Google Ventures)Hercules Capital, Inc.+9 more

Palleon Pharmaceuticalspalleonpharma.comin𝕏✓ verified

Palleon Pharma develops small molecule and biologic drugs targeting autoimmune and inflammatory diseases using proprietary glycoscience platforms.

BiotechDigital HealthMedical DevicesWaltham, US

James W. Broderick(Executive Officer, Director)Jim Broderick(Co-Founder)John Hennessy(Executive Officer)Karen Hong(Director)James Lee(Director)Stephen Hoffman(Director)

Co-investorsPfizer VenturesPfizer Venture InvestmentsSR One Capital ManagementBioHealth Innovation, Inc.Takeda VenturesVertex Ventures HC

Solve Therapeuticssolvetx.comin✓ verified

Solve Therapeutics is a clinical-stage oncology biotech developing antibody-drug conjugates (ADCs) and radiopharmaceuticals for solid tumors, built around its CloakLink hydrophilic cleavable linker platform and an integrated diagnostic for patient selection.

BiotechDeep TechHealthtech

David Johnson(Chief Executive Officer)Clayton Knox(President)Katti Jessen(SVP, Translational Sciences)Yakov Kogan(Head of Operations)Brian Lannutti(Research & Development Leadership)Langdon Miller(Clinical Development Leadership)

Co-investorsDecheng CapitalYosemiteB Capital GroupB4 Capital

Anumanaanumana.aiin𝕏Apr 2025

Anumana is an AI-driven health technology company developing software-as-a-medical-device (SaMD) solutions that apply AI to standard 12-lead ECG data to detect early signs of cardiovascular disease and support clinical decision-making.

AI & Machine LearningBiotechDigital HealthMedical DevicesCambridge, US

Murali Aravamudan(Executive Chairman of the Board; co-founder of nference)inMaulik Nanavaty(Chief Executive Officer)inHarris Fishman(Executive Officer)Alan Colowick(Director)Cheranjit Rihal(Director)David Goel(Director)

Co-investorsNTT Venture CapitalMatrix

Bardavonbardavon.cominOct 2021 · $90M

Bardavon Health Innovations provides clinical case management and care coordination services for injured workers in the workers' compensation space, guiding them through recovery and return-to-work processes.

Digital HealthEnterprise SoftwareHealthtechInsurTechOverland Park, US

Matthew Condon(CEO (until early 2024))inJeff Hogland(Executive Officer, Director)Paul Morris(Executive Officer, Director)in

BoardRobert K Green(Director)Matthew Ferguson(Director)

Co-investorsCobalt VenturesKCRise FundNewRoad Capital Partners, LLC

Blockdaemonblockdaemon.comin𝕏Sep 2021

Blockdaemon provides blockchain infrastructure services including staking, node deployment, APIs, and wallet management across 60+ protocols for financial institutions and developers.

Crypto & Web3Data & InfrastructureEnergyEnterprise SoftwareFintechLos Angeles, US

Konstantin Richter(CEO and Founder)in

BoardEd Sim(Director)inGil Beyda(Director)in

Co-investors10SQ Capital (TenSquared)Amplify.LAAurum Venture PartnersBaroda VenturesBlockchain Coinvestorsboldstart ventures+31 more

Cyphortcyphort.comMay 2015Acquired

Santa Clara-based provider of advanced threat protection software for detecting next-generation malware.

Santa Clara, US

Manoj Leelanivas(Executive Officer, Director)

Co-investorsClear VenturesDell Technologies CapitalSapphire VenturesZouk CapitalFoundation CapitalMatrix+1 more

Encoded Therapeuticsencoded.comin𝕏Jul 2020

Encoded develops gene therapies for neurological disorders through an integrated platform approach.

BiotechSouth San Francisco, US

Stephanie Tagliatela(Co-founder, Chief Scientific Officer & Board Member)inKartik Ramamoorthi, Ph.D.(Co-founder, Chief Executive Officer & Board Member)

Co-investorsARCH Venture PartnersBioBritGV (Google Ventures)Illumina VenturesMenlo VenturesSoftBank Vision Fund+2 more

Rgenta Therapeuticsrgentatx.cominMay 2021 · $38M

Rgenta develops orally available small molecule therapies that target RNA to address diseases previously considered undruggable, with programs in oncology (targeting proteins such as MYB in solid tumors and hematologic cancers) and central nervous system repeat expansion disorders like Huntington's disease.

AI & Machine LearningBiotechDeep TechHealthtechCambridge, US

Travis Wager(Co-founder, President and CSO)inHualin Simon Xi(Executive Officer, Director)Zhiping Weng(Co-founder)inSimon Xi(Co-founder and CEO)inJackie Walling(CMO)Debasish Roychowdhury(Director)

Co-investorsDelos CapitalVivo CapitalAMR Action FundBoehringer Ingelheim Venture FundKorea Investment PartnersLilly Asia Ventures+1 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

EpiBiomePredible Health

Exits · 3

1 IPOs · 2 acquisitions · showing 2

Maze TherapeuticsNASDAQ: MAZEPredible Healthacq. by nference

Portfolio news

latest coverage across their companies

Public market activity · per SEC filings

what is this? ⓘ
SC 13G filingSC 13G

Disclosed stake · filed May 2005

view filing ↗

Files 13F institutional holdings reports · latest Aug 2007

From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.

Frequently asked questions

How many investments has Matrix Capital Management made?
Matrix Capital Management has 11 tracked investments, 3 of which have exited, including 2 dated in the last 24 months.
What sectors does Matrix Capital Management focus on?
Matrix Capital Management focuses on Crypto & Web3.
Where is Matrix Capital Management located?
Matrix Capital Management is headquartered in Portsmouth, US.

Co-investors · 6

ARCH Venture Partners

ARCH Venture Partners is a venture capital firm that invests in and helps build transformational companies, with a strong focus on the life sciences and biotechnology sector.

$50K – $250M
General Catalyst

General Catalyst is a venture capital firm operating as a partnership focused on company building and accelerating the growth of the businesses it backs.

Both backed · 1
$30M
SignalFire

SignalFire is a seed-stage venture capital firm that combines a full-team support model with its data-driven Beacon AI platform to back founders.

Both backed · 1
$250K – $15M
Gradient Ventures

Gradient is a seed-stage venture fund focused on backing founders building artificial intelligence companies, providing hands-on support as builders and mentors.

$100K – $10M
Base10 Partners

Base10 Partners is a venture capital firm investing in automation technologies for the real economy, backing companies that solve problems for the '99%'. The firm donates a portion of its proceeds to support the next generation of technology founders.

$100K – $5M
Flashpoint Venture Capital

Flashpoint is a technology investment firm that backs tech founders throughout their journey via venture growth equity, growth debt, and secondary transactions.

$1M – $15M

Firms observed investing alongside Matrix Capital Management, from public investor directories. Shared companies are the overlap with Matrix Capital Management's recorded portfolio.

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