How many investments has SR One Capital Management made?

SR One Capital Management has 48 tracked investments, including 4 dated in the last 24 months.

What stage does SR One Capital Management invest at?

SR One Capital Management invests at the Seed, Series A, Series B stages.

What sectors does SR One Capital Management focus on?

SR One Capital Management focuses on Biotech.

Where is SR One Capital Management located?

SR One Capital Management is headquartered in Redwood City, US.

Who does SR One Capital Management co-invest with?

SR One Capital Management most often shares deals with OrbiMed, New Enterprise Associates (NEA), Quan Capital, among 64 tracked co-investors.

SR One Capital Management

Venture capitalActively deploying

Redwood City · Seed–Series B · 29 people tracked

Also known as SR ONE CAPITAL MANAGEMENT, LP

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Investment thesis

SR One is a biotechnology venture capital firm that backs companies translating novel science into medicines. It uses a 'back-and-build' approach, focusing on companies with strong fundamentals, a clearly defined development pathway, and novel approaches to treating disease. With an investing team based in West Coast biotech hubs in the USA and in London, UK, the firm leverages its transatlantic footprint to act as a strategic partner, offering geographic reach and regional expertise to source opportunities and provide real-time business support to portfolio companies.

Invests inBiotech Redwood City United Kingdom United States

Source: firm website, verified Aug 25, 2026.

Stage

Seed–Series B

Redwood City, California, US

Instruments

Equity

Founded

1985

Last 12 months

3 investments

AUM

$2.4B

Tracked investments

Team · 29 people

from the firm's website & public directories

Rajeev Dadoo· COO and Managing Partner· San Francisco Bay Areain

Rajeev Dadoo is COO and Managing Partner at SR One, which he joined in 2004, and is an alum of the Kauffman Fellows Program. He invests in therapeutics and healthcare-technology companies, drawing on operational and strategic experience from prior roles at GSK's Competitive Excellence group, Genentech, Bio-Rad Laboratories, and Genome Therapeutics, and he co-founded Unimicro Technologies. He holds a BA in Chemistry and Mathematics from Knox College, a PhD in Chemistry from Stanford University, and an MBA from the Wharton School.

r•••@srone.comreveal

Simeon J. George· Partnerin

s•••@srone.comreveal

Brian Gallagher· Partner· Boston, Massachusettsin 𝕏

Deborah Harland· Partner

Amit Shah· Principal· San Francisco Bay Areain 𝕏

Amit Shah is a Principal in SR One's London office, focusing on venture capital investments in biotech. Before joining SR One in early 2018, he held roles at GlaxoSmithKline spanning late-phase clinical development, global medical affairs, and early pipeline commercial strategy, and he is a board-certified-equivalent plastic surgeon specializing in microsurgical cancer reconstruction. He holds a B.A. in Medical Sciences, an M.A. in Neuroscience, and an M.D. from the University of Cambridge, and since 2020 has served on the venture capital panel for the BioInnovation Institute.

a•••@srone.comreveal

Jill Carroll· Operating Partner· East Coast (US)in

Jill Carroll is an Operating Partner at SR One, which she first joined in 2011, and manages several of the firm's investments. She holds a BS in Chemistry from Duke University and an MS in Biochemistry from Johns Hopkins University. Before SR One, she worked in strategy consulting and biotech corporate development, including at Dynavax Technologies.

j•••@srone.comreveal

Katarina Pance· Principal· San Francisco Bay Areain

Katarina Pance is a Principal at SR One, based in the San Francisco Bay Area, having joined the firm in 2023. She previously co-founded EpiBiologics, where she served as head of discovery biology, building on her graduate research on bispecific antibodies for extracellular protein degradation. She earned a BA in Biochemistry from the University of Pennsylvania and a PhD in Chemistry and Chemical Biology from UCSF, where she studied with Dr. Jim Wells, and was earlier a venture fellow at MPM Capital.

k•••@srone.comreveal

Laetitia Schwab· Principal· Londonin

Laetitia Schwab is a Principal at SR One in the London office, joining in 2022. She previously worked in clinical development at Orchard Therapeutics, contributing to the delivery of the gene therapy Libmeldy for Marketing Authorisation, and has experience across early and late-phase clinical programs with expertise in gene therapy, neuroscience, and rare diseases. She holds a B.Sc in Medical Sciences from the University of Edinburgh, an MPhil in Translational Medicine and a Ph.D in Clinical Neuroscience from the University of Cambridge, and an MBA from INSEAD.

l•••@srone.comreveal

Amit Mehta· Venture Partner· San Francisco Bay Area

Amit Mehta is a Venture Partner at SR One, which he joined in 2024, and also serves as COO and CBO at Dren Bio, an SR One portfolio company. He previously spent 18 years at Genentech, most recently as Vice President and Head of Business Development, where he held roles across technical development, CMC, product strategy, and business development. He holds a B.E. in Chemical Engineering from Bangalore University and a Ph.D. in Chemical Engineering from Pennsylvania State University.

s•••@sambrown.comreveal

Chris Chai· Venture Partner· San Francisco Bay Areain

Chris Chai is an Operating Partner at SR One who advises portfolio companies on financing strategy and their engagement with Wall Street. He has more than 20 years of experience in biotech executive management and investment banking, having served as CFO at Principia Biopharma and MAP Pharmaceuticals and in treasury and investor relations at CV Therapeutics, and previously worked in investment banking at JP Morgan. He holds a BS in Operations Research and Industrial Engineering from Cornell University.

s•••@sambrown.comreveal

Jake Bauer· Venture Partner· San Francisco Bay Areain

Jake Bauer is a Venture Partner at SR One who works with emerging clinical biotechnology companies. He previously served as Chief Business Officer of MyoKardia, which was acquired by Bristol Myers Squibb in 2020, and held earlier roles at Ablexis, Third Rock Ventures, Royalty Pharma, Endo Pharmaceuticals, and Putnam Associates. He holds a BS in Biology and BA in Economics from Duke University and an MBA from Harvard Business School.

s•••@sambrown.comreveal

Jake Nunn· Partner· San Francisco Bay Areain

Jake Nunn is a Partner at SR One focusing on later-stage private and public biotech investments, with over 25 years in the life sciences industry as an investor, board director, research analyst, and investment banker. He was previously an investing partner at New Enterprise Associates (NEA) from 2006 to 2019, where he founded the firm's public healthcare investing practice, and earlier held roles at MPM Capital, Franklin Templeton Investments, and Alex. Brown & Sons. He holds an MBA from Stanford Graduate School of Business and a BA in Economics from Dartmouth College, and is a CFA charterholder.

j•••@srone.comreveal

Matthew R. Patterson· Venture Partner· San Francisco Bay Area

Matthew R. Patterson is a Venture Partner at SR One Capital Management with over 30 years in the research, development, and commercialization of therapeutics. He co-founded Audentes Therapeutics in 2012 and served as its CEO until its 2020 acquisition by Astellas Pharma, and previously worked at Genzyme, BioMarin Pharmaceutical, Amicus Therapeutics, and Iris Medicine, as well as serving as an Entrepreneur-In-Residence at OrbiMed. He holds a Bachelor's degree in Biochemistry from Bowdoin College.

s•••@sambrown.comreveal

Peter Van Vlasselaer, PhD· Venture Partner· San Francisco Bay Areain

Rodger Novak· Venture Partner· Switzerlandin 𝕏

Alicia Hasson· Executive Administrative Support· San Francisco Bay Areain

Alicia Hasson joined SR One in 2024 and works in the San Francisco Bay Area office, providing executive administrative support to Rajeev Dadoo, Jill Carroll, and Jake Nunn. She has 15 years of administrative experience in the biotech industry across large and small pharmaceutical companies. She studied Business Administration at City College of San Francisco (CCSF).

Ann Ng· Finance Director· Londonin

Ann Ng is the Finance Director at SR One, based in the firm's London office, where she manages accounting, financial statements, and fund reporting while supporting the CFO on operations. She previously spent ten years at CITIC Capital Partners Limited in private equity fund management and operations. She holds a BA in Accounting & Finance from Curtin University of Technology and is a CPA (Australia).

s•••@sambrown.comreveal

Briana Wilson· Senior Administrative Assistant· San Francisco Bay Area

Briana Wilson joined SR One in 2023 and provides administrative support to team members as well as assisting with event planning. She previously worked at Huntsman Gay Global Capital, where she handled administrative support, reception, and vendor relations. She holds a Bachelor of Science in Kinesiology from San Jose State University.

s•••@sambrown.comreveal

Catalina Kazi· Legal and Compliance Counsel· San Francisco Bay Areain

Catalina Kazi is Legal and Compliance Counsel at SR One, which she joined in 2024. She previously worked for over five years as in-house counsel handling regulatory compliance at retail and institutional investment managers, and served as an attorney in the Securities Division of the Secretary of the Commonwealth of Massachusetts. She holds a B.A. in International Relations from Florida International University and a J.D. from Boston University School of Law, and is licensed to practice law in New York and Registered In-House Counsel in California.</bio_summary> <parameter name="investments">[]

s•••@sambrown.comreveal

Frances Benson· Chief of Staff· San Francisco Bay Areain

Frances Benson joined SR One in 2020 as Chief of Staff, overseeing business functions such as operations, events, marketing, and PR. She previously worked at Sofinnova Investments, where she handled administrative support, reception, and vendor relations. She studied Interior Architecture and Design at the Academy of Arts University in San Francisco.

s•••@sambrown.comreveal

Iqbal Mufti· Operating Partner· Londonin

Iqbal Mufti is an Operating Partner at SR One's London office, working on company creation, later-stage investments, and portfolio companies' industry engagement and partnering strategy. He previously worked at Hoffmann-La Roche, where he co-led the rare blood disorders portfolio strategy team and served as global Lifecycle Leader for Hemlibra (emicizumab). His background covers pharmaceutical product and portfolio strategy, late-stage development, global commercialization, business development, and M&A. He holds a BSc in Biotechnology from University College London and an MBA from Duke University's Fuqua School of Business.

s•••@sambrown.comreveal

James Macadam· Chief Financial Officer· Londonin

James Macadam is Chief Financial Officer at SR One, based in the firm's London office, where he oversees financial matters and helps manage a range of the firm's operations. He joined SR One in 2019 after holding corporate finance and commercial roles at GlaxoSmithKline. He holds an MA in Geography from Oxford University, an MPhil in Polar Studies from Cambridge University, and an MBA from HEC Paris.</bio_summary> <parameter name="investments">[]

s•••@sambrown.comreveal

Lyla Youssef· Associate· San Francisco Bay Areain

Lyla Youssef is an Associate at SR One, based in the San Francisco Bay Area, where she joined in 2024 with a background in biotechnology and therapeutics equities. She previously worked as an Associate Analyst covering therapeutics at Hudson Bay Capital, in biotech equity research as a Vice President at TD Cowen, and in equity research at Oppenheimer & Co., along with roles at Columbia University's Translational Therapeutics Accelerator and Columbia Tech Ventures. She holds a Ph.D. in Microbiology & Immunology from Columbia University and a B.A. in Biological Sciences and Economics from Cornell University.

l•••@srone.comreveal

Mahesh Kudari· Senior Associate· Londonin

Mahesh Kudari is a Senior Associate at SR One's London office, which he joined in 2024. He previously served as VP Business Operations at Xap Therapeutics and Head of Clinical Development at Orchard Therapeutics, where he led cross-functional gene therapy development programs, and earlier held early clinical development and medical affairs roles at GSK. He holds a medical degree from University College London and an M.A. in Medical Sciences from the University of Cambridge, and has a background in diagnostic and interventional radiology.

m•••@srone.comreveal

Mary Mirt· Administrative Assistant· San Francisco Bay Areain

Mary Mirt joined SR One in 2025, where she provides administrative and office management support to team members. She previously held office management roles at Peakspan Capital and Pacific Lake Partners, handling vendor management and reception. She holds a Bachelor of Arts in Communication & Media Studies from CSU East Bay.

s•••@sambrown.comreveal

Philip Habib· Leads Capital Partnering at SR One· Londonin

Philip Habib leads SR One's Capital Partnering effort and is based in London, with over 15 years of experience across venture capital, private equity, and real estate. He began his career in the Private Equity & Venture Capital group at Cambridge Associates advising institutional investors, and later worked at General Electric in Business Development (M&A) and Sponsor Leveraged Finance, covering sectors including healthcare. He holds an MBA from London Business School and an MA in Economics from the University of Edinburgh.

s•••@sambrown.comreveal

Sasha Keough· General Counsel and Chief Compliance Officer· East Coastin

Sasha Keough serves as General Counsel and Chief Compliance Officer at SR One, which she joined in 2022. She previously spent over 12 years as an in-house attorney at New Enterprise Associates, working on compliance, venture capital financings, and fund operations. She holds a B.A. in History from the University of Virginia and a J.D. from the University of Baltimore School of Law.

s•••@sambrown.comreveal

Tanya McGlashan· Manager, UK Operations· Greater London, England, United Kingdomin

Tanya McGlashan joined SR One in October 2020, where she oversees risk, financial, and operational functions. Previously she worked at an investment bank managing data analytics projects and business support, and earlier held roles in accounts, compliance, and operations at a private equity and HNWI family office. She holds a BA in English and Spanish from N. Novgorod Linguistic University, a Diploma in Professional Accounting (AAT), and ACCA certificates in management accounts, performance management, taxation, and corporate/business law.

s•••@sambrown.comreveal

Viraj Pillai· Finance Director· Londonin

Viraj Pillai is the Finance Director at SR One, based in the London office, where he oversees the fund's accounting, financial statements, and reporting, and works with external stakeholders and suppliers. He has over ten years of post-qualification experience, including five years with fund administrators and earlier work as an auditor at PwC (Sri Lanka/Botswana) and Deloitte UK. He holds a chartered accountancy qualification from the Institute of Chartered Accountants of Sri Lanka and is an associate member of the Institute of Certified Management Accountants.

What they invest in

from 37 of 59 portfolio companies

Biotech ×34Healthtech ×25Medical Devices ×6AI & Machine Learning ×5Deep Tech ×3Digital Health ×3Construction Tech ×1Enterprise Software ×1

HQs:United States×24Denmark×1

Who they back

founder profiles across 9 portfolio companies

67%

solo founders

6 of 9 mapped founding teams

~4 yrs

old at investment

median across 8 dated deals

Founding team size:solo founder×62 founders×24+ founders×1

Investments · 59 tracked

founders shown can be your intro path

By year:2026 · 1 2025 · 3 2024 · 2 2023 · 1 2022 · 2 2021 · 2 2020 · 3 2018 · 1 2016 · 2 2015 · 118 dated

Addex Therapeuticsaddextherapeutics.com in 𝕏NASDAQ: ADXNApr 2023SEC filingmedium confidence

Addex Therapeutics is a clinical-stage pharmaceutical company that develops orally available small molecule drugs known as allosteric modulators for neurological disorders.

BiotechHealthtechGeneva

Roger Mills(Executive Officer, Director)Mikhail Kalinichev(Executive Officer)Jean-Philippe Rocher(Executive Officer)Robert Lutjens(Executive Officer)Timothy Dyer(Executive Officer, Director)Vincent Lawton(Director)

Board seatJake Nunn· per SEC Form D · $3.7M raise · filed Apr 2023

Co-investorsNew Enterprise Associates (NEA)Sofinnova Partners ACORN BIOVENTURES

Veradermicsveradermics.com inNYSE: MANEOct 2025

Veradermics is developing VDPHL01, an extended-release oral minoxidil tablet intended as a non-hormonal prescription treatment for pattern hair loss in women and men.

BiotechHealthtechWest Hartford, US

Reid Waldman(Chief Executive Officer and Board Member)Tim Durso(Chief Technical Officer)Dominic Carrano(Chief Financial Officer and Treasurer)Mark Neumann(Chief Commercial and Strategy Officer)John W. Childs(Director)Jane Grant-Kels(Director)

Board seatKatarina Pance· per SEC Form D

Co-investorsLongitude Capital Connecticut Innovations OUP (Osage University Partners)

Zenas Biopharmazenasbio.com inNASDAQ: ZBIOMay 2024

Zenas BioPharma is a biopharmaceutical company developing therapies for autoimmune diseases, with two late-stage drug candidates: obexelimab, a bifunctional monoclonal antibody targeting CD19 and FcγRIIb to suppress B cell activity, and orelabrutinib, an oral BTK inhibitor.

BiotechHealthtechWaltham, US

LEON O. MOULDER, JR.(Director)Lonnie Moulder(Founder, CEO & Chairman)JOSEPH FARMER(Executive Officer)HUA MU(Executive Officer, Director)

BoardPATRICK GERALD ENRIGHT(Director)inHONGBO LU(Director)

Board seatJake Nunn· per SEC Form D

Co-investorsDelos Capital Longitude Capital New Enterprise Associates (NEA)Norwest Venture Partners Quan Capital Vivo Capital +1 more

Alumisalumis.com in 𝕏NASDAQ: ALMS

Alumis is a clinical-stage biopharmaceutical company developing a late-stage portfolio of targeted therapies for immune-mediated diseases.

AI & Machine LearningBiotechDigital HealthHealthtechLongevitySouth San Francisco, US

Martin Babler(President, Chief Executive Officer and Chairman of the Board)Mark Bradley(Chief Development Officer)Kolbot By(SVP, Head of Technical Operations)Jack Danilkowicz(Chief Commercial Officer)Jörn Drappa(Chief Medical Officer)David M Goldstein(Chief Scientific Officer)

Co-investorsForesite Capital Nextech Invest OrbiMed Samsara BioCapital venBio Partners Westlake Village BioPartners +1 more

Avalyn Pharma Incavalynpharma.com inNASDAQ: AVLN

Avalyn Pharma develops inhaled therapies for pulmonary fibrosis, using a nebulization approach that delivers treatment directly to the lungs to reduce the tolerability problems of existing oral therapies.

BiotechHealthtech

Lyn Baranowski(CEO)in

Co-investorsAndera Partners Catalio Capital Management, LP F-Prime Capital InVivium Capital Norwest Venture Partners RiverVest Venture Partners +7 more

Design TherapeuticsNASDAQ: DSGN

Co-investorsRA Capital

KALA BIOkalarx.comNASDAQ: KALA

BiotechArlington, US

Justin Hanes(Director)Kevin Pojasek(Executive Officer)Darius Kharabi(Executive Officer)Todd Bazemore(Executive Officer)Mark Iwicki(Executive Officer, Director)Mary Reumuth(Executive Officer)

Co-investorsLongitude Capital Ysios Capital Atlas Venture Lux Capital Third Rock Ventures

Mineralys Therapeuticsmineralystx.com in 𝕏NASDAQ: MLYSJun 2022

Mineralys Therapeutics is a clinical-stage pharmaceutical company developing lorundrostat, a treatment targeting dysregulated aldosterone.

BiotechHealthtechRadnor, US

Eric Warren(Chief Commercial Officer)Alex Gold(Chief Medical Officer)Adam Levy(Executive Officer)Alexander Asam(Director)

BoardBrian Taylor Slingsby(Founder & former CEO / Board Director)Olivier Litzka(Director)in

Co-investorsAndera Partners Samsara BioCapital Ysios Capital Boulder Ventures Catalys Pacific RA Capital

Nkarta, Inc.nkartatx.com inNASDAQ: NKTX

Nkarta is a biotech company developing allogeneic CAR NK cell therapies for autoimmune diseases, aiming to offer safer and more accessible alternatives to autologous CAR-T treatments.

BiotechHealthtechSouth San Francisco, US

Paul Hastings(Executive Officer, Director)inPaul H.inPaul J. Hastings(Chief Executive Officer)Matthew Plunkett(Executive Officer)Michael Dybbs(Director)Fouad Azzam(Director)

Co-investorsNew Enterprise Associates (NEA)Samsara BioCapital Norwest Venture Partners

Oruka Therapeutics IncNASDAQ: ORKA

Addition Therapeuticsadditiontx.com inDec 2025

Addition Therapeutics develops genetic medicines using its all-RNA, non-viral, LNP-based PRINT platform, which combines the profile of RNA therapeutics with the durability of gene therapies.

BiotechHealthtechSouth San Francisco, US

Kathleen Collins(Director)Matthew Patterson(Director)Lawrence Kong(Executive Officer)Jennifer Lee(Director)Ronald Park(Executive Officer, Director)

BoardJayson Punwani(Director)

Board seatLaetitia SchwabMatthew R. Patterson· per SEC Form D

Co-investorsAbingworth Osage University Partners Pivotal Life Sciences

Ars Pharmaars-pharma.com in 𝕏Sep 2021

ARS Pharma develops needle-free epinephrine treatments, including neffy, an FDA-approved epinephrine nasal spray for patients and caregivers managing allergic reactions.

BiotechHealthtechMedical DevicesSan Diego, US

Richard Lowenthal(Executive Officer, Director)Pratik Shah(Director)

BoardJonathan Leff(Director)

Board seatRajeev Dadoo· per SEC Form D

Co-investorsNextech Invest OrbiMed RA Capital

Bird Rock BioDec 2016SEC filingmedium confidence

La Jolla, US

Richa Nand(Executive Officer)Alan Glicklich(Executive Officer)Mark Saad(Executive Officer)Paul A. Grayson(Executive Officer, Director)Erik Karrer(Executive Officer)Ray Stevens(Director)

Board seatSimeon J. George· per SEC Form D · $2.5M raise · filed Jan 2017

Co-investors5AM Ventures

CRISPR Therapeutics AGOct 2016SEC filingmedium confidence

BiotechBasel

Sven Ante Lundberg(Executive Officer)Thomas Woiwode(Director)Pablo Cagnoni(Director)Bradley Bolzon(Director)N. Anthony Coles(Director)Kala Subramanian(Executive Officer)

Board seatSimeon J. George· per SEC Form D · $35M raise · filed Nov 2016

Co-investorsAbingworth New Enterprise Associates (NEA)Versant Venture Capital

Dermiradermira.comDec 2018SEC filingmedium confidence

HealthtechMenlo Park, US

THOMAS G. WIGGANS(Executive Officer, Director)EUGENE A. BAUER(Executive Officer, Director)Christopher M. Griffith(Executive Officer, Promoter)Luis C. Pena(Executive Officer, Promoter)Thomas G. Wiggans(Executive Officer, Director, Promoter)Eugene A. Bauer(Executive Officer, Director, Promoter)

Board seatJake Nunn· per SEC Form D · $1M raise · filed Dec 2018

Co-investorsAisling Capital Bay City Capital Canaan Partners Foresite Capital New Enterprise Associates (NEA)Fidelity Investments +1 more

Dren Biodrenbio.comMar 2022

Dren Bio is a clinical-stage biopharmaceutical company developing novel antibody therapeutics designed to selectively eliminate pathogenic cells and disease-causing agents, with a pipeline targeting oncology, autoimmune diseases, immunology, and neurology.

BiotechHealthtechMedical DevicesFoster City, US

Nenad Tomasevic(Executive Officer, Director)

BoardIvan Trifunovich(Director)John Wesley(Director)

Board seatRajeev Dadoo· per SEC Form D

Co-investors8VC Aisling Capital Mission Bay Capital Mission Biocapital Olive Tree Capital Taiho Ventures, LLC +1 more

Entasis Therapeutics HoldingsAug 2020SEC filingmedium confidence

BiotechWaltham, US

Manoussos Perros(Executive Officer, Director)Michael Gutch(Executive Officer)David Altarac(Executive Officer)Elizabeth Keiley(Executive Officer)Ruben Tommasi(Executive Officer)John Mueller(Executive Officer)

Board seatHeather Behanna· per SEC Form D · $25M raise · filed Sep 2020

Navitor Pharmaceuticalsnavitorpharma.com inApr 2020SEC filingmedium confidence

BiotechCambridge, US

Rick Lundberg(Executive Officer)George P. Vlasuk(Executive Officer, Director)George Vlasuk(Executive Officer, Director)

BoardJean-Francois Formela(Director)inAlan Crane(Director)Marian Nakada(Director)

Board seatRajeev Dadoo· per SEC Form D · $20.2M raise · filed May 2020

Co-investorsage1 Brace Pharma Sanofi Ventures Atlas Venture Polaris Partners

Odyssey Therapeuticsodysseytx.com in 𝕏Jun 2025

Odyssey Therapeutics develops small molecule and protein therapeutics targeting upstream signaling nodes and innate immune system mechanisms to prevent pathological inflammation.

BiotechMedical DevicesCambridge, US

Gary D Glick(Executive Officer, Director)

BoardCarl Gordon(Director)inValerie Odegard(Director)Jeffrey Leiden(Director)Charles Baum(Director)

Board seatJill Carroll· per SEC Form D

Co-investorsActivant Capital Balderton Capital Catalio Capital Management, LP Foresite Capital Global BioAccess Fund GreatPoint Ventures +6 more

Palleon Pharmaceuticals inSep 2020

BiotechWaltham, US

James W. Broderick(Executive Officer, Director)John Hennessy(Executive Officer)Karen Hong(Director)James Lee(Director)Stephen Hoffman(Director)

BoardJens Eckstein(Director)

Board seatRajeev Dadoo· per SEC Form D

Co-investorsPfizer Ventures Takeda Ventures Vertex Ventures HC

Regulus Therapeutics Inc.regulusrx.com in 𝕏Dec 2021SEC filingmedium confidence

BiotechHealthtechSan Diego, US

Neil Gibson(Executive Officer)Kleanthis Xanthopoulos(Executive Officer, Director)

BoardB. Lynne Parshall(Director)Mark G. Foletta(Director)John Maraganore(Director)Douglas E. Williams(Director)

Board seatJake Nunn· per SEC Form D · $34.6M raise · filed Dec 2021

Co-investorsNew Enterprise Associates (NEA)

Trivasculartrivascular.com in 𝕏Aug 2015acquired by EndologixSEC filingmedium confidence

HealthtechMedical DevicesSanta Rosa, US

MICHAEL V. CHOBOTOV(Executive Officer)Michael Chobotov(Executive Officer, Director)SHARI L. O'QUINN(Executive Officer)MICHAEL R. KRAMER(Executive Officer)KIMBERLEY ELTING(Executive Officer)CHRISTOPHER CHAVEZ(Executive Officer, Director)

Board seatJake Nunn· per SEC Form D · $10M raise · filed Aug 2015

Co-investorsKaiser Permanente Ventures

ADARx Pharmaceuticals

Co-investorsBain Capital Life Sciences

Airnexis Therapeutics Inc inJan 2026

BiotechPalo Alto, US

James Li(Executive Officer, Director)Maria Fardis(Executive Officer, Director)

BoardAnna Chen(Director)Colin Walsh(Director)Evan Caplan(Director)Jill Carroll(Director)in

Akamis Bioakamisbio.com in 𝕏

Akamis Bio develops oncolytic immunotherapies for colorectal cancer treatment, aiming to offer alternatives to surgery that preserve patient function and quality of life.

BiotechDigital HealthHealthtechMedical Devices

Co-investorsARCH Venture Partners

Ancora Biotech

Antag Therapeuticsantagtherapeutics.com in

Antag Therapeutics develops GIP receptor antagonist therapies for obesity, diabetes, and overweight patients.

BiotechHealthtechCopenhagen, DK

Jens Juul Holst(Founder)Mette Rosenkilde(Founder)

Co-investorsBroadview Ventures Novo Holdings

Arcellxarcellx.com in

Arcellx develops CAR T-cell therapies that are individually designed for each patient, using the immune system to target and attack cancer.

BiotechHealthtechGaithersburg, US

Han Lee(Executive Officer)Rami Elghandour(Executive Officer, Director)

BoardJill Carroll(Director)inAli Behbahani(Director)inDerek Yoon(Director)inTiba Aynechi(Director)in

Co-investorsLG Technology Ventures New Enterprise Associates (NEA)Quan Capital Samsara BioCapital Sixty Degree Capital Solasta Ventures +2 more

Asceneuronasceneuron.com in 𝕏

Co-investorsKurma Partners M Ventures Sofinnova Partners

Avenzoavenzotx.com in

Avenzo Therapeutics is a clinical-stage biopharmaceutical company developing therapeutic treatments.

Biotech

Athena Countouriotis(Co-Founder, Chief Executive Officer)

Co-investorsDelos Capital Foresite Capital INCE Capital Longwood Fund New Enterprise Associates (NEA)OrbiMed +3 more

Bicyclebicycletherapeutics.com in 𝕏May 2024

Bicycle Therapeutics develops precision-guided therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, designed to penetrate deep into tissues and target intractable solid tumor cancers.

BiotechHealthtechCambridge

GREGORY WINTER(Director)KEVIN LEE(Executive Officer, Director)NIGEL CROCKETT(Executive Officer)NICHOLAS KEEN(Executive Officer)SANTIAGO ARROYO(Executive Officer)MICHAEL HANNAY(Executive Officer)

Co-investorsAhren Innovation Capital Astellas Venture Management LLC Cambridge Innovation Capital Longwood Fund SV Health Investors Vertex Ventures HC

Biotheryxbiotheryx.com in

Biotheryx is a clinical-stage biopharmaceutical company developing first-in-class targeted protein degraders, including molecular glues and bifunctional degraders, with an initial focus on cancer and inflammatory disease.

BiotechDeep TechMedical DevicesSan Diego, US

Kyle Chan, PhD(Executive Officer)Lawrence Zaslow(Executive Officer, Director)Frank Mercurio, PhD(Executive Officer)Leah Fung(Chief Executive Officer & Board Member (former Chief Scientific Officer))Raymond W. Urbanski(Acting Chief Medical Officer)David Stirling, PhD(Executive Officer, Director)

Co-investorsLumira Ventures Revelation Partners

CHARM Therapeuticscharmtx.com in

CHARM is a biotech company developing a next-generation menin inhibitor for acute myeloid leukemia (AML), designed to address resistance seen with first-generation approaches.

AI & Machine LearningBiotechHealthtechLondon

Lakshyaditya Singh Aithani(Executive Officer, Director)

BoardRishi Gupta(Director)Nihal Sinha(Director)inMuzammil Mansuri(Director)Gary Glick(Director)

Co-investorsF-Prime Capital New Enterprise Associates (NEA)OrbiMed Axial VC NVentures

Codify Therapeutics

Corxel Pharmaceuticals Limited

CRISPR Therapeutics

Co-investorsKhosla Ventures Versant Ventures

Crystalys Therapeutics, Inc.

Draig Therapeuticsdraigtherapeutics.com in

Draig Therapeutics is a clinical-stage biotech company developing neuromodulator therapies for neuropsychiatric disorders such as major depressive disorder.

BiotechDeep TechDigital Health

Co-investorsAccess Biotechnology Canaan Partners Sanofi Ventures SV Health Investors British Business Bank Janus Henderson Investors

Econic Biosciences

Elektrofi, Inc.

Boston, US

Co-investorsSofinnova Ventures

Fore Biotherapeutics

Provides functional information about mutations and drug responses to enable precision oncology treatments.

Co-investorsNovartis Venture Fund Windham Capital Partners

HotSpot Therapeuticshotspotthera.com in 𝕏

HotSpot Therapeutics is a drug discovery company developing small-molecule allosteric medicines by targeting "natural hotspots" — regulatory on/off switches on proteins.

AI & Machine LearningBiotechHealthtech

Co-investorsAtlas Venture B Capital Group B4 Capital MRL Ventures Fund Sofinnova Partners Solasta Ventures

Immutrin Limited

Kartostherakartosthera.com in 𝕏

Kartos Therapeutics develops targeted oral therapeutics for cancer, including Navtemadlin, an MDM2 inhibitor aimed at the MDM2-p53 interaction to treat selected solid tumors and hematological malignancies.

BiotechHealthtech

Co-investorsOrbiMed

Mission Therapeuticsmissiontherapeutics.com in 𝕏

Mission Therapeutics develops therapeutics targeting deubiquitylating enzymes (DUBs), such as USP30, which regulate ubiquitylation and processes including mitophagy and protein homeostasis.

BiotechHealthtech

Co-investorsPfizer Venture Investments Roche Venture Fund Sofinnova Partners

Nimbus

Nomicnomic.ai in 𝕏

Nomic is an AI platform for architecture, engineering, and construction (AEC) teams that orchestrates agents across drawings, specs, submittals, RFIs, and building codes to automate coordination and review work.

AI & Machine LearningConstruction TechEnterprise Software

Brandon Duderstadt(Founder)in

Co-investorsBetaworks Coatue Management Contrary

Poplar Therapeutics

Pulmocidepulmocide.com in

Pulmocide is a biopharmaceutical company developing inhaled therapies for difficult-to-treat respiratory diseases, currently focused on respiratory fungal infections such as pulmonary aspergillosis.

BiotechHealthtech

Pete Strong(Co-founder)Garth Rapeport(Co-founder)Kazuhiro Ito(Co-founder)John Murray(Co-founder)David Mantusin

Co-investorsAdjuvant Capital F-Prime Capital Jeito Capital Longwood Fund SV Health Investors Vivo Capital +1 more

Renalys

Rezo Therapeuticsrezotx.com

Rezo maps disease networks to find insights into disease biology for drug discovery.

AI & Machine LearningBiotechDeep TechSan Francisco, US

Nevan Krogan(Co-Founder)Sourav Bandyopadhyay(Co-Founder)Norbert Bischofberger(Co-Founder)Natalia Jura(Co-Founder)George Scangos(Co-Founder)Kevan Shokat(Co-Founder)

Co-investorsAndreessen Horowitz Norwest Venture Partners HAWKTAIL Valkyrie Ventures Management, Llc ARCH Venture Partners

River Renal

Clinical-stage company developing novel therapies for orphan renal diseases.

Co-investorsBain Capital Life Sciences Pureos Bioventures

Simcha Therapeuticssimchatx.com in

Simcha is a biotechnology company developing new cancer medicines based on immune biology research.

BiotechHealthtechNew Haven, US

Aaron Ring(Executive Officer, Director)Beatrice McQueen(Chief Operating Officer)Sanuj Ravindran(Chief Executive Officer)Jeremy Barton(Chief Medical Director)Hirdesh Uppal(Senior Vice President Translational Research and Development Sciences)Joseph Catino(Executive Officer)

Co-investorsConnecticut Innovations Pfizer Venture Investments Axial VC

Telios Pharma

Topo Therapeuticstopo-tx.com

Topo Therapeutics is a drug discovery company developing treatments targeting ion channels and transmembrane proteins for conditions such as pain, epilepsy, and CNS, pulmonary, and renal diseases.

BiotechHealthtechCambridge, US

Hui Tian(Executive Officer, Director)Madgalene Moran(Executive Officer, Director)Magdalene Moran(Chief Executive Officer)

BoardKarin Kleinhans(Director)Bruce Bean(Director)James Jeffrey Goater, Jr.(Director)

Co-investorsThe Column Group MRL Ventures Fund

Tranquis Therapeuticstranquis.com

Co-investorsVivo Capital

Vibrant Biomedicines

Windward Biowindwardbio.com in

Windward Bio is a clinical-stage biotechnology company developing long-acting monoclonal and bispecific antibodies for serious immunological conditions such as asthma, COPD, and dermatological diseases.

BiotechHealthtech

Co-investorsOrbiMed Quan Capital RA Capital Sanofi Ventures Janus Henderson Investors Novo Holdings +3 more

Xap Therapeutics

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 11

IPOs and acquisitions across the tracked portfolio

Addex TherapeuticsNASDAQ: ADXNVeradermicsNYSE: MANEZenas BiopharmaNASDAQ: ZBIOAlumisNASDAQ: ALMSAvalyn Pharma IncNASDAQ: AVLNDesign TherapeuticsNASDAQ: DSGNKALA BIONASDAQ: KALAMineralys TherapeuticsNASDAQ: MLYSNkarta, Inc.NASDAQ: NKTXOruka Therapeutics IncNASDAQ: ORKATrivascularacq. by Endologix

Portfolio news

latest coverage across their companies

INVESTOR ALERT: Pomerantz Law Firm Reminds Investors with Losses on their Investment in ARS Pharmaceuticals, Inc. of Class Action Lawsuit and Upcoming Deadlines - SPRY

Ars Pharma · prnewswire.com · Aug 20, 2026

Mineralys Builds $661 Million War Chest Ahead of FDA Decision - MyChesCo

Mineralys Therapeutics · mychesco.com · Aug 18, 2026

So, You Want to Join a Life Science Startup? A 2026 Resource Guide for Job Seekers | BioBuzz

Arcellx · biobuzz.io · Aug 14, 2026

KALA BIO Announces Brief Delay in Quarterly Filing - TipRanks.com

KALA BIO · tipranks.com · Aug 14, 2026

Alumis posts $235M loss, holds $502M in cash | ALMS Quarterly Report (10-Q)

Alumis · stocktitan.net · Aug 13, 2026

Fierce Biotech Fundraising Tracker '26: InduPro assembles $77M; Vaderis nets $152M series B

Draig Therapeutics · fiercebiotech.com · Aug 12, 2026

Irvine’s new JOST Bicycle and Pedestrian Bridge raises riders over the 5 Freeway

Bicycle · ocregister.com · Aug 11, 2026

Odyssey Therapeutics (ODTX) Looks Fully Valued As Earnings And Evotec Deal Refocus Attention

Odyssey Therapeutics · finance.yahoo.com · Aug 11, 2026

Fund performance · per public LP disclosures · 2

as of Jun 2025

Fund	Vintage	Committed	Net IRR	TVPI	DPI
SR One Capital Fund II-A, LPLPs: California Public Employees' Retirement System	2023	—	—	0.89x	0.04x
SR One Capital Opportunities Fund I, LPLPs: California Public Employees' Retirement System	2023	—	—	0.63x	0.00x

Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).

Frequently asked questions

How many investments has SR One Capital Management made?: SR One Capital Management has 48 tracked investments, including 4 dated in the last 24 months.
What stage does SR One Capital Management invest at?: SR One Capital Management invests at the Seed, Series A, Series B stages.
What sectors does SR One Capital Management focus on?: SR One Capital Management focuses on Biotech.
Where is SR One Capital Management located?: SR One Capital Management is headquartered in Redwood City, US.
Who does SR One Capital Management co-invest with?: SR One Capital Management most often shares deals with OrbiMed, New Enterprise Associates (NEA), Quan Capital, among 64 tracked co-investors.

Co-investors · 42

New Enterprise Associates (NEA)

New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.

Both backed · 9

Addex Therapeutics Nkarta, Inc.Zenas Biopharma Arcellx Avenzo CHARM Therapeutics Dermira Regulus Therapeutics Inc.CRISPR Therapeutics AG

$200K – $40M

OrbiMed

OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.

Both backed · 7

Alumis Ars Pharma Avenzo CHARM Therapeutics Kartosthera Odyssey Therapeutics Windward Bio

$1M – $75M

RA Capital

RA Capital is a multi-stage investment firm focused on healthcare, life sciences, and planetary health, investing across public and private markets and creating new companies through its Raven incubation platform.

Both backed · 4

Mineralys TherapeuticsDesign TherapeuticsArs Pharma Windward Bio

Sofinnova Partners

Sofinnova Partners is a life sciences venture capital firm investing across the value chain from seed to later stage, with a focus on healthcare and sustainability. It backs companies in biopharma, medtech, digital medicine, agriculture and industrial processes.

Both backed · 4

Addex Therapeutics HotSpot Therapeutics Mission TherapeuticsAsceneuron

$540K – $27M

Samsara BioCapital

Samsara BioCapital is an investment firm backing the development of transformative therapeutics for patients, bringing together scientists, physicians, drug developers, and business leaders to support next-generation therapeutic breakthroughs.

Both backed · 4

Alumis Mineralys Therapeutics Nkarta, Inc.Arcellx

Atlas Venture

Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.

Both backed · 3

KALA BIO HotSpot Therapeutics Navitor Pharmaceuticals

$500K – $1M

Pivotal Life Sciences

Pivotal Life Sciences is an investment platform focused on funding innovative companies developing therapeutic products and technologies aimed at major unmet medical needs.

Both backed · 3

Avalyn Pharma Inc Addition Therapeutics Windward Bio

Canaan Partners

Canaan Partners is a venture capital firm with over 30 years of history, backing companies across technology and healthcare sectors through close, hands-on partnerships with founders.

Both backed · 2

Dermira Draig Therapeutics

$500K – $20M

ARCH Venture Partners

ARCH Venture Partners is a venture capital firm that invests in and helps build transformational companies, with a strong focus on the life sciences and biotechnology sector.

Both backed · 2

Akamis Bio Rezo Therapeutics

$50K – $250M

Abingworth

Abingworth is a life science venture capital firm that backs early-stage biopharma and biotech companies, helping entrepreneurs translate scientific discoveries into new therapeutics.

Both backed · 2

Addition TherapeuticsCRISPR Therapeutics AG

$15M – $30M

Pfizer Venture Investments

Pfizer Venture Investments is a strategic venture fund that doesn't require product or technology rights as a condition of investing, giving founders independence while still aiming for future collaboration with Pfizer, and its team blends venture investing with business development and drug discovery expertise to back frontier scientific bets—such as neuroscience, in-vivo cell engineering, dark-genome target discovery, and the blockchain-based longevity accelerator VitaDAO—that many biotech investors avoid. The fund also runs an active China strategy through a locally based venture vehicle and direct investments like OTR Therapeutics, and it has become a channel for strategic deals, with portfolio companies acquired by AbbVie, Ipsen, and Gilead/Kite.

Both backed · 2

Mission Therapeutics Simcha Therapeutics

$5M – $20M

Sofinnova Ventures

Sofinnova is an investment firm focused on the life sciences and biotechnology sector, partnering with companies from inception through drug development, regulatory approval, company building, and IPO.

Both backed · 2

AvenzoElektrofi, Inc.

$100K – $15M

▶30 more co-investors

Aisling Capital Andreessen Horowitz B Capital Group Polaris Partners OUP (Osage University Partners)Versant Ventures 5AM Ventures The Column Group Third Rock Ventures Novartis Venture Fund Kurma Partners Roche Venture Fund RiverVest Venture Partners General Catalyst GV (Google Ventures)Kleiner Perkins Venrock Highbury Holdings EQT Life Sciences Johnson & Johnson Innovation – JJDC MPM BioImpact Stanford University Morgenthaler Advent Life Sciences Dolby Family Ventures Lightstone Ventures HBM Partners Lilly Asia Ventures 3B Future Health Fund Remiges Ventures, Inc.

Firms observed investing alongside SR One Capital Management, from public investor directories. Shared companies are the overlap with SR One Capital Management's recorded portfolio.

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