Fundraising Fox

SR One Capital Management

Venture capitalActively deploying

Redwood City · Seed–Series B · 32 people tracked

Also known as SR ONE CAPITAL MANAGEMENT, LP

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Investment thesis

SR One is a biotechnology venture capital firm that backs companies translating novel science into medicines. It uses a 'back-and-build' approach, focusing on companies with strong fundamentals, a clearly defined development pathway, and novel approaches to treating disease. With an investing team based in West Coast biotech hubs in the USA and in London, UK, the firm leverages its transatlantic footprint to act as a strategic partner, offering geographic reach and regional expertise to source opportunities and provide real-time business support to portfolio companies.

Invests inBiotechRedwood CityUnited KingdomUnited States

Source: firm website, verified Aug 3, 2026.

Stage
Seed–Series B
HQ
Redwood City, California, US
Instruments
Equity
Founded
1985
Last 12 months
3 investments
AUM
$2.4B
Tracked investments
62

Team · 32 people

from the firm's website & public directories
Deborah Harland· Partner
Peter Van Vlasselaer, PhD· Venture Partnerin
Rodger Novak· Venture Partnerin𝕏

What they invest in

from 24 of 62 portfolio companies

Biotech ×21Healthtech ×8Medical Devices ×4AI & Machine Learning ×2Digital Health ×2Deep Tech ×1

HQs:United States×23Denmark×1

Investments · 62 tracked

founders shown can be your intro path

By year:2026 · 12025 · 32024 · 22023 · 12022 · 22021 · 22020 · 32018 · 12016 · 22015 · 118 dated

Addex Therapeutics Ltd.NASDAQ: ADXNApr 2023SEC filingmedium confidence

Geneva

Board seatJake Nunn· per SEC Form D · $3.7M raise · filed Apr 2023

ARS PharmaceuticalsNASDAQ: SPRYSep 2021SEC filingmedium confidence

BiotechSan Diego, US

Jonathan Leff(Director)Richard Lowenthal(Executive Officer, Director)Pratik Shah(Director)

Board seatRajeev Dadoo· per SEC Form D · $55M raise · filed Sep 2021

Odyssey TherapeuticsNASDAQ: ODTXJun 2025

Creating next generation precision medicines for patients with cancer and inflammatory diseases by targeting key signaling nodes.

BiotechCambridge, US

Valerie Odegard(Director)Jill Carroll(Director)Carl Gordon(Director)Jeffrey Leiden(Director)Charles Baum(Director)Gary D Glick(Executive Officer, Director)

Board seatJill Carroll· per SEC Form D

Veradermicsveradermics.cominNYSE: MANEOct 2025

Veradermics is a dermatologist-founded, late clinical-stage biopharmaceutical company developing therapeutics for pattern hair loss in men and women.

BiotechHealthtechWest Hartford, US

John W. Childs(Director)Reid Waldman(Executive Officer, Director)Jane Grant-Kels(Director)Vladimir Coric(Director)Timothy Durso(Executive Officer, Director)

Board seatKatarina Pance· per SEC Form D

Zenas BioPharma, Inc.NASDAQ: ZBIOMay 2024SEC filingmedium confidence

Waltham, US

Board seatJake Nunn· per SEC Form D · $200.1M raise · filed May 2024

Alumisalumis.comin𝕏NASDAQ: ALMS

Alumis is a clinical-stage biopharmaceutical company developing a late-stage portfolio of targeted oral therapies for immune-mediated diseases such as plaque psoriasis.

AI & Machine LearningBiotechDigital Health

Avalyn PharmaNASDAQ: AVLN

A biotechnology company developing targeted therapies for rare respiratory diseases.

Bicycle TherapeuticsNASDAQ: BCYCMay 2024

Biotech company that reached IPO

BiotechCambridge

KEVIN LEE(Executive Officer, Director)FELIX J. BAKER(Director)RICHARD N. KENDER(Director)GREGORY WINTER(Director)STEPHEN SANDS(Director)NIGEL CROCKETT(Executive Officer)

Design TherapeuticsNASDAQ: DSGN
KALA BIOkalarx.comNASDAQ: KALA

BiotechArlington, US

Darius Kharabi(Executive Officer)Todd Bazemore(Executive Officer)Mark Iwicki(Executive Officer, Director)Mary Reumuth(Executive Officer)Kim Brazzell(Executive Officer)Charles McDermott(Executive Officer)

Mineralys Therapeuticsmineralystx.cominNASDAQ: MLYSJun 2022

BiotechRadnor, US

Brian Taylor Slingsby(Director)Olivier Litzka(Director)Derek DiRocco(Director)Adam Levy(Executive Officer)Jon Congleton(Executive Officer, Director)Srinivas Akkaraju(Director)

Nkarta, Inc.NASDAQ: NKTX

Developing allogeneic or off-the-shelf cell therapies for cancer and auto-immune disease based on Natural Killer cells.

South San Francisco, US

Oruka Therapeutics IncNASDAQ: ORKA
Zenas Biopharmazenasbio.cominNASDAQ: ZBIO

BiotechWaltham, US

JOSEPH FARMER(Executive Officer)PATRICK GERALD ENRIGHT(Director)HONGBO LU(Director)TOMAS KISELAK(Director)LEON O. MOULDER, JR.(Director)JOHN JACOB ORLOFF(Director)

Addition Therapeutics, Inc.Dec 2025SEC filinghigh confidence

South San Francisco, US

Board seatLaetitia SchwabMatthew R. Patterson· per SEC Form D · $28M raise · filed Dec 2025

Bird Rock BioDec 2016SEC filingmedium confidence

La Jolla, US

Peppi Presit(Director)Richa Nand(Executive Officer)Bradley Bolzon(Director)Ray Stevens(Director)Simon Nebel(Director)Simeon George(Director)

Board seatSimeon J. George· per SEC Form D · $2.5M raise · filed Jan 2017

CRISPR Therapeutics AGOct 2016SEC filingmedium confidence

BiotechBasel

Kurt von Emster(Director)Sven Ante Lundberg(Executive Officer)Thomas Woiwode(Director)Ali Behbahani(Director)Rodger Novak(Executive Officer, Director)Pablo Cagnoni(Director)

Board seatSimeon J. George· per SEC Form D · $35M raise · filed Nov 2016

Dermiradermira.comDec 2018SEC filingmedium confidence

HealthtechMenlo Park, US

LUIS PENA(Executive Officer)CHRISTOPHER GRIFFITH(Executive Officer)KATHLEEN SEBELIUS(Director)DAVID E. COHEN(Director)FRED CRAVES(Director)THOMAS G. WIGGANS(Executive Officer, Director)

Board seatJake Nunn· per SEC Form D · $1M raise · filed Dec 2018

Dren Biodrenbio.comMar 2022SEC filingmedium confidence

Dren Bio is a clinical-stage biopharmaceutical company developing novel antibody therapeutics designed to selectively eliminate pathogenic cells and disease-causing agents, with a pipeline targeting oncology, autoimmune diseases, immunology, and neurology.

BiotechHealthtechMedical DevicesFoster City, US

Nenad Tomasevic(Executive Officer, Director)Ivan Trifunovich(Director)John Wesley(Director)

Board seatRajeev Dadoo· per SEC Form D · $80M raise · filed Mar 2022

Entasis Therapeutics HoldingsAug 2020SEC filingmedium confidence

BiotechWaltham, US

Michael Gutch(Executive Officer)John Mueller(Executive Officer)Heather Behanna(Director)David Altarac(Executive Officer)David Meek(Director)David Hastings(Director)

Board seatHeather Behanna· per SEC Form D · $25M raise · filed Sep 2020

Navitor Pharmaceuticalsnavitorpharma.comApr 2020SEC filingmedium confidence

BiotechCambridge, US

Jean-Francois Formela(Director)Rick Lundberg(Executive Officer)Alan Crane(Director)David Madden(Director)Marian Nakada(Director)Brian Gallagher(Director)

Board seatRajeev Dadoo· per SEC Form D · $20.2M raise · filed May 2020

Palleon PharmaceuticalsSep 2020

BiotechWaltham, US

John Hennessy(Executive Officer)Jens Eckstein(Director)Karen Hong(Director)James W. Broderick(Executive Officer, Director)James Lee(Director)William Burkoth(Director)

Board seatRajeev Dadoo· per SEC Form D

Regulus Therapeutics Inc.Dec 2021SEC filingmedium confidence

San Diego, US

Board seatJake Nunn· per SEC Form D · $34.6M raise · filed Dec 2021

Trivasculartrivascular.comin𝕏Aug 2015SEC filingmedium confidence

Endologix develops medical devices for treating vascular disease, including the DETOUR™ System for endovascular aortic repair (EVAR) procedures.

HealthtechMedical DevicesSanta Rosa, US

DOUGLAS A. ROEDER(Director)SHARI L. O'QUINN(Executive Officer)MICHAEL V. CHOBOTOV(Executive Officer)MICHAEL R. KRAMER(Executive Officer)RYAN D. DRANT(Director)DANIEL J. MOORE(Director)

Board seatJake Nunn· per SEC Form D · $10M raise · filed Aug 2015

ADARx Pharmaceuticals
Addition Therapeutics
Airnexis Therapeutics IncJan 2026

BiotechPalo Alto, US

Anna Chen(Director)Colin Walsh(Director)Evan Caplan(Director)James Li(Executive Officer, Director)Maria Fardis(Executive Officer, Director)

BoardJill Carroll(Director)

Akamis Bioakamisbio.comin𝕏

Akamis Bio develops oncolytic immunotherapies for colorectal cancer treatment, aiming to offer alternatives to surgery that preserve patient function and quality of life.

BiotechDigital HealthHealthtechMedical Devices

Ancora Biotech
Antag Therapeuticsantagtherapeutics.comin

Antag Therapeutics develops GIP receptor antagonist therapies for obesity, diabetes, and overweight patients.

BiotechHealthtechCopenhagen, DK

Jens Juul Holst(Founder)Mette Rosenkilde(Founder)

Arcellxarcellx.com

Arcellx develops CAR T-cell therapies that are individually designed for each patient, using the immune system to target and attack cancer.

BiotechHealthtechGaithersburg, US

Han Lee(Executive Officer)Lewis T. Rusty Williams(Director)Jill Carroll(Director)David Lubner(Director)Ali Behbahani(Director)Rami Elghandour(Executive Officer, Director)

Ars Pharmaars-pharma.comin𝕏
Asceneuronasceneuron.comin𝕏
Avenzo Therapeutics
Biotheryxbiotheryx.comin

Biotheryx discovers and develops targeted protein degrader drugs designed to treat cancer and inflammatory diseases.

BiotechMedical DevicesSan Diego, US

Kyle Chan, PhD(Executive Officer)David Stirling, PhD(Executive Officer, Director)Louis DeGennaro, PhD(Director)Lawrence Zaslow(Executive Officer, Director)Frank Mercurio, PhD(Executive Officer)

CHARM Therapeutics Inc.

HealthtechLondon

Gary Glick(Director)Rishi Gupta(Director)Nihal Sinha(Director)Lakshyaditya Singh Aithani(Executive Officer, Director)Muzammil Mansuri(Director)

Codify Therapeutics
Corxel Pharmaceuticals Limited
CRISPR Therapeutics
Crystalys Therapeutics, Inc.
Draig Therapeutics, Ltd
Econic Biosciences
Elektrofi, Inc.

Boston, US

Fore Biotherapeutics

Provides functional information about mutations and drug responses to enable precision oncology treatments.

HotSpot Therapeutics

Allosteric drug discovery unlocking on/off switches in proteins.

Immutrin Limited
Kartos Therapeutics
Mission Therapeutics
Nimbus
Nomicnomic.aiin𝕏
Poplar Therapeutics
Pulmocidepulmocide.comin
Renalys
Rezo Therapeuticsrezotx.com

Rezo Therapeutics is a drug discovery and development company focused on oncology and inflammation therapeutic areas.

AI & Machine LearningBiotechDeep TechSan Francisco, US

Nevan Krogan(Co-Founder)Sourav Bandyopadhyay(Co-Founder)Norbert Bischofberger(Co-Founder)Natalia Jura(Co-Founder)George Scangos(Co-Founder)Kevan Shokat(Co-Founder)

River Renal

Clinical-stage company developing novel therapies for orphan renal diseases.

Simcha Therapeuticssimchatx.comin

A drug discovery company advancing novel medicines targeting unexplored areas of immune biology, with a focus on cancer treatments.

Biotech

Yiming Li(Director)Axel Hoos(Director)Terry Rosen(Director)Aaron Ring(Executive Officer, Director)Jake Bauer(Executive Officer, Director)Beatrice McQueen(Executive Officer)

Telios Pharma
Topo Therapeutics, Inc.

BiotechCambridge, US

Hui Tian(Executive Officer, Director)Madgalene Moran(Executive Officer, Director)

BoardKarin Kleinhans(Director)Bruce Bean(Director)James Jeffrey Goater, Jr.(Director)

Vibrant Biomedicines

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 14

IPOs and acquisitions across the tracked portfolio

Addex Therapeutics Ltd.NASDAQ: ADXNARS PharmaceuticalsNASDAQ: SPRYOdyssey TherapeuticsNASDAQ: ODTXVeradermicsNYSE: MANEZenas BioPharma, Inc.NASDAQ: ZBIOAlumisNASDAQ: ALMSAvalyn PharmaNASDAQ: AVLNBicycle TherapeuticsNASDAQ: BCYCDesign TherapeuticsNASDAQ: DSGNKALA BIONASDAQ: KALAMineralys TherapeuticsNASDAQ: MLYSNkarta, Inc.NASDAQ: NKTXOruka Therapeutics IncNASDAQ: ORKAZenas BiopharmaNASDAQ: ZBIO

Portfolio news

latest coverage across their companies

Fund performance · per public LP disclosures · 2

as of Jun 2025
FundVintageCommittedNet IRRTVPIDPI
SR One Capital Fund II-A, LPLPs: California Public Employees' Retirement System20230.89x0.04x
SR One Capital Opportunities Fund I, LPLPs: California Public Employees' Retirement System20230.63x0.00x

Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).

Frequently asked questions

What stage does SR One Capital Management invest at?
SR One Capital Management invests at the Seed, Series A, Series B stages.
What sectors does SR One Capital Management focus on?
SR One Capital Management focuses on Biotech.
Where is SR One Capital Management located?
SR One Capital Management is headquartered in Redwood City, US.

Co-investors · 42

RA Capital

RA Capital invests in public and private healthcare and life science companies developing pharmaceuticals, medical devices, and diagnostic tools. The firm operates as a crossover fund across multiple investment stages.

Both backed · 4
ARS PharmaceuticalsMineralys TherapeuticsDesign TherapeuticsWindward Bio
New Enterprise Associates (NEA)

New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.

Both backed · 3
Nkarta, Inc.ArcellxCRISPR Therapeutics AG
$200K – $40M
OrbiMed

OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.

Both backed · 3
AlumisArs PharmaWindward Bio
$1M – $75M
Sofinnova Partners

Sofinnova Partners is a life sciences venture capital firm investing across the value chain from seed to later stage, with a focus on healthcare and sustainability. It backs companies in biopharma, medtech, digital medicine, agriculture and industrial processes.

Both backed · 3
AsceneuronHotSpot TherapeuticsMission Therapeutics
$540K – $27M
Samsara BioCapital

Samsara BioCapital is an investment firm backing the development of transformative therapeutics for patients, bringing together scientists, physicians, drug developers, and business leaders to support next-generation therapeutic breakthroughs.

Both backed · 3
Atlas Venture

Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.

$500K – $1M
ARCH Venture Partners

ARCH Venture Partners is a venture capital firm that backs and helps build transformational companies, with a strong focus on the life sciences and biotech sector.

$50K – $250M
Aisling Capital

Aisling Capital is an investment firm focused on companies developing and commercializing innovative healthcare products, services, and technologies.

Both backed · 2
Andreessen Horowitz

Andreessen Horowitz's Strategic Partnerships page describes collaborations that connect its portfolio companies with established institutions to help scale and deploy their technology.

Both backed · 1
$500K – $50M
Canaan Partners

Canaan is an early-stage venture capital firm backing founders with transformative ideas across technology and healthcare.

Both backed · 1
$500K – $20M
Polaris Partners

Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.

$500K – $5M
OUP (Osage University Partners)

OUP (Osage University Partners) is a venture capital firm that backs science-driven startups commercializing deep technology innovations emerging from university and breakthrough research.

Both backed · 1
$1M – $20M
30 more co-investors

Versant Ventures5AM VenturesThird Rock VenturesAbingworthPfizer Venture InvestmentsKurma PartnersSofinnova VenturesRiverVest Venture PartnersGeneral CatalystGV (Google Ventures)Kleiner PerkinsB Capital GroupVenrockHighbury HoldingsEQT Life SciencesJohnson & Johnson Innovation – JJDCThe Column GroupPivotal bioVenture PartnersStanford UniversityMorgenthalerNovartis Venture FundMPM CapitalAdvent Life SciencesDolby Family VenturesRoche Venture FundLightstone VenturesHBM PartnersLilly Asia Ventures3B Future Health FundRemiges Ventures, Inc.

Firms observed investing alongside SR One Capital Management, from public investor directories. Shared companies are the overlap with SR One Capital Management's recorded portfolio.

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