How well does SR One Capital Management fit your startup? Fox weighs their thesis, check size, portfolio pattern and your traction to tell you exactly how to position the conversation.
SR One is a biotechnology venture capital firm that backs companies translating novel science into medicines. It uses a 'back-and-build' approach, focusing on companies with strong fundamentals, a clearly defined development pathway, and novel approaches to treating disease. With an investing team based in West Coast biotech hubs in the USA and in London, UK, the firm leverages its transatlantic footprint to act as a strategic partner, offering geographic reach and regional expertise to source opportunities and provide real-time business support to portfolio companies.
Invests inBiotechRedwood CityUnited KingdomUnited States
Rajeev Dadoo is COO and Managing Partner of SR One, which he joined in 2004, and is an alum of the Kauffman Fellows Program. He invests in therapeutics and healthcare-technology companies, drawing on prior roles in GSK's Competitive Excellence group, technology and clinical development at Genentech, and product and business development positions at Bio-Rad Laboratories and Genome Therapeutics; he also co-founded Unimicro Technologies. He holds a BA in Chemistry and Mathematics from Knox College, a PhD in Chemistry from Stanford University, and an MBA from the Wharton School.
Amit Shah is a Principal in SR One's London office, focusing on venture capital investments in biotech. Before joining SR One in early 2018, he held roles at GlaxoSmithKline spanning late-phase clinical development, global medical affairs, and early pipeline commercial strategy, and he is a board-certified-equivalent plastic surgeon specializing in microsurgical cancer reconstruction. He holds a B.A. in Medical Sciences, an M.A. in Neuroscience, and an M.D. from the University of Cambridge, and since 2020 has served on the venture capital panel for the BioInnovation Institute.
Jill Carroll is an Operating Partner at SR One, based on the US east coast, having first joined the firm in 2011. She holds a BS in Chemistry from Duke University and an MS in Biochemistry from Johns Hopkins University. Before SR One, she worked in strategy consulting and in biotech corporate development at Dynavax Technologies.
Katarina Pance is a Principal at SR One, based in the San Francisco Bay Area, having joined the firm in 2023. She previously co-founded EpiBiologics, where she served as head of discovery biology, building on her graduate research on bispecific antibodies for extracellular protein degradation. She earned a BA in Biochemistry from the University of Pennsylvania and a PhD in Chemistry and Chemical Biology from UCSF, where she studied with Dr. Jim Wells, and was earlier a venture fellow at MPM Capital.
Laetitia Schwab is a Principal at SR One in the London office, joining in 2022. She previously worked in clinical development at Orchard Therapeutics, contributing to the delivery of the gene therapy Libmeldy for Marketing Authorisation, and has experience across early and late-phase clinical programs with expertise in gene therapy, neuroscience, and rare diseases. She holds a B.Sc in Medical Sciences from the University of Edinburgh, an MPhil in Translational Medicine and a Ph.D in Clinical Neuroscience from the University of Cambridge, and an MBA from INSEAD.
Heather Behanna is a Venture Partner at Forge Life Science Partners with a background in chemistry, equity research, and venture capital investing in the biotech sector.
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Vikas Goyal· Principal· Cambridge, Massachusetts, United Statesin
Vikas Goyal is a Partner focused on Growth Investments at Longwood Fund. He previously worked as an investor at Pandion before joining the company's team in a business development capacity, where he worked on autoimmune disease therapeutics.
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Amit Mehta· Venture Partner· San Francisco Bay Area
Amit Mehta is a Venture Partner at SR One, which he joined in 2024, and also serves as COO and CBO at Dren Bio, an SR One portfolio company. He previously spent 18 years at Genentech, most recently as Vice President and Head of Business Development, where he held roles across technical development, CMC, product strategy, and business development. He holds a B.E. in Chemical Engineering from Bangalore University and a Ph.D. in Chemical Engineering from Pennsylvania State University.
Chris Chai· Venture Partner· San Francisco Bay Areain
Chris Chai is an Operating Partner at SR One who advises portfolio companies on financing strategy and their engagement with Wall Street. He has more than 20 years of experience in biotech executive management and investment banking, having served as CFO at Principia Biopharma and MAP Pharmaceuticals and in treasury and investor relations at CV Therapeutics, and previously worked in investment banking at JP Morgan. He holds a BS in Operations Research and Industrial Engineering from Cornell University.
Jake Bauer· Venture Partner· San Francisco Bay Areain
Jake Bauer is a Venture Partner at SR One who works with emerging clinical biotechnology companies. He previously served as Chief Business Officer of MyoKardia, which was acquired by Bristol Myers Squibb in 2020, and held earlier roles at Ablexis, Third Rock Ventures, Royalty Pharma, Endo Pharmaceuticals, and Putnam Associates. He holds a BS in Biology and BA in Economics from Duke University and an MBA from Harvard Business School.
Jake Nunn· Venture Partner· Menlo Park, Californiain
Jake Nunn is a Partner at SR One focused on later-stage private and public biotech investments, with over 25 years in the life sciences industry as an investor, board director, research analyst and investment banker. He previously spent 2006 to 2019 at New Enterprise Associates, where he established the firm's public healthcare investing practice, and earlier worked at MPM Capital, Franklin Templeton Investments and Alex. Brown & Sons. He holds an MBA from Stanford Graduate School of Business, a BA in Economics from Dartmouth College, and the CFA designation.
Matthew R. Patterson is a Venture Partner at SR One Capital Management with over 30 years in the research, development, and commercialization of therapeutics. He co-founded Audentes Therapeutics in 2012 and served as its CEO until its 2020 acquisition by Astellas Pharma, and previously worked at Genzyme, BioMarin Pharmaceutical, Amicus Therapeutics, and Iris Medicine, as well as serving as an Entrepreneur-In-Residence at OrbiMed. He holds a Bachelor's degree in Biochemistry from Bowdoin College.
Alicia Hasson· Executive Administrative Support· San Francisco Bay Area
Alicia Hasson joined SR One in 2024 and works in the San Francisco Bay Area office, providing executive administrative support to Rajeev Dadoo, Jill Carroll, and Jake Nunn. She has 15 years of administrative experience in the biotech industry across large and small pharmaceutical companies. She studied Business Administration at City College of San Francisco (CCSF).
Ann Ng is the Finance Director at SR One, based in the firm's London office, where she manages accounting, financial statements, and fund reporting while supporting the CFO on operations. She previously spent ten years at CITIC Capital Partners Limited in private equity fund management and operations. She holds a BA in Accounting & Finance from Curtin University of Technology and is a CPA (Australia).
Briana Wilson· Senior Administrative Assistant· San Francisco Bay Area
Briana Wilson joined SR One in 2023 and provides administrative support to team members as well as assisting with event planning. She previously worked at Huntsman Gay Global Capital, where she handled administrative support, reception, and vendor relations. She holds a Bachelor of Science in Kinesiology from San Jose State University.
Catalina Kazi· Legal and Compliance Counsel· San Francisco Bay Area
Catalina Kazi is Legal and Compliance Counsel at SR One, which she joined in 2024. She previously worked for over five years as in-house counsel handling regulatory compliance at retail and institutional investment managers, and served as an attorney in the Securities Division of the Secretary of the Commonwealth of Massachusetts. She holds a B.A. in International Relations from Florida International University and a J.D. from Boston University School of Law, and is licensed to practice law in New York and Registered In-House Counsel in California.</bio_summary>
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Frances Benson is Chief of Staff at SR One, which she joined in 2020, where she oversees operations, events, marketing, and PR among the firm's business functions. She previously worked at Sofinnova Investments, providing administrative support and handling reception and vendor relations. She studied Interior Architecture and Design at the Academy of Art University in San Francisco.
Iqbal Mufti is an Operating Partner at SR One Capital Management, based in London, where he focuses on company creation, later-stage investments, and helping portfolio companies with industry engagement and partnering strategy. He previously worked as a pharmaceutical executive at Hoffmann-La Roche, where he co-led the rare blood disorders portfolio strategy team and served as global Lifecycle Leader for Hemlibra (emicizumab). He holds a BSc in Biotechnology from University College London and an MBA from Duke University's Fuqua School of Business.
James Macadam is Chief Financial Officer at SR One, based in the firm's London office, where he oversees financial matters and helps manage a range of the firm's operations. He joined SR One in 2019 after holding corporate finance and commercial roles at GlaxoSmithKline. He holds an MA in Geography from Oxford University, an MPhil in Polar Studies from Cambridge University, and an MBA from HEC Paris.</bio_summary>
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Lyla Youssef is an Associate at SR One, based in the San Francisco Bay Area, where she joined in 2024 with a background in biotechnology and therapeutics equities. She previously worked as an Associate Analyst covering therapeutics at Hudson Bay Capital, in biotech equity research as a Vice President at TD Cowen, and in equity research at Oppenheimer & Co., along with roles at Columbia University's Translational Therapeutics Accelerator and Columbia Tech Ventures. She holds a Ph.D. in Microbiology & Immunology from Columbia University and a B.A. in Biological Sciences and Economics from Cornell University.
Mahesh Kudari is a Senior Associate at SR One's London office, which he joined in 2024. He previously served as VP Business Operations at Xap Therapeutics and Head of Clinical Development at Orchard Therapeutics, where he led cross-functional gene therapy development programs, and earlier held early clinical development and medical affairs roles at GSK. He holds a medical degree from University College London and an M.A. in Medical Sciences from the University of Cambridge, and has a background in diagnostic and interventional radiology.
Mary Mirt· Administrative Assistant· San Francisco Bay Areain
Mary Mirt joined SR One in 2025, where she provides administrative and office management support to team members. She previously held office management roles at Peakspan Capital and Pacific Lake Partners, handling vendor management and reception. She holds a Bachelor of Arts in Communication & Media Studies from CSU East Bay.
Philip Habib· Leads Capital Partnering at SR One· Londonin
Philip Habib leads SR One's Capital Partnering effort and is based in London, with over 15 years of experience across venture capital, private equity, and real estate. He began his career in the Private Equity & Venture Capital group at Cambridge Associates advising institutional investors, and later worked at General Electric in Business Development (M&A) and Sponsor Leveraged Finance, covering sectors including healthcare. He holds an MBA from London Business School and an MA in Economics from the University of Edinburgh.
Sasha Keough· General Counsel and Chief Compliance Officer· East Coast (US)in
Sasha Keough serves as General Counsel and Chief Compliance Officer at SR One, which she joined in 2022. She previously spent more than 12 years as an in-house attorney at New Enterprise Associates, where she worked on compliance, venture capital financings, and fund operations. She holds a B.A. in History from the University of Virginia and a J.D. from the University of Baltimore School of Law.
Tanya McGlashan· Manager, UK Operations· Greater London, England, United Kingdomin
Tanya McGlashan joined SR One in October 2020, where she oversees risk, financial, and operational functions. Previously she worked at an investment bank managing data analytics projects and business support, and earlier held roles in accounts, compliance, and operations at a private equity and HNWI family office. She holds a BA in English and Spanish from N. Novgorod Linguistic University, a Diploma in Professional Accounting (AAT), and ACCA certificates in management accounts, performance management, taxation, and corporate/business law.
Viraj Pillai is the Finance Director at SR One, based in the London office, where he oversees the fund's accounting, financial statements, and reporting, and works with external stakeholders and suppliers. He has over ten years of post-qualification experience, including five years with fund administrators and earlier work as an auditor at PwC (Sri Lanka/Botswana) and Deloitte UK. He holds a chartered accountancy qualification from the Institute of Chartered Accountants of Sri Lanka and is an associate member of the Institute of Certified Management Accountants.
Sharif Vakili is co-founder and CEO of UpDoc, a healthcare AI company developing Remote Patient Intervention models for supervised AI care delivery. He is a primary care physician on faculty at Stanford and teaches at the Graduate School of Business. Vakili has background experience in venture capital and clinical research.
Alumis is a clinical-stage biopharmaceutical company developing a late-stage portfolio of targeted oral therapies for immune-mediated diseases such as plaque psoriasis.
AI & Machine LearningBiotechDigital Health
AV
Avalyn PharmaNASDAQ: AVLN
A biotechnology company developing targeted therapies for rare respiratory diseases.
BI
Bicycle TherapeuticsNASDAQ: BCYCMay 2024
Biotech company that reached IPO
BiotechCambridge
KEVIN LEE(Executive Officer, Director)FELIX J. BAKER(Director)RICHARD N. KENDER(Director)GREGORY WINTER(Director)STEPHEN SANDS(Director)NIGEL CROCKETT(Executive Officer)
JOSEPH FARMER(Executive Officer)PATRICK GERALD ENRIGHT(Director)HONGBO LU(Director)TOMAS KISELAK(Director)LEON O. MOULDER, JR.(Director)JOHN JACOB ORLOFF(Director)
Kurt von Emster(Director)Sven Ante Lundberg(Executive Officer)Thomas Woiwode(Director)Ali Behbahani(Director)Rodger Novak(Executive Officer, Director)Pablo Cagnoni(Director)
Board seatSimeon J. George· per SEC Form D · $35M raise · filed Nov 2016
LUIS PENA(Executive Officer)CHRISTOPHER GRIFFITH(Executive Officer)KATHLEEN SEBELIUS(Director)DAVID E. COHEN(Director)FRED CRAVES(Director)THOMAS G. WIGGANS(Executive Officer, Director)
Board seatJake Nunn· per SEC Form D · $1M raise · filed Dec 2018
Dren Bio is a clinical-stage biopharmaceutical company developing novel antibody therapeutics designed to selectively eliminate pathogenic cells and disease-causing agents, with a pipeline targeting oncology, autoimmune diseases, immunology, and neurology.
Endologix develops medical devices for treating vascular disease, including the DETOUR™ System for endovascular aortic repair (EVAR) procedures.
HealthtechMedical DevicesSanta Rosa, US
DOUGLAS A. ROEDER(Director)SHARI L. O'QUINN(Executive Officer)MICHAEL V. CHOBOTOV(Executive Officer)MICHAEL R. KRAMER(Executive Officer)RYAN D. DRANT(Director)DANIEL J. MOORE(Director)
Board seatJake Nunn· per SEC Form D · $10M raise · filed Aug 2015
Akamis Bio develops oncolytic immunotherapies for colorectal cancer treatment, aiming to offer alternatives to surgery that preserve patient function and quality of life.
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 14
IPOs and acquisitions across the tracked portfolio
SR One Capital Fund II-A, LPLPs: California Public Employees' Retirement System
2023
—
—
0.89x
0.04x
SR One Capital Opportunities Fund I, LPLPs: California Public Employees' Retirement System
2023
—
—
0.63x
0.00x
Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).
Frequently asked questions
What stage does SR One Capital Management invest at?
SR One Capital Management invests at the Seed, Series A, Series B stages.
What sectors does SR One Capital Management focus on?
SR One Capital Management focuses on Biotech.
Where is SR One Capital Management located?
SR One Capital Management is headquartered in Redwood City, US.
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Firms observed investing alongside SR One Capital Management, from public investor directories. Shared companies are the overlap with SR One Capital Management's recorded portfolio.