Fundraising Fox

OrbiMed

Venture capitaloperating company · company profile

New York · Pre-Seed–Late Stage · 117 people tracked

Also known as ORBIMED ADVISORS LLC

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Investment thesis

OrbiMed invests globally across the healthcare industry, backing companies from early-stage private ventures to large multinational corporations. Its focus spans biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services, with the aim of supporting innovations that help people live healthier, longer, and more productive lives. The firm brings tailored financing solutions alongside global team resources drawn from scientific, medical, and investment professionals to help build world-class healthcare companies.

Source: firm website, verified Aug 25, 2026.

Stage
Pre-Seed–Late Stage
Check
$1M – $75M
HQ
New York, NY, US
Leads rounds
Leads
Instruments
Equity · Debt
Founded
1999
Last 12 months
13 investments
AUM
$20.6B
Tracked investments
284

Team · 117 people

from the firm's website & public directories
Evan Caplan· Partnerin

Partner at OrbiMed holding an M.D.

Sunny Sharma· Partnerin

Partner at OrbiMed holding an M.D.

Topher Orr· Partnerin
Iris Wang· Partnerin
William Sawyer· Partnerin
Dimitri Krainc· Venture Partnerin
Robert Glassman· Venture Partner
Ji Wangin
Madeline Huberin
Mark R. Jelley· Partnerin
Michael Eggenberg· Partnerin
Roy Amariglio, Ph.D.in
Alexandria Huynh· Analystin
Anat Nursella· Venture Partnerin
Brendan Weber· Principalin
Charles Steinman· Analystin
Lars Enstrom· Managing Directorin
Natasha Shervani· Senior Associatein
Nate Yee· Vice Presidentin
William Price· Managing Directorin

7 people who came through OrbiMed went on to found or lead other companies.

What they invest in

from 239 of 284 portfolio companies

Biotech ×184Healthtech ×143Medical Devices ×72Digital Health ×31AI & Machine Learning ×29Deep Tech ×21Hardware ×12Consumer ×8

HQs:United States×130China×10India×7Switzerland×2United Kingdom×2Australia×1

Who they back

founder profiles across 58 portfolio companies
59%
solo founders
34 of 58 mapped founding teams
26%
repeat founders
of 23 founders with career history
~4 yrs
old at investment
median across 19 dated deals

Founding team size:solo founder×342 founders×173 founders×44+ founders×3

Where their founders studiedfrom 17 founders with education data

IE Business School ×2Tel Aviv University ×2

Where their founders worked beforefrom 23 founders with career history

Aisling Capital ×2Amgen ×2Stanford University ×2

Accelerator rootsportfolio companies that came through a program

Y Combinator ×2

13 founders hold a PhD · 4 hold an MBA (of 22 with degree data)

Investments · 284 tracked

founders shown can be your intro path

By year:2026 · 52025 · 192024 · 62023 · 42022 · 22021 · 92020 · 52019 · 72018 · 42017 · 22016 · 82015 · 982 dated

Q32 Bioq32bio.comin𝕏NASDAQ: QTTB✓ verified

Q32 Bio is a biotechnology company developing therapies for autoimmune and inflammatory diseases, with a scientific focus on the complement system and immune regulation in conditions such as inflammation, autoimmunity and fibrosis.

BiotechHealthtech

Shelia Violette(Founder & Chief Scientific Officer)Michael Holers(Co-founder)Jodie Morrison(Chief Executive Officer)Lee Kalowski(President & Chief Financial Officer)Maria Marzilli(Chief Business Officer)David Appugliese(Senior Vice President, Head of People)

Co-investorsAtlas VentureCU Healthcare Innovation FundOUP (Osage University Partners)Sanofi VenturesAgent Capital

Scribe Therapeuticsscribetx.comin𝕏NASDAQ: SCTXMar 2021✓ verified

Scribe is a molecular engineering company developing CRISPR-based genetic therapies to treat cardiometabolic disease and other conditions.

BiotechDeep TechHealthtechMedical DevicesBerkeley, US

Benjamin Oakes(Founder & CEO)Jennifer A. Doudna, PhD(Co-founder, Scientific Advisor)Benjamin L. Oakes, PhD(Co-founder, President and CEO)David F. Savage, PhD(Co-founder, Scientific Advisor)Brett Staahl, PhD(Co-founder, VP of External Innovation)

BoardVijay Pande(Director)in

Co-investorsAndreessen HorowitzAvoro Capital AdvisorsMenlo VenturesRA CapitalAvoro Ventures

Aadi Bioscienceaadibio.cominNASDAQ: WHWKMar 2017SEC filingmedium confidence

Aadi Bioscience develops therapies targeting mTOR-driven diseases using precision medicine and albumin-bound nanoparticle technology, applying genomic profiling to identify patients most likely to benefit from mTOR inhibition.

BiotechHealthtechMorristown, US

Scott Giacobello(Executive Officer)Bryan Ball(Executive Officer)Dave Lennon(Executive Officer, Director)David Dornan(Executive Officer)James Murphy(Executive Officer)Stephen Pakola(Executive Officer)

Board seatChau Khuong· per SEC Form D · $41.8M raise · filed Mar 2017

Co-investors3B Future Health FundAlly Bridge GroupDecheng CapitalVivo CapitalAvoro Ventures

Adicet Bioadicetbio.comNASDAQ: ACETAug 2015

Adicet Bio develops allogeneic gamma delta CAR T cell therapies for patients with autoimmune diseases and cancer.

BiotechHealthtechMenlo Park, US

Aya Jakobovits(Executive Officer, Director)Nathan Hubbard(Executive Officer)

BoardFlorent Gros(Director)Erez Chimovits(Director)in

Board seatJonathan SilversteinCarl Gordon· per SEC Form D

Co-investorsForesite CapitalPontifax Venture CapitalQuan CapitalaMoonNovartis Venture Fund

Arvinas Holding Co. LLCarvinas.comin𝕏NASDAQ: ARVNOct 2015SEC filingmedium confidence

Arvinas is a biopharmaceutical company developing PROTAC protein degrader therapies, with a pipeline focused on oncology and neurology.

BiotechHealthtechNew Haven, US

Sean Cassidy(Executive Officer)Manuel Litchman(Executive Officer, Director)

BoardLiam Ratcliffe(Director)Tim Shannon(Director)inKush Parmar(Director)

Board seatStephen Squinto· per SEC Form D · $55M raise · filed Apr 2018

Co-investors5AM VenturesAccess BiotechnologyCanaan PartnersConnecticut InnovationsNextech InvestRA Capital+1 more

CalcimedicainNASDAQ: CALCJul 2019SEC filingmedium confidence

BiotechLa Jolla, US

Eric W. Roberts(Executive Officer, Director)Kenneth A. Stauderman(Executive Officer)Daniel Geffken(Executive Officer)A. Rachel Leheny(Executive Officer, Director)Sudarshan Hebbar(Executive Officer)Michael J. Dunn(Executive Officer)

Board seatChau Khuong· per SEC Form D · $80M raise · filed Aug 2019

Co-investorsSanderling VenturesClarus

Compass Therapeuticscompasstherapeutics.comin𝕏NASDAQ: CMPXJun 2020

Compass Therapeutics develops antibody-based therapies targeting the tumor microenvironment to treat cancer.

BiotechHealthtechCambridge, US

Schuetz Thomas(Executive Officer, Director)Errik Anderson(Executive Officer, Director)Steve Tregay(Director)

Board seatStephen SquintoCarl Gordon· per SEC Form D

Co-investorsBioBritF-Prime CapitalForesite CapitalvenBio PartnersVivo Capital

ImaraNASDAQ: ELVNMar 2019

BiotechCambridge, US

James G. McArthur(Executive Officer, Director)Christoph M. Adams(Executive Officer, Director)

BoardSara Nayeem(Director)Barbara Dalton(Director)David Mott(Director)Robert Hopfner(Director)

Board seatDavid Bonita· per SEC Form D

Co-investorsBay City CapitalNew Enterprise Associates (NEA)RA CapitalArix Bioscience

Keros TherapeuticsNASDAQ: KROSMar 2020SEC filingmedium confidence

BiotechLexington, US

Jasbir S. Seehra(Executive Officer, Director)

BoardJulius Knowles(Director)Alon Lazarus(Director)inOhad Hammer(Director)Ran Nussbaum(Director)

Board seatCarl Gordon· per SEC Form D · $56M raise · filed Mar 2020

Co-investorsArkin CapitalForesite Capital

Mirna TherapeuticsOTC: SYBXJun 2019SEC filingmedium confidence

BiotechAustin, US

Matthew Winkler(Director)Sinil Kim(Executive Officer)Paul Lammers(Executive Officer, Director)Jon Irvin(Executive Officer)Casi DeYoung(Executive Officer)

BoardMichael Powell(Director)

Board seatChau Khuong· per SEC Form D · $80M raise · filed Jun 2019

Co-investorsPfizer Venture Investments

NextCurenextcure.comNASDAQ: NXTCDec 2015SEC filingmedium confidence

Nextcure is a clinical-stage biopharmaceutical company developing immunotherapies targeting IO pathways, with a focus on oncology applications.

BiotechBeltsville, US

Michael Richman(Executive Officer, Director)Timothy Mayer(Executive Officer)Udayan Guha(Executive Officer)Steven P. Cobourn(Executive Officer)Sourav Kundu(Executive Officer)Kevin Shaw(Executive Officer)

Board seatChau Khuong· per SEC Form D · $93.4M raise · filed Nov 2018

Co-investorsBay City CapitalCanaan PartnersLAVLilly Asia VenturesPfizer Venture InvestmentsQuan Capital+2 more

Prelude Therapeuticspreludetx.comin𝕏NASDAQ: PRLDJun 2016

Prelude Therapeutics is a precision oncology company developing cancer treatments for areas of high unmet need, with a pipeline including selective KAT6A degraders and mutant-selective JAK2V617F JH2 inhibitors.

BiotechHealthtechNewark, US

Krishna Vaddi(Executive Officer, Director)

BoardPaul Friedman(Director of Issuer)

Board seatDavid Bonita· per SEC Form D

Co-investorsThe Innovation Space

SI-BONENASDAQ: SIBNJun 2016SEC filingmedium confidence

San Jose, US

Mark Reiley(Director)Jeffrey Dunn(Executive Officer, Director)Mark A. Reiley(Director)Jeffrey W. Dunn(Executive Officer, Director)Laura Francis(Executive Officer)Robert E. Johnson(Executive Officer)

Board seatDavid Bonita· per SEC Form D · $21M raise · filed Jun 2016

Co-investorsArboretum Ventures

Spruce Biosciencessprucebiosciences.comin𝕏NASDAQ: SPRBFeb 2020SEC filingmedium confidence

Spruce Biosciences develops and commercializes therapies for serious neurological and endocrine disorders with unmet medical need, with a lead investigational enzyme replacement therapy (TA-ERT) for Mucopolysaccharidosis Type IIIB (Sanfilippo Syndrome Type B).

BiotechHealthtechSouth San Francisco, US

Javier Szwarcberg(Executive Officer, Director)Samir Gharib(Executive Officer)RICHARD KING(Executive Officer, Director)

BoardSimpson Camilla(Director)Tiba Aynechi(Director)inBali Muralidhar(Director)in

Board seatDina Chaya· per SEC Form D · $53.6M raise · filed Feb 2023

Co-investorsAisling CapitalHealthCapRiverVest Venture PartnersAbingworthNorwest Venture Partners

Synlogicsynlogictx.comin𝕏OTC: SYBXMay 2017SEC filingmedium confidence

Synlogic develops synthetic biology-based biotherapeutics that use engineered living organisms to treat diseases.

BiotechDeep TechMedical DevicesCambridge, US

Bharatt Chowrira(Executive Officer)Michael Sheahan(Executive Officer)Jose Carlos Gutierrez-Ramos(Executive Officer, Director)Paul Miller(Executive Officer)Aoife Brennan(Executive Officer)Todd Shegog(Executive Officer)

Board seatChau Khuong· per SEC Form D · $42M raise · filed May 2017

Co-investorsAtlas VentureNew Enterprise Associates (NEA)NSG VenturesPfizer Venture InvestmentsSofinnova VenturesSolasta Ventures

Adaptive Biotechnologiesadaptivebiotech.comin𝕏NASDAQ: ADPT

Adaptive Biotechnologies applies the genetics of the adaptive immune system to diagnostics and therapeutics, translating immune-system data into clinical insights for clinicians and biopharma companies.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesSeattle, US

Chad Robins(Executive Officer, Director)Harlan Robins(Executive Officer)inKathleen Determann(Executive Officer)Dean Schorno(Executive Officer)Chris Carlson(Executive Officer)

BoardArnold Levine(Director)

Co-investorsDecheng CapitalFMG CapitalForesite CapitalKhosla Ventures

Alumisalumis.comin𝕏NASDAQ: ALMS

Alumis is a clinical-stage biopharmaceutical company developing a late-stage portfolio of targeted therapies for immune-mediated diseases.

AI & Machine LearningBiotechDigital HealthHealthtechLongevitySouth San Francisco, US

Martin Babler(President, Chief Executive Officer and Chairman of the Board)Mark Bradley(Chief Development Officer)Kolbot By(SVP, Head of Technical Operations)Jack Danilkowicz(Chief Commercial Officer)Jörn Drappa(Chief Medical Officer)David M Goldstein(Chief Scientific Officer)

Co-investorsForesite CapitalNextech InvestSamsara BioCapitalSR One Capital ManagementvenBio PartnersWestlake Village BioPartners+1 more

Aura Biosciencesaurabiosciences.comin𝕏NASDAQ: AURA

Aura Biosciences develops Virus-Like Drug Conjugates (VDCs), a platform using Virus-Like Particles conjugated with drugs or loaded with nucleic acids to target solid tumors.

BiotechHealthtechMedical DevicesCambridge, US

Elisabet de los Pinos, Ph.D.(Executive Officer, Director)Elisabet de los Pinos, Ph.d.(President and Treasurer)Elisabet de los Pinos(Founder)inMichael Wyzga(Executive Officer)Dale Pfost, Ph.D.(Director)Alan E. Walts, Ph.D.(Director)

Co-investorsAdvent Life SciencesChiesi VenturesDroia VenturesForesite CapitalJazzya InvestmentsMedicxi+4 more

Avita Medicalavitamedical.comin𝕏NASDAQ: RCELNov 2019

AVITA Medical develops therapeutic acute wound care technologies, including the FDA-approved RECELL System that uses a patient's own skin to create a Spray-On Skin cell suspension for treating thermal burn wounds and full-thickness skin defects.

BiotechHealthtechMedical DevicesMelbourne, US

Dale A Sander(Executive Officer)

BioAge Labsbioagelabs.comin𝕏NASDAQ: BIOAFeb 2024

BIOAGE develops therapies targeting the molecular pathways that drive aging to increase healthspan and address age-related chronic diseases.

BiotechHealthtechLongevityRichmond, US

Kristen Fortney, PhD(Co-Founder, CEO)Eric Morgen, MD(Co-Founder, COO)Kristen Fortney(Executive Officer, Director)inEric Morgen(Director)Dov Goldstein(Executive Officer)

BoardPatrick Enright(Director)in

Co-investorsAndreessen HorowitzElad GilFelicis VenturesIA Seed VenturesLongitude CapitalPear VC+2 more

BiomXbiomx.comin𝕏NYSE: PHGE

BiomX builds a portfolio of defense and security companies through subsidiaries, partnerships, and acquisitions, focusing on detection systems, aerial technologies, and infrastructure security.

AI & Machine LearningBiotechCybersecurityDeep TechDefense TechHardware

Jonathan Solomon(Chief Executive Officer)Merav Bassan(Chief Development Officer)Marina Wolfson(Chief Financial Officer)Jesse Goodman(Director)Alan Moses(Director)Jonathan Leff(Director)

Co-investorsAMR Action FundBaruch Future VenturesNSG Ventures8VC

Caris Life Sciencescarislifesciences.comin𝕏NASDAQ: CAI

Caris Lifesciences operates a precision oncology platform that analyzes DNA, RNA and proteins across tissue and blood to profile a patient's cancer and match treatments and clinical trials.

AI & Machine LearningBiotechHealthtech

David Dean Halbert(Chairman, Founder and CEO)

Co-investorsCoatue ManagementSilver Lake PartnersSixth Street

Cullinan Therapeuticscullinantherapeutics.comin𝕏NASDAQ: CGEM

Cullinan Therapeutics is a clinical-stage biotechnology company developing therapies for autoimmune diseases and cancer, with a pipeline that includes CD19- and BCMA-targeted T cell engagers.

BiotechHealthtech

Co-investorsForesite CapitalNextech InvestBiotechnology Value Fund

Disc Medicinediscmedicine.comin𝕏NASDAQ: IRON

Disc Medicine is a biopharmaceutical company developing therapies from discovery through clinical development for patients in need.

BiotechHealthtech

John Quisel(Chief Executive Officer)Jean Franchi(Chief Financial Officer)Jonathan Yu(Chief Operating Officer)Will Savage(Chief Medical Officer)Pamela Stephenson(Chief Commercial Officer)Steve Caffé(Chief Regulatory Officer)

Co-investorsAccess BiotechnologyAtlas VentureBain Capital Life SciencesForesite CapitalFrazier Life Sciences

Emergent Biosolutionsemergentbiosolutions.comin𝕏NYSE: EBSOct 2018

Emergent BioSolutions is a public health company that develops, manufactures, and supplies medical countermeasures for national security and preparedness, along with commercialized products addressing threats such as the opioid epidemic.

Advanced ManufacturingBiotechHealthtechGaithersburg, US

Fuad El-Hibri(Director, Executive Officer)Robert G Kramer(Executive Officer)Katherine Strei(Executive Officer)Adam R Havey(Executive Officer)Daniel J Abdun-Nabi(Executive Officer, Director)Zsolt Harsanyi(Director)

Co-investorsAdvent Life Sciences

Enliven Therapeuticsenliventherapeutics.cominNASDAQ: ELVN

Enliven Therapeutics is a biopharmaceutical company developing small molecule precision therapeutics, including ELVN-001, a selective active site inhibitor of BCR::ABL1 for patients with chronic myeloid leukemia (CML).

BiotechHealthtechBoulder, US

Co-investors5AM VenturesPfizer Venture InvestmentsRoche Venture FundARCH Venture Partners

Insmedinsmed.comin𝕏NASDAQ: INSM

Insmed is a biopharmaceutical company that provides grants and charitable funding to support healthcare provider education and patient care initiatives focused on nontuberculous mycobacterial lung disease, non-cystic fibrosis bronchiectasis, and other serious lung diseases.

BiotechDigital HealthHealthtechMedical Devices

Will LewisinGeoffrey Allanin

Co-investorsBessemer Venture PartnersF-Prime CapitalForesite CapitalProspect Venture PartnersNVIDIA

InspireMDinspiremd.comNASDAQ: NSPR

BiotechHealthtechMiami, US

Patrick Verta(Executive Officer)Pete Ligotti(Executive Officer)Mike Lawless(Chief Financial Officer)Shane Gleason(Executive Officer)Marvin Slosman(President and Chief Executive Officer)Andrea Tommasoli(Chief Operating Officer)

NeuroPaceneuropace.comin𝕏NASDAQ: NPCEAug 2020

NeuroPace is a commercial-stage medical device company that develops the RNS System, a brain-responsive neurostimulation platform delivering real-time treatment at the seizure source for patients with drug-resistant epilepsy and other brain disorders.

Digital HealthHardwareHealthtechMedical DevicesMountain View, US

Rebecca Kuhn(Executive Officer)Frank Fischer(Executive Officer, Director)Vince Burgess(Director)Renee Ryan(Director)Ray Larkin(Director)Greg Garfield(Director)

Co-investorsAccelmed PartnersNew Enterprise Associates (NEA)

Oncology InstituteNASDAQ: TOI

HealthtechCerritos, US

Robert Carter(Executive Officer)Jeremy Castle(Executive Officer)Daniel Virnich(Executive Officer, Director)Yale Podnos(Executive Officer)Brad Hively(Director)Mihir Shah(Executive Officer)

Shattuck Labsshattucklabs.cominNASDAQ: STTK

Shattuck Labs is a biopharmaceutical company developing a DR3 blocking antibody for the treatment of Inflammatory Bowel Disease and other inflammatory and immune-mediated diseases.

BiotechAustin, US

Josiah Hornblower(President/CEO)

BoardWalter Loewenbaum(Director)

Co-investorsEcoR1 CapitalHatteras Venture PartnersT. Rowe Price

SonendoOTC: SONX

HealthtechLaguna Hills, US

Bjarne Bergheim(Executive Officer, Director)John McGaugh(Executive Officer)John Bostjancic(Executive Officer)Hugh Neuharth(Executive Officer)

BoardOlav Bergheim(Director)Olav B. Bergheim(Director)

Co-investorsEssex Woodlands Healthcare PartnersFjord VenturesGeneral AtlanticMeritech Capital PartnersWelsh, Carson, Anderson & Stowe

TELA Bioin𝕏NASDAQ: TELA

BiotechMalvern, US

Antony Koblish(Executive Officer, Director)Francis Conway(Executive Officer)Maarten Persenaire(Executive Officer)Christine Arasin(Executive Officer)Vince Burgess(Director)

BoardKevin Rakin(Director)

Co-investorsCheckmate Capital Group LLCEssex Woodlands Healthcare PartnersSignet Healthcare Partners1315 Capital

Trawspharmatrawspharma.comNASDAQ: TRAW

Traws Pharma is a clinical-stage biopharmaceutical company developing oral small molecule antiviral therapies for respiratory viral diseases.

BiotechHealthtech

Upstream Bioupstreambio.comin𝕏NASDAQ: UPB

Upstream Bio is a clinical-stage biotechnology company developing verekitug, an antagonist that targets the TSLP receptor to inhibit pro-inflammatory signaling.

BiotechHealthtech

Rand Sutherlandin

Co-investorsAccess BiotechnologyBain Capital Life SciencesDecheng CapitalSamsara BioCapitalTCG CrossoverVenrock Healthcare Capital Partners

Verastemverastem.comin𝕏NASDAQ: VSTM

Verastem Oncology is a biopharmaceutical company that discovers and develops drugs to treat cancer patients.

BiotechMedical DevicesNeedham, US

Robert WeinbergRICHARD ALDRICH(Director)AMY C. CAVERS(Executive Officer)CATHY CAREW(Executive Officer)JONATHAN PACHTER(Executive Officer)ROB GAGNON(Executive Officer)

Co-investorsBessemer Venture PartnersCardinal PartnersForesite CapitalLightstone VenturesLongwood FundOberland Capital

Aer Therapeuticsaertherapeutics.comin✓ verified

Aer Therapeutics develops a science-driven therapeutic aimed at eliminating mucus plugs in the lungs to treat muco-obstructive lung diseases such as COPD and asthma.

BiotechHealthtechMedical DevicesRaleigh, US

THOMAS MATHERS(Executive Officer, Director)James Shaffer(Executive Officer, Director)Thomas Mathers(Executive Officer, Director)John Fahy(Director)in

BoardChristy Shaffer(Director)inRishi Gupta(Director)

Co-investorsHatteras Venture PartnersCanaan PartnersPappas Capital

Aspen Neuroscienceaspenneuroscience.comin𝕏✓ verified

Aspen Neuroscience develops iPSC-derived autologous cell therapies for neurological diseases, with a lead product (ANPD001) in Phase 1/2a clinical trials for Parkinson's disease.

BiotechDeep TechDigital HealthMedical Devices

Andrés Bratt-Leal(Co-Founder and Senior Vice President, Research & Development)Damien McDevitt(President and Chief Executive Officer)

Co-investorsARCH Venture PartnersLifeforce CapitalDomain AssociatesEDB InvestmentsSection 32Frazier Life Sciences+3 more

Brenigbrenigther.comin𝕏✓ verified

Brenig Therapeutics is a biotechnology company developing small-molecule therapies for Parkinson's disease and other neurodegenerative disorders, using AI-driven drug discovery.

AI & Machine LearningBiotechHealthtech

Megan McGill(Chief Executive Officer)Iain Dukes(Chief Business Officer / Chairman of the Board)Nikolay Savchuk(Chief Operating Officer)Tien Dam(Chief Medical Officer)

Co-investorsNew Enterprise Associates (NEA)BGVTorrey Pines Investment

Congruencetxcongruencetx.comin✓ verified

Congruence is a drug discovery company that applies protein dynamics, biophysics, machine learning, and computational chemistry to model proteins in their full dynamic state and predict disease correction in silico.

AI & Machine LearningBiotechDeep Tech

Clarissa Desjardins(Founder)

Co-investorsAlexandriaDIMENSIONBDC Thrive Venture Fund for WomenLumira Ventures

GentiBiogentibio.comin𝕏✓ verified

GentiBio develops engineered regulatory T-cell (EngTreg) therapies designed to reset the immune system and treat autoimmune and acute inflammatory diseases.

BiotechHealthtechMedical Devices

Jane Buckner(Scientific Co-founder (President, Benaroya Research Institute))Chandra Patel(Co-founder & SVP, Research and Development Operations)David Rawlings(Scientific Co-founder and Senior Scientific Advisor)Andy Scharenberg(Scientific Co-founder, SAB Chair)Andy Walker(President and CEO)Tom Wickham(Chief Scientific Officer)

Co-investorsNovartis Venture FundJDRF T1D FundRA Capital

i2020 Acceleratori2020accelerator.comin✓ verified

i2020 Accelerator (T123 LLC) is a drug discovery accelerator that de-risks early-stage science and advances drug discovery platforms toward lead and clinical candidate stage within roughly two years, working across therapeutic areas such as oncology, immunology, and infectious diseases.

BiotechDeep TechHealthtech

Co-investorsTorrey Pines InvestmentBioGeneration Ventures

Latticemedtechlatticemedtech.comin✓ verified

Lattice MedTech operates a medical device distribution and manufacturing platform in India, serving global brands and Indian manufacturers across specialties such as cardiology, orthopedics, general surgery, critical care, and IVD.

HealthtechLogistics & Supply ChainMedical Devices

Oncusp Therapeuticsoncusptx.comin✓ verified

OnCusp Therapeutics develops oncology therapeutics for cancer treatment, including antibody-drug conjugates and small molecule compounds in clinical and preclinical stages.

BiotechMedical DevicesNew York, US

Dr. Bing Yuan(Co-Founder, Chief Executive Officer)Dr. Eric Slosberg(Co-Founder, Chief Development Officer)Dr. Andy Fu(Co-Founder, Chief Business Officer)

Co-investorsCatalio Capital Management, LPF-Prime CapitalSofinnova VenturesInsight PartnersNVIDIA

Sionnatxsionnatx.comin𝕏✓ verified

Sionna Therapeutics is a biopharmaceutical company founded in 2019 that develops small-molecule therapies for cystic fibrosis by targeting and stabilizing NBD1, the domain of the CFTR protein where the common ΔF508 mutation occurs.

BiotechHealthtechMedical Devices

Greg(Co-founder & Senior Vice President of Discovery Research)Mark(Co-founder & Senior Vice President of Medicinal Chemistry)Mike(President & CEO)Charlotte(Chief Medical Officer)Elena(Chief Financial Officer)Caroline(Chief Business Officer)

Co-investorsAtlas VentureRA Capital

Siriusrnasiriusrna.com✓ verified

Sirius is a biotech company developing RNAi-based therapies focused on cardiovascular diseases for global markets.

BiotechHealthtech

Co-investorsDelos CapitalCreacion Ventures

Variantyxvariantyx.cominFeb 2021✓ verified

Variantyx is a molecular diagnostics company offering genetic testing for rare genetic disorders, reproductive genetics, and precision oncology.

AI & Machine LearningBiotechDigital HealthHealthtechFramingham, US

Haim Neerman(Co-founder)inTomer Jackman(Co-founder & VP Customer Support and Lab Services)inJeffrey Weisberg(Chief Financial Officer)inYaron Rachmany(Operations, R&D, IT (executive))inChristine Stanley(Chief Genomics and Compliance Officer)inEyal Reinstein(Chief Medical Officer)in

Co-investors20/20 HealthCare Partners LLCBosch VenturesNew Era Capital PartnersPeregrine VenturesPitangoQuark Venture Inc.+2 more

Acutus Medicalacutusmedical.comJun 2022

HealthtechCarlsbad, US

Christoph Scharf(Director)Randy Werneth(Executive Officer, Director)Graydon Beatty(Executive Officer)Vince Burgess(Director)John Dahldorf(Executive Officer)

BoardAditya Puri(Director)

Board seatDavid Bonita· per SEC Form D

Co-investorsAdvent Life SciencesDeerfield Management CompanyGE VenturesIndex Ventures

Adelabioadelabio.comin𝕏Apr 2026

Adela develops blood-based diagnostic tests that analyze cell-free DNA using whole methylome analysis to detect and monitor cancer.

BiotechDigital HealthHealthtechFoster City, US

Daniel Diniz De Carvalho(Executive Officer, Promoter)Scott Bratman(Executive Officer, Director)Anne-Renee Hartman(Founder)Alan Williams(Executive Officer)Lisa Alderson(Executive Officer, Director)Priscilla Huang(Executive Officer)

Board seatDavid Bonita· per SEC Form D

Co-investorsDecheng CapitalF-Prime CapitalDeerfield Management CompanyMenlo Ventures

Aerpio Therapeuticsaerpio.comMar 2016SEC filingmedium confidence

BiotechCincinnati, US

Joseph H. Gardner(Executive Officer)Robert Shalwitz(Executive Officer)Joseph Gardner(Founder)inDuane Nash(Director)Kevin Peters(Executive Officer)Steve Pakola(Executive Officer)

Board seatChau Khuong· per SEC Form D · $9.2M raise · filed Apr 2016

Co-investorsCincyTechSofinnova Ventures

Alpheus Medicalalpheusmedical.cominMay 2025

Clinical-stage company developing novel treatment for recurrent high-grade gliomas

HealthtechChanhassen, US

Jeremy Ling(Executive Officer)Steve Weiner(Executive Officer)Vijay Agarwal(Executive Officer, Director)William Davis(Executive Officer, Director)

BoardImran Eba(Executive Officer)in

Board seatKlaus Veitinger· per SEC Form D

Co-investorsSV Health InvestorsAction Potential Venture Capital Ltd.

Angiexangiex.comin𝕏Jul 2025SEC filingmedium confidence

Angiex develops Nuclear-Delivered Antibody-Drug Conjugate (ND-ADC) therapies for solid cancers, using a platform that delivers chemotherapeutic payloads to the nucleus of tumor cells and tumor blood vessel endothelial cells.

BiotechHealthtechMedical DevicesCambridge, US

Paul Jaminet(Executive Officer, Director)in

BoardErrik Anderson(Director)Jason Camm(Director)inJonathan Adams(Director)inFabian Hansen(Director)in

Board seatIain Dukes· per SEC Form D · $28.4M raise · filed Sep 2025

Co-investorsGreen Meadow VenturesK5 Global

Audentes Therapeuticsastellasgenetherapies.cominAug 2015SEC filingmedium confidence

BiotechSan Francisco, US

Matthew Patterson(Executive Officer, Director)

BoardSteve Squinto(Director)inKush Parmar(Director)Jonathan Leff(Director)Thomas Woiwode(Director)

Board seatJonathan Silverstein· per SEC Form D · filed Sep 2015

Co-investorsAsset Management CompanyRA CapitalvenBio PartnersDeerfield Management CompanyVenrock

Averna TherapeuticsApr 2024SEC filingmedium confidence

Creates gene therapies that integrate therapeutic genes into patients' genomes to treat genetic disorders.

HealthtechWatertown, US

Thomas Barnes(Chief Executive Officer/President)Richard Morris(Chief Financial Officer)

BoardRoy Amariglio(Director)Nick Olsen(Director)Michal Silverberg(Director)

Board seatStephen Squinto· per SEC Form D · $85M raise · filed Mar 2026

Co-investorsDeep InsightNovartis Venture Fund

Belenosbiobelenosbio.comJul 2024

Belenos Biosciences develops long-acting bispecific antibody therapeutics for chronic inflammatory diseases such as COPD, asthma, atopic dermatitis, CRSwNP, and CSU.

BiotechHealthtechNew York, US

Donnie McGrath(CEO & Co-Founder)Megan Dow(COO & Co-Founder)Tania Dimitrova(CFO & Co-Founder)Glenn Rosen(Chief Translational Officer & Co-Founder)StJohn Donnie McGrath(Executive Officer, Director)

BoardBo Chen(Director)

Board seatCarl Gordon· per SEC Form D

BELLUS HealthDec 2018SEC filingmedium confidence

BiotechLaval

Francois Desjardins(Vice President, Finance)Denis Garceau(Senior Vice President, Drug Development)Franklin Berger(Director)Roberto Bellini(President and Chief Executive Officer)Joseph Rus(Director)Youssef L. Bennani(Director)

Board seatChau Khuong· per SEC Form D · $24M raise · filed Jan 2019

Cerapedicscerapedics.comin𝕏Feb 2015SEC filingmedium confidence

Cerapedics develops P-15 peptide enhanced bone graft products, marketed as bone growth accelerators, for spinal fusion procedures.

BiotechHealthtechMedical DevicesWestminster, US

Andrew J Tofe(Director)Britt Pearson(Executive Officer)Jeff Marx(Executive Officer)Glen Kashuba(Executive Officer, Director)Jerome Connor(Executive Officer)Andrew Handwerker(Executive Officer)

Board seatChau KhuongJonathan Silverstein· per SEC Form D · $4M raise · filed Feb 2015

Chemomabchemomab.cominMar 2021

Chemomab Therapeutics is a clinical-stage biotechnology company developing therapeutics for fibro-inflammatory diseases.

BiotechTel Aviv

Adi Mor(Executive Officer, Director)Adi Mor George(Executive Officer, Director)Jill Quigley(Director)Sigal Fattal(Executive Officer)Matthew Frankel(Executive Officer)Arnon Aharon(Executive Officer)

Board seatStephen Squinto· per SEC Form D

Co-investorsAltium Capital

Clementia PharmaceuticalsJun 2015SEC filingmedium confidence

BiotechDorval

Francois Nader(Director)Donna Roy Grogan(Executive Officer)Jean-Francois Pariseau(Executive Officer, Director)Michael Singer(Executive Officer)David P. Bonita(Director)inRobert Heft(Director)

Board seatDavid Bonita· per SEC Form D · $60M raise · filed Jul 2015

Curevo, Inc.Mar 2025SEC filingmedium confidence

Bothell, US

Board seatTal Zaks· per SEC Form D · $84.8M raise · filed Mar 2025

Browse all 284 investments with full details →

84 more tracked companies

MBXMBX BiosciencesMdcloneMDxHealthMedpharmMendraMinervaXMinghuipharmaMirador TherapeuticsMobileodtMondegobioMybinxhealthMyriadNanotronicsNerre TherapeuticsNeurelisNewmedNorchem PharmaNucleixNucleusradOdyssey TherapeuticsOttimopharmaPathaiPathalysPeesafePic TherapeuticsPinnaclePMV PharmaPrincipia BiopharmaProlynxincPropellerProVerumPulnovomedQuantxbioRadiuspharmRampartbioRAPT TherapeuticsRayTheraReCode TherapeuticsReliabiotechRenasant BioReparerxSeroba LifesciencesSidewinderbioSikkasoftSitalaSiteOne TherapeuticsSneuroSpectronrxStairmedStar SportsmedStar TherapeuticsStarlingoncologyStratustxSurakshanetTandemaiTELA BioTendfoTerremotobioThe Oncology InstituteTigerConnectTopaz TxTreelineTreelineTrisaluslifesciTriveniTrunativTurnstone BiologicsTyto CareUquifaVanquabioVelosbioVelseraVerdiva BioVerricaVivacta BioVvardisWhaleimagingWindward BioYarrowbioscienceZaiZenteratxZionpharmaZyloxtb

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 38

IPOs and acquisitions across the tracked portfolio

Q32 BioNASDAQ: QTTBScribe TherapeuticsNASDAQ: SCTXAadi BioscienceNASDAQ: WHWKAdicet BioNASDAQ: ACETArvinas Holding Co. LLCNASDAQ: ARVNCalcimedicaNASDAQ: CALCCompass TherapeuticsNASDAQ: CMPXImaraNASDAQ: ELVNKeros TherapeuticsNASDAQ: KROSMirna TherapeuticsOTC: SYBXNextCureNASDAQ: NXTCPrelude TherapeuticsNASDAQ: PRLDSI-BONENASDAQ: SIBNSpruce BiosciencesNASDAQ: SPRBSynlogicOTC: SYBXAdaptive BiotechnologiesNASDAQ: ADPTAlumisNASDAQ: ALMSAura BiosciencesNASDAQ: AURAAvita MedicalNASDAQ: RCELBioAge LabsNASDAQ: BIOABiomXNYSE: PHGECaris Life SciencesNASDAQ: CAICullinan TherapeuticsNASDAQ: CGEMDisc MedicineNASDAQ: IRONEmergent BiosolutionsNYSE: EBSEnliven TherapeuticsNASDAQ: ELVNInsmedNASDAQ: INSMInspireMDNASDAQ: NSPRNeuroPaceNASDAQ: NPCEOncology InstituteNASDAQ: TOIShattuck LabsNASDAQ: STTKSonendoOTC: SONXTELA BioNASDAQ: TELATrawspharmaNASDAQ: TRAWUpstream BioNASDAQ: UPBVerastemNASDAQ: VSTMAvedroacq. by GlaukosAvitideacq. by Repligen

Portfolio news

latest coverage across their companies

Fund performance · per public LP disclosures · 10

as of Sep 2025
FundVintageCommittedNet IRRTVPIDPI
OrbiMed Private Investments IX, LPLPs: California State Teachers' Retirement System, New Mexico Educational Retirement Board, Kern County Employees' Retirement Association202229.3%1.16x0.21x
OrbiMed Royalty & Credit Opportunities IVLPs: California State Teachers' Retirement System, Sacramento County Employees' Retirement System, Kern County Employees' Retirement Association202214.1%1.28x0.25x
OrbiMed Private Investments VIII, L.P.LPs: California State Teachers' Retirement System, New Mexico Educational Retirement Board20206.9%1.19x0.30x
OrbiMed Royalty & Credit Opportunities III, LPLPs: California State Teachers' Retirement System, Sacramento County Employees' Retirement System201915.1%1.20x0.95x
OrbiMed Private Investments VILPs: Oregon Public Employees Retirement System201513.0%1.64x1.18x
OrbiMed Private Investments VLPs: Oregon Public Employees Retirement System, California State Teachers' Retirement System201338.2%2.35x2.14x
OrbiMed Private Investments IVLPs: Oregon Public Employees Retirement System, California State Teachers' Retirement System, The Regents of the University of California +1 more200931.8%2.73x2.72x
Orbimed Private lnvesuncnts IV, L PLPs: The Regents of the University of California200936.2%2.67x0.45x
Orbimed Private Investments III, LPLPs: The Regents of the University of California200618.1%2.34x1.48x
Orbimed Private lnvesunents Ill, LPLPs: The Regents of the University of California200618.4%2.32x

Source: public limited-partner disclosures (CalPERS, CalSTRS). Net IRR / TVPI / DPI as reported by the limited partner; a fund's early-year IRR is an interim estimate (J-curve).

Frequently asked questions

How many investments has OrbiMed made?
OrbiMed has 205 tracked investments, 2 of which have exited via acquisition or IPO, including 12 dated in the last 24 months.
What stage does OrbiMed invest at?
OrbiMed invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth, Late Stage stages.
What is OrbiMed's typical check size?
OrbiMed typically writes checks of $1M – $75M.
What sectors does OrbiMed focus on?
OrbiMed focuses on Biotech, Digital Health, Healthtech, Longevity, Medical Devices.
Where is OrbiMed located?
OrbiMed is headquartered in New York, US.
Does OrbiMed lead rounds?
Yes, OrbiMed leads investment rounds.
Who does OrbiMed co-invest with?
OrbiMed most often shares deals with RA Capital, Foresite Capital, Frazier Life Sciences, among 218 tracked co-investors.

Media · Podcasts & interviews

featuring the team

Geoffrey C. Hsu, CFA, General Partner, OrbiMed Advisors LLC

Biotechnology Innovation Organization · Geoffrey C. Hsu

Co-investors · 87

New Enterprise Associates (NEA)

New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.

$200K – $40M
F-Prime Capital

F-Prime Capital is an early-stage-focused investment firm backing companies across life sciences, technology, healthtech and services, and crypto.

$3M – $10M
Sofinnova Ventures

Sofinnova is an investment firm focused on the life sciences and biotechnology sector, partnering with companies from inception through drug development, regulatory approval, company building, and IPO.

$100K – $15M
Lilly Asia Ventures

Lilly Asia Ventures (LAV) is a biomedical venture capital firm with offices in Hong Kong, Shanghai, and Palo Alto, backing entrepreneurs building companies focused on breakthrough products that treat disease and improve human health.

Atlas Venture

Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.

$500K – $1M
Sanofi Ventures

Sanofi Ventures is the corporate venture capital arm of Sanofi, investing in early-stage biotech and digital health companies focused on improving human health. It serves as Sanofi's entry point into the innovation ecosystem.

$5M
Pfizer Venture Investments

Pfizer Venture Investments is a strategic venture fund that doesn't require product or technology rights as a condition of investing, giving founders independence while still aiming for future collaboration with Pfizer, and its team blends venture investing with business development and drug discovery expertise to back frontier scientific bets—such as neuroscience, in-vivo cell engineering, dark-genome target discovery, and the blockchain-based longevity accelerator VitaDAO—that many biotech investors avoid. The fund also runs an active China strategy through a locally based venture vehicle and direct investments like OTR Therapeutics, and it has become a channel for strategic deals, with portfolio companies acquired by AbbVie, Ipsen, and Gilead/Kite.

$5M – $20M
Samsara BioCapital

Samsara BioCapital is an investment firm backing the development of transformative therapeutics for patients, bringing together scientists, physicians, drug developers, and business leaders to support next-generation therapeutic breakthroughs.

Nextech Invest

Nextech Invest is a Zurich-based investment firm focused on emerging biotechnology companies, backing transformative cancer medicines and precision medicine advances worldwide.

$648K – $3.2M
SR One Capital Management

SR One is a biotechnology-focused venture capital firm that partners with founders to develop innovative science into new medicines.

75 more co-investors

5AM VenturesVivo CapitalCanaan PartnersvenBio PartnersAvoro Capital AdvisorsAndreessen HorowitzUS Venture PartnersAdvent Life SciencesGV (Google Ventures)OUP (Osage University Partners)Aisling CapitalVida VenturesWestlake Village BioPartnersLightspeed Venture PartnersMenlo VenturesVersant VenturesDeerfield Management CompanyThird Rock VenturesAbingworthSV Health InvestorsAndera PartnersHatteras Venture PartnersNew Leaf Venture PartnersLongwood FundRTW Investments L.P.General CatalystBessemer Venture PartnersKhosla VenturesKleiner PerkinsTrinity VenturesThe Column GroupYsios CapitalRiverVest Venture PartnersFounders FundCRV (Charles River Ventures)Tiger Global ManagementMeritech Capital PartnersVenrockPear VCGeneral AtlanticPitangoEQT Life SciencesDimension CapitalSofinnova PartnersMPM BioImpactDomain AssociatesPivotal Life SciencesOmega FundsBorealis VenturesAction Potential Venture Capital Ltd.CincyTechSignet Healthcare PartnersWelsh, Carson, Anderson & StoweSequoia CapitalDCVC (Data Collective)Polaris PartnersZetta Venture PartnersWildcat Venture PartnersM12 (Microsoft's Venture Fund)BDC Venture CapitalForbionFlagship PioneeringFrazier Healthcare PartnersTencent Holdings6 Dimensions Capital1955 CapitalCofounders Capital+ND CapitalDFJSeroba Life SciencesJMI EquityAmplitude Venture CapitalHBM PartnersACORN BIOVENTURESDe Novo Ventures

Firms observed investing alongside OrbiMed, from public investor directories. Shared companies are the overlap with OrbiMed's recorded portfolio.

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