Fundraising Fox
New York · Seed–Series B · 25 people tracked
Also known as Two Sigma · Two Sigma Venture
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Investment thesis
Originating from a quantitative hedge fund, they use quant models and embed data scientists, engineers, and researchers to tackle ML and data-pipeline challenges for AI, software infrastructure, and hardtech.
Source: firm website, verified Aug 3, 2026.
Team · 25 people
from public directories
Founder mafia
4 people who came through Two Sigma Ventures went on to found or lead other companies.
What they invest in
from 77 of 94 portfolio companiesAI & Machine Learning ×35SaaS ×25Enterprise Software ×22Developer Tools ×15Healthtech ×15Data & Infrastructure ×14Biotech ×11Deep Tech ×10
HQs:United States×73Canada×1Finland×1Israel×1Mexico×1
Investments · 94 tracked
founders shown can be your intro pathBy year:2026 · 132025 · 62024 · 62023 · 92022 · 42021 · 142020 · 72019 · 52018 · 102017 · 42015 · 12014 · 181 dated
DevvStream develops and manages technology-based sustainability projects that generate environmental assets such as carbon credits and renewable energy certificates for corporations and governments seeking to offset emissions.
EnergySacramento, US
Sunny Trinh(Chief Executive Officer)inChris Merkel(Chief Operating Officer)inDavid Goertz(Chief Financial Officer)
BoardCarl Stanton(Director)Stephen Kukucha(Director)
Board seatWray Thorn· per SEC Form D · $2M raise · filed Dec 2025
XCF is a publicly traded renewable fuels company that produces sustainable aviation fuel and renewable diesel from low-carbon feedstocks such as waste oils, agricultural residues, and distillers corn oil.
CleantechClimate TechEnergyHouston, US
William Dale Dale(Chief Financial Officer)Christopher Cooper(Chief Executive Officer)
BoardCarter McCain(Director)Si-Yeon Kim(Director)Sanford Cockrell(Director)
Board seatWray Thorn· per SEC Form D · $10M raise · filed Feb 2026
GitLab is an intelligent orchestration platform for DevSecOps that enables teams and AI agents to collaborate on the full software development lifecycle, from planning through deployment, with integrated security and compliance capabilities.
AI & Machine LearningCybersecurityDeveloper ToolsEnterprise SoftwareSan Francisco, US
Sid Sijbrandij(CEO)inDmytro Zaporozhets(CTO)inDmitriy Zaporozhets(Founder)inPaul Machle(Executive Officer)inSytse Sijbrandij(Founder)
BoardBruce Armstrong(Director)in
Co-investorsAlkeon InnovationAugust CapitalBase PartnersBling CapitalCategory VenturesCoatue Management+36 more
Recursion applies computational and data-driven approaches to biological science, aiming to accelerate drug discovery and develop new treatments.
AI & Machine LearningBiotechData & InfrastructureDeep TechMedical DevicesSalt Lake City, US
Chris Gibson(Co-founder and Chairman of the Board)inBlake C. Borgeson(Executive Officer, Director)inDean Y. Yi(Executive Officer, Director)Najat Khan(Chief Executive Officer)inNajat Khan, Ph.D.(CEO and President)inBlake Borgeson(Founder)
Co-investorsDCVC (Data Collective)Lux CapitalBaillie GiffordAdvantage Capital PartnersAir Street CapitalAmplify Partners+22 more
Flatfile is an AI-powered data migration platform that lets enterprises collect, map, clean, transform, and validate data from files, APIs, webhooks, databases, and cloud storage.
AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSDenver, US
David Boskovic(Founder)inEric Crane(Founder)AVERY CHASE(Executive Officer, Director)
BoardRORY O'DRISCOLL(Director)inFRANCES SCHWEIP(Director)
Co-investorsAfore CapitalGradient VenturesScale Venture PartnersTiger Global ManagementWorkday VenturesDesigner Fund+5 more
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Hyper provides avatar and AI storytelling tools that enable consumers to create their own content and experiences, positioning itself in the creator economy space.
AI & Machine LearningConsumerCreator EconomyMedia & EntertainmentSocialSan Francisco, US
Aaron Ng(CEO)inLevanJimAndrew Breckenridge(Executive Officer, Director)
Co-investorsY CombinatorMakers Fund1337.fundAmazon Alexa FundSequoia Capital
Isabl develops whole genome and transcriptome sequencing technology for cancer diagnosis, delivering comprehensive genomic profiling and treatment options to physicians and research teams.
BiotechDigital HealthHealthtechMedical DevicesNew York City, US
Juan Medina(CTO and Technical Co-founder)inAndrew Kung(MD PhD, Medical Co-Founder)inElli Papaemmanuil(PhD, CEO and Scientific Co-founder)in
Co-investorsY CombinatorBoxOne VenturesEvolution VC PartnersSand Hill AngelsAmino CapitalThomas James
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Tive provides real-time location and condition tracking for shipments, helping supply chain teams monitor temperature, humidity, light, and shock throughout transit.
AI & Machine LearningEdTechIoTLogistics & Supply ChainSector AgnosticSiberia, US
Semyon DukachinIvan Crewkov(CEO and co-founder)Krenar Komoni
Co-investorsEducapitalFifth WallGoodwater CapitalPoint72 VenturesQualcomm VenturesRRE Ventures+6 more
Freeform develops additive manufacturing (3D printing) technology aimed at bringing this production method to industrial applications across multiple sectors.
Advanced ManufacturingAI & Machine LearningDeep TechHardwareRoboticsHawthorne, US
Thomas J. Ronacher(Executive Officer, Director)inErik Palitsch(Founder)inTasso Lappas(Chief Scientific Officer)inTJ Ronacher(Founder)
BoardMohammad Islam(Director)in
Board seatDusan Perovic· per SEC Form D
Co-investorsDeviation CapitalLinse CapitalMVP VenturesThreshold VenturesValor Equity PartnersW ventures+4 more
Gameto develops cell therapy and reproductive technologies to treat infertility and improve women's health outcomes.
BiotechFemTechHealthtechMedical DevicesAustin, US
Dina Turner(Co-founder & Chief Executive Officer)inMartin Varsavsky(Co-founder & Chairman)inDina Radenkovic(Founder)inMartín Varsavsky(Founder)
BoardDylan Morris(Director)in
Board seatDusan Perovic· per SEC Form D
Co-investorsBold Capital PartnersDeviation CapitalFJ LabsFuture VenturesIngeborg InvestmentsInsight Partners+18 more
Lytics is a customer data platform for building and using unified customer profiles.
AI & Machine LearningData & InfrastructureMarketing TechSaaSPortland, US
Aaron Raddon(Executive Officer, Director)inJames McDermott(CEO)inDrew Lanenga(CTO)inDan Abelon(Director)
BoardScott Irwin(Director)inBrett Queener(Director)in
Board seatDan Abelon· per SEC Form D
Co-investorsComcast VenturesVoyager CapitalJMI EquityEPIC VENTURESR/GA VenturesRembrandt Venture Partners+1 more
Odeko provides software and operational systems for independent food service businesses to compete with chain restaurants through cost optimization and margin improvement.
Enterprise SoftwareFoodTechLogistics & Supply ChainRetail TechSaaSNew York City, US
James Burkhardt(Founder)inDane Atkinson(CEO)inTom Hore(Chief Product Officer)inStephen Mar(Chief Legal & Administrative Officer)inTodd Sunsted(Executive Officer)Bernar Bekirov(Executive Officer)in
Board seatDan Abelon· per SEC Form D
Co-investorsAlumni VenturesB Capital GroupB4 CapitalBoxGroupEmles Venture PartnersFirst Round Capital+29 more
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Spruce Up! is a locally owned residential cleaning service in Seattle that emphasizes quality, consistent results, and customer communication.
ConsumerSeattle, US
Holly WhiteJeff WhiteFridgen Mike(Executive Officer, Director)Lewin Mia(Executive Officer, Director)
Board seatDan Abelon· per SEC Form D · $6.6M raise · filed May 2019
Co-investorsMadrona Venture Group
WHOOP is a wearable health monitoring device that provides 24/7 tracking of sleep, strain, stress, and heart health metrics to help users optimize their fitness and wellness.
HealthtechWellness & FitnessBoston, US
Will Ahmed(Founder)inAurelian Nicolae(Founder)John Capodilupo(Founder)Will Ahmed John Capodilupo(Founder)
BoardJeff Fagnan(Director)
Board seatWray Thorn· per SEC Form D · $30.2M raise · filed Mar 2018
Co-investorsAccompliceBose VenturesCAVU Consumer PartnersCollaborative FundDeviation CapitalDrive by DraftKings+16 more
Amper is a production monitoring and intelligence platform that uses IoT sensors to track machines, operators, and jobs in real time, helping manufacturers identify hidden capacity and reduce downtime.
Advanced ManufacturingIoTSaaSChicago, US
Akshat Thirani(Founder & CEO)inStephen Bell(Director)Sachin Lal(Executive Officer, Director)
Co-investorsConvergeCorazon CapitalLewis & Clark VenturesSterling Road1517Advancit Capital+7 more
New York City, US
Andrew H. Silverstein(Executive Officer, Director)in
Co-investorsAdvancit CapitalTechstarsFoundryHorizons VenturesKiwi Venture PartnersPresence Capital+1 more
Ansel Health provides health benefit solutions focused on cost-sharing and coverage for unexpected medical bills for employer groups and individuals.
ConsumerHealthtechInsurTechHoboken, US
Veer GidwaneyinAmanda Turcotte(Executive Officer)in
BoardColin Beire(Director)Elizabeth Bierbower(Director)
Co-investors500 GlobalAlumni VenturesCity LightFounder CollectiveBrewer Lane VenturesDigitalis Ventures+2 more
Antioch provides simulation tools that replicate real-world deployment environments, letting users import site scans or use sim-ready assets to build realistic scenes with configurable motion and weather.
Advanced ManufacturingAI & Machine LearningDeep TechRoboticsSaaSNew York City, US
Collin Schlager(Founder)inColton Swingle(Founder)inMichael C.(Founder)in
Co-investorsA*Abstract VenturesCategory VenturesMaC Venture CapitalGreylock Partners
Arda develops therapeutics using single-cell computational biology to target and eliminate pathogenic cells in chronic diseases.
AI & Machine LearningBiotechDigital HealthLongevityMedical DevicesAustin, US
Adam Freund(Founder & Chief Executive Officer)inRemi-Martin Laberge(Founder and Chief Technology Officer)in
BoardVineeta Agarwala(Director)in
Co-investorsage1Alumni VenturesAndreessen HorowitzGV (Google Ventures)LifelinkOlima Ventures+7 more
Artemis is an AI-native security operations platform that builds a live model of an organization's environment across identity, cloud, endpoint, and SaaS to detect, investigate, and respond to attacks autonomously.
AI & Machine LearningCybersecurityEnterprise Software
Co-investorsBrightmindFelicis VenturesFirst Round CapitalSPRINGROCK VENTURESTheory Ventures
Artemis Real Estate Partners is a real estate investment firm.
PropTech
Co-investorsInvestcorpBrightmindFelicis VenturesFirst Round CapitalLockstep VenturesTheory Ventures
Bark builds parental control and monitoring software for families and schools to help keep children safe online.
AI & Machine LearningConsumerDigital HealthSaaSRichmond Hill, US
Brian Bason(CEO)inCarly Strife(Cofounder)in
Co-investorsAmerican Family Insurance Institute for Corporate and Social ImpactAtlanta SeedBYU Cougar CapitalDeviation CapitalSocial StartsStudio VC+4 more
Boundless provides U.S. immigration services that combine software with in-house legal review to help applicants prepare and submit family green card, employment-based, O-1, and EB-1 visa applications.
LegalTechSaaSSeattle, US
BoardAmy McCullough(Director)inGreg Gottesman(Director)inBrad Feld(Director)in
Co-investorsAlumni VenturesEscalate Capital PartnersForefront VentureFoundryNextView VenturesTrilogy Equity Partners+6 more
Candu is a no-code UX editor that lets product and growth teams build, launch, and A/B test in-app content such as onboarding flows, banners, and product tours using a drag-and-drop editor and a JavaScript snippet.
Developer ToolsEnterprise SoftwareMarketing TechSaaSLos Altos, US
Jonathan Anderson(Executive Officer, Director)inMichele Riccardo Esposito(Executive Officer, Director)inAnthony Esposito(Executive Officer, Director)Jeffrey L Monda(Executive Officer, Director)Richard Warner(Executive Officer, Director)
BoardGil Dibner(Director)in
Co-investorsAngular VenturesEntrepreneur FirstMaverick SiliconSoftBank Group
Carbon Health operates a chain of clinics offering urgent care, primary care, and chronic condition management, combining technology with in-person care to provide broader access to health services.
Digital HealthHealthtechMedia & Entertainment
Eren Bali(Founder)inGreg Burrell(Founder)inTom Berry(Founder)Caesar Djavaherian(Founder)Greg Burell(Founder)
Co-investors500 Emerging Europe500 Global515 VenturesAkkadian VenturesAnnex InvestmentsBuilders VC+30 more
Castor developed decision-support software that analyzed CAD files to help manufacturers decide between additive manufacturing and traditional production, offering cost and lead-time comparisons.
AI & Machine LearningCloud ComputingData & InfrastructureDigital HealthHealthtechMedical DevicesSaaSTel Aviv, IL
Co-investorsAsahi Kasei Corporate Venture CapitalF-Prime CapitalInkefTechstarsChartered Group
Cerby provides an identity security platform that extends password management, SSO, MFA, user provisioning/deprovisioning, and privileged access management to disconnected applications that lack SAML, OIDC, or SCIM support.
CybersecurityEnterprise SoftwareSaaS
Belsasar Lepe(Founder)inVidal(Co-Founder & CTO)inErnie Tkac(Chief Revenue Officer)inMatt McCawley(VP of Customer Experience, Business Development & Partnerships)inMiles Lavin(Chief Financial and Operating Officer)inVidal Gonzalez(Founder)
Co-investors515 VenturesAlumni VenturesAV8 VenturesBowery CapitalCarnrite VenturesCategory Ventures+14 more
Charlotte-based developer of mobile ordering and pickup software for independent coffee shops and small businesses.
Co-investorsMPG FundVentureSouqGGV CapitalPrimary Venture PartnersY Combinator
Comet builds infrastructure for developing, evaluating, and deploying AI applications in production.
AI & Machine LearningData & InfrastructureDeveloper ToolsNew York City, US
Gideon Mendels(Founder)inNimrod Lahav(Founder)inDishant Daryani(Founder)Utkarsh Gupta(Founder)
Co-investorsElevation CapitalGiTV, Inc.Invest In DataScale Venture PartnersTechstarsTrilogy Equity Partners+4 more
Cosmos Innovation develops a machine learning platform for optimizing recipe development in semiconductor and solar process engineering.
AI & Machine LearningDeep TechSemiconductors
Vijay Chandrasekhar(Founder)inJoel Li(Founder)in
Co-investorsXoraAIX VenturesInnovation EndeavorsTemasekXora Innovation Pte Ltd
An insurance brokerage offering personalized policy solutions for small businesses across multiple sectors including healthcare providers, attorneys, dentists, and nonprofits.
InsurTechNew York, US
Inaki Berenguer(Founder)inInaki Berenguer Rashmi Melgiri(Founder)Rashag Jhunjhunwala(Founder)
BoardCharles Moldow(Director)inJohn Buttrick(Director)
Co-investorsDeviation CapitalFoundation CapitalFounder CollectiveKibo VenturesKleiner PerkinsR136 Ventures+6 more
Cylera provides a healthcare cybersecurity platform focused on connected medical devices, IoT, and IT assets, giving hospitals and health systems visibility, risk assessment, and threat detection across their environments.
CybersecurityHealthtechIoTNew York, US
Timur Ozekcin(Executive Officer, Director)inSean Abraham(Executive Officer, Director)inApostolos Bakoyiannis(Executive Officer)Owen Wilson(Director)
Co-investorsAlumni VenturesContour Venture PartnersDreamit VenturesEpsilon Health InvestorsFrontier Path VCGreat Oaks Venture Capital+7 more
Etched designs custom inference chips, racks, and software co-designed for running frontier AI models, including large sparse mixture-of-experts models, long-context, and agentic workloads.
AI & Machine LearningHardwareSemiconductorsSan Jose, US
Gavin Uberti(Founder)inRobert Wachen(Founder)Chris Zhu(Founder)inMark Ross(CTO)inBrian Loiler(VP of Platform)inWayne Cao(VP of Production)in
Co-investorsThiel CapitalAntiAZURO CAPITAL VENTURESBain Capital VenturesBeyond CapitalConversion Capital+29 more
Experiment is a platform for discovering, funding, and sharing scientific research.
Deep TechHealthtechMarketplacesSaaSHonolulu, US
Denny Luan(Founder)inSkander Mzali(CTO)Cindy Wu
Co-investorsK5 VenturesMetaplanetY Combinator500 GlobalAndreessen HorowitzFounder Collective+11 more
Facet provides personal financial planning and investment management, using diversified low-cost, tax-efficient ETF portfolios paired with a dedicated CFP professional.
ConsumerFintechSaaSBaltimore, US
ANDERSON JONES(Executive Officer, Director, Promoter)Anders Jones(Founder)inPatrick McKenna(Founder)inPAUL MARTIN(Executive Officer)inSHRUTI JOSHI(Executive Officer)inDARSHAN PATEL(Executive Officer)in
Co-investorsAccelerator VenturesMultiplier CapitalWarburg PincusAccelBasis Set VenturesDurable Capital Partners+4 more
New York, US
Dustin Byrne(Director)David Eisenberg(Executive Officer, Director)
BoardStuart Ellman(Director)
Co-investorsLerer HippeauFelicis VenturesRRE Ventures
Freestyle provides Linux virtual machines that provision in milliseconds with integrated version control, designed for running distributed agents at scale.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US
Bۙۚۨ۫ۙۚۨ۫ۙۚۨ۫ۙۚۨ۫enjamin Sweۖۖۖۖۘۘۘۘۖۖۖۖۘۘۘۘۖۖۖۖrdlow(Founder)inJacob Zwang(CTO)inAllen Naliath(Founder)inBenjamin Swerdlow(CEO)in
Co-investorsTranspose Platform ManagementY Combinator468 CapitalAdapt VenturesECP GrowthFoundry+3 more
Hexagon Bio develops novel payload mechanisms for antibody-drug conjugates (ADCs) aimed at overcoming resistance to current cancer treatments and expanding ADC indications.
BiotechDeep TechHealthtechMenlo Park, US
Colin James Bell Harvey(Director)Brian T. Naughton(Director)inMaureen Hillenmeyer(CEO & Co-Founder)in
BoardAlex Kolich(Director)
Co-investorsATEL VenturesB3 HoldingNextech InvestSoftBank Vision FundThe Column Group8VC+1 more
HeyMilo provides AI-powered recruiting tools for hiring teams, including adaptive voice, video, phone, and SMS interviews, resume screening, cheat/impersonation detection, and analytics.
AI & Machine LearningHR TechSaaSNew York City, US
Ramie R(Founder)Sabashan Ragavan Ramie Raufdeen(Founder)
Co-investorsAlumni VenturesCanaan PartnersCategory VenturesEntrepreneurs Roundtable Accelerator (ERA)Remarkable Ventures
Highbeam is a financial technology company (not a bank) offering banking services, credit, spend management, and AI agents that automate finance tasks like treasury, reporting, and scenario analysis.
AI & Machine LearningDirect to ConsumerE-commerceFintechSaaSNew York, US
Samir Shergill(Founder)inGautam Gupta(Founder)in
BoardJohn Gardner(Director)inAmish Jani(Director)inRishi Garg(Director)
Co-investorsAcrew CapitalFirstMark CapitalMana VenturesMayfield FundVesey Ventures
New York, US
Colin Beirne(Director)Adam Simowitz-Price(Executive Officer, Director, Promoter)Jeffrey Silverman(Director)in
Co-investorsAlpine MeridianFJ LabsLaconiaLerer HippeauRSE Ventures
Analytics and forecasting solutions for revenue teams.
Boston, US
Frederick Shilmover(Executive Officer, Director)Courtland Cunningham(Director)
BoardJeff Fagnan(Director)
Co-investorsNextView VenturesOnStartupsTola CapitalAccompliceDraper Fisher Jurvetson (DFJ)
insitro is a drug discovery and development company that uses machine learning and cellular data to identify therapeutic insights and accelerate the creation of new medicines.
AI & Machine LearningBiotechSouth San Francisco, US
Daphne Koller(Founder)inDuane Valz(General Counsel)inMary Rozenman(Chief Financial Officer)in
BoardRobert Nelsen(Director)Vijay Pande(Director)in
Co-investorsAndreessen HorowitzARCH Venture PartnersDeviation CapitalForesite CapitalGV (Google Ventures)HOF Capital+9 more
Kallyope is a biotechnology company founded by neuroscientists that discovers and develops novel therapeutics targeting neural networks, with a lead candidate in pivotal studies for acute migraine treatment and metabolism programs approaching clinical studies.
BiotechHealthtechNew York City, US
Tom Maniatis(Founder)Nancy Thornberry(Executive Officer, Director)inKenneth Clark(Executive Officer)Charles Zuker(Founder)Richard Axel(Founder)
BoardTerry McGuire(Director)in
Co-investorsDns CapitalIllumina VenturesLux CapitalThe Column GroupPolaris Partners
Lully develops an under-mattress device that uses timed vibrations to prevent night terrors in children.
HealthtechWellness & FitnessSan Francisco, US
Varun Boriah(CEO)inAndy Rink(CMO)in
Co-investorsStartXY Combinator8capitaAgrolimen VenturesAstiaGFO Companies+3 more
Membrane Labs provides an institutional infrastructure platform for digital asset credit, unifying counterparty discovery, loan workflows, and collateral management with real-time visibility, automated margin enforcement, and multi-custodian connectivity.
Crypto & Web3Enterprise SoftwareFintech
Carson Cook(Founder)in
Co-investorsArca FundsBelvedere Strategic CapitalElectric CapitalFourth Revolution Capital (4RC)Lvna CapitalMarin Digital Ventures+11 more
Mio provides interoperability across collaboration platforms, enabling users to send messages, manage identities, share files, and initiate meetings across different systems.
Developer ToolsEnterprise SoftwareSaaSAustin, US
Tom Hadfield(CEO)inJames Cundle(CTO)in
Co-investorsCisco InvestmentsEniac VenturesNewtown PartnersY CombinatorCapital FactoryFour Cities+10 more
MonetizeNow provides a unified platform combining configure-price-quote (CPQ), billing, and metering capabilities for SaaS businesses.
Enterprise SoftwareFintechSaaSSanta Clara, US
Sandeep Jain(Founder)inJeff Gibson(Founder)in
Co-investorsUncork CapitalGTMfundCategory VenturesNext Frontier Capital
Nelo offers a mobile credit app for consumers in Mexico, letting users get approved for credit and pay in biweekly installments.
ConsumerFintechMexico City, MX
Kyle Miller(Founder)inStephen Hebson(Founder)in
Co-investorsEastward Capital PartnersHomebrewTop Corner CapitalAnthony PomplianoGaingelsGokul Rajaram+4 more
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NetBox Labs offers NetBox, a platform for documenting, modeling, automating, and securing network and data center infrastructure, including IP address management and a source of truth for physical and virtual assets.
Cloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareNew York, US
Bill Lapcevic(Founder)inKristopher Beevers(Founder)Salil Jani(Founder)inXiao Wei(Executive Officer)inJeremy Stretch(Founder)Kris Beevers(Founder)
Co-investorsEntrée CapitalFlybridge Capital PartnersFounder CollectiveHumans Of The InternetMango CapitalNGP Capital+3 more
NewtonX runs a B2B market research platform that combines AI with a network of vetted experts to recruit participants, collect survey and interview data, and deliver automated analysis.
AI & Machine LearningData & InfrastructureEnterprise SoftwareMarketing TechNew York, US
Sascha Eder(Founder & CEO)Jeremy Wood(Co-founder)inSascha Hoffman(Founder & CEO)Germain Chastel(Executive Officer, Director, Promoter)Rebecca Minguela(Director)
BoardWes Barton(Director)in
Co-investorsLevel One FundMana VenturesSprint VcStory VenturesThird PrimeFin Lab AG+1 more
Obvious is an AI agent platform that collaborates with users to generate work artifacts and complete tasks.
AI & Machine LearningEnterprise SoftwareSaaS
David Boskovic(Founder)inEric Crane(Founder)
Co-investorsAlumni VenturesFounder CollectiveAfore CapitalDesigner FundGradient VenturesInsight Partners+3 more
Okteto is a developer platform that enables teams to develop cloud-native applications by moving development and preview environments into the cloud.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US
Ramiro Berrelleza(Founder)inPablo Chico de Guzman(CTO)inRamon Lamana(Founder)inRamiro Antonio Berrelleza Perez(Executive Officer, Director, Promoter)Ashlynn Pericacho(Head of Marketing)Leandra Sivess(Head of People)
Co-investorsMAGIC FundRoot Ventures Manager, LlcUncorrelated VenturesY CombinatorAgrolimen VenturesHaystack+4 more
Osmo develops artificial intelligence and computational tools for fragrance creation and ingredient discovery.
AI & Machine LearningConsumerDeep TechNew Jersey, US
Alex Wiltschko(Founder)inRohinton Mehta(Founder)inJérôme Scholler(Founder)Pramod Sharma(Founder)
Co-investorsLux CapitalAlumni VenturesCollaborative FundDeviation CapitalGV (Google Ventures)Accel+2 more
Per Diem builds a mobile app builder designed for local restaurant and coffee shop owners to compete with larger chains by turning customers into loyal patrons.
ConsumerEnterprise SoftwareMarketing TechRetail TechSaaSNew York City, US
Tomer Molovinsky(Founder)inDoron Segal(Founder)inRachel Segal(Head of People)
Co-investorsY CombinatorDecent CapitalDnx VenturesShare Ventures
Pryon provides a memory layer platform that helps enterprises move AI projects into production by ingesting, governing, and securing content across multiple formats and sources.
AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSRaleigh, US
JD Vance(Director)Igor Jablokov(Founder)
Co-investors7BC Venture CapitalAperture Venture CapitalCrosscourt VenturesDuke Capital PartnersGood Growth CapitalGreycroft+9 more
Qvin develops the Q-Pad, an FDA-cleared diagnostic menstrual pad that collects menstrual blood samples for non-invasive health monitoring and disease diagnosis.
Digital HealthFemTechHealthtechMedical DevicesWellness & FitnessSan Francisco, US
Sara Naseri(Founder)inSøren Therkelsen(Founder)inJoshua Ehrlich(Software Lead)
Co-investorsAlumni VenturesbyFoundersInventureKluz VenturesSand Hill AngelsSoma Capital+15 more
Raincoat develops climate insurance solutions that interconnect insurance providers, reinsurers, distributors, and end-users by using real-time environmental data and sophisticated models.
AI & Machine LearningClimate TechInsurTech
Jonathan Gonzalez(Founder)
Co-investorsAnthemis VentureMundi VenturesOpen Opportunity FundR/GA Ventures305 VenturesDivergent Capital+2 more
Remote helps companies hire, pay, and manage employees internationally by removing barriers to cross-border employment.
Future of WorkHR TechSaaSSan Francisco, US
Marcelo Lebre(Founder)inJob van der Voort(Founder)in
BoardVilli Iltchev(Director)Brett Rochkind(Director)Miles Clement(Director)Niko Bonatsos(Director)in
Co-investorsAccelB Capital GroupB4 CapitalBase PartnersCategory VenturesDaft Capital+15 more
RentHop is an apartment rental marketplace that connects renters with listings ranked by freshness, accuracy, and property manager responsiveness, while providing brokers and property managers a platform to post listings and reach qualified tenants.
MarketplacesPropTechNew York City, US
Lawrence Zhou(Founder)inLee Lin(Founder)inLee C. Lin(Founder)Lux Chen(Director of Product Development)inShane Lee(Manager)Faye Chou(Managing Director)
Co-investorsY CombinatorJoyance PartnersSocial Starts
Replicated provides a container-based platform for software vendors to deploy cloud-native applications in customer environments.
Cloud ComputingDeveloper ToolsEnterprise Software
Grant Miller(Founder)Marc Campbell(Founder)
Co-investorsAmplify Partnersboldstart venturesFounder CollectiveHeavybitMucker CapitalPlexo Capital+7 more
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Boston, US
Rodney Brooks(Executive Officer, Director)inWilliam Scott Eckert(Executive Officer, Director)Steven Daignault(Executive Officer)
BoardPaul Maeder(Director)inPaul Flanagan(Director)Devdut Yellurkar(Director)
Co-investorsBezos ExpeditionsCRV (Charles River Ventures)Draper Fisher Jurvetson (DFJ)GE VenturesGoldman SachsHighland Capital Partners+1 more
Rive is a design and animation platform where creators build interactive experiences that run natively across web, mobile apps, games, and devices using an open-source runtime and GPU-accelerated vector graphics engine.
Creator EconomyDeveloper Tools
Guido Rosso(Founder)inCraig Sartor(Founder)inLuigi Rosso(Founder)
Co-investorsAbstract VenturesAndreessen HorowitzBMW i VenturesCategory VenturesDeviation CapitalUnusual Ventures+2 more
Sleuth helps development teams ship code faster by making knowledge accessible for AI and easy to use.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US
Dylan Etkin(Founder)inDon Brown(Founder)Michael Knighten(Founder)
Co-investorsCRV (Charles River Ventures)Felicis VenturesMenlo VenturesAmplify PartnersBenchmarkBison Ventures+15 more
Socure provides an AI-driven platform for digital identity verification, fraud prevention, and risk decisioning, serving enterprises and government agencies across financial services, gaming, healthcare, e-commerce, and other sectors.
AI & Machine LearningCybersecurityFintechNew York, US
Johnny Ayers(Founder)in
BoardJohn F. Frankel(Director)inSunil Madhu(Founder)inAlessandro Piol(Director)Pavlo Protopapa(Director)Philip Eytan(Director)
Co-investorsAccelAlpha PartnersAltaIR CapitalAmity VenturesBain Capital VenturesCommerce Ventures+23 more
Steadily provides landlord insurance policies that protect rental property owners against property damage, liability claims, and lost rental income.
FintechInsurTechPropTechBeaverton, US
Darren Nix(Founder)inDavid Tulig(Founder)inDatha Santomieri(Founder)in
BoardJake Jolis(Director)
Co-investorsClocktower VenturesDeviation CapitalMatrixNext Coast VenturesNight CapitalNine Four Ventures+3 more
Suplari provides procurement intelligence and AI agents for enterprise procurement teams, helping them consolidate fragmented data and automate decision-making and execution without replacing existing systems.
AI & Machine LearningData & InfrastructureEnterprise SoftwareSeattle, US
Jeff Gerber(Founder)inNikesh Parekh(Founder)inBrian White(Founder)inMark Jancola(Founder)in
BoardMatt McIlwain(Director)
Co-investorsAmplify PartnersMadrona Venture GroupWorkday VenturesShasta Ventures
Swarm Aero develops UAVs designed for autonomous swarming, using on-aircraft edge compute and a sensor mesh so small teams can coordinate thousands of uncrewed air, sea and ground vehicles in contested, communications-limited environments.
AI & Machine LearningDefense TechRobotics
Danny Goodman(Founder)inPeter Kalogiannis(Founder)inOliver Palmer(Founder)in
Co-investorsChampion Hill VenturesHubSpot VenturesMaC Venture CapitalScribble VenturesSilent CapitalStartX+7 more
SWARM is a decision intelligence platform that helps agrifood and manufacturing organizations solve operational challenges by defining problems clearly before deploying agentic AI and optimization algorithms.
Advanced ManufacturingAgTechAI & Machine LearningData & InfrastructureEnterprise Software
Co-investorsS2G InvestmentsHarvard Business Angels of ChicagoMiddleland CapitalVTC VenturesAlumni VenturesChampion Hill Ventures+12 more
Swarm builds uncrewed aerial vehicles (UAVs) designed for swarming, combining on-aircraft autonomy, sensor mesh, and edge compute so small teams can coordinate thousands of air, sea, and ground assets in contested, communications-limited environments.
Defense TechHardwareRobotics
Danny Goodman(Executive Chairman)inOliver Palmer(CRO)inPeter Kalogiannis(CEO)in
Co-investorsAlumni VenturesCoatue ManagementConstruct CapitalHumba VenturesMaC Venture CapitalChampion Hill Ventures+8 more
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Terray is a drug discovery company that combines proprietary hardware, large-scale experimental datasets, and AI through its EMMI platform to design small molecule medicines.
AI & Machine LearningBiotechDeep TechPasadena, US
Eli Berlin(Founder)inJacob Berlin, Ph.D.(Chief Executive Officer)Jacob Berlin(Founder)Jacob Berlin Eli Berlin(Founder)Nathan Collins(Founder)
BoardChris Picardoin
Co-investorsDeviation CapitalDigitalis VenturesMadrona Venture GroupSummit Peak InvestmentsAlexandriaKdT Ventures+5 more
Text Blaze is a productivity tool that creates text snippets and templates to reduce repetitive typing across web applications.
Developer ToolsEnterprise SoftwareFuture of WorkSaaSSan Francisco, US
Dan Barak(Founder)inScott Fortmann-Roe(Founder)inGaurang Tandon(Engineer)
Co-investorsFourth RealmY CombinatorBossa InvestFoley VenturesGlobal Founders CapitalParadox Capital+1 more
Tiger Data, creators of TimescaleDB, builds a Postgres-based time-series database for fast ingest, efficient storage, and real-time analytics at scale.
Cloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareIoTNew York, US
Ajay Kulkarni(Founder)inMikeinMichael J. Freedman(Co-founder and Chief Technology Officer)inRahil Sondhi(Founder of acquired PopSQL; joined Timescale in 2024)inKerri Damm(Chief Financial Officer)inRamon Guiu(Vice President, Product)in
Co-investorsIcon VenturesNew Enterprise Associates (NEA)Redpoint VenturesBenchmarkTiger Global Management
Tive provides visibility solutions for supply chain and shipment operations, helping stakeholders track and manage shipments to ensure on-time and complete delivery.
HardwareIoTLogistics & Supply ChainSaaSBoston, US
Krenar Komoni(Founder)in
BoardRaju Rishi(Director)Andy Cohen(Director)Alex Scherbakovsky(Director)
Co-investorsBaukunstBeaconsfield CapitalBroom VenturesBVVCFloating PointHyperplane Venture Capital+16 more
Freedom Rave Wear operates a branded resale platform for pre-loved rave fashion, enabling peer-to-peer and off-price sales of both customer items and brand-direct inventory.
Circular EconomyClimate TechDirect to ConsumerE-commerceRetail TechSan Francisco, US
Jacob Disraeli(Executive Officer, Director)Jake Disraeli(Founder)inMichael Hodgens(Chief AI Officer)inSonia Yang(Founder)
Co-investorsAlante CapitalBAM VenturesBBG VenturesBling CapitalGreen Meadow VenturesInterlace Ventures+4 more
Treet offers a web and mobile platform for remotely using pharmacy services, letting users order products and consult with pharmacists for same-day delivery within hours.
Digital HealthE-commerceHealthtech
Co-investorsNostetta VenturesAlante CapitalBAM VenturesBBG VenturesBling CapitalFirst Round Capital+5 more
Verge Labs builds AI models trained on multimodal human patient data to predict drug targets and patient populations for clinical development, primarily in neuroscience and central nervous system (CNS) disease.
AI & Machine LearningBiotechDeep TechDigital HealthHealthtechSan Francisco, US
Alice Zhang(CEO)inJason Chen(Founder)inEmily Ripka(Vice President Product \u0026 Engineering)inNaveen Jain(Investor)inGeorge Spencer(Operations)
Co-investorsAgent CapitalALS Investment FundBOLD LongevityDraper AssociatesFitz Gate VenturesGreat Oaks Venture Capital+28 more
Vilya designs novel macrocycles using AI and computational biology to create medicines that don't exist in nature.
AI & Machine LearningBiotechDeep Tech
David Baker(Founder)Patrick Salveson, PhD(Co-Founder, CTO)Adam Moyer, PhD(Co-Founder, VP of Molecular Design)David Baker, PhD(Nobel laureate, Co-Founder, Director, IPD UW, Prof. Biochemistry)Gaurav Bhardwaj, PhD(Co-Founder, UW, Asst. Prof. Medicinal Chemistry)Lance Stewart, PhD, MBA(Co-Founder, CSO & COO, IPD)
Co-investorsARCH Venture PartnersMadrona Venture GroupMenlo VenturesAltitude Ventures Management, LlcAlumni VenturesAtomic+10 more
Walden Robotics develops general-purpose robots that combine hardware, software, and physical AI systems for deployment in manufacturing and logistics environments.
Advanced ManufacturingAI & Machine LearningHardwareRoboticsCambridge, US
Russell Louis Tedrake(Executive Officer, Director)Ben Burchfiel(Founder)inKerri M. Fetzer-Borelli(Executive Officer)David Marvin Slaughter Johnson(Executive Officer)Adrien David Gaidon(Executive Officer)Russ Tedrake(Founder)
Co-investorsDeviation CapitalCalibrate VenturesColle Capital PartnersNextView VenturesShine CapitalThe E14 Fund+7 more
Wealthsimple is a Canadian financial services company offering investing, stock and crypto trading, saving and spending accounts, and tax filing through a simplified consumer platform.
ConsumerCrypto & Web3FintechSaaSToronto, CA
Michael Katchen(Founder)inBrett Huneycutt(Founder)inRudy Adler(Founder)inRadhika Kakkar(Chief Operating Officer)inDiederik van Liere(Chief Technology Officer)inLeen Li(Former CFO; CEO, Wealthsimple Foundation)in
Co-investorsAlkeon InnovationAllianz XDeviation CapitalDiagramDragoneer Investment GroupDST Global+19 more
Weights & Biases is an AI developer platform that enables teams to build, train, and monitor AI agents, applications, and models with tools for experiment tracking, model management, and agent evaluation.
AI & Machine LearningData & InfrastructureDeveloper ToolsSan Francisco, US
Shawn Lewis(Founder)inLukas Biewald(Founder)inChris Van Pelt(Founder)inMariah Nagy(Executive Officer)inYan-David Erlich(Executive Officer)inCameron Kinloch(Executive Officer)in
Co-investorsAIX VenturesBond Capital ManagementBrighter CapitalBrilliant Phoenix CapitalCoatue ManagementDiagram Capital+41 more
Zeal is an embedded payroll and workforce payments platform for staffing companies, labor marketplaces, and workforce management tools.
FintechHR TechSaaSSan Francisco, US
Pranab Krishnan(Founder)inKirti Shenoy(Founder)inJonathan MairenaHenry Guillen(Founding Engineer)Alex Dees(Partner Growth Manager)Grace Turner(Lead Recruiter)
Co-investorsCommerce VenturesSpark CapitalBoxGroupCohen CircleLorimer VenturesY Combinator+15 more
Engineers microbes that make useful molecules for everyday materials (acquired by Ginkgo Bioworks).
Emeryville, US
Erik (Jed) Dean(Executive Officer)Zachariah Serber(Executive Officer, Director)Josh Hoffman(Founder)inEnakshi Singh(Executive Officer)Aaron Kimball(Executive Officer)Jed Dean(Founder)
Co-investorsAME Cloud VenturesCota CapitalDCVC (Data Collective)Hemisphere Ventures LLCKindred VenturesMission Biocapital+6 more
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Bark TechnologiesWings Capital PartnersAnkiDistributionalMyriad AIObjectivePer Diem Subscriptions, Inc.Small MoleculesSpellStrapXilis, Inc.
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 10
4 IPOs · 6 acquisitions · showing 8DevvStreamOTC: DEVSFXCF GlobalNASDAQ: SAFXGitlabNASDAQ: GTLBRecursion PharmaceuticalsNASDAQ: RXRXLyticsacq. by ContentstackCoverWalletacq. by AonInsightSquaredacq. by MediaflyObjectiveacq. by Upwork
Portfolio news
latest coverage across their companies
Socure · angelinvestorsnetwork.com · Sep 22, 2026
XCF Global · stocktitan.net · Aug 27, 2026
Etched · techcrunch.com · Aug 18, 2026
Walden · finsmes.com · Jul 15, 2026
Steadily · steadily.com · Jun 28, 2026
HeyMilo · finsmes.com · Jun 16, 2026
Antioch · finsmes.com · Apr 20, 2026
Frequently asked questions
- How many investments has Two Sigma Ventures made?
- Two Sigma Ventures has 94 tracked investments, 10 of which have exited, including 21 dated in the last 24 months.
- What stage does Two Sigma Ventures invest at?
- Two Sigma Ventures invests at the Seed, Series A, Series B stages.
- What is Two Sigma Ventures's typical check size?
- Two Sigma Ventures typically writes checks of $2M – $15M.
- What sectors does Two Sigma Ventures focus on?
- Two Sigma Ventures focuses on Biotech, Consumer, Data & Infrastructure, EdTech, Enterprise Software, Fintech, Hardware, Healthtech, SaaS, Sector Agnostic.
- Where is Two Sigma Ventures located?
- Two Sigma Ventures is headquartered in New York, US.
- Does Two Sigma Ventures lead rounds?
- Yes, Two Sigma Ventures leads investment rounds.
- Who does Two Sigma Ventures co-invest with?
- Two Sigma Ventures most often shares deals with DST Global, Greylock Partners, ICONIQ, among 19 tracked co-investors.
Media · Podcasts & interviews
featuring the teamInvesting in Disruptive Tech for Manufacturing Industry - Colin Beirne, Two Sigma Ventures #shorts
VentureFizz · Colin Beirne
#125 Frances Schwiep | Partner @ Two Sigma Ventures - WIN/WIN: Women in Innovation | Acast
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25 Years of Curiosity: 5 Roles, 2 Continents | Wei, Quant
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Co-investors · 128
Alumni Ventures (AV) is a venture capital firm that co-invests alongside lead VCs in startups, backing founders with capital and access to a large investor and operator community.
Founder Collective is a seed and pre-seed stage venture capital firm that invests across sectors, describing itself as sector agnostic and anti-thematic.
Andreessen Horowitz (a16z) is a venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz, known for pioneering the platform model with a large team of operators supporting founders across stages.
Coatue Management is a technology-focused investment firm that invests in innovation across both public and private markets with responsible risk management.
Tiger Global Management operates public equity strategies (long/short, long-focused and crossover) and a private equity business investing in early- through late-stage growth companies across new and existing industries.
Techstars is a global startup accelerator and early-stage investor that funds and mentors ambitious founders, providing $220K in capital, a three-month program, and access to a worldwide network of mentors, investors, and corporate partners.
Lux Capital is a venture capital firm that backs founders building transformative deep technologies, having been among the first investors in category-defining companies across AI, robotics, biotech, defense, and infrastructure.
Sequoia Capital is a venture capital firm that partners with founders to build technology companies.
GV (Google Ventures) is a venture capital firm that has invested in AI and machine learning since its early days, backing more than 100 AI companies across infrastructure, life sciences, and applications.
Founders Fund is a venture capital firm that backs technology companies building transformative products.
Scale Venture Partners is an early-stage venture capital firm that partners with AI companies, supporting their transition from founder-led growth to a scalable go-to-market operation.
SoftBank Vision Fund invests globally in AI-focused companies working to transform and create industries.
▶116 more co-investors
FoundryAccelKhosla VenturesIndex VenturesInsight PartnersBoxGroupDCVC (Data Collective)Madrona Venture GroupAmplify PartnersAccompliceRedpoint VenturesFirst Round CapitalSound VenturesCRV (Charles River Ventures)Susa VenturesBling CapitalSoma CapitalPrimary Venture PartnersScribble VenturesThe Column GroupInkefGreylock PartnersLong Journey VenturesNotable CapitalBenchmarkGradient VenturesCaffeinated CapitalAfore CapitalSouth Park Commons8VCBase10 PartnersHomebrewAIX VenturesWorklife VenturesICONIQ CapitalARCH Venture PartnersHeavybitPresence CapitalRA CapitalConstruct CapitalDigitalis VenturesBrewer Lane VenturesDesigner FundMPG FundGovtech FundUncork CapitalTrue VenturesFirstMark CapitalFundersClubFreestyle CapitalInnovation EndeavorsStellar CapitalAdditionResolute VenturesBowery CapitalF-Prime CapitalElectric CapitalIA VenturesRevolutionDCM VenturesTribe CapitalCiti VenturesFuel Capital23andMeAugust Capital468 CapitalWork-BenchBaruch Future VenturesFika9Yards CapitalWhat If VenturesBootstrapLabsDay One VenturesPortage VenturesAV8 VenturesFirsthandVCSignal Peak VenturesA*Ingeborg InvestmentsNextech InvestDTCPGood Growth CapitalOverwater Ventures LlcAtomicoGoat CapitalPartech VenturesOak HC/FTPhysical IntelligenceForerunner VenturesLookout VenturesEmergence Capital PartnersCrosslink CapitalRed Swan VenturesTrajectory VenturesOperator LPBlockchain CapitalPareto HoldingsCoinbase VenturesGotham Gal VenturesFuture Perfect VenturesZ47Convective CapitalRace CapitalBasecamp FundAsset Management VenturesEight Roads VenturesEVE AtlasHorizonIndie.vcAudaciousSTILLMARKUnicorn India VenturesNew Markets Venture PartnersAmerica's Frontier FundBonsal CapitalMetalayer
Firms observed investing alongside Two Sigma Ventures, from public investor directories. Shared companies are the overlap with Two Sigma Ventures's recorded portfolio.
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