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Third Rock Ventures

Venture capitalActively deploying

Boston · Seed–Series C · 76 people tracked

Also known as THIRD ROCK VENTURES, LLC

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Investment thesis

Third Rock Ventures focuses on creating and building transformative healthcare and life sciences companies. It works closely with founders to discover, launch, build, and scale ventures developing breakthrough therapeutics and medical technologies across areas such as oncology, immunology, genetic medicine, gene therapy, precision genome engineering, and mental health. The firm emphasizes founding companies around ambitious scientific ideas that can address serious unmet medical needs and deliver meaningful patient impact, with a track record of advancing assets to FDA approval and successful acquisitions by major pharmaceutical companies.

Source: firm website, verified Aug 3, 2026.

Stage
Seed–Series C
Check
$100K – $5M
HQ
Boston, Massachusetts, US
Leads rounds
Follows
Instruments
Equity
Founded
2007
AUM
$3.8B
VC funds
5
Tracked investments
49

Team · 76 people

from the firm's website & public directories
Corey O'Keeffein
Greg O'Brienin
Jefte Drijversin
Jesper Gromadain
Julia O'Connor
Marc Crowley
Nicole Matthews
Nicole Raby
Rebecca Mancusiin
Richard Chesworthin
Sara DeAmicisin
Scott Frechettein
Stacey Heroin
Stephen Sherwin
Tracy Nicholson

What they invest in

from 40 of 49 portfolio companies

Biotech ×37Healthtech ×7Medical Devices ×7AI & Machine Learning ×4Deep Tech ×1Digital Health ×1Enterprise Software ×1

HQs:United States×41

Investments · 49 tracked

founders shown can be your intro path
CytomX TherapeuticsNASDAQ: CTMXSEC filingmedium confidence

Clinical-stage biotechnology company developing conditionally activated, masked biologics designed to be localized to the tumor microenvironment.

BiotechSouth San Francisco, US

Tim Shannon(Director)Frederick W. Gluck(Director)Elaine V. Jones(Director)Sean McCarthy(Executive Officer, Director)Neil Exter(Director)Hoyoung Huh(Director)

Board seatNeil Exter· per SEC Form D · $30M raise · filed Jan 2015

Fulcrum TherapeuticsNASDAQ: FULCSEC filinghigh confidence

BiotechCambridge, US

Alan Ezekowitz(Director)James Collins(Director)Mark Levin(Director)Robert Gould(Executive Officer, Director)James Geraghty(Director)

Board seatMark Levin· per SEC Form D · $55M raise · filed Jul 2017

KALA BIOkalarx.comNASDAQ: KALASEC filingmedium confidence

BiotechArlington, US

Darius Kharabi(Executive Officer)Todd Bazemore(Executive Officer)Mark Iwicki(Executive Officer, Director)Mary Reumuth(Executive Officer)Kim Brazzell(Executive Officer)Charles McDermott(Executive Officer)

Board seatRobert Tepper· per SEC Form D · $7M raise · filed Aug 2015

Pliant Therapeuticspliantrx.comin𝕏NASDAQ: PLRXSEC filinghigh confidence

Pliant Therapeutics is a clinical-stage biopharmaceutical company developing integrin-based therapeutics to treat serious diseases.

BiotechSouth San Francisco, US

Kevin Raidy(Director)Suzanne Bruhn(Director)Johannes Hull(Executive Officer)John Curnutte(Director)Hoyoung Huh(Director)Neil Exter(Director)

Board seatCharles HomcyNeil Exter· per SEC Form D · $62.1M raise · filed Jul 2018

Revolution MedicinesNASDAQ: RVMDSEC filinghigh confidence

BiotechRedwood City, US

Laurence Lasky(Director)Alexis Borisy(Director)Margaret Horn(Executive Officer)Michael Bonney(Director)Mark A. Goldsmith(Executive Officer, Director)Elizabeth Anderson(Director)

Board seatNeil ExterBarbara Weber· per SEC Form D · $100.3M raise · filed Nov 2019

Rhythm PharmaceuticalsNASDAQ: RYTMSEC filingmedium confidence

BiotechBoston, US

Edward T. Mathers(Director)David J. McGirr(Director)Jonathan Silverstein(Director)Keith Gottesdiener(Executive Officer, Director)David P. Meeker, M.D.(Director)Neil Exter(Director)

Board seatNeil Exter· per SEC Form D · $40M raise · filed Dec 2015

SepternaNASDAQ: SEPNSEC filingmedium confidence

South San Francisco, US

Board seatJeffrey Tong· per SEC Form D · $150M raise · filed Jul 2023

Tango Therapeuticstangotx.comNASDAQ: TNGX

Tango Therapeutics develops genetically targeted medicines using synthetic lethality principles to treat specific tumors.

BiotechBoston, US

John Ketchum(Director)Barbara Weber(Executive Officer, Director)Malte Peters(Director)Kanishka Pothula(Director)Lesley Ann Calhoun(Director)Mace Rothenberg(Director)

Board seatAlexis BorisyReid Huber· per SEC Form D

Agios Pharmaceuticalsagios.comin𝕏NASDAQ: AGIO

Agios is a biopharmaceutical company developing therapies for rare diseases, with a primary focus on hemolytic anemias including pyruvate kinase deficiency, thalassemia, and sickle cell disease.

BiotechHealthtechMedical Devices<UNKNOWN>

Azalea Therapeuticsazaleatx.comin✓ verified

Azalea Therapeutics develops precision genome editing therapies that engineer T cells directly inside the patient's body to create cancer immunotherapies, using proprietary delivery vehicles to target and modify specific genetic loci without ex vivo cell manipulation.

AI & Machine LearningBiotechMedical DevicesSan Francisco, US

Jennifer Doudna(Co-founder, Nobel Laureate in Chemistry and Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences, UC Berkeley)Rodolphe Barrangou(Co-founder, Associate Professor of Medicine, UCSF)Krishnendu Roy(Co-founder, Professor of Bioengineering, Stanford University)Connor Tsuchida(Scientific Cofounder)

Vibe Biovibebio.comin𝕏✓ verified

Vibe Bio funds and supports overlooked drug development programs by combining AI and capital to identify promising treatments and reduce funding gaps.

AI & Machine LearningBiotechEnterprise Software

Alok Tayi(CEO & Founder)

Abata TherapeuticsSEC filinghigh confidence

BiotechCambridge, US

SAMANTHA SINGER(Executive Officer, Director)ABBIE CELNIKER(Director)MITCH FINER(Director)NAGESH MAHANTHAPPA(Director)LORENCE KIM(Director)SANDY LAZZARI(Executive Officer)

Board seatDavid KaufmanAbbie Celniker· per SEC Form D · filed Dec 2023

Afferent PharmaceuticalsSEC filingmedium confidence

BiotechSan Mateo, US

Kevin Starr(Director)Michael Kitt(Executive Officer)Arthur Pappas(Director)Anthony Ford(Executive Officer)Kathleen Sereda Glaub(Executive Officer, Director)Peter Hirth(Director)

Board seatKevin Starr· per SEC Form D · $55M raise · filed Jul 2015

Arbor Biotechnologiesarbor.bioin𝕏SEC filingmedium confidence

Arbor develops programmable DNA editors for genetic medicine, aiming to enable functional cures for patients by addressing genetic diseases through bespoke gene editing approaches.

BiotechDigital HealthMedical DevicesCambridge, US

KEITH CRANDELL(Director)DAVID ARTHUR SCOTT(Executive Officer)WINSTON XIA YAN(Executive Officer)ANNIE HAZLEHURST(Director)FENG ZHANG(Director)

BoardDAVID R. WALT(Director)

Board seatMark Angelino· per SEC Form D · $215M raise · filed Nov 2021

Asher Biotherapeutics, Inc.SEC filingmedium confidence

BiotechSouth San Francisco, US

Yik Andy Yeung(Executive Officer, Director, Promoter)Ivana Djuretic(Executive Officer, Director, Promoter)

Board seatJeffrey TongReid Huber· per SEC Form D · $55M raise · filed Apr 2024

AtterocorSEC filingmedium confidence

BiotechAnn Arbor, US

Carol Gallagher(Director)Randall Whitcomb(Director)James Topper(Director)Julia C. Owens(Executive Officer, Director)William Harrington(Director)

Board seatMary Lynne Hedley· per SEC Form D · $59.1M raise · filed Dec 2017

Cardurion Pharmaceuticals, Inc.SEC filingmedium confidence

BiotechBurlington, US

Michael Mendelsohn(Executive Officer, Director)

BoardEvan Rachlin(Director)Peter Lawrence(Executive Officer, Director)Edward Mathers(Director)Adam Koppel(Director)Nicholas Downing(Director)

Board seatJeb Keiper· per SEC Form D · $10M raise · filed Nov 2019

Cedilla Therapeutics, Inc.SEC filinghigh confidence

BiotechCambridge, US

Abbie Celniker(Director)Alexandra Glucksmann(Executive Officer, Director)Dominik Naczynski(Director)Eli Casdin(Director)Chris Bowden(Director)Neil Exter(Director)

Board seatAbbie CelnikerNeil Exter· per SEC Form D · $82.6M raise · filed Oct 2021

Constellation PharmaceuticalsSEC filingmedium confidence

BiotechCambridge, US

Tom Maniatis(Director)Michael R. Cooper(Executive Officer)Anthony Evnin(Director)James E. Audia(Executive Officer)Keith Dionne(Executive Officer, Director)Matthias Jaffe(Executive Officer)

Board seatRobert Tepper· per SEC Form D · $55.8M raise · filed Dec 2015

Corvia MedicalSEC filingmedium confidence

BiotechTewksbury, US

Paul LaViolette(Director)Kevin Gillis(Director)Gerald Brunk(Director)George J. Fazio(Executive Officer, Director)Dan B. Curtis(Executive Officer)David Celermajer(Director)

Board seatKevin Gillis· per SEC Form D · $11.1M raise · filed Jun 2025

Decibel Therapeutics, Inc.SEC filinghigh confidence

Cambridge, US

Board seatNeil ExterCraig MuirKevin Starr· per SEC Form D · $82.2M raise · filed Nov 2020

Element Sciencemyjewel.comin

Jewel is a wearable patch cardioverter defibrillator designed to provide continuous protection from sudden cardiac arrest, using machine learning to minimize false alarms while requiring no daily maintenance for up to a week.

AI & Machine LearningHealthtechMedical DevicesSan Francisco, US

Russell Hirsch(Director)William H. Kucheman(Director)Uday N. Kumar(Executive Officer, Director)Neil Exter(Director)Krishna Yeshwant(Director)

Board seatNeil Exter· per SEC Form D

Eleven BiotherapeuticsSEC filingmedium confidence

BiotechCambridge, US

Daniel S. Lynch(Director)Paul G. Chaney(Director)Stephen Hurly(Executive Officer, Director)John McCabe(Executive Officer)Jay S. Duker(Director)Wendy L. Dixon(Director)

Board seatAbbie Celniker· per SEC Form D · $996K raise · filed Apr 2018

Faze Medicines

BiotechCambridge, US

Cary Pfeffer(Executive Officer, Director)Ed Freedman(Executive Officer, Director)Robert Tepper(Director)Charles Homcy(Director)

PartnerCary Pfeffer· quoted

Board seatCharles HomcyRobert Tepper· per SEC Form D

Goldfinch BioPharmaSEC filinghigh confidence

HealthtechCambridge, US

ABBIE CELNIKER(Executive Officer, Director)LOUIS BRENNER(Director)NEIL EXTER(Executive Officer, Director)PETER THOMSON(Executive Officer)

Board seatAbbie CelnikerNeil Exter· per SEC Form D · filed Jul 2020

Hookipa PharmaSEC filingmedium confidence

BiotechNew York, US

Joern Aldag(Executive Officer, Director)Christoph Lengauer(Director)Paul-Henri Lambert(Director)Jan van de Winkel(Director)Michael Kelly(Director)Reinhard Kandera(Executive Officer, Director)

Board seatChristoph Lengauer· per SEC Form D · filed Feb 2019

ImaginabSEC filingmedium confidence

BiotechInglewood, US

Isaac Bright(Director)K. Leonard Judson(Director)Campbell Murray(Director)Abbie Celniker(Director)Jeffrey D. Quan(Executive Officer)Thilo Schroeder(Director)

Board seatAbbie Celniker· per SEC Form D · $9.5M raise · filed Apr 2016

Jounce Therapeuticsjouncetx.comSEC filinghigh confidence

BiotechCambridge, US

Robert Tepper(Director)Kim C. Drapkin(Executive Officer)Anna L. Barry(Executive Officer)Richard Murray(Executive Officer, Director)Cary Pfeffer(Director)Robert Kamen(Director)

Board seatRobert KamenCary PfefferRobert Tepper· per SEC Form D · $56M raise · filed Apr 2015

Kamal TherapeuticsSEC filingmedium confidence

BiotechHingham, US

Mark de Souza(Executive Officer, Director)Philip Reilly(Director)John Parker(Director)Alexander Silver(Director)Hal Landy(Director)Joff Masukawa(Director)

Board seatPhilip Reilly· per SEC Form D · $17.3M raise · filed Nov 2025

LyceraSEC filingmedium confidence

BiotechAnn Arbor, US

Robert Kamen(Director)Michael Hayden(Director)Michael Steinmetz(Director)Steven Gillis(Director)Paul Sekhri(Executive Officer)Kristina Burow(Director)

Board seatRobert Kamen· per SEC Form D · filed Jun 2015

MyokardiaSEC filinghigh confidence

BiotechSouth San Francisco, US

Kevin Starr(Director)Charles Homcy(Director)Mark Perry(Director)Katherine Bowdish(Director)Tassos Anastasios Gianakakos(Executive Officer, Director)

Board seatCharles HomcyKevin Starr· per SEC Form D · $46M raise · filed Apr 2015

Neon Therapeuticsneontherapeutics.comSEC filinghigh confidence

BiotechCambridge, US

Richard Gaynor, M.D.(Executive Officer)Cary Pfeffer, M.D.(Director)Robert Kamen(Director)Eric Lander(Director)Robert Ang, M.D.(Executive Officer)Yasir Al-Wakeel(Executive Officer)

Board seatRobert KamenRobert Tepper· per SEC Form D · $106M raise · filed Dec 2017

NinePoint MedicalSEC filingmedium confidence

HealthtechBedford, US

Russell Hirsch(Director)Christopher von Jako(Executive Officer, Director)Mark Stautberg(Director)Curt Weinstein(Director)Eric Swanson(Director)Scott Gazelle(Director)

Board seatMark Levin· per SEC Form D · $40.7M raise · filed Nov 2015

PanOpticaSEC filingmedium confidence

BiotechMt. Arlington, US

Abbie Celniker(Director)David Guyer(Director)Paul Chaney(Executive Officer, Director)Bruce Peacock(Director)

Board seatAbbie Celniker· per SEC Form D · $47.3M raise · filed Apr 2019

Rheos MedicinesSEC filinghigh confidence

BiotechCambridge, US

Gad Soffer(Executive Officer)Ryan Cohlhepp(Executive Officer)Abbie Celniker(Director)J. Duncan Higgons(Director)Cary Pfeffer(Director)Jeffrey Bluestone(Director)

Board seatAbbie CelnikerCary Pfeffer· per SEC Form D · filed Nov 2018

Strand Therapeutics Inc.SEC filingmedium confidence

Boston, US

Board seatJeb Keiper· per SEC Form D · $120.1M raise · filed Mar 2026

Terremoto BiosciencesSEC filingmedium confidence

BiotechSouth San Francisco, US

Michael Goller(Director)Grace Lu(Executive Officer)James Christensen(Executive Officer, Director)Peter Thompson(Director)Daniel O'Connell(Director)Charles Baum(Executive Officer, Director)

Board seatReid Huber· per SEC Form D · $108.6M raise · filed Apr 2026

Triana Biomedicines, Inc.SEC filingmedium confidence

Lexington, US

Board seatJigar Raythatha· per SEC Form D · $120.1M raise · filed Dec 2025

Agios

Developer of Aqvesme (mitapivat), an FDA-approved medicine for anemia in thalassemia.

Alcrestaalcresta.comin

Alcresta Therapeutics develops enzyme-based therapeutic products to address nutritional care for enterally fed patients living with rare diseases.

BiotechHealthtechMedical DevicesMassachusetts, US

Daniel Orlando(Chief Executive Officer)Jeremy Lack(Director)Stephen Krauss(Director)Tasos Konidaris(Executive Officer)James Topper(Director)Steve Dubin(Director)

Asher Bioasherbio.comin𝕏

Asher Bio develops selective immunotherapy drugs that target specific immune cell types to promote beneficial effects while minimizing toxicity.

BiotechHealthtechMedical DevicesSan Francisco, US

Ivana Djuretic(Founder)inAndy Yeung(Founder)in

Candid Therapeuticscandidrx.comin

CandidRx develops T-cell engager antibodies to treat autoimmune diseases by redirecting T-cells to eliminate autoreactive B-cells.

BiotechHealthtechSan Diego, US

Ken Song(Chairman, President and CEO)Kenneth Song, M.D.(Executive Officer, Director)Arvind Kush(Executive Officer)Timothy Lu, M.D.(Executive Officer)Bernie Huyghe, Ph.D.(Executive Officer)

BoardJeffrey Tong, Ph.D.(Director)

Decibel Therapeuticsacquired by Regeneron

Originator of Otarmeni (lunsotogene parvec-cwha), an FDA-approved gene therapy for genetic hearing loss; acquired by Regeneron in 2023.

Insitroinsitro.comin𝕏

insitro is a drug discovery and development company that uses machine learning and cellular data to identify therapeutic insights and accelerate the creation of new medicines.

AI & Machine LearningBiotechSouth San Francisco, US

Daphne Koller(CEO & Founder)Robert Nelsen(Director)Vijay Pande(Director)Duane Valz(General Counsel)Mary Rozenman(Chief Financial Officer)

Merida Biosciencesmeridabio.comin

Biotech

Michael Naill(Senior Vice President, Process and Product Development)

MOMA Therapeutics
Synnovation Therapeuticssynnovationtx.comin

A drug discovery company founded by an experienced medicinal chemistry team with expertise in successful pharmaceutical development and clinical advancement.

BiotechDeep TechMedical DevicesWilmington, US

Liangxing Wu(Executive Officer, Director)Reid Huber(Director)Ting Feng(Director)Wenqing Yao(Executive Officer, Director)

Taris Bioacquired by Johnson & Johnson

Originator of Inlexzo (gemcitabine intravesical system), an FDA-approved treatment for certain bladder cancers; acquired by Johnson & Johnson in 2019.

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Public market activity · per SEC filings

what is this? ⓘ

Files 13F institutional holdings reports · latest Nov 2015

From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.

Frequently asked questions

What stage does Third Rock Ventures invest at?
Third Rock Ventures invests at the Seed, Series A, Series B, Series C stages.
What is Third Rock Ventures's typical check size?
Third Rock Ventures typically writes checks of $100K – $5M.
What sectors does Third Rock Ventures focus on?
Third Rock Ventures focuses on Biotech, Digital Health, Healthtech, Medical Devices.
Where is Third Rock Ventures located?
Third Rock Ventures is headquartered in Boston, US.
Does Third Rock Ventures lead rounds?
Third Rock Ventures typically participates in rounds rather than leading them.

Media · Podcasts & interviews

from their channel

Connected By Our Mission

Third Rock Ventures

Third Rock: First Decade Video

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Co-investors · 35

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GV (Google Ventures)

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$250K – $50M
Bessemer Venture Partners

Bessemer Venture Partners is a venture capital firm that partners with entrepreneurs from early stages through every stage of growth, publishing investment roadmaps across multiple technology sectors.

$5M – $100M
Bain Capital Ventures

Bain Capital Ventures is the venture arm of Bain Capital, backing founders from incubation and seed through growth-stage, leveraging Bain Capital's global platform, industry expertise, and network.

$1M – $100M
Unknown Ventures

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B Capital Group

B Capital is a global venture capital firm led by Eduardo Saverin, Raj Ganguly, and Howard Morgan that invests in early to late-stage technology companies across critical sectors including technology, healthcare, and energy and resilience. The firm leverages an in-house platform team and strategic partnership with Boston Consulting Group to provide founders with advisory services, talent acquisition support, and market expansion guidance.

$100K – $60M
Canaan Partners

Canaan is an early-stage venture capital firm backing founders with transformative ideas across technology and healthcare.

$500K – $20M
F-Prime Capital Partners

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$3M – $10M
Venrock

Venrock is a venture capital firm investing across technology and healthcare, backing companies in fintech, developer infrastructure, life sciences, therapeutics, semiconductors, and consumer products.

$500K – $10M
Atlas Venture

Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.

$500K – $1M
ARCH Venture Partners

ARCH Venture Partners is a venture capital firm that backs and helps build transformational companies, with a strong focus on the life sciences and biotech sector.

$50K – $250M
OrbiMed

OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.

$1M – $75M
23 more co-investors

RA CapitalFlare Capital PartnersS32SR One Capital ManagementForbionJohnson & Johnson Innovation – JJDCvenBio PartnersThe Column GroupFlagship PioneeringPfizer Venture InvestmentsSofinnova VenturesSV Health InvestorsFrazier Healthcare PartnersVivo CapitalAndera PartnersNextech InvestYsios CapitalSamsara BioCapitalCatalio Capital ManagementCatalio Capital Management, LPAstellas Venture Management LLCCasdin CapitalActivate Venture Partners

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