Third Rock Ventures
Venture capitalActively deployingBoston · Seed–Series C · 76 people tracked
Also known as THIRD ROCK VENTURES, LLC
Investment thesis
Third Rock Ventures focuses on creating and building transformative healthcare and life sciences companies. It works closely with founders to discover, launch, build, and scale ventures developing breakthrough therapeutics and medical technologies across areas such as oncology, immunology, genetic medicine, gene therapy, precision genome engineering, and mental health. The firm emphasizes founding companies around ambitious scientific ideas that can address serious unmet medical needs and deliver meaningful patient impact, with a track record of advancing assets to FDA approval and successful acquisitions by major pharmaceutical companies.
Source: firm website, verified Aug 3, 2026.
Team · 76 people
from the firm's website & public directoriesWhat they invest in
from 40 of 49 portfolio companiesBiotech ×37Healthtech ×7Medical Devices ×7AI & Machine Learning ×4Deep Tech ×1Digital Health ×1Enterprise Software ×1
HQs:United States×41
Investments · 49 tracked
founders shown can be your intro pathClinical-stage biotechnology company developing conditionally activated, masked biologics designed to be localized to the tumor microenvironment.
BiotechSouth San Francisco, US
Tim Shannon(Director)Frederick W. Gluck(Director)Elaine V. Jones(Director)Sean McCarthy(Executive Officer, Director)Neil Exter(Director)Hoyoung Huh(Director)
Board seatNeil Exter· per SEC Form D · $30M raise · filed Jan 2015
BiotechCambridge, US
Alan Ezekowitz(Director)James Collins(Director)Mark Levin(Director)Robert Gould(Executive Officer, Director)James Geraghty(Director)
Board seatMark Levin· per SEC Form D · $55M raise · filed Jul 2017
BiotechArlington, US
Darius Kharabi(Executive Officer)Todd Bazemore(Executive Officer)Mark Iwicki(Executive Officer, Director)Mary Reumuth(Executive Officer)Kim Brazzell(Executive Officer)Charles McDermott(Executive Officer)
Board seatRobert Tepper· per SEC Form D · $7M raise · filed Aug 2015
Pliant Therapeutics is a clinical-stage biopharmaceutical company developing integrin-based therapeutics to treat serious diseases.
BiotechSouth San Francisco, US
Kevin Raidy(Director)Suzanne Bruhn(Director)Johannes Hull(Executive Officer)John Curnutte(Director)Hoyoung Huh(Director)Neil Exter(Director)
Board seatCharles HomcyNeil Exter· per SEC Form D · $62.1M raise · filed Jul 2018
BiotechRedwood City, US
Laurence Lasky(Director)Alexis Borisy(Director)Margaret Horn(Executive Officer)Michael Bonney(Director)Mark A. Goldsmith(Executive Officer, Director)Elizabeth Anderson(Director)
Board seatNeil ExterBarbara Weber· per SEC Form D · $100.3M raise · filed Nov 2019
BiotechBoston, US
Edward T. Mathers(Director)David J. McGirr(Director)Jonathan Silverstein(Director)Keith Gottesdiener(Executive Officer, Director)David P. Meeker, M.D.(Director)Neil Exter(Director)
Board seatNeil Exter· per SEC Form D · $40M raise · filed Dec 2015
South San Francisco, US
Board seatJeffrey Tong· per SEC Form D · $150M raise · filed Jul 2023
Tango Therapeutics develops genetically targeted medicines using synthetic lethality principles to treat specific tumors.
BiotechBoston, US
John Ketchum(Director)Barbara Weber(Executive Officer, Director)Malte Peters(Director)Kanishka Pothula(Director)Lesley Ann Calhoun(Director)Mace Rothenberg(Director)
Board seatAlexis BorisyReid Huber· per SEC Form D
Agios is a biopharmaceutical company developing therapies for rare diseases, with a primary focus on hemolytic anemias including pyruvate kinase deficiency, thalassemia, and sickle cell disease.
BiotechHealthtechMedical Devices<UNKNOWN>
Azalea Therapeutics develops precision genome editing therapies that engineer T cells directly inside the patient's body to create cancer immunotherapies, using proprietary delivery vehicles to target and modify specific genetic loci without ex vivo cell manipulation.
AI & Machine LearningBiotechMedical DevicesSan Francisco, US
Jennifer Doudna(Co-founder, Nobel Laureate in Chemistry and Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences, UC Berkeley)Rodolphe Barrangou(Co-founder, Associate Professor of Medicine, UCSF)Krishnendu Roy(Co-founder, Professor of Bioengineering, Stanford University)Connor Tsuchida(Scientific Cofounder)
BiotechCambridge, US
SAMANTHA SINGER(Executive Officer, Director)ABBIE CELNIKER(Director)MITCH FINER(Director)NAGESH MAHANTHAPPA(Director)LORENCE KIM(Director)SANDY LAZZARI(Executive Officer)
Board seatDavid KaufmanAbbie Celniker· per SEC Form D · filed Dec 2023
BiotechSan Mateo, US
Kevin Starr(Director)Michael Kitt(Executive Officer)Arthur Pappas(Director)Anthony Ford(Executive Officer)Kathleen Sereda Glaub(Executive Officer, Director)Peter Hirth(Director)
Board seatKevin Starr· per SEC Form D · $55M raise · filed Jul 2015
Arbor develops programmable DNA editors for genetic medicine, aiming to enable functional cures for patients by addressing genetic diseases through bespoke gene editing approaches.
BiotechDigital HealthMedical DevicesCambridge, US
KEITH CRANDELL(Director)DAVID ARTHUR SCOTT(Executive Officer)WINSTON XIA YAN(Executive Officer)ANNIE HAZLEHURST(Director)FENG ZHANG(Director)
BoardDAVID R. WALT(Director)
Board seatMark Angelino· per SEC Form D · $215M raise · filed Nov 2021
BiotechSouth San Francisco, US
Yik Andy Yeung(Executive Officer, Director, Promoter)Ivana Djuretic(Executive Officer, Director, Promoter)
Board seatJeffrey TongReid Huber· per SEC Form D · $55M raise · filed Apr 2024
BiotechAnn Arbor, US
Carol Gallagher(Director)Randall Whitcomb(Director)James Topper(Director)Julia C. Owens(Executive Officer, Director)William Harrington(Director)
Board seatMary Lynne Hedley· per SEC Form D · $59.1M raise · filed Dec 2017
BiotechBurlington, US
Michael Mendelsohn(Executive Officer, Director)
BoardEvan Rachlin(Director)Peter Lawrence(Executive Officer, Director)Edward Mathers(Director)Adam Koppel(Director)Nicholas Downing(Director)
Board seatJeb Keiper· per SEC Form D · $10M raise · filed Nov 2019
BiotechCambridge, US
Abbie Celniker(Director)Alexandra Glucksmann(Executive Officer, Director)Dominik Naczynski(Director)Eli Casdin(Director)Chris Bowden(Director)Neil Exter(Director)
Board seatAbbie CelnikerNeil Exter· per SEC Form D · $82.6M raise · filed Oct 2021
BiotechCambridge, US
Tom Maniatis(Director)Michael R. Cooper(Executive Officer)Anthony Evnin(Director)James E. Audia(Executive Officer)Keith Dionne(Executive Officer, Director)Matthias Jaffe(Executive Officer)
Board seatRobert Tepper· per SEC Form D · $55.8M raise · filed Dec 2015
BiotechTewksbury, US
Paul LaViolette(Director)Kevin Gillis(Director)Gerald Brunk(Director)George J. Fazio(Executive Officer, Director)Dan B. Curtis(Executive Officer)David Celermajer(Director)
Board seatKevin Gillis· per SEC Form D · $11.1M raise · filed Jun 2025
Cambridge, US
Board seatNeil ExterCraig MuirKevin Starr· per SEC Form D · $82.2M raise · filed Nov 2020
Jewel is a wearable patch cardioverter defibrillator designed to provide continuous protection from sudden cardiac arrest, using machine learning to minimize false alarms while requiring no daily maintenance for up to a week.
AI & Machine LearningHealthtechMedical DevicesSan Francisco, US
Russell Hirsch(Director)William H. Kucheman(Director)Uday N. Kumar(Executive Officer, Director)Neil Exter(Director)Krishna Yeshwant(Director)
Board seatNeil Exter· per SEC Form D
BiotechCambridge, US
Daniel S. Lynch(Director)Paul G. Chaney(Director)Stephen Hurly(Executive Officer, Director)John McCabe(Executive Officer)Jay S. Duker(Director)Wendy L. Dixon(Director)
Board seatAbbie Celniker· per SEC Form D · $996K raise · filed Apr 2018
BiotechCambridge, US
Cary Pfeffer(Executive Officer, Director)Ed Freedman(Executive Officer, Director)Robert Tepper(Director)Charles Homcy(Director)
PartnerCary Pfeffer· quoted
Board seatCharles HomcyRobert Tepper· per SEC Form D
HealthtechCambridge, US
ABBIE CELNIKER(Executive Officer, Director)LOUIS BRENNER(Director)NEIL EXTER(Executive Officer, Director)PETER THOMSON(Executive Officer)
Board seatAbbie CelnikerNeil Exter· per SEC Form D · filed Jul 2020
BiotechNew York, US
Joern Aldag(Executive Officer, Director)Christoph Lengauer(Director)Paul-Henri Lambert(Director)Jan van de Winkel(Director)Michael Kelly(Director)Reinhard Kandera(Executive Officer, Director)
Board seatChristoph Lengauer· per SEC Form D · filed Feb 2019
BiotechInglewood, US
Isaac Bright(Director)K. Leonard Judson(Director)Campbell Murray(Director)Abbie Celniker(Director)Jeffrey D. Quan(Executive Officer)Thilo Schroeder(Director)
Board seatAbbie Celniker· per SEC Form D · $9.5M raise · filed Apr 2016
BiotechCambridge, US
Robert Tepper(Director)Kim C. Drapkin(Executive Officer)Anna L. Barry(Executive Officer)Richard Murray(Executive Officer, Director)Cary Pfeffer(Director)Robert Kamen(Director)
Board seatRobert KamenCary PfefferRobert Tepper· per SEC Form D · $56M raise · filed Apr 2015
BiotechHingham, US
Mark de Souza(Executive Officer, Director)Philip Reilly(Director)John Parker(Director)Alexander Silver(Director)Hal Landy(Director)Joff Masukawa(Director)
Board seatPhilip Reilly· per SEC Form D · $17.3M raise · filed Nov 2025
BiotechAnn Arbor, US
Robert Kamen(Director)Michael Hayden(Director)Michael Steinmetz(Director)Steven Gillis(Director)Paul Sekhri(Executive Officer)Kristina Burow(Director)
Board seatRobert Kamen· per SEC Form D · filed Jun 2015
BiotechSouth San Francisco, US
Kevin Starr(Director)Charles Homcy(Director)Mark Perry(Director)Katherine Bowdish(Director)Tassos Anastasios Gianakakos(Executive Officer, Director)
Board seatCharles HomcyKevin Starr· per SEC Form D · $46M raise · filed Apr 2015
BiotechCambridge, US
Richard Gaynor, M.D.(Executive Officer)Cary Pfeffer, M.D.(Director)Robert Kamen(Director)Eric Lander(Director)Robert Ang, M.D.(Executive Officer)Yasir Al-Wakeel(Executive Officer)
Board seatRobert KamenRobert Tepper· per SEC Form D · $106M raise · filed Dec 2017
HealthtechBedford, US
Russell Hirsch(Director)Christopher von Jako(Executive Officer, Director)Mark Stautberg(Director)Curt Weinstein(Director)Eric Swanson(Director)Scott Gazelle(Director)
Board seatMark Levin· per SEC Form D · $40.7M raise · filed Nov 2015
BiotechMt. Arlington, US
Abbie Celniker(Director)David Guyer(Director)Paul Chaney(Executive Officer, Director)Bruce Peacock(Director)
Board seatAbbie Celniker· per SEC Form D · $47.3M raise · filed Apr 2019
BiotechCambridge, US
Gad Soffer(Executive Officer)Ryan Cohlhepp(Executive Officer)Abbie Celniker(Director)J. Duncan Higgons(Director)Cary Pfeffer(Director)Jeffrey Bluestone(Director)
Board seatAbbie CelnikerCary Pfeffer· per SEC Form D · filed Nov 2018
Boston, US
Board seatJeb Keiper· per SEC Form D · $120.1M raise · filed Mar 2026
BiotechSouth San Francisco, US
Michael Goller(Director)Grace Lu(Executive Officer)James Christensen(Executive Officer, Director)Peter Thompson(Director)Daniel O'Connell(Director)Charles Baum(Executive Officer, Director)
Board seatReid Huber· per SEC Form D · $108.6M raise · filed Apr 2026
Lexington, US
Board seatJigar Raythatha· per SEC Form D · $120.1M raise · filed Dec 2025
Developer of Aqvesme (mitapivat), an FDA-approved medicine for anemia in thalassemia.
Alcresta Therapeutics develops enzyme-based therapeutic products to address nutritional care for enterally fed patients living with rare diseases.
BiotechHealthtechMedical DevicesMassachusetts, US
Daniel Orlando(Chief Executive Officer)Jeremy Lack(Director)Stephen Krauss(Director)Tasos Konidaris(Executive Officer)James Topper(Director)Steve Dubin(Director)
CandidRx develops T-cell engager antibodies to treat autoimmune diseases by redirecting T-cells to eliminate autoreactive B-cells.
BiotechHealthtechSan Diego, US
Ken Song(Chairman, President and CEO)Kenneth Song, M.D.(Executive Officer, Director)Arvind Kush(Executive Officer)Timothy Lu, M.D.(Executive Officer)Bernie Huyghe, Ph.D.(Executive Officer)
BoardJeffrey Tong, Ph.D.(Director)
Originator of Otarmeni (lunsotogene parvec-cwha), an FDA-approved gene therapy for genetic hearing loss; acquired by Regeneron in 2023.
insitro is a drug discovery and development company that uses machine learning and cellular data to identify therapeutic insights and accelerate the creation of new medicines.
AI & Machine LearningBiotechSouth San Francisco, US
Daphne Koller(CEO & Founder)Robert Nelsen(Director)Vijay Pande(Director)Duane Valz(General Counsel)Mary Rozenman(Chief Financial Officer)
Biotech
Michael Naill(Senior Vice President, Process and Product Development)
A drug discovery company founded by an experienced medicinal chemistry team with expertise in successful pharmaceutical development and clinical advancement.
BiotechDeep TechMedical DevicesWilmington, US
Liangxing Wu(Executive Officer, Director)Reid Huber(Director)Ting Feng(Director)Wenqing Yao(Executive Officer, Director)
Originator of Inlexzo (gemcitabine intravesical system), an FDA-approved treatment for certain bladder cancers; acquired by Johnson & Johnson in 2019.
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Public market activity · per SEC filings
what is this? ⓘFiles 13F institutional holdings reports · latest Nov 2015
From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.
Frequently asked questions
- What stage does Third Rock Ventures invest at?
- Third Rock Ventures invests at the Seed, Series A, Series B, Series C stages.
- What is Third Rock Ventures's typical check size?
- Third Rock Ventures typically writes checks of $100K – $5M.
- What sectors does Third Rock Ventures focus on?
- Third Rock Ventures focuses on Biotech, Digital Health, Healthtech, Medical Devices.
- Where is Third Rock Ventures located?
- Third Rock Ventures is headquartered in Boston, US.
- Does Third Rock Ventures lead rounds?
- Third Rock Ventures typically participates in rounds rather than leading them.
Media · Podcasts & interviews
from their channelConnected By Our Mission
Third Rock Ventures
Third Rock: First Decade Video
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Co-investors · 35
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Venrock is a venture capital firm investing across technology and healthcare, backing companies in fintech, developer infrastructure, life sciences, therapeutics, semiconductors, and consumer products.
Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.
ARCH Venture Partners is a venture capital firm that backs and helps build transformational companies, with a strong focus on the life sciences and biotech sector.
OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.
▶23 more co-investors
RA CapitalFlare Capital PartnersS32SR One Capital ManagementForbionJohnson & Johnson Innovation – JJDCvenBio PartnersThe Column GroupFlagship PioneeringPfizer Venture InvestmentsSofinnova VenturesSV Health InvestorsFrazier Healthcare PartnersVivo CapitalAndera PartnersNextech InvestYsios CapitalSamsara BioCapitalCatalio Capital ManagementCatalio Capital Management, LPAstellas Venture Management LLCCasdin CapitalActivate Venture Partners
Firms observed investing alongside Third Rock Ventures, from public investor directories.
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