Twist Bioscience

Twist Bioscience is a biotechnology company headquartered in South San Francisco, California that manufactures synthetic DNA and DNA-derived products for customers across a range of industries [7]. Its catalog spans arrayed and pooled genes (clonal genes, gene fragments, gene pools, multiplexed gene fragments), oligo pools and cloned oligo pools, and variant libraries including TCR libraries, combinatorial variant libraries, site saturation libraries and enzyme screening kits [0][1].

A second major product line covers next-generation sequencing (NGS) workflows: target enrichment panels (custom panels, Exome 2.0, DNA comprehensive genomic profiling, RNA Exome, Human Methylome), hybridization solutions and enzymes such as TrueAmp Polymerase Mix, library preparation kits (TrueAmp, PCR-free WGS, cfDNA, RNA, EM-seq v2 methylation detection), and synthetic controls such as cfDNA pan-cancer reference standards and respiratory and monkeypox virus controls [0][1]. Through Twist Biopharma Solutions the company offers antibody discovery and engineering services, including in vitro and in vivo discovery, antibody optimization, production and characterization, bispecific and VHH antibodies, plus pipeline licensing and partnerships [3][4]. The site also lists IVDR solutions, an ordering platform with a Twist API and procurement integrations, and an NGS ProLab certified services program [0][1].

Business model

Twist sells synthetic DNA products and NGS reagents/kits directly through an online ordering platform (including API and procurement-system integrations) and via channel partners and distributors, and additionally provides antibody discovery and characterization services to biopharma customers under partnership, collaboration and licensing arrangements [0][1][3].

Traction

Wikipedia cites revenue of $54.2 million for 2019 and approximately 400 employees [7]. Company materials cite antibody discovery throughput of more than 6,000 IgGs per week with full characterization data in as few as 15 days [0][1][3].

Latest developments

Recent or newly flagged products on the company site include the TrueAmp Library Preparation Kit, cfDNA Library Prep Kit and cfDNA Pan-Cancer Reference Standard v2, EM-seq v2 methylation detection system, Human Methylome panel, multiplexed gene fragments, TCR libraries, enzyme screening kits and an MRD Express offering [0][1].