Lightstone Ventures
Venture capitalPortola Valley · Pre-Seed–Late Stage · 30 people tracked
Also known as LSV CAPITAL MANAGEMENT, LLC
Investment thesis
Lightstone Ventures pursues a thesis-driven life sciences strategy focused on biotech and medtech. In biotech it seeks first-in-class drugs across all modalities including small molecules, biologics, and cell and gene therapies, with emphasis on CNS, immunology and autoimmune diseases, oncology, and ophthalmology. In medtech it targets the convergence of technology, medicine, and consumer health, including personalized medicines, targeted therapeutics leveraging data analytics, and medical technologies addressing immunology, cardiovascular, neurology, and ophthalmology. The firm invests with long-term, patient capital funding companies from startup through commercialization, and partners hands-on with founders on strategy and company building rather than simply providing capital.
Source: firm website, verified Aug 7, 2026.
Team · 30 people
from the firm's website & public directories
What they invest in
from 47 of 99 portfolio companiesHealthtech ×29Biotech ×28Medical Devices ×25Deep Tech ×6Digital Health ×5AI & Machine Learning ×4Hardware ×3Advanced Manufacturing ×1
HQs:United States×28Canada×1United Kingdom×1Ireland×1Netherlands×1Singapore×1
Investments · 99 tracked
founders shown can be your intro pathShoulder Innovations develops InSet® glenoid technology for shoulder joint implants that reduce the rocking horse effect and provide mechanical stability, serving patients with severe shoulder arthritis.
HardwareHealthtechMedical DevicesNorthern California, US
Robert Ball(CEO & Executive Chairman)Matthew Ahearn(Chief Operating Officer)Geoff Pardo(Director)Jeff Points(Executive Officer)Paul Buckman(Director)Mike Carusi(Director)
Board seatMike Carusi· per SEC Form D
Verastem Oncology is a biopharmaceutical company that discovers and develops drugs to treat cancer patients.
BiotechMedical DevicesNeedham, US
Robert WeinbergTIMOTHY BARBERICH(Director)ALISON LAWTON(Director)ERIC ROWINSKY(Director)BRUCE WENDEL(Director)GINA CONSYLMAN(Director)
Contego Medical develops cardiovascular intervention technologies, founded by an interventional cardiologist inventor.
HealthtechMedical DevicesRaleigh, US
Ravish Sachar(CEO & Founder)Paul Sanders(Chief Operating Officer)Elizabeth K. Saylors(Corporate Secretary)
Board seatHanson S. Gifford· per SEC Form D
Allay Therapeutics develops ultra-sustained analgesic products for post-surgical pain management.
BiotechHealthtechMedical DevicesSan Jose, US
Adam Gridley(Executive Officer, Director)Kristen Howells(Executive Officer)Josh Makower(Director)Hanson S. Gifford III(Director)Tak Cheung(Director)Karun D. Naga(Executive Officer, Director)
Board seatMichael A. CarusiHanson S. Gifford· per SEC Form D
Menlo Park, US
Board seatHanson S. GiffordMichael A. Carusi· per SEC Form D · $130.6M raise · filed Aug 2025
Burlingame, US
Board seatMichael A. Carusi· per SEC Form D · $18M raise · filed Feb 2016
BiotechSouth San Fransicso, US
Augustine Lawlor(Director)Ralph Christoffersen(Director)Nassim Usman(Executive Officer, Director)Harold Selick(Director)Jeff Himawan(Director)Michael Powell(Director)
Board seatRalph (Chris) Christoffersen· per SEC Form D · $5M raise · filed Feb 2015
Hologic develops medical technologies for women's health that detect, diagnose and treat health conditions across multiple countries.
FemTechHealthtechMedical DevicesRedwood City, US
Ken Haas(Director)Jonathan MacQuitty(Director)Karen Talmadge(Director)Mike Carusi(Director)Doug Fisher(Director)Christopher Owens(Executive Officer, Director)
Board seatMike Carusi· per SEC Form D
HealthtechMenlo Park, US
Mark Deem(Director)Hanson S. Gifford, III(Executive Officer, Director)
Board seatHanson S. Gifford· per SEC Form D · $1M raise · filed Feb 2023
Innovations for vascular disease treatment including strokes and pulmonary embolisms
HealthtechCampbell, US
Matthew Garrett(Executive Officer)Charles Alpuche(Executive Officer)Scott Elliott(Executive Officer)Farhad Khosravi(Executive Officer, Director)Nick Hopkins(Director)
BoardJames Rogers(Director)
Board seatHenry Albert Plain, Jr.· per SEC Form D · $100M raise · filed Mar 2026
BiotechBellevue, US
Louis Cannon(Director)Christopher Shen(Director)Immanuel Thangaraj(Director)Henry A. Plain, Jr.(Director)Michael Gertner(Executive Officer, Director)Brian Halak(Director)
Board seatHenry A. Plain, Jr.· per SEC Form D · $22.4M raise · filed Sep 2015
Singapore
Board seatMichael A. Carusi· per SEC Form D · $20.4M raise · filed Oct 2019
HealthtechSanta Clara, US
Hanson Gifford III(Director)Henry Plain, Jr.(Director)R. Michael Kleine(Executive Officer, Director)Nimesh Shah(Director)Mark Deem(Director)Stacy Seltzer(Director)
Board seatHanson S. Gifford· per SEC Form D · $33.6M raise · filed Jun 2016
Nuvaira is a privately held medical device company that develops the dNerva Lung Denervation System, a catheter-based technology used in Targeted Lung Denervation to treat overactive airway nerves in patients with obstructive lung diseases such as COPD and asthma.
HealthtechMedical DevicesMinneapolis, US
Geoffrey Duyk(Director)Doug Sisson(Director)Timothy Herbert(Director)Dennis W. Wahr(Executive Officer, Director)Kirk Nielsen(Director)Dave Stassen(Director)
Board seatMichael A, CarusiHenry PlainMichael A. CarusiMike CarusiHank Plain· per SEC Form D · $17.3M raise · filed Dec 2023
Belmont, US
Board seatMichael Carusi· per SEC Form D · $46M raise · filed Jul 2016
Reprieve Cardiovascular develops therapies for heart failure patients, focusing on intelligent decongestion management to accelerate fluid removal.
HealthtechMedical DevicesMilford, US
Hanson S. Gifford III(Director)Tony Fields(Executive Officer)Adam Bartnik(Executive Officer)Mark Pacyna(Executive Officer, Director)Jim Dillon(Executive Officer, Director)Gregory W Mann(Executive Officer)
Board seatHanson S. Gifford· per SEC Form D
Tangible Science develops contact lens solutions designed to improve comfort and durability for wearers and to provide eye care professionals with more effective treatment options.
HealthtechMedical DevicesMenlo Park, US
Chip Heath(Director)Brandon Felkins(Director)Karen Havenstrite(Director)Victor McCray(Executive Officer, Director)Richard Popp(Director)Hanson Gifford(Director)
Board seatHanson S. Gifford· per SEC Form D · $4.6M raise · filed Nov 2016
Twelve transforms CO2 into chemicals, fuels, and materials through carbon transformation technology.
Advanced ManufacturingCleantechClimate TechHealthtechNew MaterialsMoses Lake, US
Nicholas Flanders(Founder & CEO)inEtosha Cave(Founder)Kendra Kuhl(Founder)inMarc-Henri Galletti(Director)Nimesh Shah(Director)Charles Warden(Director)
Board seatHanson S. GiffordHenry A. Plain, Jr.· per SEC Form D · $35.3M raise · filed Apr 2015
A drug discovery and therapeutic company creation platform that accelerates the development of new medicines from research institutions in Singapore.
BiotechDeep TechSingapore, SG
BioSpace is a platform providing news, job listings, and recruitment marketing solutions for the life sciences industry.
BiotechHealthtechHR TechMarketing TechMedia & EntertainmentMedical DevicesSaaSDes Moines, US
Josh Goodwin(CEO)
Alchemab uses adaptive immunity and deep learning to develop antibody therapeutics for difficult-to-treat diseases by studying resilient individuals such as long-term cancer survivors.
AI & Machine LearningBiotechDeep Tech
Amber Therapeutics develops medical technology focused on treating mixed urinary incontinence, advancing toward pivotal clinical trials in the US with expanded feasibility studies in Europe.
Medical Devices
Cala Health develops non-invasive prescription therapies for movement disorders, starting with a treatment for hand tremor and essential tremor.
Deep TechDigital HealthHealthtechMedical DevicesSilicon Valley, US
Kate Rosenbluth, PhD(President & Chief Innovation Officer)Deanna Harshbarger(Chief Executive Officer)
CardiacBooster is a medical device company developing a high-flow, low-profile percutaneous ventricular assist device (pVAD) for temporary cardiac support in patients with cardiogenic shock and those undergoing high-risk coronary procedures (high-risk PCI).
HardwareHealthtechMedical DevicesGalway, IE
Carrick Therapeutics is a biopharmaceutical company with a leadership team experienced in oncology drug development and commercialization.
BiotechDigital HealthHealthtechMedical Devices
Timothy Pearson(CEO)Ash Bahl(CSO)Jenny Horsfield(CBO)Stuart McIntosh(CMO)David Sutherland(VP Finance & Controller)
Cerevance is a clinical-stage drug discovery and development company developing non-dopaminergic, orally-delivered therapies for brain and central nervous system disorders, including Parkinson's disease, schizophrenia, Alzheimer's disease, and ALS.
BiotechDeep TechHealthtech
Craig Thompson(Chief Executive Officer)Sagar Vaidya(Chief Medical Officer)Carrie Ann Cook(Chief Business Officer)
HealthtechCambridge, US
Kevin Mills(Executive Officer, Director)Barry Mills(Director)Ronald Goldstein(Executive Officer)Donald Corcoran(Executive Officer, Director)Timothy Romberger(Director)Markus Renschler(Director)
Cyteir is a clinical-stage oncology company developing CYT-0851, an oral investigational drug that inhibits monocarboxylate transporters.
BiotechHealthtech
EndoGastric Solutions offers the Transoral Incisionless Fundoplication (TIF 2.0) procedure and the EsophyX device used to treat GERD, along with reimbursement and technical/administrative support (TAP program) for medical practices.
BiotechHealthtechMedical DevicesSan Mateo, US
Michael Carusi(Director)Scott Ward(Director)Arda Minocherhomjee(Director)Philip Macdonald(Executive Officer)Brent Ahrens(Director)Jordan Davis(Director)
Flex Pharma provides accessible generic vasodilator medications, including PDE5 inhibitors, to U.S. patients at lower costs than brand-name alternatives.
BiotechDigital HealthHealthtechMedical Devices
Dr. Rod MacKinnon(Founder)
HealthtechMenlo Park, US
Robert C. Bellas, Jr.(Director)K. Angela Macfarlane(Executive Officer, Director)Jim Glasheen(Director)Andy Corley(Director)Aaron Davidson(Director)William J. Link, Ph.D.(Director)
BiotechCambridge, US
James McLaughlin(Executive Officer, Director)Jason Rhodes(Director)Carl Gordon(Director)
BoardJean George(Director)
BiotechCambridge, US
Paul Goldenheim(Director)Magdalene Moran, Ph.D.(Executive Officer)Bert Chenard, Ph.D.(Executive Officer)Vincent Miles(Director)Russell Herndon(Executive Officer, Director)Robert Carpenter(Director)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Lightstone Ventures invest at?
- Lightstone Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does Lightstone Ventures focus on?
- Lightstone Ventures focuses on Biotech, Digital Health, Healthtech, Medical Devices.
- Where is Lightstone Ventures located?
- Lightstone Ventures is headquartered in Portola Valley, US.
- Does Lightstone Ventures lead rounds?
- Yes, Lightstone Ventures leads investment rounds.
Co-investors · 19
Canaan is an early-stage venture capital firm backing founders with transformative ideas across technology and healthcare.
F-Prime Capital Partners is a venture capital firm whose team of scientists, engineers, physicians, operators, and investors supports companies in scaling and accelerating growth.
Arboretum Ventures is a Midwest-based healthcare venture capital firm that invests in early-stage healthcare startups across medical devices, life science tools and diagnostics, tech-enabled care delivery, and pharma adjacencies.
SV Health Investors is a healthcare-focused private equity and venture capital investment platform managing specialized and diversified funds across biotechnology, healthcare growth equity, and medtech.
New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.
JAZZ Venture Partners is a venture capital firm investing in companies at the intersection of technology, neuroscience, and human performance, spanning digital health, biosciences, and AI.
The Novartis Venture Fund invests in innovative life science companies, focusing on biotechnology and biopharmaceuticals at various stages of growth, aiming to drive patient benefit and generate returns.
Venrock is a venture capital firm investing across technology and healthcare, backing companies in fintech, developer infrastructure, life sciences, therapeutics, semiconductors, and consumer products.
Sofinnova Partners is a life sciences venture capital firm investing across the value chain from seed to later stage, with a focus on healthcare and sustainability. It backs companies in biopharma, medtech, digital medicine, agriculture and industrial processes.
SR One is a biotechnology-focused venture capital firm that partners with founders to develop innovative science into new medicines.
Johnson & Johnson Innovation is the innovation arm of Johnson & Johnson, working to advance life science innovation through early partnerships, incubation via JLABS, venture investing through JJDC, and late-stage partnerships to address global health challenges.
The Column Group (TCG) is a venture capital firm focused on building and backing biotechnology companies, applying an edge-to-edge investment model centered on company formation with capacity for long-term private and public capital support.
▶7 more co-investors
MorgenthalerOptum VenturesRoche Venture FundSamsara BioCapitalNew Leaf Venture PartnersSante VenturesClarus Ventures
Firms observed investing alongside Lightstone Ventures, from public investor directories. Shared companies are the overlap with Lightstone Ventures's recorded portfolio.
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