SOSV
San Francisco · Pre-Seed · 5 people tracked
Investment thesis
SOSV invests in deep tech startups at the pre-seed stage, particularly those addressing human and planetary health challenges. The firm provides founders intensive support through General Partner-led teams, access to 85,000 square feet of specialized labs (biosafety, chemical, mechatronics, engineering), and a global network of 2,700+ co-investors spanning 82 countries. SOSV typically makes ~60 pre-seed investments annually of up to $550k each, followed by participation in early-stage follow-on rounds through Series B, emphasizing hands-on product development, regulatory strategy, and long-term founder relationships.
Source: firm website, verified Jul 20, 2026.
Team · 5 people
from the firm's website
What they invest in
from 20 of 25 portfolio companiesBiotech ×5Medical Devices ×5Cleantech ×4AgTech ×3Climate Tech ×3FoodTech ×3Hardware ×3SaaS ×3
HQs:United States×7United Kingdom×2Canada×1India×1Japan×1Kenya×1
Investments · 25 tracked
founders shown can be your intro pathFundersClub is a venture capital platform that sources early-stage investment opportunities in seed and series A rounds through direct relationships, referrals, and connections to top incubators and VC firms, offering accredited investors access to vetted startups. The platform provides software tools for deal evaluation, investor management, and portfolio tracking, along with support services including software access and community resources for portfolio founders.
Enterprise SoftwareFintechMarketplacesSaaSSan Francisco, US
LexxPluss develops autonomous mobile robots and infrastructure systems that enable industrial equipment at factories and logistics hubs to operate independently without human direction. The company addresses labor shortages and productivity challenges in manufacturing and logistics.
Advanced ManufacturingLogistics & Supply ChainRoboticsTokyo, JP
Masaya Aso(CEO)
Afynia develops diagnostic technology for endometriosis, a condition affecting approximately 1 in 10 women of reproductive age, which causes chronic pelvic pain and impacts fertility. The company addresses the significant diagnostic delay that worsens patient outcomes across physical, emotional, and social dimensions.
Digital HealthFemTechMedical Devices
Beeflow provides pollination services and consulting to optimize crop pollination and harvest outcomes. The company serves agricultural producers seeking to improve pollination effectiveness.
AgTech
Calder Biosciences is a molecular engineering company developing novel vaccines against RSV, influenza, and other viral infections using platform technology for vaccine design and manufacturing.
BiotechMedical DevicesNYC, US
CarbonBridge develops a proprietary direct gas bioprocessing platform for bioreactor operations that eliminates solubility barriers without traditional equipment like spargers or agitators. The platform serves biotech and industrial biology companies seeking higher productivity and faster response times in bioprocessing.
AgTechBiotechCleantechClimate TechDeep TechSan Jose, US
Cocoon manufactures LoopCem™, a low-carbon supplementary cementitious material made from electric arc furnace slag waste, enabling cement and concrete producers to reduce embodied CO₂ by up to 27% without cost premium. The company operates within the steel and cement industries to address their combined 14% share of global CO₂ emissions.
Circular EconomyCleantechClimate TechLondon, GB
Earnest develops microbial seed coatings and agricultural biology products derived from prairie ecosystems to improve soil health and crop performance for farmers. The company has expanded from soil amendments to seed coatings that deliver biology directly on seeds, with plans to scale planter box treatments.
AgTechBiotech
Eddy Mejia(Founder)Dr. Gabe Price(Founder)
Endless West applies molecular science to create custom spirits, offering bulk liquids, packaged brands, concentrates, and co-packing services with emphasis on sustainability and production efficiency.
Circular EconomyFoodTechNew MaterialsDetroit, US
Farmshelf manufactures at-home hydroponic indoor garden systems that enable consumers to grow fresh leafy greens and herbs without pesticides or plastic packaging. The company provides seedpods, nutrients, and remote monitoring via machine learning to automate the growing process for residential customers.
FoodTechHardwareIoT
Kiko Live is a digital platform that enables local retailers, including kiranas, pharmacies, and stationeries, to digitize their businesses and offer home delivery services through ONDC buyer apps. The platform provides technology, seller training, and marketing support to help neighborhood retailers compete with quick commerce providers.
E-commerceRetail TechSaaS
Level Zero Health develops electrochemical and microfluidic biosensor platforms for point-of-care and continuous diagnostic devices. The company serves healthcare providers and patients requiring faster, more accessible diagnostic solutions.
BiotechHealthtechMedical Devices
UlaIreneBobi
Mechasys develops an XR Projector for the construction industry, providing robotics and advanced layout solutions to improve field productivity and worker efficiency on construction sites.
Construction TechHardwareRoboticsMontreal, CA
OncoPrecision develops precision oncology medicines, including antibody-drug conjugates and bispecific antibodies, for blood cancers and hard-to-treat solid tumors. The company uses patient-derived tumor biology and AI-enhanced discovery to identify therapeutic targets and engineering approaches.
AI & Machine LearningBiotechMedical Devices
Gastón Soria(Co-Founder & CSO)
Sharper Sense develops single-use neurostimulation patches worn on the neck to enhance cognition and sensory processing by stimulating nerves and releasing norepinephrine. The product targets military personnel, first responders, shift workers, students, and older adults seeking improved clarity and reduced fatigue-related errors.
HardwareHealthtechMedical Devices
Charles Rodenkirch(CEO)Linh Le(CCO)Qi Wang(Inventor)
Still Bright develops electrochemical copper extraction technology that replaces traditional smelting, enabling faster, cleaner copper production from previously unrecoverable sources. The technology serves mining companies and the broader copper supply chain to address projected copper shortages driven by increased demand from electronics, transmission, and construction industries.
CleantechNew MaterialsNew Jersey, US
Tappi provides AI-powered reputation and loyalty platform tools for businesses, helping them turn customer interactions and payments data into insights, reviews, and revenue growth. The platform is designed for African businesses and entrepreneurs seeking to scale.
AI & Machine LearningMarketing TechSaaSNairobi, KE
The Supplant Company produces a sugar substitute derived from plant fiber byproducts like corn cobs and agricultural residue, designed to deliver the taste and texture of conventional sugar while providing lower calories, lower glycemic impact, and prebiotic benefits for food manufacturers.
ConsumerFoodTechCambridge, GB
Unspun develops 3D weaving technology and software for apparel and textile manufacturing, enabling fast, automated, and low-waste garment production for brands and manufacturers. The company positions its Vega system as a solution for local, on-demand production that reduces carbon emissions from fashion.
Advanced ManufacturingCleantechClimate Tech
Frequently asked questions
- What stage does SOSV invest at?
- SOSV invests at the Pre-Seed stage.
- What is SOSV's typical check size?
- SOSV typically writes checks of $550K.
- What sectors does SOSV focus on?
- SOSV focuses on Advanced Manufacturing, AgTech, AI & Machine Learning, Biotech, Circular Economy, Cleantech, Climate Tech, Deep Tech, Digital Health, New Materials.
- Where is SOSV located?
- SOSV is headquartered in San Francisco, US.
- Does SOSV lead rounds?
- Yes, SOSV leads investment rounds.
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