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BoxOne Ventures

Venture capital

Montréal · Pre-Seed–Series A · 8 people tracked

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Investment thesis

BoxOne Ventures focuses on backing passionate, emerging talent at an early stage, aiming to supercharge founders to maximize their impact and potential. Its areas of interest span biotechnology, the future of food, markets, longevity, intelligence (AI), and clean energy, with a broad emphasis on technologies that improve quality of life.

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Series A
Check
$500K
HQ
Montréal, CA
Leads rounds
Leads
Instruments
Equity
Founded
2018
Tracked investments
176

Team · 8 people

from the firm's website & public directories
Mike· AI and Engineering Lead

What they invest in

from 79 of 176 portfolio companies

Biotech ×36AI & Machine Learning ×31Healthtech ×27Deep Tech ×19Medical Devices ×14SaaS ×11Data & Infrastructure ×10Fintech ×10

HQs:United States×21Canada×19United Kingdom×2

Investments · 176 tracked

founders shown can be your intro path

By year:2025 · 22024 · 42023 · 12022 · 18 dated

Isablisabl.infoin𝕏✓ verified

Isabl develops genomic sequencing technology for cancer diagnosis, enabling whole genome and transcriptome testing in clinically relevant timeframes to provide comprehensive treatment options.

BiotechDigital HealthMedical Devices

Co-investorsTwo Sigma VenturesY CombinatorEvolution VC Partners

ISABL INC.isabl.comin𝕏✓ verified

Isabl provides a genomic cancer test that analyzes the entire tumor genome and transcriptome to identify cancer-associated mutations and biomarkers for diagnosis.

BiotechHealthtechMedical Devices

Co-investorsTwo Sigma Ventures

Abalone Bioabalonebio.comin

Abalone Bio develops target-activating antibodies for difficult-to-drug disease targets by combining engineered biology with machine learning.

AI & Machine LearningBiotechDeep TechHealthtechSan Francisco, US

Richard Yu(Founder)inGustavo Pesce(Founder)in

Co-investorsHorizons VenturesMetaplanetY Combinator

Aggeneaggene.ca

AgGene develops crop traits to improve resilience, harvest stability, and seed value, with a primary focus on canola addressing challenges like environmental stress and pod shatter, plus pulse programs for improved protein and ingredient quality.

AgTechBiotech

Co-investorsStartup TNTTall Grass VenturesUCeed Funds

AI agent building platform
AI agriculture and forestry platform
AI photocatalysts for water purification
AI-based radiofrequency systems
AI-driven business decision optimization
Alectifyalectify.ai

Alectify applies AI to construction drawings and project documents to pull out relevant technical data.

Advanced ManufacturingEnergyToronto, CA

Ajay Gupta(CEO)inNaveen Vedula(CTO)in

Co-investorsEntrepreneur First

Algae-based fuel from CO2
Altiro Energyaltiroenergy.com

Altiro Energy develops an iron-based energy storage system that stores renewable or excess energy as reusable CO2-free iron fuel and later releases it as on-demand heat or power, producing rust that is recharged for the next cycle.

CleantechClimate TechEnergy

Co-investorsCreative Destruction Lab (CDL)HAXUCeed Funds

Angstrom Insightsangstrom-insights.ai
Animal-free milk producer
Antibody-drug conjugate optimization
Arpeggio Bioarpeggiobio.comin𝕏

Arpeggio Bio develops pharmaceutical drugs that target transcription factors using artificial intelligence and RNA-sequencing technology, with lead programs in development for melanoma treatment and rare disease applications.

BiotechHealthtechBoulder, US

Joey Azofeifa(Founder)inJoseph G. Azofeifa(Executive Officer, Director)Laura Norris(Executive Officer, Director)Timothy Read(Executive Officer, Director)Eric Martin(Executive Officer)

BoardAmit Mehta(Director)

Co-investorsFifty YearsFundersClubTau VenturesvenBio PartnersY CombinatorvenBio Global Strategic+1 more

Avian and human antibody discovery
AVIEWaviewint.comin𝕏

Aview provides multimedia translation and dubbing services to help content creators and entertainers expand their audience internationally across social media platforms.

AI & Machine LearningCreator EconomyMarketing TechMedia & EntertainmentAncaster, CA

Co-investorsCreative Destruction Lab (CDL)Techstars

Axonis Therapeuticsaxonis.usinOct 2024

Axonis Therapeutics is a biotechnology company developing small-molecule medicines that target KCC2, a mediator of inhibition in the brain, to treat neurological disorders such as epilepsy and pain.

BiotechDeep TechBoston, US

Shane Hegarty(Executive Officer)Shane V. Hegarty(Chief Scientific Officer & Co-Founder)Jeffrey Imbaro(Executive Officer)Joanna Stanicka(Chief Executive Officer, President & Co-Founder)inJeff Imbaro(Chief Operating Officer)Tiasha Shafiq(Chief of Staff)

Co-investorsvenBio PartnersMRL Ventures FundSofinnova VenturesCivilization Ventures Management, LlcCreative Destruction Lab (CDL)Hatteras Venture Partners+7 more

Besidehabitatbesidehabitat.comin

BESIDE Habitat operates architecturally designed cabins for short stays in a preserved natural park setting, offering guests activities such as trail running, wildlife observation, sauna, snowshoeing and cross-country skiing.

ConsumerTravel & HospitalityRawdon, CA

Bioinformatics workflow management
Biological network medicine engineering
BioLoomicsbioloomics.comin

Boulder-based preclinical biotech using human-cell directed evolution to create target-degrading antibodies and next-generation ADCs.

Boulder, US

Douglas A Chapnick(85 FORREST LANE BOULDER, CO 80302)

BoardJoel Dudley(Director)inNicholas Saccomano(Director)

Co-investorsHorizons VenturesBoom Capital VenturesInnovation EndeavorsTechU Ventures

Biomanufacturing genome digitalization
Biopharma collaboration management
Bioprinting 3D tissue systems
Bitcoin cashback shopping platform
Blank Bioblank.bioin𝕏

Blank Bio develops RNA foundation models for precision oncology, helping pharmaceutical companies identify the right patients for clinical trials and predict disease progression using bulk RNA-seq data.

AI & Machine LearningBiotechHealthtechSan Francisco, US

Jonny Hsu(Founder)inPhilip Fradkin(Founder)inIan Shi(Founder)in

Co-investorsIA Seed VenturesLeonis CapitalRipple VenturesSignalFireY Combinator

Blockchain betting exchange
Botpressbotpress.comin

Botpress builds AI agents for customer support and offers a helpdesk product (Botpress Desk) that resolves support tickets end-to-end, either on top of an existing helpdesk or as a standalone ticket management system.

AI & Machine LearningEnterprise SoftwareSaaS

Sylvain Perron(Founder)in

Co-investorsCreative Destruction Lab (CDL)Decibel PartnersHubSpot VenturesInovia CapitalHike Ventures

Cell-free biocatalyst
Cell-therapy modular assembly platform
Clinical trial patient identification
Coding Biocoding.bioin𝕏

Coding Bio develops modular immunotherapies for cancer patients, using a high-throughput lab to screen millions of protein candidates in living cells and a machine learning platform to design and optimize therapies for immune activation.

AI & Machine LearningBiotechHealthtech

Simon Bornschein(Co-founder & CEO)Yulia Lampi(Co-founder & CSO)Nils Hammerla(CTO)

Co-investors2048 VenturesMetaplanetSamos InvestmentsThe Venture Collective

Coinmilescoinmiles.io

Co-investorsAngels of ManyFulgur Ventures

Colabracolabra.app

Colabra provides an AI workspace for M&A due diligence that converts sell-side document dumps into a clause-linked risk register, entity map, and gap analysis.

AI & Machine LearningFintechSaaS

Compliance transformation automation
Comprehensive workforce database
Contxtfulcontxtful.comin

Contxtful offers Receptiv, a product that scores each programmatic bid request in real time for user receptivity and bundles high-scoring impressions into a Deal ID synced to a buyer's DSP seat.

AdTechAI & Machine Learning

Co-investorsCreative Destruction Lab (CDL)TandemLaunch

Covariancecovariance.aiin

Covariance offers an AI product, Conrad, that answers questions about the US consumer economy — category and brand trends, competitor market share, and audience personas — grounded in purchase data from millions of households and merchants.

AI & Machine LearningData & InfrastructureMarketing Tech

Custom protein-producing fruit flies
Cytotronicscytotronics.cominMar 2024

Cytotronics develops Pixel, a semiconductor-to-live-cell interface platform that measures cell viability, morphology, electrophysiology, and metabolism at single-cell resolution across any cell type or 3D organoid system.

BiotechDeep TechSemiconductorsBoston, US

Jeffrey Abbott(Co-Founder & CEO)Vince Wu(Co-Founder & CTO)Duane Sword(Co-Founder & CBO)inDonhee Ham(Scientific Co-Founder)Hongkun Park(Scientific Co-Founder)Vince (Wenxuan) Wu(Founder)in

Co-investorsAnzu PartnersLYFE CapitalBantam GroupDraper Associates

Data-centric problem-solving platform
Decentralized allergy testing
Decentralized dialysis provider
Deep learning drug discovery
Digital electrical infrastructure company
Digital employee benefits wallet
Dispersadispersa.cain

Dispersa manufactures biosurfactants derived entirely from food waste, offering a platform of biodegradable bioproducts such as its flagship PuraSurf M ingredient for home, industrial, and institutional (HI&I) formulations.

BiotechCircular EconomyNew Materials

Co-investorsBDC Thrive Lab for WomenFront Row VenturesNàdarra Ventures

Drug resistance and treatment enhancement
DTC e-commerce brand scaling platform
Dynomicsdynomics.com
Elementaielementai.com

Element AI is a Canadian company that develops artificial intelligence software along with related services and tools.

Future of Work

Anne MartelGabriel DufordJean-Francois GagnéNicolas ChapadosYoshua Bengio

Co-investors500 Global

Encellinencellin.comin𝕏

Encellin develops next-generation therapies for patients with chronic unmet clinical needs, using technology originating from Dr.

BiotechDeep TechHealthtechMedical DevicesSan Francisco, US

Tejal Desai(Technology Expert, Founder)Ronald Martell(Strategic Advisor, Founder)Crystal Nyitray(Executive Officer, Director, Promoter)inGrace Wei(Executive Officer, Director, Promoter)in

BoardMaria del Consuelo Valverde(Director)

Co-investorsEvolution VC PartnersHow Women InvestITERATIVEMetaplanetKhosla VenturesSV Latam Capital+1 more

Endocrine disorder therapy developer
Endofoldendofold.bio
EV charging infrastructure
Fabricnanofabricnano.comin

FabricNano develops cell-free biocatalysis technology that immobilizes engineered enzymes onto scalable, environmentally friendly support materials for use in bio-processes.

BiotechCleantechNew MaterialsClaymont, US

Grant Aarons(Executive Officer, Director, Promoter)inFerdinando Randisi(Director)

BoardSiraj Khaliq(Director)inRobert Kniaz(Director)in

Co-investorsBackedEntrepreneur FirstHoxton VenturesPace VenturesAtomico

Fathomfathom.video

Fathom provides a platform that records and analyzes customer conversations, internal syncs, and strategy calls to give teams a shared view of information and identify patterns.

Enterprise SoftwareSaaS

Richard White(Founder)in

Co-investorsACTAI VenturesImmeasurableMaven VenturesRackhouse Venture Management LpChemistryEarl Grey Capital+2 more

Exits · 2

IPOs and acquisitions across the tracked portfolio

Valence Discoveryacq. by RecursionVolumetricacq. by 3D Systems

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has BoxOne Ventures made?
BoxOne Ventures has 85 tracked investments.
What stage does BoxOne Ventures invest at?
BoxOne Ventures invests at the Pre-Seed, Seed, Series A stages.
What is BoxOne Ventures's typical check size?
BoxOne Ventures typically writes checks of $500K.
What sectors does BoxOne Ventures focus on?
BoxOne Ventures focuses on AI & Machine Learning, Biotech, Cleantech, Energy, FoodTech, Healthtech, Longevity.
Where is BoxOne Ventures located?
BoxOne Ventures is headquartered in Montréal, CA.
Does BoxOne Ventures lead rounds?
Yes, BoxOne Ventures leads investment rounds.

Images

BoxOne Ventures photoBoxOne Ventures photo

Co-investors · 2

Entrepreneur First

Entrepreneur First (EF) is a talent investor that helps individuals build and launch startups, providing support such as US visa guidance, office space, fundraising preparation, and investor introductions culminating in a San Francisco Demo Day.

$1M – $7M
Sofinnova Ventures

Sofinnova is an investment firm focused on the life sciences and biotechnology sector, partnering with companies from inception through drug development, regulatory approval, company building, and IPO.

Both backed · 1
$100K – $15M

Firms observed investing alongside BoxOne Ventures, from public investor directories. Shared companies are the overlap with BoxOne Ventures's recorded portfolio.

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