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Lewis & Clark Ventures

Venture capital

St. Louis · Seed–Series A · 13 people tracked

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Investment thesis

Lewis & Clark Ventures partners with visionary founders to build iconic B2B software companies. The firm invests at the late seed through Series A stages, looking for founders with a big vision, a bold idea, and the ability to build and lead strong teams. Managed by former founders and operators, the firm brings an entrepreneurial mindset and aims to provide portfolio founders with the tools, guidance, and resources they need to succeed. Initial investments typically range from $2M to $3M, with flexibility in either direction.

Source: firm website, verified Aug 3, 2026.

Stage
Seed–Series A
Check
$2M – $3M
HQ
St. Louis, Missouri, US
Leads rounds
Leads
Instruments
Equity
Founded
2014
AUM
$104M
Tracked investments
19

Team · 13 people

from the firm's website & public directories
Courtney Moffat· Chief of Staff
Jessie Chapel· Investor Relations Managerin
Meg Lane· CFO & CCOin
Nick Nardacci· Vice Presidentin

What they invest in

from 13 of 19 portfolio companies

SaaS ×5AI & Machine Learning ×4Enterprise Software ×3Healthtech ×3AgTech ×2Data & Infrastructure ×2Developer Tools ×2HR Tech ×2

HQs:United States×6

Investments · 19 tracked

founders shown can be your intro path

By year:2023 · 12022 · 12020 · 13 dated

Sailessailes.comAug 2023

AI-powered sales enablement solution using natural language processing for top-of-funnel prospecting.

Kansas City, US

Nicholas Smith(Executive Officer, Director)

BoardJean-Luc Vanhulst(Director)John Tedesco(Director)

Board seatMichael Rockhold· per SEC Form D

Amperamper.xyzin
ArborXRarborxr.comin𝕏

ArborXR provides a device management platform for remotely managing, deploying content to, and controlling augmented and virtual reality headsets used in enterprise, healthcare, and education settings.

Deep TechDeveloper ToolsEnterprise Software

Brad Scoggin(CEO & Co-Founder)

Beam Benefitsbeambenefits.comin𝕏

Beam Benefits is a digitally-native employee benefits company offering dental, vision, life, and supplemental health insurance through an online platform with personalized rewards and AI-powered underwriting.

HealthtechHR TechInsurTechMadison, US

Alex Frommeyer(CEO)Alex CurryDan Dykes

Benson Hill Inc.bensonhill.com

Benson Hill develops genetically optimized soy seed varieties using AI-driven plant science, targeting agricultural producers seeking more nutritious, sustainable, and energy-dense crop solutions.

AgTechAI & Machine LearningNew Materials

Bindplanebindplane.comin𝕏

Bindplane provides an observability platform that collects, processes, and routes telemetry data from IT infrastructure and applications.

Data & InfrastructureDeveloper ToolsEnterprise Software

ChatLingualchatlingual.comin

ChatLingual provides a cloud-based multilingual AI messaging platform that lets enterprise customer support teams handle conversations in real time across any language and digital channel.

AI & Machine LearningEnterprise SoftwareSaaS

Daliadalia.coAug 2022

Dalia provides a platform for employers to optimize candidate conversion through career site tools, job matching, and AI-powered support.

HR TechSaaSWestwood, US

Samuel Fitzroy(Executive Officer, Director)Brian Hopcraft(Director)Jason Whitman(Executive Officer, Director)

GreenLight Biosciencesgreenlightbiosciences.comin

GreenLight Biosciences develops RNA-based solutions for agriculture and pest control, including a Colorado potato beetle bio-insecticide and a Varroa destructor mite-control product for sustainable food production.

AgTechBiotechImpact & Social GoodMedford, US

Andrey Zarur(Executive Officer, Director)Marta Ortega-Valle(Executive Officer)William Blake(Executive Officer)

BoardDavid Furneaux(Director)Jonathan Fleming(Director)James Swartz(Director)

Kaizenhealthkaizenhealth.org
Mealogicmealogic.ioin

Mealogic provides an end-to-end commerce platform that enables businesses to launch personalized meal delivery programs featuring chef-crafted, nutrition-led meals.

E-commerceFoodTechSaaS

Medavailmedavail.comNov 2020

HealthtechMississauga

Gerard van Hamel Platerink(Director)Gerald Gradwell(Director)Helen Ciesielski(Director)Glen Stettin(Director)Robert C. Faulkner(Director)Michael R. Kramer(Director)

Occuspaceoccuspace.io

Occuspace develops AI-enabled sensors that detect occupancy and space utilization through wireless signal scanning, without cameras or personal data collection.

AI & Machine LearningIoT

Onespaceonespace.comin

Flywheel provides AI-powered commerce software and services for CPG and retail brands, enabling them to optimize sales and market share across digital marketplaces and retail channels.

AI & Machine LearningRetail TechSaaS

Paygroundpayground.com

Chandler, US

Andrew Mercer(Executive Officer, Director)

Springbukspringbuk.comin𝕏

Springbuk provides a health data analytics platform that helps benefit leaders analyze employee health claims data to guide healthcare decision-making and benefit strategy.

Data & InfrastructureDigital HealthHealthtechSaaS

Text Linksummersalt.com
TomoCredittomocredit.comin

FintechSan Francisco, US

Kevin Irwin(Director)Ashwini Gupta(Director)Dukkyu Park(Director)Soyeon Kim(Executive Officer, Director)

Waldophotoswaldophotos.com

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Lewis & Clark Ventures invest at?
Lewis & Clark Ventures invests at the Seed, Series A stages.
What is Lewis & Clark Ventures's typical check size?
Lewis & Clark Ventures typically writes checks of $2M – $3M.
What sectors does Lewis & Clark Ventures focus on?
Lewis & Clark Ventures focuses on Advanced Manufacturing, Energy, Enterprise Software, Fintech, Healthtech, Medical Devices, SaaS.
Where is Lewis & Clark Ventures located?
Lewis & Clark Ventures is headquartered in St. Louis, US.
Does Lewis & Clark Ventures lead rounds?
Yes, Lewis & Clark Ventures leads investment rounds.

Images

Lewis & Clark Ventures photoLewis & Clark Ventures photoLewis & Clark Ventures photoLewis & Clark Ventures photoLewis & Clark Ventures photoLewis & Clark Ventures photo

Co-investors · 1

Valor Ventures

Valor Ventures is an early-stage venture capital firm focused on backing founders in the U.S. South, positioning the region as an under-resourced but fast-growing wealth center. It builds a community connecting founders, investors, and industry leaders through events and research.

Both backed · 1
$500K – $3M

Firms observed investing alongside Lewis & Clark Ventures, from public investor directories. Shared companies are the overlap with Lewis & Clark Ventures's recorded portfolio.

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