Wireframe Ventures
Venture capitalActively deployingSan Francisco · Pre-Seed–Seed · 3 people tracked
Also known as WIREFRAME MANAGEMENT, LLC
Investment thesis
Wireframe backs founders tackling some of the world's most important challenges. Drawing on the team's experience as investors and operators, the firm has developed networks and domain expertise across themes it cares about, and works closely with founders from inception through success. As first-check investors, Wireframe positions itself as fully aligned with founders from the outset. The firm also emphasizes building a community where founders can exchange hard-earned lessons with peers and support the next generation of entrepreneurs as they succeed.
Source: firm website, verified Aug 3, 2026.
Team · 3 people
from public directories
What they invest in
from 29 of 54 portfolio companiesAI & Machine Learning ×8Biotech ×8Climate Tech ×7Energy ×6SaaS ×6Data & Infrastructure ×5Cleantech ×4Enterprise Software ×4
HQs:United States×25United Kingdom×2
Investments · 54 tracked
founders shown can be your intro pathLos Angeles, US
Board seatPaul Straub· per SEC Form D · $6M raise · filed Aug 2022
London
William Earle A'Hern(Director)Eliot Brooks(Chief Executive Officer, President, Secretary, Treasurer)Frederic Scott(Director)William Knapp(Director)Lily Bernicker(Director)
Board seatLily Bernicker· per SEC Form D · $5.5M raise · filed Jun 2024
San Francisco, US
Muffadal Ghadiali(Executive Officer, Director, Promoter)Paul Straub(Director)Julie Lein(Director)Naeem Zafar(Director)
Board seatPaul Straub· per SEC Form D
Salient provides AI-powered weather and climate forecasts spanning from 1 day to 1 year using deep learning models trained on ocean and land-surface data.
AI & Machine LearningClimate TechData & InfrastructureFalmouth, US
Paul Straub(Director)Matthew Stein(Executive Officer, Director)Raymond Schmitt(Executive Officer, Director)
Board seatPaul Straub· per SEC Form D
San Francisco, US
Board seatPaul Straub· per SEC Form D · $32M raise · filed Apr 2021
Applied Carbon develops technologies to regenerate soil and sequester atmospheric carbon for climate change mitigation and soil health improvement.
AgTechCleantechClimate Tech
Jason Aramburu(CEO + Co-Founder)inMorgan M. Williams(COO + Co-Founder)in
Astronomer provides Astro, a platform for running Apache Airflow, the open-source data orchestration tool used by enterprises to manage AI, ML, and analytics pipelines at scale.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper Tools
Ry Walker(Founder)
EnergyLos Angeles, US
Joel Wishkovsky(Executive Officer, Director)Silviu Livescu(Executive Officer)Paul Straub(Director)Joselyn Lai(Executive Officer, Director)
Caladan Bio develops high-throughput benchtop bioreactor hardware and software for laboratory bioprocessing, enabling faster experimentation and lower costs for biotech R&D teams.
AI & Machine LearningBiotechHardwareNew York, US
Michael J. Kobida(Executive Officer, Director)Robert Jauquet(Executive Officer, Director)
Cocoon manufactures LoopCem™, a low-carbon supplementary cementitious material made from electric arc furnace slag waste, enabling cement and concrete producers to reduce embodied CO₂ by up to 27% without cost premium.
Circular EconomyCleantechClimate TechLondon, GB
Fierce Biotech is a news publication covering the biotechnology, pharmaceutical, and medtech industries, reporting on clinical trials, deals, venture capital, drug development, and research.
BiotechMedia & Entertainment
DNAnexus is a cloud platform for precision health research that enables pharmaceutical, biotech, and academic organizations to process and analyze genomic and multi-omics data at scale.
BiotechCloud ComputingData & InfrastructureMountain View, US
HANNES SMARASON(Director)Richard Daly(Executive Officer, Director)MICHAEL GOLDBERG(Director)GEOFF DUYK(Director)STEPHEN THAU(Executive Officer)NATHANIEL GOLDHABER(Director)
Leverages AI and metabolomics to translate molecules found in nature into new therapeutics.
Full Harvest builds an agentic intelligence platform that orchestrates transactions and operations across the North American fresh produce supply chain, helping buyers and growers navigate climate volatility, labor shortages, and regulatory complexity.
AgTechAI & Machine LearningLogistics & Supply ChainUnknown, US
Geneticure provides genetic testing and precision medicine services to support cardiovascular and hypertension management through pharmacogenomic analysis and personalized clinical insights.
BiotechDigital HealthMedical DevicesEden Prairie, US
Scott Snyder(Chief Executive Officer)inEric Snyder(Chief Operating Officer)Ryan Sprissler(Chief Scientific Officer)Tom Olson(Chief Clinical Officer)
Gridware provides real-time monitoring and visibility of electrical grid conditions through sensors deployed on power lines, enabling utilities and line workers to detect and respond to problems faster.
Advanced ManufacturingClimate TechEnergyEnterprise SoftwareHardwareIoTSan Francisco, US
Tim Barat(Founder)inOmar B(Founder)inHall Chen(Co-Founder & CTO)in
LevelTen Energy operates a platform that connects renewable energy developers with customers and market participants, facilitating project visibility and deal-making in the renewable energy sector.
B2B MarketplacesCleantechClimate TechEnergySaaSSeattle, US
Bryce Smith(Executive Officer, Director)Smith Bryce(Executive Officer, Director)William Thomas(Executive Officer)
BoardDavid Cohen(Director)Karly Wentz(Director)Greg Lyons(Director)
Developing in-vivo CRISPR-based gene editing therapies.
Mammoth Bio develops technology to read and write the code of life, operating in the biotechnology sector.
BiotechDeep TechMedical DevicesBrisbane, US
Jennifer Doudna(Founder)inTrevor Martin(Co-founder, Chief Executive Officer)Janice Chen(Co-founder, Chief Scientific Officer & President, Research)Lucas Harrington(Co-founder)inUrshit Parikh(Director)Ashley Tehranchi(Executive Officer, Director)
Near Space Labs provides high-resolution 7cm geospatial imagery captured from stratospheric altitudes, serving government, utilities, insurance, and environmental monitoring applications with frequent data refresh cycles and wide-scale coverage.
Climate TechData & InfrastructureSpace Tech
Rema Matevosyan(Founder & CEO)in
OpenInvest builds investment portfolio management software that customizes stock and bond holdings based on individual investor values and ethical preferences, while maintaining performance relative to standard market benchmarks.
FintechSan Francisco, US
Phytoform Labs develops GM-free genome editing tools and trait engineering technologies for crop improvement, with a focus on potato and tomato varieties.
AgTechAI & Machine LearningBiotechHarpenden, GB
William Pelton(Executive Officer, Director)Nicholas Kral(Director)Dhiraj Singh(Director)
Regeneron discovers, develops, and manufactures biologics and genetic medicines for treating serious diseases including metabolic disorders, ophthalmology conditions, and rare diseases.
BiotechHealthtechMedical DevicesTarrytown, US
Semafor is a global news platform designed to deliver journalism with transparency by separating facts, analysis, opinion, and counter-narratives, serving a global audience of informed citizens.
Media & EntertainmentNew York, US
Justin Brainerd Smith(CEO)Garett Wiley(Executive Officer)Ben
SuperCircle is a technology and reverse logistics platform that helps retail brands launch trade-in programs and manage excess inventory to reduce textile waste.
Circular EconomyLogistics & Supply ChainSaaS
Synop provides an all-in-one platform for managing electric vehicle fleets and charging infrastructure, optimizing performance and energy management for commercial fleet operators.
EnergyEnterprise SoftwareSaaSCarmel, US
Gagandeep Dhillon(Executive Officer, Director)Andrew Blejde(Executive Officer, Director)
Building a laser-driven nuclear fusion prototype system.
EnergyFoster City, US
ALEXANDER VALYS(Executive Officer, Director)Conner Galloway(Executive Officer, Director)
Zivian Health builds compliance infrastructure and workforce management software for healthcare providers, nurses practitioners, and physician assistants operating across multiple states or remotely.
Digital HealthHealthtechSaaS
Rafid Fadul(Co-founder, Chief Medical Officer)Griffin Mulcahey(Co-founder, CEO)Jaclyn Miller(Chief Product Officer)Vanessa(Engineering Leader)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Wireframe Ventures invest at?
- Wireframe Ventures invests at the Pre-Seed, Seed stages.
- What is Wireframe Ventures's typical check size?
- Wireframe Ventures typically writes checks of $500K – $2M.
- What sectors does Wireframe Ventures focus on?
- Wireframe Ventures focuses on Biotech, Cleantech, Climate Tech, Energy, Healthtech, Impact & Social Good, Sector Agnostic.
- Where is Wireframe Ventures located?
- Wireframe Ventures is headquartered in San Francisco, US.
- Does Wireframe Ventures lead rounds?
- Yes, Wireframe Ventures leads investment rounds.
Media · Podcasts & interviews
featuring the teamPaul Straub | Co-Founder & Managing Director, Wireframe Ventures
ZNRG - The ZENERGY Podcast · Paul Straub
Ventures #5 w/ Harsh Patel - Managing Partner & Co-Founder @ Wireframe Ventures | BIOS
BIOS · Harsh Patel
Ep.#47: Partnering with founders for human and planetary health: Paul Straub from Wireframe Ventures
StartupBasecamp org · Paul Straub
EDGE Chats: Paul Straub, Co-Founder and Managing Partner, Wireframe Ventures
Duke University - The Fuqua School of Business · Paul Straub
Why Apply to SkyDeck? | Why Apply to SkyDeck? Harsh Patel of Wireframe Ventures shares why early-stage VCs work with SkyDeck to identify Cal's top tech talent. | By Berkeley SkyDeckFacebook
Harsh Patel · facebook.com
Co-investors · 11
Gigascale Capital is an early-stage investment firm backing founders building physical systems and infrastructure across energy, factories, supply chains, and infrastructure for climate impact.
GV (formerly Google Ventures) is a venture investment firm that backs founders across many industries, aiming to build long-term relationships and support companies across multiple stages and milestones.
SOSV is a deep tech venture capital firm that makes first-check pre-seed investments and follow-on rounds in startups focused on human and planetary health, providing lab space and hands-on support at its US locations.
Urban Innovation Fund is a seed-stage venture firm that invests in startups transforming large, regulated industries, providing capital, hands-on support, and regulatory insight.
Allos Ventures is a Midwest-focused venture capital firm that invests in early-stage B2B software and tech-enabled services companies, drawing on decades of experience to take a hands-on approach.
G2 Venture Partners is a venture capital firm that invests in technology companies at their inflection points to help transform traditional industries toward sustainability.
muru-D is Telstra's innovation hub focused on incubating ideas, products, and technologies, prototyping solutions and accelerating a portfolio of start-ups across Australia, Asia, and the USA.
Piva Capital is a venture capital firm that invests in companies aiming to shape the future for humanity.
1517 is a venture capital fund and community backing college dropouts, uncredentialed founders, and deep tech scientists at the earliest stages, from R&D/idea through seed. It was founded by the cofounders of the Thiel Fellowship and also provides grants and a global community of hackers, makers, and scientists.
Active Impact Investments is a climate tech seed fund based in Canada, backing early-stage companies that advance planetary sustainability by innovating across production and consumption industries.
VentureUs is an angel investment group focused on seed and early-stage companies in the Pacific Northwest, using a member-advised, participatory process to source, evaluate, and fund startups.
Firms observed investing alongside Wireframe Ventures, from public investor directories. Shared companies are the overlap with Wireframe Ventures's recorded portfolio.
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