E12 Venture Capital, Llc
Los Altos · Seed–Series A · 11 people tracked
Investment thesis
E12 Ventures believes machine intelligence and data infrastructure will fundamentally reshape how intelligent systems are built across industries. The firm targets emerging companies positioned to exploit the evolving compute and data environment by developing machine intelligence technologies. Their investment thesis is grounded in the conviction that the massive volume of globally generated data creates a generational shift requiring responsive infrastructure for billions of interconnected people and devices to enable the next wave of AI-driven innovation.
Source: firm website, verified Jul 20, 2026.
Team · 11 people
from the firm's website
What they invest in
from 13 of 13 portfolio companiesAI & Machine Learning ×6Healthtech ×5Enterprise Software ×4Cleantech ×3Digital Health ×3Advanced Manufacturing ×2Biotech ×2Climate Tech ×2
HQs:United States×3
Investments · 13 tracked
founders shown can be your intro pathArchetype AI develops a platform and foundation model called Newton that deploys physical intelligence agents for real-world operations. The platform enables enterprises in construction, manufacturing, telecommunications, and other industries to build, deploy, and manage AI agents that monitor equipment, detect anomalies, and make decisions on physical assets using sensor fusion and edge AI.
AI & Machine LearningDeep TechEnterprise Software
C16 Biosciences produces high-value lipid ingredients using fermentation of naturally occurring microorganisms for manufacturers of beauty, personal care, home care, and food products. The company's biomanufacturing platform enables sustainable production with 250x greater land efficiency than traditional ingredient sources.
BiotechCleantechClimate TechConsumerHealthtechNew MaterialsNew York City, US
Shara Ticku(Co-Founder & Chief Executive Officer)inDavid Heller(Co-Founder & Chief Operating Officer)inHarry McNamara(Founder)in
Ciba Health provides an AI-powered virtual chronic care platform designed to manage Type 2 diabetes, obesity, and other chronic conditions for employers, health plans, and health systems. The platform delivers clinical outcomes and pharmaceutical cost savings through predictive analytics and whole-person care coordination.
AI & Machine LearningDigital HealthHealthtech
Ellipsis Health builds Sage, an AI voice agent designed to support healthcare organizations by handling patient interactions and expanding clinical capacity. The platform aims to improve patient care coordination across physical, mental, and social needs while freeing clinicians to focus on complex care.
AI & Machine LearningDigital HealthHealthtech
Fiddler provides an AI control plane that offers monitoring, guardrails, and governance for enterprise AI agents and compound AI systems. The platform delivers real-time visibility and enforcement along an agent's request and response path.
AI & Machine LearningDeveloper ToolsEnterprise Software
Neura Health provides telemedicine video visits with board-certified neurologists for conditions including migraine, epilepsy, sleep disorders, tremor, concussion, and stroke. The platform offers both one-time consultations and ongoing management care plans for patients seeking remote neurological care.
Digital HealthHealthtechNew York, US
One.bio develops food products designed to provide beneficial molecular signals to support health and address chronic inflammatory disease. The company applies rigorous molecular science to food composition and production.
BiotechFoodTechHealthtechWellness & Fitness
Matt Amicucci(Co-Founder & Chief Science Officer)Matt Barnard(Co-Founder & CEO)
Pattern Labs develops autonomous robotics and software systems for airport ground operations and dynamic logistics. The company leverages expertise in unstructured autonomy and complex process optimization to improve efficiency and safety in fast-paced logistics environments.
AI & Machine LearningLogistics & Supply ChainRobotics
Rhino Federated Computing provides enterprise software infrastructure enabling organizations to run AI, analytics, and data workflows across distributed data environments while preserving privacy and security. The platform serves healthcare, life sciences, financial services, and public sector organizations managing sensitive, regulated data.
AI & Machine LearningData & InfrastructureEnterprise Software
Dr. Ittai Dayan
TELO designs and manufactures the MT1, an all-electric compact pickup truck combining the capability of a Toyota Tacoma with Tesla-like range and efficiency in a Mini Cooper-sized footprint. The vehicle targets consumers seeking a practical, technically advanced EV truck for both urban and off-town use.
CleantechHardwareMobility & Transportation
Oishii grows specialty berries and tomatoes using vertical farming technology in controlled indoor environments, with a focus on non-GMO, sustainable production. The company distributes premium produce to high-end retailers including Whole Foods in the northeastern United States.
AgTechFoodTechNew York, US
Hiroki KogaBrendan Somerville
Unspun develops 3D weaving technology and software for apparel and textile manufacturing, enabling fast, automated, and low-waste garment production for brands and manufacturers. The company positions its Vega system as a solution for local, on-demand production that reduces carbon emissions from fashion.
Advanced ManufacturingCleantechClimate Tech
First Resonance builds ION, a manufacturing execution system (MES) platform that helps hard-tech companies manage digital manufacturing, inventory, production scheduling, and analytics across their factory operations. The platform serves hardware engineers and manufacturers building products in sectors like electric vehicles, aerospace, and advanced manufacturing.
Advanced ManufacturingDeep TechEnterprise Software
Frequently asked questions
- What stage does E12 Venture Capital, Llc invest at?
- E12 Venture Capital, Llc invests at the Seed, Series A stages.
- What sectors does E12 Venture Capital, Llc focus on?
- E12 Venture Capital, Llc focuses on AgTech, Climate Tech, Fintech, FoodTech, Logistics & Supply Chain, Robotics.
- Where is E12 Venture Capital, Llc located?
- E12 Venture Capital, Llc is headquartered in Los Altos, US.
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