/Investor DB

Fifty Years

Venture capitalActively deployingoperating company · company profile

San Francisco · Pre-Seed–Seed · 14 people tracked

Also known as 50 Years · FIFTY YEARS INDUSTRIES, LLC

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Investment thesis

Fifty Years invests at the pre-seed and seed stages in founders who apply breakthrough science and technology to address humanity's biggest challenges, including climate change, disease, connectivity, and malnutrition. The firm has a strong emphasis on deep tech and scientist-founders, having backed dozens of PhD founders and CEOs, and positions itself as helping world-class scientists become world-class entrepreneurs. Beyond capital, 50Y helps start companies and is backed by a network of founders of billion-dollar technology companies who support the next generation. Its guiding philosophy is to use capitalism as a force for good.

Source: firm website, verified Sep 29, 2026.

Stage
Pre-Seed–Seed
Check
$250K – $2M
HQ
San Francisco, CA, US
Leads rounds
Follows
Instruments
Equity
Founded
2015
Last 12 months
8 investments
Private fund assets
$854.7M
VC funds
5
Tracked investments
177
Unicorns
4
IPOs
4
Acquisitions
7

Team · 14 people

from the firm's website
Kasia Bojanowska· Designer

Artist, illustrator, and designer responsible for visual work at Fifty Years.

Kia Fathi· Head of Engineeringin

Veteran engineer, builder, and former founder.

Souvid· Creative Director (UK)in

Storyteller and filmmaker bringing human-centered storytelling to deep tech.

7 people who came through Fifty Years went on to found or lead other companies.

What they invest in

from 154 of 177 portfolio companies

Biotech ×77AI & Machine Learning ×66Deep Tech ×65Healthtech ×46Advanced Manufacturing ×20Climate Tech ×20Medical Devices ×20Digital Health ×18

HQs:United States×88United Kingdom×5Canada×4Germany×2Australia×1Spain×1

Who they back

founder profiles across 111 portfolio companies
19%
solo founders
21 of 111 mapped founding teams
34%
repeat founders
of 164 founders with career history
~3 yrs
old at investment
median across 26 dated deals

Founding team size:solo founder×212 founders×443 founders×244+ founders×22

Where their founders studiedfrom 147 founders with education data

Massachusetts Institute of Technology ×14University of California, Berkeley ×13Harvard University ×8University of Cambridge ×8Stanford University ×5University of Colorado Boulder ×5Princeton University ×4Technical University of Munich ×4

What their founders studiedfrom 158 founders with field-of-study data

Engineering ×53Life Sciences ×38Computer Science ×30Business & Management ×14Mathematics & Statistics ×11Chemistry ×9Physics ×7Medicine ×6

Where their founders worked beforefrom 164 founders with career history

Stanford University ×21Caltech ×6Google ×5Harvard Medical School ×5Massachusetts Institute of Technology ×4Microsoft ×4Tesla ×4Freenome ×3

Accelerator rootsportfolio companies that came through a program

Y Combinator ×44

83 founders hold a PhD · 4 hold an MBA (of 169 with degree data)

Investments · 177 tracked

founders shown can be your intro path

By year:2026 · 42025 · 72024 · 42023 · 52022 · 92021 · 82020 · 22019 · 32018 · 32017 · 146 dated

BillionToOnebilliontoone.comin𝕏NASDAQ: BLLNSeed

BillionToOne is a precision diagnostics company that uses molecular counting technology to develop non-invasive prenatal screening and liquid biopsy tests for early disease detection.

BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US

Oguzhan Atay(Founder)inDavid Tsao(CTO)inSukrit Silas(Founder)inBrett Huff(Director of Engineering)Mihir Sewak(Software Engineering Manager)Jen Katzburg(Principal Recruiter)

Co-investors500 Emerging Europe500 GlobalAsymmetry VenturesCivilization Ventures Management, Llce2vcFriale+23 more

Health Catalysthealthcatalyst.comin𝕏NASDAQ: HCAT

Health Catalyst provides a data platform, analytics applications, and AI-powered insights that help healthcare organizations improve clinical, financial, and operational performance.

AI & Machine LearningData & InfrastructureDigital Health

Benjamin Albert(Chief Executive Officer and Director)Jason Alger(Chief Financial Officer)inLinda Llewelyn(Chief People Officer)inSteve Barlow(Founder)Tom Burton(Founder)

Co-investorsDecheng CapitalEPIC VENTURESKaiser Permanente VenturesNorwest Venture PartnersOSF VenturesSequoia Capital+2 more

Mednaxpediatrix.comNYSE: MDOct 2021 · $25M

Pediatrix provides physician-led specialized medical care for women, babies, and children, delivered both in person and virtually across the United States.

Digital HealthHealthtechSunrise, US

Roger J. Medel, M.D.(Executive Officer, Director)Joseph M. Calabro(Executive Officer)Vivian Lopez-Blanco(Executive Officer)Dominic Andreano(Executive Officer)Mark S. Ordan(Chief Executive Officer and Chair of the Board)Kasandra H. Rossi(Executive Vice President, Chief Financial Officer and Treasurer)

Co-investorsCity LightCollaborative FundGaingelsGreycroftY Combinator

Solugensolugen.comin𝕏Seed · Sep 2021 · $357M✓ verified

Solugen develops a biomanufacturing platform using fermentation and bioprocessing technology to produce specialty chemicals at scale.

Advanced ManufacturingBiotechCleantechClimate TechHealthtechHouston, US

Sean Hunt(CTO)inGaurab Chakrabarti(Founder)inJonathan Tang(Investor)inSlava Solonitsyn(Investor)in

Board seatSeth Bannon· per SEC Form D

Co-investorsFounders FundLowercarbon CapitalY CombinatorBaillie GiffordGICKdT Ventures+40 more

Waferwafer.aiin𝕏Seed✓ verified

Wafer develops performance optimization tools and services across GPU accelerators, architectures, and computing stack layers.

AI & Machine LearningCloud ComputingDeep TechDeveloper ToolsEnterprise SoftwareSan Francisco, US

Emilio Andere(CEO)inSteven Arellano(Cofounder)in

Co-investorsY CombinatorWingLiquid VenturesVercel

54Gene54gene.comin𝕏SeedDefunct

54Gene conducts genomics research and provides related services to increase the representation of African genetic data in medical research, which aims to advance healthcare solutions globally.

HealthtechWellness & FitnessLagos, NG

Gatumi Aliyu(Founder)inAbasi Ene-Obong(CEO)inOgochukwu Francis Osifo(Founder)inDamilola Oni

Co-investorsAdjuvant CapitalBVP InvestorsEndeavor CatalystFuture AfricaKairos AngelsThe Raba Partnership+16 more

64x64-x.comin𝕏Jan 2022

64x provides a platform and product suite for manufacturing advanced therapeutics, including gene therapies, cell therapies, and biologics.

BiotechDeep TechMedical Devices

Co-investorsBoxGroupFirst Round CapitalFuture VenturesLifeforce CapitalNorthpond VenturesRefactor Capital+1 more

64x Bio64xbio.comin𝕏Seed · Jan 2022 · $55M

64x develops infrastructure and manufacturing systems for next-generation medicines, focusing on genetic engineering, cell line development, and computational biology to enable scalability of advanced therapies.

AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesSan Francisco, US

Lexi Rovner(CEO)inAlexis Rovner(Founder)Ryan GallagherEmily Hawkins(Head of Talent)

Co-investorsFuture VenturesG VenturesLifeforce CapitalRaptor GroupY CombinatorAlix Ventures+8 more

Aalo Atomicsaalo.comin𝕏

Aalo develops advanced nuclear reactor technology aimed at producing electricity at under 3 cents per kilowatt-hour.

Climate TechDeep TechEnergyHardware

Matt(Co-founder)inYasir(Co-founder)inMatt Loszak(Founder)inYasir Arafat(Founder)

Co-investorsAkkaAlumni VenturesAtaraxia CapitalBanca Investis — Family OfficeBasecamp FundBlack Flag+35 more

Able Healthablehealth.cominSeed · Mar 2019Acquired

Able Health provides software for physician organizations to administer value-based care programs, including quality measure calculation and health plan coordination to reduce administrative overhead.

HealthtechSan Francisco, US

Rachel Katz(CEO)inSteve Daniels(President)in

Co-investorsLifeforce CapitalMission and MarketSoma CapitalY CombinatorGreat Oaks Venture CapitalRefactor Capital

AcouBattacoubatt.ai

AcouBatt provides acoustic monitoring and AI-based detection for battery energy storage systems, identifying abnormal cell behavior and safety risks in real time.

Advanced ManufacturingAI & Machine LearningDeep TechEnergyHardwareIoTLondon, GB

Dr. Arthur Fordham(Co-founder)

Co-investorsAda VenturesCreator Fund

Acreacre.fiin𝕏Feb 2022 · $37M

Acre is a Bitcoin-focused DeFi protocol offering auto-compounding vaults that let BTC holders earn yield through curated onchain strategies while retaining self-custody of their private keys.

Crypto & Web3Fintech

Co-investorsDraper DragonFlowdeskSilvermine CapitalCollaborative FundFootPrint CoalitionLowercarbon Capital+1 more

Adaptionadaptionlabs.aiin𝕏Feb 2026

Adaption Labs builds adaptive AI systems that continually learn and adjust to specific industries, languages, and use cases, positioning itself against large monolithic, one-size-fits-all models.

AI & Machine LearningDeep Tech

Sara Hooker(Founder)Sudip Roy(Founder)

Co-investorsAlpha Intelligence CapitalEmergence Capital PartnersMozilla VenturesThe E14 FundThreshold VenturesZ21 Ventures+1 more

Advanoadvano.ioin𝕏

Advano manufactures silicon-based anode materials for lithium-ion batteries that improve energy density and reduce costs for electric vehicles.

Advanced ManufacturingCleantechClimate TechNew Orleans, US

Shiva Adireddy(CTO)inAlexander Girau(CEO)in

Co-investorsAAF Management Ltd.Boot64 VenturesGlobivestInnovation CatalystManta International Consultancy S.A.LNew Orleans Startup Fund+22 more

AlemHealthalemhealth.comin𝕏Seed

AlemHealth develops hardware and software tools for hospitals and diagnostic centers in emerging markets to deliver radiological imaging services and analysis with minimal requirements for reliable power, internet connectivity, or on-site specialists.

AI & Machine LearningHealthtechSingapore, SG

Aschkan Abdul Malek(Founder)inSajjad Kamal(CTO)

Co-investorsDCVC (Data Collective)Y CombinatorEnabling FutureS2 CapitalVenture Investment Associates

Algiplexalgiplex.co.ukin

Algiplex develops synthetic microbial ecosystems designed to boost microalgae biomass yields for algae producers, improving culture growth rate and resistance to culture crash events with minimal additional nutrient or energy costs.

AgTechBiotechCleantech

Alpine Bionobellfoods.comin𝕏Series B

Nobell Foods produces plant-based dairy cheese made from soybean plants engineered to grow casein protein, working with Midwest farmers.

BiotechClimate TechConsumerFoodTechSan Francisco, US

Magi Richani(CEO)inShu Li(Founder/CSO)

BoardChris Rivest(Director)Vijay Pande(Director)inKyle Vogt(Director)

Co-investorsAgFunderAndreessen HorowitzDCVC (Data Collective)Mission BiocapitalUnovis Asset ManagementY Combinator+7 more

Alpine Bioalpbio.comin

Alpine Bio develops and commercializes functional proteins and bioactive ingredients for food, nutrition, and health applications, targeting formulators who need performance, supply reliability, and clean-label positioning.

AgTechBiotechFoodTechNew Materials

Co-investorsBreakthrough Energy VenturesGermin8 VenturesPear VC

Ansa Biotechnologiesansabio.comin𝕏Seed

Ansa provides an enzymatic DNA synthesis platform that directly synthesizes complex sequences up to 900 bp and delivers constructs up to 50 kb without assembly-based methods.

BiotechDeep TechHealthtechEmeryville, US

Dan Lin-Arlow(Founder)inSebastian Palluk(Founder)inDaniel Hillel Lin-Arlow(Executive Officer, Director)Jason T. Gammack(Executive Officer, Director)inDaniel Lin-Arlow(Founder)Jared Ellefson(Founder)

Co-investorsCarbon SiliconCerberus VenturesDauntless VenturesJude GomilaMetaplanetY Combinator+12 more

Antora Energyantora.comin𝕏

Antora manufactures thermal battery systems for long-duration energy storage, serving manufacturers and data centers seeking to tap into low-cost renewable power.

CleantechClimate TechEnergyEnterprise SoftwareFintechHardwareImpact & Social GoodNew MaterialsSunnyvale, US

Andrew Ponec(Founder)inDavid Bierman(Founder)inJustin Briggs(Founder)inDavid Bierman, Ph.D.(Chief Commercial Officer, co-founder)Justin Briggs, Ph.D.(Chief Operating Officer, co-founder)Alfred Johnson(CEO & Co-Founder)

Co-investorsAndreessen HorowitzBlackRockTemasekBreakthrough Energy VenturesCongruent VenturesCreative Destruction Lab (CDL)+23 more

Apollo Atomics, Inc.apolloatomics.comin𝕏

Apollo Atomics develops compact nuclear power systems designed for rapid deployment.

Advanced ManufacturingClimate TechDeep TechEnergyBoston, US

Assil Halimi(CEO)inDrew Walker(COO)in

Co-investorsAlumni VenturesAngel Operator Partners (aop)Cliff CapitalKima VenturesKoru CapitalNeutron Power Ventures+42 more

Aralez Bioaralezbio.comin

Aralez Bio produces noncanonical amino acids using biocatalysis, including compounds that add rigidity to peptide backbones and increase enzyme resistance.

BiotechCleantechClimate TechDeep TechNew MaterialsBerkeley, US

Tina Boville(Co-founder & CEO)inDavid Romney(Co-founder)inFrances Arnold(Co-founder / Scientific Founder)

Co-investorsAstiaFREEFLOWGood Growth CapitalISVJuniperPaladin Capital Group+2 more

Arpeggio Bioarpeggiobio.comin𝕏Seed

Arpeggio Bio develops pharmaceutical drugs that target transcription factors using artificial intelligence and RNA-sequencing technology, with lead programs in development for melanoma treatment and rare disease applications.

BiotechHealthtechBoulder, US

Joey Azofeifa(Founder)inLaura Norris(Executive Officer, Director)inTimothy Read(Executive Officer, Director)Eric Martin(Executive Officer)in

BoardAmit Mehta(Director)

Co-investorsATEM Capital FundFundersClubTau VenturesvenBio PartnersY CombinatorAlamo Angels+9 more

AssureDropassuredrop.comin𝕏

AssureDrop develops droplet microfluidics-based screening technology that works within standard multiwell plates for pipette-free, high-throughput screening of 3D cell models such as spheroids.

BiotechDeep TechHealthtech

Ankur Chaurasia(Founder)in

Astranisastranis.comin𝕏Seed · Apr 2021

Astranis manufactures small, high-powered geosynchronous satellites equipped with advanced digital processing technology for global telecommunications and connectivity services.

Advanced ManufacturingDeep TechHardwareSpace TechSan Francisco, US

John Gedmark(CEO)inRyan McLinko(CTO)inMike Mancini(Executive Officer)Siamak Ebadi(Lead RF Engineer)inHall Chen(RF Payload Design)inShraddha Pandya(Talent Acquisition)

Co-investorsAndreessen HorowitzATEL VenturesBlack FlagBoxGroupCantos VenturesCherubic Ventures+85 more

Athelasathelas.comin𝕏Seed · Jan 2022

Athelas develops software tools for private practice healthcare providers to reduce administrative burden, improve operational efficiency, and enhance patient scheduling and navigation capabilities.

AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US

Deepika Bodapati(Founder)inTanay Tandon(Founder)inSteve Moffatt(Hardware and Operations)Wiley Jones(Hardware Engineer)Cynthia Jiang(Recruiter)John Zhao(Vice President \u0026 GM)

Co-investorsAmity VenturesDorm RoomGeneral CatalystHuman CapitalInitialized CapitalLiquid Ventures+10 more

Atom Computingatom-computing.comin𝕏

Atom Computing develops large-scale quantum computers using optically-trapped neutral atoms for on-premises deployment.

Deep TechHardwareQuantum ComputingBerkeley, US

Ben Bloom(Founder)inBenjamin Bloom(Founder)Jonathan King(Founder)

BoardDror Berman(Director)inEthan Batraski(Director)in

Co-investorsAbstract VenturesAlumni VenturesBerkeley FrontierBlue Ivy VenturesBoxGroupCantos Ventures+21 more

Avail Bioavail.bioin

Data and software platform to better understand the immune system

Nima C Emamiin

Co-investorsHAWKTAIL

Avro Life Scienceavrolifesci.comSeed

Avro Life Sciences develops platform technology for novel drug delivery through passive transdermal administration.

BiotechHealthtechMedical DevicesWaterloo, CA

Shak Lakhani(Founder)inKeean Sarani(Founder)in

Co-investorsCreative Destruction Lab (CDL)Embark VenturesGarage CapitalHeuristic Capital PartnersJude GomilaUpHonest Capital+10 more

Azulene Labsazulenelabs.comin𝕏

Azulene Labs develops physics-powered molecular discovery technology.

AI & Machine LearningBiotechDeep TechNew MaterialsBerkeley, US

Co-investorsEntrada Ventures

Bioqore AIbioqore.aiin

Bioqore builds Voyager, an AI-powered closed-loop bioprocess intelligence platform that combines predictive modeling with micro-scale laboratory experiments to recommend and validate optimal process conditions for producing preclinical- and clinic-ready therapeutic candidates.

AI & Machine LearningBiotechDeep Tech

Joshua Hinckley(CEO)inBrendan Dang(COO)in

Co-investorsAdverb VenturesMaC Venture Capital

BioRenderbiorender.comin𝕏Seed

BioRender is a software tool that enables scientists to create and share professional scientific illustrations and figures.

BiotechEdTechEnterprise SoftwareSaaSToronto, CA

Ryan Marien(Founder)inKatya Shteyn(Founder)inShiz Aoki(CEO)inEmily Bush(Talent Acquisition Manager)Jenn Huynh(Recruiter)Kayoko Omatsu(Senior Technical Recruiter)

Co-investorsY CombinatorFundersClubOlima VenturesStandard CapitalBraewick HoldingsBragiel Brothers+5 more

BIOS Healthbios.healthin𝕏Seed · Jun 2023

BIOS develops neural digital therapy technology to deliver treatments for neurological conditions.

AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesCambridge, GB

Oliver Armitage(Founder)inEmil Hewage(Director)in

Co-investorsFOUNDER.orgHeuristic Capital PartnersKern Venture GroupThe Venture CollectiveY CombinatorAgrolimen Ventures+6 more

BioSens8biosens8.comin𝕏

Biosens8 develops wearable health monitoring devices that track physiological markers including cortisol and women's health metrics.

BiotechDeep TechDigital HealthFemTechHardwareHealthtechMedical DevicesWellness & FitnessCambridge, US

Uroš Kuzmanović(CEO)in

BloomAPIbloomtext.cominSeed

BloomText provides HIPAA-compliant messaging software built specifically for healthcare organizations.

Digital HealthHealthtechSaaSSeattle, US

Michael Wasser(CEO)inHeather Milone(Executive Business Advisor)inBrent DormanTyler Brown(CEO)Eric Jain(CTO)

Co-investorsY CombinatorAvlok CapitalBuckley Ventures Management Company LlcFounders' Co-opFrialeLiquid Ventures+4 more

Bnextbnext.bio

b.next develops technologies and infrastructure for building synthetic cells from scratch, working with researchers, universities, governments, and funders.

BiotechDeep Tech

Akshay Maheshwari, MD, PhD(Founder)in

Co-investorsCometaConexo VenturesDN CapitalEnernFounders FutureKreos Capital+2 more

Boltzboltz.bioin

Boltz develops generative AI models for biomolecular design and drug discovery, used by researchers across pharmaceutical, biotech, agricultural, and academic sectors.

AI & Machine LearningBiotechDeep TechLondon, GB

Gabriele Corso(Founder)inSaro Passaro(Founder)inJeremy Wohlwend(Founder)

Co-investorsAmplify PartnersAndreessen HorowitzFactorial CapitalObvious VenturesZetta Venture Partners

Boundary Layer Technologiesboundarylayer.techin𝕏Seed

Valo produces modular hydrofoil systems for boat manufacturers to integrate into vessels, enabling boats to achieve higher speeds while reducing energy consumption and operational noise.

Advanced ManufacturingClimate TechSan Francisco, US

Ed Kearney(CEO)inJeremy Osborne(Founder)in

Co-investorsHemisphere Ventures LLCJude GomilaSoma CapitalUtopian VenturesV1 VCY Combinator+10 more

Brave Carebravecare.com𝕏Seed · Aug 2019 · $5MDefunct

Brave Care operates pediatric primary and urgent care clinics designed to treat common acute conditions in children, supplemented by remote consultations delivered by clinicians.

HealthtechPortland, US

Asa Miller(Founder)inDarius "Bubs" Monsef(Founder)inMaryam Taheri(Founder)inCorey Fish, MD(Founder)inGary Gerlacher(Executive Officer, Director)Corey Fish, M.D.(Executive Officer, Director)

Co-investorsAlumni VenturesAV8 VenturesVentureSouqY CombinatorZillionizeAVG+16 more

Cache Dnacache-dna.comin𝕏

Cache develops a platform for reliable long-term storage and access of biomolecules to support precision medicine and fundamental research.

BiotechDeep TechHealthtech

Co-investorsHAWKTAILJuniperLifeX VenturesTaihill VentureTrousdale VenturesValkyrie

Catalogcatalogdna.comin𝕏

Biomemory develops DNA-based data storage systems for data centers, offering an alternative storage tier optimized for long-term archival, density, and energy efficiency.

Climate TechData & InfrastructureDeep Tech

Hyunjun Park(CEO)

Co-investorsCivilization Ventures Management, LlcHemisphere Ventures LLCNew Enterprise Associates (NEA)Prefix CapitalZ Venture CapitalCantos Ventures+3 more

Caucellcaucell.com

A biotech company associated with immunology and cellular research, listing medical and scientific advisors.

Biotech

Mark Davis(Founder and scientific advisor)Kate Medetgul-Ernar(Founder and COO)Kwat Medetgul-Ernar(Founder and CEO)Pablo Tamayo, PhD(Founder and scientific advisor)

Co-investorsHumba Ventures

Clear Geneticscleargenetics.com𝕏Seedacquired by Invitae

Gia is an AI-powered chatbot designed to help patients and doctors with genetic testing workflows, including risk assessment, family history collection, and results delivery.

AI & Machine LearningDigital HealthHealthtechWellness & FitnessSan Francisco, US

Moran Snir(CEO)inGuy Snir(COO)inMotti Shohat M.D.(Founder)Brian CerceoJeff Froom

Co-investorsMeron CapitalY CombinatorAlchemist AcceleratorCompoundiAngels

Clippershipclippership.coin

Clippership designs and builds autonomous wind-powered vessels with wing-sails to move cargo across water using wind instead of fuel.

CleantechLogistics & Supply ChainRoboticsRedwood City, US

Kai Matsuka(CTO)inNiccolo Cymbalist(Founder)inNico Cymbalist(CEO)Luca Cymbalist(COO)

Co-investorsBlack FlagFounders Factory

Cofactor Genomicscofactorgenomics.comin𝕏

Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response.

AI & Machine LearningBiotechHealthtechMedical DevicesSt. Louis, US

Dave Messina(COO)inJarret Glasscock(CTO)inJarret Glassock(Executive Officer, Director)Jon Armstrong(COO)inJonathan Wald(Software Engineering Intern)

BoardMatthew A. Ocko(Director)in

Co-investorsArgonautic VenturesAscension VenturesDCVC (Data Collective)iSelect FundJude GomilaMenlo Ventures+11 more

Cosmic Aerospace, Inc.cosmicaerospace.com

Ultra efficient all-electric passenger aircraft with real range capabilities

Marshall Gusman(Co-founder & CTO)inChristopher Chahine, PhD(Co-founder & CEO)

Co-investorsAera VCCourse Corrected VC Holding IIPossible VenturesSamurai IncubateSyndicate OnePale Blue Dot

Coverbuildcover.com𝕏

Cover designs and builds modular homes using technological and material innovations to reduce construction waste and improve energy efficiency.

Climate TechConstruction TechPropTechGardena, Los Angeles, US

Alexis Xavier Rivas(Founder)in

Co-investorsEarl Grey CapitalGigafundGreat Oaks Venture CapitalManta Ray VenturesPartners Resolute

Deepcelldeepcell.comin

Deepcell uses artificial intelligence and high-resolution imaging to analyze cell morphology for biological research and discovery.

AI & Machine LearningBiotechDeep TechMedical DevicesSunnyvale, US

Mahdokht Masaeli(Executive Officer, Director, Promoter)Mahyar Salek(Executive Officer, Director, Promoter)inMaddison Masaeli(Founder)inEuan Ashley(Director, Promoter)

Co-investorsAndreessen HorowitzBow CapitalDCVC (Data Collective)Horizons VenturesLifeX VenturesManta Ray Ventures

Digital Biodigit.bioin

Digital Biology (Digit Bio) develops precision biologics and combination therapies for solid tumors, using its M×P (Molecules × Phenotypes) Platform that combines high-resolution imaging, next-generation sequencing, computation, and AI to map the spatial molecular organization of tumor tissues.

AI & Machine LearningBiotechDeep TechHealthtech

Co-investorsA91 PartnersGoldman SachsHSBCMorgan StanleyPeak XV PartnersSteadview Capital

Dipole Labsdipolelabs.com

Dipole Labs develops photonic (optical) hardware intended to serve as the optical layer for AI and quantum computing infrastructure, aiming to overcome the physical limits of silicon in speed, density, and efficiency.

Advanced ManufacturingAI & Machine LearningDeep TechHardwareQuantum ComputingBoston, US

Gabriele Pasquale(CTO)inDeepankur Thureja(CEO)in

Co-investorsY CombinatorCisco InvestmentsSpot VCSurgePoint AngelTranspose Platform ManagementBatch Ventures+5 more

EARTH AIearth-ai.comin𝕏Seed

Earth AI uses AI to locate critical mineral deposits by analyzing geological data, supporting the supply chain for hardware and emerging technologies.

Advanced ManufacturingAI & Machine LearningClimate TechDeep TechNew MaterialsSan Francisco, US

Roman Teslyuk(Founder)inRoman(Founder)

BoardIan Rountree(Director)inMikhail Taver(Director)inJamie Lee(Director)inIsabella Sykes(Director)

Co-investorsAirTree VenturesAlpaca VCBlackbird VenturesCantos VenturesCorigin VenturesDCVC (Data Collective)+25 more

Electrofloweflowtech.cominSep 2025

eFlow extracts lithium from dilute brines in North America using direct lithium extraction technology, serving the clean energy and electric vehicle supply chain.

CleantechEnergyNew MaterialsSan Bruno, US

Eric McShane(CEO and co-founder)Evan Gardner(CTO and co-founder)in

Co-investorsBlack FlagHarpoon VenturesUnion Square Ventures (USV)Voyager Partners

Elicitelicit.comin𝕏Jul 2023

Elicit is an AI-powered research assistant that helps users discover, analyze, and synthesize scientific literature and research findings.

AI & Machine LearningEdTechEnterprise SoftwareSaaSOakland, US

Andreas Stuhlmüller(Founder)inJungwon Byun(Founder)inAdam Heneghan(Executive Officer)in

BoardKevin Willer(Director)John Elton(Director)John McGee(Director)

Co-investorsavraBasis Set VenturesFootworkMythos Ventures Management, LlcPreston-Werner VenturesWinklevoss Capital

Enodaenoda.bioinFeb 2025

Enoda develops synthetic cytokine receptors, called MIMICs, that link therapeutic "Signal 3" cytokine functions to controllable inputs to engineer cell therapies without systemic toxicity.

BiotechDeep TechLondon

Andrew John Scobie(Executive Officer, Director)Michael Chavez(Co-founder & CEO)inPaul B. Finn(Founder)inJennifer Urquhart(Executive Officer, Director)inJacqueline Elizabeth Porch(Executive Officer, Director)Lindsay James Whitelaw(Executive Officer, Director)

Co-investorsMBX Capital

ethicethic.comin

Ethic offers direct indexing and tax-smart portfolio management, providing customizable passive portfolios engineered for tax efficiency, factor exposures, and values alignment.

FintechImpact & Social GoodPropTechSaaSNew York, US

Doug Scott(CEO & Co-founder)inJay Lipman(Founder)inJohny Mair(Founder)inJordan Lipman(Director)

BoardJohn Morris(Director)

Co-investors500 GlobalBetter Tomorrow VenturesBlackhorn VenturesFarvatn VentureKapor CapitalKima Ventures+8 more

Externaexterna.bio

Externa develops biologics using genetic code expansion, a technology aimed at incorporating synthetic amino acids into proteins of any type and size.

BiotechDeep Tech

Factionfaction.usin𝕏Seed · Oct 2023Defunct

Faction develops a hybrid autonomous vehicle platform called DriveLink that combines autonomy with remote human assistance (TeleAssist) for driverless fleet operations.

Advanced ManufacturingAI & Machine LearningLogistics & Supply ChainMobility & TransportationRoboticsSan Francisco, US

Ain McKendrick(Founder)inDanish Raza(Founder)Kunal Barman(Founder)Andrea Mariotti(Vice President of Vehicle Engineering)Mike Lowe(Vice President of Mechanical Design Engineering)Andrea Borbely(VIce President Operations \u0026 Finance)

Co-investorsDell Technologies CapitalFlucas VenturesKube VCTDK VenturesUncorrelated VenturesWhoa I Lp, By: Whoa Ventures+9 more

Farcastfarcast.cominPre-Seed · Dec 2019 · $570K

Farcast develops advanced satellite communication user terminals with flat panel phased array antennas that electronically track satellite movement for reduced size, weight, power, and cost.

Advanced ManufacturingHardwareSpace TechSan Francisco, US

Siamak Ebadi(Founder)inSteph Wang(Head of Operations)

BoardDavid Byrd(Director)inGuido Jouret(Director)

Co-investorsBlueYard CapitalGarage CapitalJude GomilaMaC Venture CapitalY CombinatorLockheed Martin Ventures+3 more

Find What Matters AIfindwhatmatters.ai

IGOR is a multi-agent AI platform, or "AI co-scientist," designed to accelerate R&D and experimental discovery by closing the loop between hypothesis and empirical validation.

AI & Machine LearningBiotechDeep Tech

Dr. Scott C. Riggs(Founder)in

Co-investorsStartX

Floatfloatcargo.comin𝕏

Float builds large rigid-frame autonomous airships as an industrial freight platform, using modern materials, sensing, autonomy, and meteorology for lighter-than-air cargo logistics.

Deep TechLogistics & Supply ChainRoboticsSan Francisco, US

Conor Lenahan(Founder & CEO)inJames Harvey(CTO)in

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Advancing reproductive medicineAirwattBirdwoodBlueprint Bryan JohnsonBrightseed, Inc.Cypher AIDeck BioDevonian SystemsKlona BiotechMemphis MeatsMetalafNeela BiotechPowerhouse BioSculptaSerova BioTera

Exits · 11

4 IPOs · 7 acquisitions · showing 5

BillionToOneNASDAQ: BLLNHealth CatalystNASDAQ: HCATMednaxNYSE: MDClear Geneticsacq. by InvitaeValence Discoveryacq. by Recursion

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has Fifty Years made?
Fifty Years has 177 tracked investments, 11 of which have exited, including 12 dated in the last 24 months.
What stage does Fifty Years invest at?
Fifty Years invests at the Pre-Seed, Seed stages.
What is Fifty Years's typical check size?
Fifty Years typically writes checks of $250K – $2M.
What sectors does Fifty Years focus on?
Fifty Years focuses on AgTech, AI & Machine Learning, Biotech, Climate Tech, Deep Tech.
Where is Fifty Years located?
Fifty Years is headquartered in San Francisco, US.
Does Fifty Years lead rounds?
Fifty Years typically participates in rounds rather than leading them.
Who does Fifty Years co-invest with?
Fifty Years most often shares deals with Y Combinator, Jude Gomila, Metaplanet, among 564 tracked co-investors.

Media · Podcasts & interviews

featuring the team

How to Spinout from Academic Labs with Alex Teng of Fifty Years

The Climate Vine · Alex Teng

Mr. and Mrs: Fifty Years: Sneak Peek Into The Life of Ela Madej and Seth Bannon I Slush 2021

Slush · Ela Madej

Sean Hunt (Solugen) & Seth Bannon (Fifty Years): From Academia to Entrepreneurship | Slush 2021

Slush · Seth Bannon

Impact Investing 🌟 w/ Seth Bannon - Founding Partner @ Fifty Years | BIOS

BIOS · Seth Bannon

New Type of Therapeutic Unicorns 🎉 w/ Seth Bannon - Founding Partner @ Fifty Years | BIOS

BIOS · Seth Bannon

What Will Biotech Look Like in 2050? ✨ w/ Seth Bannon - Founding Partner @ Fifty Years | BIOS

BIOS · Seth Bannon

Co-investors · 53

SV Angel

SV Angel is a San Francisco-based firm that invests long-term in founders, supporting them with advice, introductions, and network access at key business inflection points.

$150K – $20M
Refactor Capital

Refactor is a seed-stage venture firm run as a solo capitalist by Zal, backing founders building hard tech companies that address real-world problems.

$1M – $2M
UpHonest Capital

UpHonest Capital is a Silicon Valley-based investment firm founded in 2017 that supports cross-border entrepreneurship and investment between China and the United States, and runs media, scout, and incubation programs.

$50K – $1M
Pioneer

Pioneer Fund is an investment fund backed by 540+ Y Combinator alumni that invests in and supports top startups coming out of Y Combinator.

Sequoia Capital

Sequoia Capital is a venture capital firm that partners with founders to build technology companies.

$100K – $50M
Lux Capital

Lux Capital is a venture capital firm that backs founders building transformative deep technologies, having been among the first investors in category-defining companies across AI, robotics, biotech, defense, and infrastructure.

$100K – $100M
Union Square Ventures (USV)

Union Square Ventures is a New York-based venture capital firm that invests across a broad range of technology sectors, presenting a large portfolio spanning crypto, fintech, climate, AI, education, health, and marketplaces.

$1M – $8M
Buckley Ventures Management Company Llc

Buckley Ventures is a venture capital firm that makes concentrated early-stage investments in internet, software, and frontier technology companies.

$300K
Lowercase Capital

Lowercase Capital is a venture capital firm that backs early-stage startups, including companies working on democracy reform, climate solutions, and criminal justice reform.

Hack VC

Hack VC is a venture capital firm investing in early-stage crypto, blockchain infrastructure, decentralized finance, and AI companies.

$3M
Preston-Werner Ventures

PWV (Preston-Werner Ventures) provides early-stage capital to technology founders building the future, investing through PWV Fund I and the PWV Rolling Fund.

$500K – $3M
▶41 more co-investors

Founders FundAmplify PartnersArray Ventures Management LlcWinklevoss CapitalBlueYard CapitalAxial VCBain Capital VenturesSusa VenturesUncorrelated VenturesAnorak VenturesMango CapitalHelium-3 VenturesAvalanche VCInflection.xyzCraft VenturesOffline VenturesThrive CapitalM13LightbankPlayground GlobalHighbury HoldingsFoundamentalNIVEvolve VC FundsAmino CollectiveAir Street CapitalPi LabsCambridge Angels groupPalo Santo VCMystic VenturesKrakenHaun VenturesDawn CapitalNotation CapitalSweet CapitalStealth CapitalAmbush Capital8090 IndustriesGemini Israel VenturesPTC PolymarketCerulean Ventures

Firms observed investing alongside Fifty Years, from public investor directories. Shared companies are the overlap with Fifty Years's recorded portfolio.

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