Fifty Years
Actively deployingSan Francisco Β· Pre-SeedβSeed
Fund manager profile
Fifty Years is a venture fund manager based in San Francisco. SEC filings show 1 venture fund on record, most recently Fifty Years Fund V, LP filed March 2026.
Source: SEC EDGAR Form D filings. Firm website data not yet available.
What they invest in
from 66 of 92 portfolio companiesBiotech Γ29AI & Machine Learning Γ27Healthtech Γ26Deep Tech Γ17Medical Devices Γ13Advanced Manufacturing Γ12Climate Tech Γ11Enterprise Software Γ10
HQs:United StatesΓ41CanadaΓ2AustraliaΓ1GermanyΓ1SpainΓ1United KingdomΓ1
Investments Β· showing 60 of 92
founders shown can be your intro pathSolugen develops a biomanufacturing platform using fermentation and bioprocessing technology to produce specialty chemicals at scale. The company serves customers in energy, chemicals, and related industries with cost-effective alternatives to traditional petrochemical-based manufacturing.
Advanced ManufacturingBiotechCleantechClimate TechHealthtechHouston, US
Sean Hunt(Co-founder)inGaurab Chakrabarti(Co-founder & CEO)in
64x develops infrastructure and manufacturing systems for next-generation medicines, focusing on genetic engineering, cell line development, and computational biology to enable scalability of advanced therapies.
AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesSan Francisco, US
Lexi Rovner(Co-founder & CEO)in
Aalo develops advanced nuclear reactor technology aimed at producing electricity at under 3 cents per kilowatt-hour. The company serves the global energy market and is focused on enabling virtually unlimited clean power generation.
Climate TechDeep TechEnergyHardware
Matt(Co-founder)Yasir(Co-founder)Mark NefzgerinDavid Jaluvkain
Advano manufactures silicon-based anode materials for lithium-ion batteries that improve energy density and reduce costs for electric vehicles. The company supplies engineered materials that integrate into existing battery designs.
Advanced ManufacturingCleantechClimate TechNew Orleans, US
Ansa Biotechnologies develops an enzyme-based process to manufacture DNA, offering an alternative to the established chemical synthesis methods used in the industry. The technology targets research and industrial applications across therapeutics, diagnostics, and biological production.
BiotechHealthtechEmeryville, US
Arpeggio Bio develops pharmaceutical drugs that target transcription factors using artificial intelligence and RNA-sequencing technology, with lead programs in development for melanoma treatment and rare disease applications.
BiotechHealthtechBoulder, US
Joey Azofeifa(Founder)in
Cover designs and builds modular homes using technological and material innovations to reduce construction waste and improve energy efficiency.
Climate TechConstruction TechPropTechGardena, Los Angeles, US
Atom Computing develops gate-based quantum computers using optically-trapped neutral atoms. The company targets applications requiring large numbers of error-corrected qubits and aims to deliver scalable quantum computing systems.
Deep TechHardwareQuantum Computing
Avro Life Sciences develops platform technology for novel drug delivery through passive transdermal administration. The company operates in the biotech sector, focusing on dermatological and systemic therapeutics.
BiotechHealthtechMedical DevicesWaterloo, CA
BillionToOne is a precision diagnostics company that uses molecular counting technology to develop non-invasive prenatal screening and liquid biopsy tests for early disease detection. The company focuses on making molecular diagnostics accurate, fast, and accessible to patients.
BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US
Oguzhan Atay, PhD(Co-Founder, CEO, and Board Chair)David Tsao, PhD(Co-Founder, CTO, and Board Member)Oguzhan Atay(Founder)inDavid Tsao(Founder/CTO)in
Science Corporation develops brain-computer interface and neural engineering technology to restore vision, cognition, and mobility to patients with debilitating conditions. The company also provides components and vertically integrated infrastructure through Science Foundry to support innovation across the neural technology industry.
AI & Machine LearningBiotechDeep TechDigital HealthMedical DevicesAlameda, US
Max Hodak(Chief Executive Officer)
BioRender is a software tool that enables scientists to create and share professional scientific illustrations and figures. The platform serves researchers and scientists across life sciences disciplines globally.
BiotechEdTechEnterprise SoftwareSaaSToronto, CA
Ryan Marien(Co-founder)inKatya Shteyn(Co-founder)inShiz Aoki(CEO and Co-founder)
BIOS develops neural digital therapy technology to deliver treatments for neurological conditions. The company combines neural engineering with AI and machine learning to improve healthcare outcomes and restore patient control over bodily function.
AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesCambridge, GB
BloomText provides HIPAA-compliant messaging software built specifically for healthcare organizations. The platform enables secure staff communication across Windows desktops and mobile devices with compliance features built in, requiring no separate configuration or compliance infrastructure.
Digital HealthHealthtechSaaSSeattle, US
Michael Wasser(Founder/CEO)inHeather Milone(Founder/Executive Business Advisor)in
Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response. The company serves oncology and precision medicine markets by enabling more accurate patient-to-therapy matching.
AI & Machine LearningBiotechHealthtechMedical DevicesSt. Louis, US
Dave Messina(Founder/COO)inJarret Glasscock(Founder & CEO)in
Deepcell uses artificial intelligence and high-resolution imaging to analyze cell morphology for biological research and discovery. The company serves scientists and life science researchers across multiple biological domains.
AI & Machine LearningBiotechDeep TechMedical Devices
eFlow extracts lithium from dilute brines in North America using direct lithium extraction technology, serving the clean energy and electric vehicle supply chain. The company focuses on domestic lithium production with minimal water and chemical use, positioning itself as an alternative to traditional mining operations.
CleantechEnergyNew Materials
Eric McShane(CEO and co-founder)Evan Gardner(CTO and co-founder)David Diaz(Founding Engineer)Peter Benedek(Founding Engineer)
Elicit is an AI-powered research assistant that helps users discover, analyze, and synthesize scientific literature and research findings. The platform serves researchers, academics, and professionals in life sciences, healthcare, and related fields who need to conduct evidence-based analysis at scale.
AI & Machine LearningEdTechEnterprise SoftwareSaaS
Andreas StuhlmΓΌller(Co-founder)Jungwon Byun
Faction develops a hybrid autonomous vehicle platform called DriveLink that combines autonomy with remote human assistance (TeleAssist) for driverless fleet operations. The platform serves fleet operators seeking near-term commercial deployment of autonomous vehicles.
Advanced ManufacturingAI & Machine LearningLogistics & Supply ChainMobility & TransportationRoboticsSan Francisco, US
Ain McKendrick(Founder)inFaction
Farcast develops advanced satellite communication user terminals with flat panel phased array antennas that electronically track satellite movement for reduced size, weight, power, and cost. The company serves mobile users and fixed applications requiring satellite internet connectivity globally.
Advanced ManufacturingHardwareSpace TechSan Francisco, US
Siamak Ebadi(Founder & CEO)in
Garten provides healthy food, meditation, mindfulness and community wellness services for workplace environments. The company delivers nutritious meals and holistic health programs to employers seeking to improve employee wellbeing and productivity.
AI & Machine LearningEnterprise SoftwareFoodTechFuture of WorkWellness & FitnessSan Francisco, US
Michael Heinrich(Founder and CEO)in
Gordian uses a proprietary in vivo drug discovery platform to identify therapeutic targets and treatments for complex age-related diseases. The company develops novel therapies with higher probability of clinical success.
AI & Machine LearningBiotechLongevity
Gridware provides real-time monitoring and visibility of electrical grid conditions through sensors deployed on power lines, enabling utilities and line workers to detect and respond to problems faster. The platform serves electric utilities and their field teams to improve grid reliability, reduce outage response time, and prevent wildfire ignition.
Advanced ManufacturingEnergyEnterprise SoftwareHardwareIoTSan Francisco, US
Tim Barat(Founder)inOmar B(Founder)inHall Chen(Co-Founder & CTO)inCo-founded by a lineman turned engineer
Harmonic Discovery applies medicinal chemistry, cheminformatics, data science and machine learning expertise to advance drug discovery. The company is supported by investors at the intersection of technology, biology and medicine.
AI & Machine LearningBiotechDeep TechHealthtechNew York City, US
Rayees Rahman(Founder CEO)inJ Lee(Founder)inMarcel Patek(Founder)in
Health Catalyst provides data analytics, AI-powered insights, and healthcare solutions to help hospital systems and healthcare organizations improve clinical, financial, and operational outcomes. The company serves healthcare providers focused on value-based care and patient engagement.
AI & Machine LearningData & InfrastructureHealthtech
Helix Nanotechnologies develops mRNA-based therapeutics for disease treatment and environmental applications, currently advancing a COVID-19 vaccine candidate for immunocompromised patients and testing interventions targeting climate challenges.
AI & Machine LearningBiotechHealthtechBoston, US
Nikolai Eroshenko(Founder/CSO)in
Invitae provides genetic testing services to patients and clinicians across the United States, offering broad test offerings and genetic counseling to inform health decisions at every stage of life. Now part of Labcorp, the company leverages a nationwide network of patient service centers and coverage by most health plans to make genetic testing more accessible.
Digital HealthHealthtechMedical Devices
Journey Clinical provides ketamine-assisted psychotherapy (KAP) for depression, anxiety, and PTSD, partnering patients with licensed therapists and medical teams while coordinating with major insurance providers.
Digital HealthMedical DevicesMental Health
Kin Euphorics manufactures non-alcoholic functional beverages infused with adaptogens, nootropics, and botanics designed to enhance mood, brain function, and overall wellness. The company sells directly to consumers through retail and e-commerce channels.
ConsumerFoodTechWellness & Fitness
Lively provides AI-powered customer service and support for the benefits administration industry, combining intelligent technology with human representatives to resolve employee and customer inquiries. The platform serves benefits administrators and employees seeking faster, more personalized service for health and financial benefits management.
AI & Machine LearningEnterprise SoftwareFintechHealthtechHR TechSaaSSan Francisco, US
Varda industrializes low Earth orbit by manufacturing pharmaceuticals and other specialized products in space, then returning them to Earth via reusable reentry capsules. The company develops both in-space production infrastructure and the vehicles needed to support commercial orbital manufacturing.
BiotechDeep TechSpace TechEl Segundo, US
Will Bruey(Founder)Delian Asparouhov(Founder)
Meati produces meat alternatives made from mycelium, the root structure of fungi, offering a plant-based protein source with complete amino acids and additional nutritional benefits. The company serves consumers seeking sustainable alternatives to conventional meat products.
ConsumerFoodTech
Merge Labs creates AR/VR learning tools for K-12 education, including the Merge Cube handheld interface and Merge EDU platform, enabling immersive hands-on STEM and science learning in classrooms and educational spaces.
AI & Machine LearningEdTechHardwareSan Antonio, US
<UNKNOWN>
Microverse is an online education platform that trains people globally for remote work opportunities, with a focus on building collaboration and communication skills needed in distributed teams. The company targets talent from underserved regions worldwide seeking access to high-quality technical education and remote job placements.
Developer ToolsEdTechFuture of WorkCT, ES
Ariel Camus(Founder & CEO)in
Mindset Health develops digital health programs using hypnotherapy and mind-body medicine to help patients manage gastrointestinal disorders and improve health outcomes. The platform is delivered via mobile app and partnerships with health plans and medical centers globally.
Digital HealthHealthtechMedical DevicesMental HealthWellness & FitnessMelbourne, AU
Alex Naoumidis(Co-founder & Co-CEO)inChris Naoumidis(Founder)inHypnotherapist/Psychophysiologist Founder(Founder)
Molten Industries develops chemical reactor technology that splits natural gas into hydrogen and graphite using electrical resistive heating for battery anode production and industrial hydrogen supply. The company serves battery manufacturers and heavy industry (steel, chemicals, fertilizers) seeking lower-cost, US-made graphite and hydrogen production.
Advanced ManufacturingCleantechEnergyNew MaterialsWest Oakland, US
KevinCaleb
Frequently asked questions
- What stage does Fifty Years invest at?
- Fifty Years invests at the Pre-Seed, Seed stages.
- Where is Fifty Years located?
- Fifty Years is headquartered in San Francisco, US.
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