Prefix Capital
Venture capitalSan Francisco Β· Pre-SeedβSeed Β· 3 people tracked
Investment thesis
Early-stage VC focused on deep-tech startups building foundational technologies.
Source: firm website, verified Aug 7, 2026.
Team Β· 3 people
from the firm's website
What they invest in
from 18 of 21 portfolio companiesAI & Machine Learning Γ9Deep Tech Γ5Biotech Γ4Data & Infrastructure Γ4Enterprise Software Γ4Cleantech Γ3Cybersecurity Γ3Hardware Γ3
HQs:United StatesΓ9United KingdomΓ1
Investments Β· 21 tracked
founders shown can be your intro pathBillerica, US
Raymond Chang(Executive Officer, Director)Niv Krikov(Executive Officer)Matthew S. Kressy(Director)Krishnan Varier(Director)Thomas Massie(Director)Robert Harrison(Executive Officer)
Co-investorsARCADIAN Fund
Co-investorsBerkeley CatalystTrousdale Ventures
Ample provides modular battery swapping stations that deliver a full charge to electric vehicles in under 5 minutes, regardless of vehicle make or model.
EnergyHardwareMobility & Transportation
Co-investorsHemi Ventures, LlcWorldQuant VenturesShell Ventures
Base Operations provides a security intelligence platform that turns street-level threat data into actionable insights for corporate security teams.
AI & Machine LearningCybersecurityData & InfrastructureEnterprise SoftwareSaaS
Co-investorsGlasswing VenturesGood Growth CapitalGrotech VenturesInner Loop CapitalMagma PartnersMindset Venture+2 more
Biomemory develops DNA-based data storage systems for data centers, offering an alternative storage tier optimized for long-term archival, density, and energy efficiency.
Climate TechData & InfrastructureDeep Tech
Co-investorsCivilization Ventures Management, LlcFifty YearsZ Venture CapitalCantos VenturesOS FundPathbreaker Ventures+1 more
Diamond Foundry manufactures lab-created single-crystal diamond, including diamond wafers for semiconductors and materials for its VRAI diamond jewelry consumer brand, using a vertically integrated, zero-emission manufacturing process.
CleantechDeep TechHardwareNew MaterialsSemiconductorsSan Francisco, US
Co-investorsAlpha Ascent Ventures LlcLong Journey VenturesObvious Ventures
Epoch builds autonomous software agents, collaborative platforms, and infrastructure, including a "Software Compiler" (Zerg) that turns specifications into production-grade code by continuously writing and adapting it.
AI & Machine LearningDeveloper ToolsEnterprise Software
Co-investorsTrousdale Ventures
Guava is a voice AI platform that plugs into a company's CRM, EHR, and workflow systems through code to handle inbound and outbound phone calls with compliance controls (SOC 2, HITRUST i1, PCI) and audit trails.
AI & Machine LearningEnterprise SoftwareSaaS
Co-investorsCommerce VenturesGreat Oaks Venture CapitalMouro CapitalVista Venture PartnersBloomberg BetaRothenberg Ventures
Intel offers AI-focused hardware and software solutions, including processors, data center and cloud AI hardware, AI PCs built on Intel Core Ultra processors, and open source development frameworks and tools.
AI & Machine LearningHardwareSemiconductors
Co-investorsGen Capital
Invitae provides genetic testing services to patients and clinicians across the United States, offering broad test offerings and genetic counseling to inform health decisions at every stage of life.
BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US
Sean George(Executive Officer, Director)Randal Scott(Executive Officer, Director)Shelly Guyer(Executive Officer)Lee Bendekgey(Executive Officer)Geoffrey Crouse(Director)
BoardEric Aguiar(Director)in
Co-investorsCivilization Ventures Management, LlcDecheng CapitalFifty YearsManta Ray VenturesOberland CapitalTech Wildcatters+1 more
Lemonaid Health is a national telehealth company offering online medical assessments, U.S.-based clinical review, and home delivery of prescription medicines, including GLP-1 weight loss treatments.
Digital HealthDirect to ConsumerHealthtechSan Francisco, US
Co-investorsArtis VenturesDaybreak PartnersFirebolt Ventures Management Company, LlcHikma VenturesOTVOlive Tree Ventures
Manus Bio operates a cell factory engineering platform that uses industrial biotechnology and precision fermentation to produce complex molecules such as plant-based natural products at commercial scale.
BiotechCleantechClimate TechNew MaterialsAugusta, US
Ajikumar Parayil(Executive Officer, Director)Aji Parayil(Co-founder)Greg Stephanopoulos(Co-founder)Gregory Stephanopoulos(Director)
BoardJason Whaley(Director)inCarsten Boers(Director)in
Co-investors+ND CapitalCivilization Ventures Management, LlcEnergy Impact PartnersLiebenthal VenturesNelstone VenturesNXT Ventures+2 more
Neocortix develops artificial intelligence technologies focused on large language models, including tools for LLM explainability (citing training data), hallucination detection and prevention, and royalty allocation to copyright holders.
AI & Machine LearningDeep Tech
Prellis Biologics uses the human immune system combined with machine learning to discover fully human antibody candidates for antibody therapeutics.
AI & Machine LearningBiotechDeep TechHayward, US
Melanie Matheu(Executive Officer, Director)Noelle Mullin(Executive Officer, Director)
BoardArvind Gupta(Director)Rohit Sharma(Director)in
Co-investorsBlack Diamond VenturesCivilization Ventures Management, LlcOpen Field CapitalCantos VenturesCelesta CapitalKhosla Ventures+2 more
Gene editing company, with Civilization as founding investor, acquired by Intellia for $200M.
Co-investorsCivilization Ventures Management, Llc
SwiftComply provides compliance management software for water utilities to run programs such as FOG, Industrial Pretreatment, Stormwater, and Backflow, with dashboards, reporting, and audit records.
CleantechGovTechSaaS
Co-investorsBURNT ISLAND VENTURES
Symmetry Systems provides data security and posture management for organizations, with specialized support for AI agent authentication and access control.
AI & Machine LearningCybersecurityData & Infrastructure
Co-investorsForgePoint CapitalNelstone VenturesTrousdale VenturesW11 Capital
Tractable builds computer-vision and machine-learning AI that performs visual damage assessment from customer images, enabling fast damage appraisals for uses such as accident recovery, car part salvage, and property assessment.
AI & Machine LearningEnterprise SoftwareInsurTechMobility & TransportationLondon, GB
Razvan Ranca(Executive Officer, Director)inAlex Dalyac(Founding CEO)inAlexandre Dalyac(Executive Officer, Director)Ashley Fontana(Director)Adrien Cohen(Co-Founder, Board Adviser and Former President)inVenkat Sathyamurthy(CEO)
Co-investorsAcequia Capital (AceCap)Air Street CapitalBeyond CapitalEntrepreneur FirstInsight PartnersIsomer Capital+6 more
VIA builds Web3 and blockchain-based systems designed to protect data from theft, misuse, and manipulation through decentralization, encryption, and secure handling.
Crypto & Web3CybersecurityEnergy
John(Co-inventor of core platform)
Co-investorsBMW i VenturesBosch VenturesMassMutual VenturesNXT VenturesRobert Bosch Venture CapitalThe Westly Group
CesiumAstro develops AI-enhanced, software-defined communications systems for space, air, and ground domain applications.
AI & Machine LearningData & InfrastructureDeep TechDefense TechSpace TechNew York City, US
Daniel Morozoff(Executive Officer, Director)Joseph Ellis(Executive Officer, Director)
Co-investorsCapital InnovatorsDorm RoomR/GA VenturesSamsung NextSocial StartsTechstars
Exits Β· 2
IPOs and acquisitions across the tracked portfolioAgrifyNASDAQ: RYMRewrite Therapeuticsacq. by Intellia
Portfolio news
latest coverage across their companiesVidrovr Β· spacenews.com Β· Feb 26, 2026
Frequently asked questions
- How many investments has Prefix Capital made?
- Prefix Capital has 21 tracked investments, 1 of which have exited via acquisition or IPO.
- What stage does Prefix Capital invest at?
- Prefix Capital invests at the Pre-Seed, Seed stages.
- What sectors does Prefix Capital focus on?
- Prefix Capital focuses on AI & Machine Learning, Biotech, Crypto & Web3, Deep Tech, Semiconductors.
- Where is Prefix Capital located?
- Prefix Capital is headquartered in San Francisco, US.
- Does Prefix Capital lead rounds?
- Prefix Capital typically participates in rounds rather than leading them.
- Who does Prefix Capital co-invest with?
- Prefix Capital most often shares deals with Civilization Ventures Management, Llc, Fifty Years, Nelstone Ventures, among 61 tracked co-investors.
Co-investors Β· 65
Techstars is a startup accelerator and early-stage investor that funds ambitious founders and provides capital, mentorship, and access to a global network of investors, operators, and corporate partners.
Long Journey Ventures is an early-stage venture firm that backs unconventional, 'magically weird' founders and ideas, positioning itself as a hands-on, community-oriented partner to its companies.
True Ventures is a venture capital firm established in 2005 that focuses on early-stage technology companies, with operations based in Silicon Valley.
Acequia Capital is an early-stage investment platform supporting technical founders and product teams building global technology businesses.
The Westly Group is a venture capital firm founded in 2007 that invests in entrepreneurs digitizing and decarbonizing large industries such as energy, mobility, buildings, and industrial sectors.
Andreessen Horowitz (a16z) is a venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz, known for pioneering the platform model with a large team of operators supporting founders across stages.
Founders Fund is a venture capital firm that backs technology companies building transformative products.
New Enterprise Associates (NEA) is a venture capital firm that invests in and provides long-term support to founders building new companies.
Notable Capital is a venture capital firm that has partnered with founders for over two decades, backing companies from the earliest stages through to exit.
Uncork Capital (formerly SoftTech VC) is a seed-stage venture firm that invests early in founders, with a focus on AI-native companies building leverage and scale.
FJ Labs is a venture capital firm specializing in marketplaces and network-effect businesses, having built a large portfolio of marketplace startups with over 30 becoming unicorns.
SV Angel is an investment firm that partners with and supports founders building transformative companies, providing long-term backing and close advisory relationships.
βΆ53 more co-investors
First Round CapitalBoxGroupKrakenDST GlobalEniac VenturesOffline VenturesSlow VenturesFundersClubHCVCAME Cloud VenturesFreestyle CapitalHeadlineAccel-KKRMadrona Venture GroupLookout VenturesKapor CapitalStellar CapitalSouth Park CommonsBonfire VenturesPractical Venture CapitalLowercase CapitalRidge Ventures01 AdvisorsPear VCUpfront Ventures75 & SunnyTSVCThe Chernin Group (TCG Crypto)CausalBrainchild HoldingsLead Edge CapitalAmerican Express Ventures (Amex)Kohlberg Kravis RobertsFounders' Co-opFormation GroupMorado Venture PartnersThomvest VenturesSignia Venture PartnersAlsop Louie PartnersAlpaca VCRivet VenturesBuilders VCDeep Fork CapitalIterative Instinct CapitalREMUS CapitalKrillion VenturesUnicorn India VenturesDarco CapitalCoralCMCC GlobalSlauson & Co.Gaorong VenturesNova Founders Capital
Firms observed investing alongside Prefix Capital, from public investor directories. Shared companies are the overlap with Prefix Capital's recorded portfolio.
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