Civilization Ventures Management, Llc
Tiburon · Pre-Seed–Growth · 1 people tracked
Investment thesis
Civilization Ventures invests in innovations addressing critical challenges in biology and healthcare. The firm focuses on genomics and diagnostics, digital health, and synthetic biology, supporting category-defining companies in AI, liquid biopsy technologies, gene editing, value-based care, and cell therapies. The investment approach emphasizes founder support grounded in the firm's own founding experience and combines deep operational and scientific expertise.
Source: firm website, verified Jul 20, 2026.
Team · 1 people
from the firm's website
A health and biotech investor with deep expertise in AI applications, Shahram founded Civilization Ventures after over a decade in life sciences startups and venture investing. He has been involved in more than 20 successful exits including IPOs and acquisitions, and previously served as founding CEO of Inspirna and founding CFO at NextBio, in addition to roles as an investment banker at Goldman Sachs.
What they invest in
from 54 of 69 portfolio companiesBiotech ×33Medical Devices ×24AI & Machine Learning ×21Healthtech ×19Digital Health ×17Deep Tech ×12SaaS ×6Wellness & Fitness ×3
HQs:United States×18United Kingdom×2Australia×1Italy×1
Investments · showing 60 of 69
founders shown can be your intro pathOxford Cancer Analytics develops a diagnostic platform that combines proteomic measurement with AI to generate evidence-based clinical insights for lung disease management, initially focused on COPD and lung cancer.
AI & Machine LearningDigital HealthMedical DevicesOxford, GB
10x provides an AI-powered back-office service that automates dental practice operations including hygiene recall outreach, treatment follow-up coordination, and missed-call answering. The system uses conversational AI to contact patients via text or phone and book appointments directly into practice management systems.
AI & Machine LearningHealthtechSaaSSan Francisco, US
Max Bohun(Founder)in
23andMe operates a research platform that collects genetic data from millions of users to advance genomic research and health discovery. The company enables individuals to learn about their genetic traits while contributing to medical research studies that benefit public health.
BiotechDigital HealthDirect to ConsumerHealthtechLongevityMountain View, US
Anne Wojcicki(Co-founder & CEO)Linda Avey(Co-founder)Paul Cheung(Co-founder)
Adyn uses large inclusive datasets and machine learning to advance personalized medicine for historically under-researched health conditions, with initial focus on reproductive disorders. The company aims to close race and gender knowledge gaps in medical research.
AI & Machine LearningDigital HealthHealthtechMedical DevicesWellness & FitnessSeattle, US
Elizabeth Ruzzo(Founder, CEO)
Aikium develops a platform that combines artificial intelligence and synthetic biology to design next-generation protein therapeutics, targeting previously "undruggable" proteins for drug discovery.
AI & Machine LearningBiotechDeep Tech
<UNKNOWN>
Alveo Technologies develops a portable molecular testing platform that delivers rapid pathogen detection in under one hour at the point of need, with initial focus on avian influenza testing for poultry farms and agricultural operations. The platform combines palm-sized analyzers and preloaded cartridges to enable on-site detection, traceability, and results delivered via smartphone.
AgTechHealthtechMedical Devices<UNKNOWN>
Ample operates a modular battery swapping network for electric vehicles, delivering a full charge in under five minutes through swappable battery modules that work with any EV model. The platform integrates renewable energy sources and operates stations that are cheaper and faster to deploy than traditional fast-charging infrastructure.
EnergyHardwareMobility & Transportation
Antheia manufactures biosynthetic active pharmaceutical ingredients and key starting materials for essential medicines using advanced fermentation-based biosynthesis, replacing traditional agricultural sourcing to improve pharmaceutical supply chain reliability. The company serves pharmaceutical manufacturers and drug developers seeking more efficient, sustainable, and consistent sources for complex medicine ingredients.
Advanced ManufacturingBiotechMedical Devices
Aperiam Bio uses computational methods to identify stabilizing mutations in proteins, producing variants with improved expression, solubility, and activity for applications in technical reagents, cosmetics, and pulmonary therapeutics. The company serves partners seeking to manufacture more stable and functional protein-based products across multiple industries.
AI & Machine LearningBiotechDeep Tech
Aspect Bio Systems develops bioprinted tissue therapeutics for regenerative medicine using a platform that combines AI-powered bioprinting, computational design, therapeutic cells, and biomaterials. The company targets metabolic and endocrine diseases by creating implantable tissues for replacement, repair, or supplementation of biological functions.
AI & Machine LearningBiotechDeep Tech
Axonis Therapeutics develops medicines targeting KCC2 to restore inhibition in the brain, with a focus on treating neurological disorders including epilepsy and pain. The company translates discoveries from Boston Children's Hospital, Harvard, and Laval University into first-in-class and best-in-class treatments.
BiotechMedical DevicesBoston, US
Babyscripts provides remote patient monitoring and care management software for obstetric teams to identify maternal health risks during pregnancy and postpartum, serving health systems, private practices, and payers.
Digital HealthFemTechHealthtech
Ultra-sensitive molecular diagnostics platform for prenatal and cancer care with 1M+ tests processed, completed public listing at $5B valuation.
BillionToOne is a precision diagnostics company that uses molecular counting technology to develop non-invasive prenatal screening and liquid biopsy tests for early disease detection. The company focuses on making molecular diagnostics accurate, fast, and accessible to patients.
BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US
Oguzhan Atay, PhD(Co-Founder, CEO, and Board Chair)David Tsao, PhD(Co-Founder, CTO, and Board Member)Oguzhan Atay(Founder)inDavid Tsao(Founder/CTO)in
Biomemory develops DNA-based data storage systems for data centers, offering an alternative storage tier optimized for long-term archival, density, and energy efficiency. The company manufactures synthetic DNA storage cards and servers that integrate with existing multi-tier data center architectures to reduce infrastructure costs and environmental impact.
Climate TechData & InfrastructureDeep Tech
Catena develops a conjugation platform for antibody-drug conjugates (ADCs) and multi-payload conjugates used in oncology for solid tumors. The company's technology enables therapeutic structures that deliver dual payloads to cancer targets.
BiotechDeep TechHealthtechMedical DevicesSan Francisco, US
Glyphic Biotechnologies develops ProSE™, a high-throughput de novo protein sequencing technology for analyzing proteomes with single-molecule sensitivity. The platform serves research and therapeutic development in proteomics and drug discovery.
BiotechDeep TechBerkeley, US
Convergent Genomics develops UroAmp, a non-invasive genomic urine test for detecting and monitoring bladder cancer using liquid biopsy and next-generation sequencing technology. The company serves clinicians and patients seeking earlier cancer detection and recurrence monitoring.
BiotechDigital HealthMedical Devices
Curai Health provides virtual medical care through a team of doctors and healthcare experts for diagnosis and treatment of various conditions, available with or without insurance. The service covers acute and chronic conditions, prescriptions, and wellness support for individuals and employers.
Digital HealthHealthtech
DermBiont develops SM-030, a topical drug candidate targeting melasma, a skin pigmentation disorder, by inhibiting PKC-beta to address the underlying cause of hyperpigmentation.
BiotechDigital HealthMedical Devices
One Health operates a clinical trial platform using canine cancer data to accelerate and de-risk human oncology drug development. The company leverages a dataset of 2 billion datapoints from dogs with naturally occurring cancer to serve as a comparative model for pharmaceutical R&D, helping drug developers validate efficacy and identify biomarkers before human trials.
AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesSan Francisco, US
Christina K. Lopes(CEO)christina lopes(Founder)inBen Lewis(Co-founder)Christina Lopes(Co-founder)
Single-cell analysis platform acquired by Illumina.
Fluent Bio develops software for analyzing single-cell RNA sequencing data, producing count matrices and diagnostic outputs for researchers using Illumina sequencing libraries. The software is designed for genomics and life science researchers working with single-cell gene expression data.
BiotechDeveloper Tools
Cancer recurrence testing platform acquired by Natera.
Foresight Diagnostics develops ultra-sensitive diagnostic tests using genomics and bioinformatics to detect minimal residual disease in cancer patients, serving clinical and biopharma partners in oncology drug development and patient care.
AI & Machine LearningBiotechMedical Devices<UNKNOWN>
Iantrek develops medical devices and technologies for micro-interventional ophthalmic surgery, specifically targeting glaucoma treatment through uveoscleral pathway outflow enhancement for surgeons and ophthalmologists.
Medical DevicesElkins Park, US
Integrated Biosciences develops a platform for small molecule drug discovery targeting age-related diseases by combining optogenetics, chemistry, and AI to probe disease biology with precision and explore chemical space systematically.
AI & Machine LearningBiotechLongevity
Invitae provides genetic testing services to patients and clinicians across the United States, offering broad test offerings and genetic counseling to inform health decisions at every stage of life. Now part of Labcorp, the company leverages a nationwide network of patient service centers and coverage by most health plans to make genetic testing more accessible.
Digital HealthHealthtechMedical Devices
JustPaid provides AI-powered billing automation for B2B companies, handling invoice creation, payment collection, and reconciliation across multiple finance platforms. The platform supports complex pricing models, multi-currency billing, and automated collections with integration to Stripe, QuickBooks, Xero, and Salesforce.
AI & Machine LearningFintechSaaS
Kernal Bio is a synthetic biology company developing selective mRNA drugs to treat serious illnesses, with a focus on cancer therapeutics and improving patient outcomes.
AI & Machine LearningBiotechHealthtechMedical DevicesBoston, US
Yusuf Erkul(Chief Executive Officer & Cofounder)inJeff Ozdemir(Head of Platform & Cofounder)inBurak YILMAZ(Founder)inBurak Yilmaz(President & Cofounder)
Telemedicine pioneer acquired by 23andme for $400M.
Manus develops and manufactures bioalternatives—sustainable ingredients produced using engineered microbes and cell factories—for use in food, flavor, fragrance, and other consumer products. The company offers an end-to-end scale-up platform spanning cell factory design, engineering, and biomanufacturing.
BiotechCleantechAugusta, US
Nanite develops polymer nanoparticles for gene therapy delivery using AI-driven design and high-throughput synthesis. The company creates virus-free, resorbable delivery vectors for DNA and genetic drugs, targeting applications in genetic medicine.
AI & Machine LearningBiotechNew Materials
Omada Health provides virtual-first, integrated care programs for chronic disease management, delivered as data-driven solutions for employers, health plans, and healthcare organizations. The company develops digital diabetes prevention programs, musculoskeletal care, and behavior change interventions to reduce healthcare costs and improve health outcomes.
Digital HealthHealthtechWellness & Fitness
Digital health platform for chronic disease management serving 150M+ Americans, public listing completed.
Overt Bio develops cell therapies that link genes to immune functions using genome-scale discovery platforms. The company builds programmable immunotherapies targeting cancer patients.
AI & Machine LearningBiotechMedical Devices
Dr. Legut(Co-Founder and CEO)Dr. Sanjana(Co-Founder)
Ermit designs and manufactures connected hardware devices with embedded software and AI capabilities, serving companies building IoT and field-operated products. The company offers end-to-end development from electronics and firmware through data infrastructure and user interfaces, including an integrated IoT security module.
CybersecurityHardwareIoT
Prellis develops an AI-enabled platform for antibody discovery using 3D-printed organoids that recapture human immune biology, generating therapeutic antibody candidates for multiple disease areas. The platform combines machine learning with wet lab characterization to accelerate the development of fully human antibody therapeutics.
AI & Machine LearningBiotechDeep Tech
Cision PRWeb is a press release distribution and publicity platform that helps organizations communicate with target audiences through search, social media, and industry-specific partner networks including bloggers and influencers.
Marketing TechSaaS
QUiCKR develops rapid genetic modification quantification kits for cell and gene therapy R&D programs, analyzing structural variants, edits, and genome integrity to accelerate development timelines and reduce costs.
BiotechDeep TechMedical Devices
Range Bio develops next-generation diagnostic tools using translational proteomics for clinical and research applications in human health. The company serves healthcare organizations and researchers seeking advanced diagnostic capabilities.
BiotechDigital HealthMedical Devices
Brandon Wilson, Ph.D.(Co-founder & CEO)
Gene editing pioneer and founding investment acquired by Intellia for $200M.
Rocket Pharmaceuticals develops gene therapies to treat patients with rare genetic diseases, focusing on cardiovascular and hematologic disorders. The company creates potentially curative treatments at the genetic level for inherited and rare diseases.
BiotechDigital HealthMedical Devices
Gaurav Shah(Co-founder & Chief Executive Officer)
R-Zero provides AI software that reduces HVAC energy consumption in buildings by 20-40% using real-time occupancy and air quality data, with no infrastructure changes required. The platform serves facility managers and asset managers across commercial and institutional real estate portfolios.
CleantechEnterprise SoftwareIoTUnknown, US
Sensible Biotechnologies develops a cell-based mRNA design and manufacturing platform that produces pure, low immunogenicity mRNA therapeutics for drug development. The platform addresses limitations of synthetic mRNA by enabling design-based biology approaches.
AI & Machine LearningBiotechDeep TechHealthtechOxford, GB
Genetic screening platform for early pregnancy, acquired by Invitae.
Siren Biotechnology develops next-generation AAV (adeno-associated virus) platforms for gene therapy applications, including gene repair, gene transfer, and gene editing. The company focuses on advancing treatments for a wide range of rare diseases through engineered viral vectors and directed evolution approaches.
BiotechDigital HealthMedical Devices
Dr. Nicole Paulk(CEO, Founder, and President)
Tahoe Bio AI applies machine learning and computational biology to drug discovery and development. The company leverages AI and advanced cellular modeling for pre-clinical research in the biotech industry.
AI & Machine LearningBiotechDeep Tech
<UNKNOWN>(Cofounder)
Teiko provides multi-parameter cytometry services for clinical trials, including blood preservation kits (TokuKit), spectral and mass cytometry panels, and data analysis via its Dashboard platform. The company serves biotech firms and clinical trial sponsors conducting immunology studies globally.
BiotechDigital HealthMedical Devices
TenSixty uses machine learning and cell biology expertise to identify novel antibody targets on cancer cells for the development of new cancer therapeutics. The company combines AI with high-throughput technologies to discover improved drug candidates for oncology.
AI & Machine LearningBiotechMedical Devices
Tigatx develops engineered IgA antibodies designed to engage neutrophils as a cancer treatment approach. The company focuses on first-in-class immunotherapy for cancer patients.
Biotech
Frequently asked questions
- What stage does Civilization Ventures Management, Llc invest at?
- Civilization Ventures Management, Llc invests at the Pre-Seed, Seed, Growth stages.
- What is Civilization Ventures Management, Llc's typical check size?
- Civilization Ventures Management, Llc typically writes checks of $1M.
- What sectors does Civilization Ventures Management, Llc focus on?
- Civilization Ventures Management, Llc focuses on AI & Machine Learning, Biotech, Digital Health, Longevity, Medical Devices.
- Where is Civilization Ventures Management, Llc located?
- Civilization Ventures Management, Llc is headquartered in Tiburon, US.
- Does Civilization Ventures Management, Llc lead rounds?
- Yes, Civilization Ventures Management, Llc leads investment rounds.
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