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First Bight Ventures

Venture capitalActively deploying

Houston · Seed–Series A · 20 people tracked

Also known as First Bight

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Investment thesis

First Bight Ventures focuses on scaling nature's chemistry through biomanufacturing to help major industries transition from resource extraction toward regeneration and sustainable inputs. The firm targets sectors such as chemicals, manufacturing, agriculture, construction, automotive, and textiles that need sustainable alternatives to commodity materials. It backs early-stage biomanufacturing companies, leading rounds and writing first checks from seed through Series A, taking board seats and actively supporting portfolio companies with scale-up de-risking, operational efficiency, and partnership introductions. The firm aims to build a biomanufacturing ecosystem uniting investors, corporations, governments, universities, and foundations to make scientific breakthroughs commercially viable.

Source: firm website, verified Aug 3, 2026.

Stage
Seed–Series A
Check
$1M – $2M
HQ
Houston, Texas, US
Leads rounds
Leads
Instruments
Equity
Founded
2021
Tracked investments
10

Team · 20 people

from the firm's website & public directories
Alan McCollough· Advisor

Former President and COO of Circuit City; former board member at Goodyear.

Brian Stertzer· Advisor

Sold WealthStone in 2021 and Sequoia Financial in 2024.

Carrie Song· Advisor

Global operator with $9B P&L accountability and a five-time executive building sector leaders.

Dave McClure· Advisor

Super-angel investor with 10+ IPOs and 40+ unicorns; founder of 500 Startups.

Eric Woo· Advisor

Deployed $160 million into emerging VC managers.

Gerry Garcia· Advisor

Lehman-trained dealmaker turned public-sector catalyst.

Jesse Friedlander· Advisor

Experienced in global private investment management.

Mario Maia· Advisor

Led Novozymes' corporate venturing arm.

Matt Maloney· Advisor

Managed a $12 billion book for 2,000+ clients at SVB.

Sarvin Patel· Advisor

Cargill M&A veteran who scaled Curie as COO/CFO.

Scott Nudelman· Advisor

Founded Vitrian, a turnkey biomanufacturing real estate company.

Scott Nyquist· Advisor

Created McKinsey's Global Energy & Materials practice.

Steve Brown· Advisorin𝕏

Three-decade veteran of process-simulation software.

What they invest in

from 8 of 10 portfolio companies

Biotech ×4Cleantech ×4Circular Economy ×2Energy ×2Enterprise Software ×2Healthtech ×2New Materials ×2SaaS ×2

HQs:United States×5

Who they back

founder profiles across 7 portfolio companies

Accelerator rootsportfolio companies that came through a program

Y Combinator ×2

Investments · 10 tracked

founders shown can be your intro path

By year:2024 · 12021 · 12 dated

Persephonepersephone.bioin✓ verified

Persephone develops a synbiotic supplement for infants that combines probiotics (keystone Bifidobacterium strains) with prebiotics found in human breast milk to replenish gut bacteria linked to digestion, immunity, and development.

BiotechConsumerDigital Health

Stephanie Culler(CEO & Co-Founder)Steve Van Dien(CTO & Co-Founder)

Co-investorsPropel Bio PartnersFifty YearsY Combinator

Algenesisalgenesislabs.comin

Algenesis Labs develops plant-based, biodegradable polyurethanes and polymers designed to replace petroleum-based materials while retaining durability.

Circular EconomyCleantechNew MaterialsSan Diego, US

Stephen Mayfield(Executive Officer, Director, Promoter)Dr. Stephen Mayfield(Founder)Dr. Robert Pomeroy(Co-founder)Dr. Michael Burkart(Co-founder)Nicholas Sandland(Executive Officer, Director)Peter Morgan(Executive Officer, Promoter)

Co-investorsCirculate CapitalFamily Angel Management FundMeliorate

Ark PESarkpes.com

Ark provides a customizable digital platform for venture capital and private equity firms to manage investor communications, performance reporting, and document sharing with their limited partners.

Enterprise SoftwareFintechSaaS

Co-investorsAcies InvestmentsAloft VCAlta PartnersAmity VenturesArtis VenturesAsymmetric Capital Partners+21 more

Capra Biosciencescaprabiosciences.cominApr 2024

Alexandria, US

Andrew Magyar(Executive Officer, Director)Elizabeth Onderko(Executive Officer, Director, Promoter)

BoardPae Wu(Director)inDanielle Joseph(Director)Douglas Cameron(Director)

Co-investorsBlue Ivy VenturesGS FuturesClosed Loop PartnersSOSVThe E14 Fund

Industrial Microbesimicrobes.comin𝕏

iMicrobes uses synthetic biology to develop cost-effective sustainable materials and replace conventional manufacturing processes.

BiotechCircular EconomyCleantechClimate TechHealthtechNew MaterialsSan Francisco, US

Derek Greenfield(Founder/CEO)Liz Clarke(Founder/CTO)inNoah Helman(Founder/CSO)in

Co-investorsJuniperY CombinatorUniversal Materials Incubator

Persephone Biosciencespersephonebiosciences.cominFeb 2021

Persephone Biosciences develops a synbiotic (probiotic and prebiotic combination) supplement for infants designed to replenish key beneficial gut bacteria.

BiotechFemTechHealthtechSan Diego, US

Stephanie Culler(Founder/CEO)inStephen Van Dien(Founder/CTO)in

Co-investorsBioBritFifty YearsHemi Ventures, LlcOcampo CapitalY CombinatorDCVC (Data Collective)+1 more

R2Dior2dio.comin

R2DIO provides two enterprise SaaS products, ProTools for data integration and performance measurement and ProPlatform for process improvement and control, aimed at R&D, manufacturing, and data science teams.

Data & InfrastructureEnterprise SoftwareSaaS

social mediag.co

A URL shortcut operated by Google that directs users to official Google products and services.

Co-investorsCTI Life Sciences Fund L.P.Swanlaab Venture FactoryAbstract VenturesGeneral CatalystUnion Square Ventures (USV)Y Combinator

VIA Biofuelsviabiofuels.com

VIA produces 3-Methylanisole (3-MA), a synthetic aromatic biofuel, through proprietary engineered yeast fermentation that converts starch, sugar, and cellulosic sugars into the aromatic compound.

BiotechCleantechEnergyHouston, US

Lewis Dutel(Founder)

Co-investorsVectors Angel

Visolisvisolisbio.com

Visolis engineers industrial-scale alternatives to traditional fuels and chemicals through biology and chemistry, producing MEV as a non-toxic, biodegradable drop-in replacement that can be manufactured in distributed facilities worldwide.

Advanced ManufacturingCleantechEnergy

Co-investorsBlueYard CapitalCreative VenturesGlobal Brain

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has First Bight Ventures made?
First Bight Ventures has 11 tracked investments.
What stage does First Bight Ventures invest at?
First Bight Ventures invests at the Seed, Series A stages.
What is First Bight Ventures's typical check size?
First Bight Ventures typically writes checks of $1M – $2M.
What sectors does First Bight Ventures focus on?
First Bight Ventures focuses on Advanced Manufacturing, AgTech, Biotech, Circular Economy, Cleantech, Climate Tech, Deep Tech, FoodTech, New Materials.
Where is First Bight Ventures located?
First Bight Ventures is headquartered in Houston, US.
Does First Bight Ventures lead rounds?
Yes, First Bight Ventures leads investment rounds.
Who does First Bight Ventures co-invest with?
First Bight Ventures most often shares deals with Y Combinator, BlueYard Capital, Correlation Ventures, among 60 tracked co-investors.

Media · Podcasts & interviews

from their channel

First Bight Ventures - Biomanufacturing Masterclass 9.2.25

First Bight Ventures

First Bight Biomanufacturing Fireside Chat 08.25

First Bight Ventures

2024 H-Town Roundup Panel Presentation

First Bight Ventures

Introduction to BioWell

First Bight Ventures

First Bight—Tech Rodeo

First Bight Ventures

Images

First Bight Ventures photoFirst Bight Ventures photo

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