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Breakout Ventures

Venture capitalActively deployingoperating company · company profile

San Francisco · Seed–Series A · 14 people tracked

Also known as Breakout Labs; Breakout Ventures · Breakout Labs/Ventures · BREAKOUT MANAGEMENT, LLC

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Investment thesis

Breakout Ventures backs founders building companies at the frontier where science meets technology, spanning biotech, tech-bio, deep tech, hard tech, and chemistry-driven innovation. With more than a decade investing at this edge, the firm brings a team of scientists and operators with technical depth and commercial fluency to anticipate roadblocks and navigate complexity. Beyond capital, Breakout leverages a catalytic network of corporates, strategic partners, and later-stage investors to help founders gain traction, hit milestones faster, and scale into the markets they need to win.

Source: firm website, verified Sep 29, 2026.

Stage
Seed–Series A
Check
$500K – $6M
HQ
San Francisco, CA, US
Leads rounds
Follows
Instruments
Equity
Founded
2016
Last 12 months
2 investments
AUM
$172M
VC funds
4
Tracked investments
41
Unicorns
1

Team · 14 people

from the firm's website & public directories
Lynn M Fishburne· General Partner

What they invest in

from 31 of 41 portfolio companies

Biotech ×25Deep Tech ×14AI & Machine Learning ×13Healthtech ×12Medical Devices ×6New Materials ×5Climate Tech ×4Hardware ×4

HQs:United States×23United Kingdom×1India×1

Who they back

founder profiles across 19 portfolio companies
37%
solo founders
7 of 19 mapped founding teams
32%
repeat founders
of 25 founders with career history
~6 yrs
old at investment
median across 9 dated deals

Founding team size:solo founder×72 founders×53 founders×44+ founders×3

Where their founders studiedfrom 26 founders with education data

Stanford University ×3Stanford University Graduate School of Business ×3UC San Diego ×3Harvard Medical School ×2Stanford University School of Medicine ×2The University of Texas at Austin ×2University of Illinois Urbana-Champaign ×2University of Washington ×2

What their founders studiedfrom 27 founders with field-of-study data

Engineering ×13Life Sciences ×8Computer Science ×4Medicine ×4Chemistry ×3

Where their founders worked beforefrom 25 founders with career history

Solazyme, Inc. ×2

Accelerator rootsportfolio companies that came through a program

Y Combinator ×2

17 founders hold a PhD · 4 hold an MBA (of 27 with degree data)

Investments · 41 tracked

founders shown can be your intro path

By year:2026 · 22024 · 42023 · 12022 · 62019 · 22015 · 116 dated

Debutdebutbiotech.comin✓ verified

Debut applies AI and biotechnology to discover and formulate cosmetic ingredients and beauty products, decoding skin and hair at the genomic level to create novel actives.

Advanced ManufacturingAI & Machine LearningBiotechConsumerSan Diego, US

Joshua Britton(Founder)inBrady Beauchamp(Founder)Greg Weiss(Founder)

BoardCain A. McClary(Director)in

Co-investorsGS FuturesMaterial ImpactKdT VenturesSandbox IndustriesACVC PartnersBetter Ventures Central Llc+12 more

Twelvetwelve.coin𝕏Apr 2015✓ verified

Twelve transforms CO2 into chemicals, fuels, and materials through carbon transformation technology.

Advanced ManufacturingCleantechClimate TechHealthtechNew MaterialsMoses Lake, US

Nicholas Flanders(Founder)inEtosha Cave(Founder)inKendra Kuhl(Founder)inAndrew Cleeland(Executive Officer, Director)in

BoardMarc-Henri Galletti(Director)Nimesh Shah(Director)

Co-investorsDCVC (Data Collective)Dolby Family VenturesFifth WallAdvantage Partners Inc.Aera VCBreakout Labs+36 more

▶︎ CYTOVALEcytovale.comin𝕏Jan 2022

Cytovale develops microfluidic deformability cytometry technology for immune response diagnostics, with a focus on early detection and diagnosis in hospital settings.

BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US

Ajay Shah(Founder)inHenry Tse(Co-founder & Chief Technology Officer)inDino DiCarlo(Director, Promoter)

BoardJack Fuchs(Director, Promoter)in

Board seatLindy Fishburne· per SEC Form D

Co-investorsAlumni VenturesBasecamp FundBlackhorn VenturesBreakout LabsDolby Family VenturesEMV Capital+5 more

AquaPoroaquaporo.comin𝕏Seed · Jun 2026 · $5M

Aquaporo manufactures drinking water directly from atmospheric humidity using proprietary ALMA technology, offering residential units (Droplet) and industrial modular systems (Stream) for on-site water production.

CleantechHardwareAnaheim, US

Kyle E. Cordova(Founder)in

BoardKristopher H Gilman(Director)

Board seatLindy Fishburne· per SEC Form D

Co-investorsCerberus VenturesCool Climate CollectiveE8 AngelsHumba Ventures

Checkerspotcheckerspot.cominSep 2022 · $13M

Checkerspot uses microalgae precision fermentation to produce specialized lipids and fats, including a bio-equivalent source of the sn-2 palmitate fat found in mother's milk, rare bioactive fatty acids, and tropical fat alternatives.

BiotechClimate TechFoodTechNew MaterialsAlameda, US

Scott Franklin(Executive Officer, Director)inCharles Dimmler(Executive Officer, Director)inJohn Krzywicki(CEO)inLayla Ward(CFO)inCasey Lippmeier(CTO)inLeon Parker(SVP, Molecular Biology)in

Board seatJulia Moore· per SEC Form D

Co-investorsBaruch Future VenturesCavallo VenturesViking GlobalBuilders VCCox EnterprisesDIC+5 more

▶︎ STRM.BIOstrm.bioin

STRM.BIO develops technology to deliver gene therapies, aiming to improve how these treatments reach patients.

BiotechDeep TechHealthtechLongevityMedical Devices

Michael Luther(CEO)in

Co-investorsAscension VenturesBreakout LabsDelos CapitalNYBC VenturesBoehringer Ingelheim Venture FundKdT Ventures+1 more

A-Alpha Bioaalphabio.comin𝕏Series A · Jul 2023 · $22M

A-Alpha Bio uses synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions for pharmaceutical discovery and development.

AI & Machine LearningBiotechDeep TechSeattle, US

David Younger, PhD(Chief Executive Officer & Co-Founder)Randolph Lopez, PhD(Chief Technology Officer & Co-Founder)David Younger(Founder)inRandolph Lopez(Founder)in

Co-investorsAngel Collective Opportunity FundFarvatn VentureLux CapitalMadrona Venture GroupPlanet 9 CapitalBoom Capital+2 more

Canaerycanaery.comin

Canaery develops a nose-computer interface that combines animal olfaction with neurotechnology and AI to detect substances and diagnose diseases.

AI & Machine LearningBiotechDeep TechHardwareMedical Devices

Gabriel(Chief Executive Officer)Peter(Chief Technology Officer)

BoardDmitry(Chief Science Advisor)

Co-investors15th RockFlorida Opportunity FundGood News VenturesNYU Innovation Venture FundDolby Family VenturesKdT Ventures

CellChoruscellchorus.comin𝕏Seed

CellChorus develops a visual AI platform called TIMING that performs high-throughput dynamic analysis of single cells, measuring cell activation, killing, and movement over time for biopharmaceutical research.

AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesHouston, US

Dan Meyer(Founder)inNavin Varadarajan(Founder)inLaurence Cooper(Co-founder & Board Chair)inRebecca Berdeaux(Chief Scientific Officer)in

Co-investorsHouston Angel NetworkTexas HALO FundY CombinatorAsymmetry Ventures

Constellationlabconstellationlab.io

Constellation develops foundation models of human state aimed at understanding brains, bodies, and environments.

AI & Machine LearningDeep TechHealthtech

Co-investorsMaC Venture Capital

Copernic Catalystscoperniccatalysts.cominSeed · Nov 2024 · $8M

Copernic develops catalysts for zero-carbon ammonia and e-fuels that are cost-competitive and compatible with existing industrial infrastructure.

CleantechClimate TechDeep TechEnergyCambridge, US

Aruna Ramkrishnan(Founder)inJacob Ebenstein Grose(Executive Officer, Director)

BoardLindy Fishburne(Director)inMichael Kearney(Director)inMichael LoCascio(Director)

Co-investorsFuture VenturesInnospark VenturesJuniperNew Climate VenturesThe Engine Ventures

Ecovativeecovative.comin

Ecovative grows whole-cut meat alternatives and leather-like materials from mycelium using its AirMycelium indoor cultivation platform, which integrates with existing mushroom farming infrastructure.

BiotechFoodTechNew MaterialsGreen Island, US

Eben Bayer(Cofounder)inGavin McIntyre(Founder)in

BoardEvan Lodes(Director)Jerry Weinstein(Director)Charles Deull(Director)Jessica Harris(Director)

Co-investorsBreakout LabsCool Climate CollectiveStray Dog CapitalTrousdale VenturesViking GlobalAiiM Partners+3 more

EnPlusOne Biosciencesenplusonebio.comin𝕏Seed · Sep 2022 · $12M

En Plus One Bio develops synthesis and manufacturing technology for RNA therapeutics, focused on producing high-purity long RNA with higher cycle efficiencies and novel chemical modifications.

BiotechDeep TechWatertown, US

Daniel Ahlstedt(Executive Officer, Director)inJonathan Rittichier(Founder)inDaniel Wiegand(Founder)George M. Church(Founder)

BoardPaxton Major(Director)inAndrew Lee(Director)in

Co-investorsCoatue ManagementNorthpond Ventures

Epana Bioepana.bio

Epana Bio develops therapies for autoimmune diseases by leveraging genomics and AI to identify and target cellular origins of disease, with a focus on precision medicine for patient populations.

AI & Machine LearningBiotechDigital Health

Co-investorsBreakout LabsHAWKTAILHummingbird VenturesOMX VenturesPoint Financial CapitalKdT Ventures+2 more

Fountainfountain.comin𝕏Seed

Fountain provides an applicant tracking system designed specifically for hiring hourly workers at scale.

AI & Machine LearningEnterprise SoftwareHR TechMarketplacesSaaSSan Francisco, US

Keith Ryu(CEO)inJeremy Cai(Founder)inJacqueline Senczyszyn(Recruiter)Ryan Huo(Recruiting Coordinator)Josh Harrisking(Manager, Project Management)Taylor Cotey(Recruiter)

Co-investorsB Capital GroupB4 CapitalBling CapitalCommerce VenturesCrosslink CapitalDCM Ventures+26 more

General Sensegeneralsense.comin

General Sense develops detection technology that augments trained detection animals, aiming to identify molecular threats such as narcotics, crop diseases, human diseases, and bioweapons.

BiotechDeep TechDefense TechHardware

Peter Ledochowitsch(CTO & Co-Founder)Westley Dang(CEO)in

Co-investorsDolby Family VenturesDraper AssociatesJuniperSOSV

Hormone-Free IVFvitra.bioin

Vitra Bio is a biotechnology company developing technology aimed at transforming fertility treatment.

BiotechFemTechHealthtech

Ivana Muncie-Vasic(Chief Executive Officer and Founder)inJohn Langowski(Chief Technology Officer)in

Co-investorsForeground CapitalNorth South VenturesSpacecadet VenturesBoom Capital VenturesRefactor Capital

Immusoftimmusoft.comJan 2019 · $20M

Immusoft develops a cell therapy platform called Immune System Programming (ISP) that engineers a patient's B cells into plasma cells that produce therapeutic proteins after being infused back into the patient.

BiotechDeep TechHealthtechSeattle, US

Matthew Scholz(Founder)inSean Ainsworth(Chief Executive Officer)inRobert Sikorski(Chief Medical Officer)Rob Hayes(Chief Scientific Officer)inScott McIvor(Chief Development Officer)Eric Garcia(Executive Officer)in

Co-investorsBioRock VenturesBoston Harbor AngelsEQx FundInvariantes FundMichigan Capital NetworkNYBC Ventures+6 more

Kisan Networkkisannetwork.comin𝕏SeedDefunct

A digital supply chain platform that connects smallholder farmers with buyers across India, using automated quality assessment and transaction tracking to bypass traditional intermediaries and increase farmer revenue.

Advanced ManufacturingAgTechGurugram, IN

Aditya Agarwalla(CEO)inSanjay Kumar Agarwalla(Founder)inKisan Network HR(HR \u0026 Recruiting)

Co-investorsY CombinatorAgrolimen VenturesBEENEXTFundersClubLynett Capital PartnersMistletoe+2 more

Modern meadowmodernmeadow.comin𝕏

Modern Meadow develops animal-free, bio-fabricated leather alternatives using synthetic biology and material science for the fashion, interiors, and automotive industries.

BiotechCircular EconomyNew MaterialsPine Brook, US

Gabor Forgacs(Founder)inFrancoise Marga(Founder)inKaroly Jakab(Founder)inAnna Bakst(Executive Officer, Director)inRex Liu(Executive Officer)David Williamson(CEO)in

Co-investorsArtis VenturesAstanor VenturesBreakout LabsCollaborative FundHorizons VenturesInventus Capital Partners+7 more

Noetiknoetik.aiin𝕏

Noetik builds AI models to identify cancer patients most likely to respond to treatments and to discover new oncology drug targets.

AI & Machine LearningBiotechHealthtechSouth San Francisco, US

Jacob Rinaldi(Founder)inRonald Alfa(Executive Officer, Director, Promoter)Ron Alfa, MD, PhD(Co-Founder, CEO)inRon Alfa(Founder)Ron Alfa Jacob Rinaldi(Founder)

BoardJames Hardiman(Director)in

Co-investors11.2 CapitalBreakout LabsCatalio Capital Management, LPEPIC VENTURESIntermountain HealthLinearis Ventures+6 more

Novosteoquincetx.comin𝕏

Quince Therapeutics is a clinical-stage biopharmaceutical company developing eDSP, an investigational therapy studied in a Phase 3 clinical trial (NEAT) for patients with Ataxia-Telangiectasia (A-T).

BiotechHealthtechWest Lafayette, US

Philip S. Low, Ph.D.(Executive Officer, Director)David Lamond(Director)Daniel Hasler(Director)Dirk Thye, M.D.(Executive Officer, Director)William J. Rutter(Director)Alex Andrianopoulos(Director)

Co-investorsElevate VenturesPfizer Venture Investments

Parallel Bioparallel.bioin𝕏Seed

Parallel Bio develops human immune organoids and computational tools to predict drug efficacy across diverse patient populations, replacing animal testing in drug discovery.

AI & Machine LearningBiotechDeep TechHealthtechSan Francisco, US

Robert DiFazio(Founder)inJuliana Hilliard(Founder)injennifer lee(Vice President of Finance \u0026 Operations)Christopher Riling(Vice President of Science)

Co-investorsAIX VenturesHumba VenturesImmeasurableJulian CapitalMetaplanetSpacecadet Ventures+19 more

Passkeytxpasskeytx.comin

Passkey operates Locksmith, a computational platform that uses human genetics, biology, and pharmacology to identify synergistic drug combinations from approved and late-stage drugs, allowing existing assets to be repurposed for new indications.

AI & Machine LearningBiotechDeep Tech

Co-investorsBison VenturesWireframe Ventures

Phantom Neurophantomneuro.comin𝕏

Phantom Neuro develops a minimally invasive, subcutaneous muscle-computer interface that uses under-the-skin sensors and on-device AI to translate muscle signals into control commands for robotic devices.

AI & Machine LearningBiotechMedical DevicesRoboticsAustin, US

Connor Glass(Executive Officer, Director, Promoter)in

BoardD.A. Wallach(Director)inEdward Michael(Director)inRobert Lord(Director)in

Co-investorsCapital FactoryCrosscourt VenturesDraper AssociatesLionBirdTime BioVenturesE1 Ventures

Phylagenphylagen.comFeb 2019

Technology identifying supply chain sources using the environmental microbiome.

Co-investorsDolby Family VenturesGolden SeedsJ-VenturesWorking Capital FundAgFunderBlackhorn Ventures+4 more

Reach Industriesreach.industriesin

Reach Industries builds a visual intelligence layer for science, combining AI, software, and hardware to support work in the life sciences.

AI & Machine LearningBiotechDeep TechRoboticsLondon, GB

Chris Beck(Co-founder & CTO)inSilas Adekunle(Co-founder & CEO)in

Co-investorsEntrepreneur FirstLunar VenturesPassion CapitalId4 Ventures LimitedSOSV

ShiraTronicsshiratronics.cominSeries A · Sep 2024 · $3M

ShiraTronics is a medical device company developing an implantable device to treat chronic migraine disease.

BiotechHardwareHealthtechMedical DevicesBrooklyn Park, US

Robert Binney(Executive Officer, Director)

BoardJoyce Erony(Director)inZack Scott(Director)inBrad Vale(Director)inCasey Tansey(Director)Mudit Jain(Executive Officer, Director)in

Co-investorsAmzak HealthAPERTURE Venture PartnersGlobal BioAccess FundNorwest Venture PartnersOSF VenturesSeroba Life Sciences+3 more

Surfsurf.bioin

Surf Bio is a preclinical biopharmaceutical company developing its SnapShot technology, which uses a proprietary polymer to create ultra-high-concentration antibody and biologic formulations (600+ mg/mL, doses over 1,000 mg) for delivery via a standard autoinjector.

BiotechDeep TechHealthtechPalo Alto, US

Bryan Mazlish(Chief Executive Officer, co-founder)inJennifer Schneider, MD(Co-founder, President & Chief Medical Officer)in

Co-investorsPantera Capital

Tfctxtfctx.com

A biotech company developing novel biologics designed to target and eliminate the drivers of cancer recurrence and metastasis.

Biotech

Transfyrtransfyr.aiAug 2026

Transfyr builds a sensor stack and multimodal AI models that record and analyze the physical execution of scientific experiments, capturing details that distinguish success from failure.

AI & Machine LearningBiotechDeep Tech

Co-investorsGeneral CatalystLux CapitalMVP VenturesNeoSV AngelUnderscore VC

ZymoChemzymochem.comin𝕏Series A · Jan 2024 · $21M

ZymoChem develops bio-based materials using proprietary Carbon Conserving (C2) microbes that convert renewable feedstocks into high-value materials with increased yields.

BiotechCircular EconomyClimate TechNew MaterialsSan Leandro, US

Harshal Chokhawala(Founder & CEO)inLindy Fishburne(Director)Phil Grayeski(Director)Taehong Huh(Director)Timothy Dummer(Executive Officer, Director)

Co-investorsAccelr8Breakout LabsCavallo VenturesDudley FundFreshTracks CapitalPrime Partners+8 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Common ScentsSurf Bio, Inc.AtometraConstellationIncendia TherapeuticsPasskeyPasskey TherapeuticsTFC TherapeuticsVitra Labs

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has Breakout Ventures made?
Breakout Ventures has 41 tracked investments, including 4 dated in the last 24 months.
What stage does Breakout Ventures invest at?
Breakout Ventures invests at the Seed, Series A stages.
What is Breakout Ventures's typical check size?
Breakout Ventures typically writes checks of $500K – $6M.
What sectors does Breakout Ventures focus on?
Breakout Ventures focuses on Biotech, Cleantech, Climate Tech, Deep Tech, Healthtech, New Materials.
Where is Breakout Ventures located?
Breakout Ventures is headquartered in San Francisco, US.
Does Breakout Ventures lead rounds?
Breakout Ventures typically participates in rounds rather than leading them.
Who does Breakout Ventures co-invest with?
Breakout Ventures most often shares deals with Breakout Labs, Dolby Family Ventures, Draper Associates, among 117 tracked co-investors.

Images

Breakout Ventures photoBreakout Ventures photoBreakout Ventures photo

Co-investors · 4

SOSV

SOSV is a deep tech venture capital firm that makes first-check pre-seed investments and follow-on rounds in startups focused on human and planetary health, providing lab space and hands-on support at its US locations.

$30K – $550K
Innovation Endeavors

Innovation Endeavors is an early-stage venture fund that invests in founders and supports venture creation through pre-team and pre-idea programs. The firm provides portfolio companies with access to mentors, advisors, and an entrepreneur ecosystem.

Both backed · 1
Passkey
$1M – $15M
Madrona Venture Group

Madrona Venture Group is a venture capital firm that backs founding teams at the seed, early, and acceleration stages, with a focus on Seattle, the Bay Area, and beyond.

Both backed · 1
$2M – $10M
Northpond Ventures

Northpond Ventures is a venture capital firm based in Bethesda, Maryland that invests in life sciences, technology, and related sectors.

Both backed · 1
$100K – $5M

Firms observed investing alongside Breakout Ventures, from public investor directories. Shared companies are the overlap with Breakout Ventures's recorded portfolio.

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