Breakout Ventures
Venture capitalActively deployingSan Francisco · Seed–Series B · 13 people tracked
Also known as BREAKOUT MANAGEMENT, LLC · Breakout Ventures /DE
Investment thesis
Breakout Ventures backs founders building companies at the frontier where science meets technology, spanning biotech, tech-bio, deep tech, hard tech, and chemistry-driven innovation. With more than a decade investing at this edge, the firm brings a team of scientists and operators with technical depth and commercial fluency to anticipate roadblocks and navigate complexity. Beyond capital, Breakout leverages a catalytic network of corporates, strategic partners, and later-stage investors to help founders gain traction, hit milestones faster, and scale into the markets they need to win.
Source: firm website, verified Aug 3, 2026.
Team · 13 people
from the firm's website & public directories
What they invest in
from 15 of 34 portfolio companiesBiotech ×12Healthtech ×6AI & Machine Learning ×5Deep Tech ×4Cleantech ×3Climate Tech ×3Medical Devices ×3Digital Health ×2
HQs:United States×17
Investments · 34 tracked
founders shown can be your intro path
Twelve transforms CO2 into chemicals, fuels, and materials through carbon transformation technology.
Advanced ManufacturingCleantechClimate TechHealthtechNew MaterialsMoses Lake, US
Nicholas Flanders(Founder & CEO)inEtosha Cave(Founder)Kendra Kuhl(Founder)inMarc-Henri Galletti(Director)Nimesh Shah(Director)Charles Warden(Director)
Cytovale develops microfluidic deformability cytometry technology for immune response diagnostics, with a focus on early detection and diagnosis in hospital settings.
BiotechDigital HealthHealthtechMedical DevicesSan Francisco, US
Ajay Shah(Co-founder & CEO)inHenry Tse(Co-founder & Chief Technology Officer)inDino DiCarlo(Director, Promoter)Jack Fuchs(Director, Promoter)in
Board seatLindy Fishburne· per SEC Form D
Aquaporo manufactures drinking water directly from atmospheric humidity using proprietary ALMA technology, offering residential units (Droplet) and industrial modular systems (Stream) for on-site water production.
CleantechHardwareAnaheim, US
Lindy Fishburne(Director)Kristopher H Gilman(Director)Kyle Ellis Cordova(Executive Officer, Director)
Board seatLindy Fishburne· per SEC Form D
Checkerspot develops high-performance fats and oils using precision fermentation technology, targeting food, nutrition, and other industrial applications.
BiotechClimate TechFoodTechAlameda, US
James Kim(Director)John Krzywicki(CEO)Eric Hartz(Director)Layla Ward(CFO)Scott Franklin(Executive Officer, Director)Cain McClary(Director)
Board seatJulia (Thies) Moore· per SEC Form D
Media, US
Peter Ledochowitsch(Executive Officer, Director)Lindy Fishburne(Director)
Board seatLindy Fishburne· per SEC Form D · $3.5M raise · filed Jan 2022
Palo Alto, US
Lindy Fishburne(Director)Bryan Mazlish(Executive Officer, Director)Jennifer Schneider(Executive Officer, Director)Ben Askew(Director)
Board seatLindy Fishburne· per SEC Form D · $16.3M raise · filed Apr 2022
A-Alpha Bio uses synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions for pharmaceutical discovery and development.
AI & Machine LearningBiotechDeep TechSeattle, US
David Younger, PhD(Chief Executive Officer & Co-Founder)Randolph Lopez, PhD(Chief Technology Officer & Co-Founder)David Younger(Executive Officer, Director, Promoter)
CellChorus develops a visual AI platform called TIMING that performs high-throughput dynamic analysis of single cells, measuring cell activation, killing, and movement over time for biopharmaceutical research.
AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesHouston, US
Dan Meyer(Founder)inNavin Varadarajan(Founder)inLaurence Cooper(Co-founder & Board Chair)Rebecca Berdeaux(Chief Scientific Officer)
Copernic develops catalysts for zero-carbon ammonia and e-fuels that are cost-competitive and compatible with existing industrial infrastructure.
CleantechClimate TechDeep TechEnergyCambridge, US
Jacob Ebenstein Grose(Executive Officer, Director)
BoardLindy Fishburne(Director)Michael Kearney(Director)Michael LoCascio(Director)
Green Island, US
Evan Lodes(Director)Jerry Weinstein(Director)Charles Deull(Director)Jessica Harris(Director)Gavin McIntyre(Executive Officer, Director)Steven Sherwood(Director)
Epana Bio develops therapies for autoimmune diseases by leveraging genomics and AI to identify and target cellular origins of disease, with a focus on precision medicine for patient populations.
AI & Machine LearningBiotechDigital Health
Immusoft develops novel therapeutic treatments by programming B cells to produce therapeutic proteins for patients with rare and other diseases with significant unmet medical need.
BiotechSeattle, US
Matthew Scholz(Founder)Mark Ahn, Ph.D.(Director)Sean Ainsworth(Chief Executive Officer)
Modern Meadow develops animal-free, bio-fabricated leather alternatives using synthetic biology and material science for the fashion, interiors, and automotive industries.
BiotechCircular EconomyNew MaterialsPine Brook, US
Anna Bakst(Executive Officer, Director)Andras Forgacs(Director, Promoter)Dennis Fenton(Director)Bart Swanson(Director)Klaus Hommels(Director)Rex Liu(Executive Officer)
NOETIK builds AI and computational biology platforms to discover and develop cancer therapeutics by combining large-scale multimodal spatial biology data from human tumors with machine learning models.
AI & Machine LearningBiotechHealthtechSouth San Francisco, US
Jacob Rinaldi(Executive Officer, Director, Promoter)Ronald Alfa(Executive Officer, Director, Promoter)SVP, Head of Research at Recursion(Co-founder)VP of Informatics at Parker Institute for Cancer Immunotherapy(Co-founder)Chief Corporate Development Officer at Recursion(Co-founder)
BoardJames Hardiman(Director)
Parallel Bio develops human immune organoids and computational tools to predict drug efficacy across diverse patient populations, replacing animal testing in drug discovery.
AI & Machine LearningBiotechDeep TechHealthtechSan Francisco, US
BiotechAustin, US
Connor Glass(Executive Officer, Director, Promoter)D.A. Wallach(Director)Edward Michael(Director)Robert Lord(Director)
ShiraTronics is a medical device company developing an implantable device to treat chronic migraine disease.
BiotechHardwareHealthtechMedical DevicesBrooklyn Park, US
Robert Binney(Executive Officer, Director)
BoardJoyce Erony(Director)Zack Scott(Director)Brad Vale(Director)Casey Tansey(Director)Mudit Jain(Executive Officer, Director)
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does Breakout Ventures invest at?
- Breakout Ventures invests at the Seed, Series A, Series B stages.
- What is Breakout Ventures's typical check size?
- Breakout Ventures typically writes checks of $500K – $6M.
- What sectors does Breakout Ventures focus on?
- Breakout Ventures focuses on Biotech, Cleantech, Climate Tech, Deep Tech, Healthtech, New Materials.
- Where is Breakout Ventures located?
- Breakout Ventures is headquartered in San Francisco, US.
- Does Breakout Ventures lead rounds?
- Breakout Ventures typically participates in rounds rather than leading them.
Images
Co-investors · 4
Madrona Venture Group is an early-stage venture capital firm that backs founding teams at seed, early, and acceleration stages, primarily in Seattle, the Bay Area, and beyond.
SOSV is a deep tech venture capital firm that makes first-check pre-seed investments and follow-on rounds in startups focused on human and planetary health, providing lab space and hands-on support at its US locations.
Innovation Endeavors is an early-stage venture fund that invests in founders and supports venture creation through pre-team and pre-idea programs. The firm provides portfolio companies with access to mentors, advisors, and an entrepreneur ecosystem.
Northpond Ventures is a science- and technology-driven investment firm that backs breakthrough businesses aiming to have a significant impact on humanity.
Firms observed investing alongside Breakout Ventures, from public investor directories. Shared companies are the overlap with Breakout Ventures's recorded portfolio.
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