Fundraising Fox

Main Sequence Ventures

Venture capital

Sydney · Pre-Seed–Growth · 25 people tracked

Fox Verdict
Sign up to see your fit

Investment thesis

Main Sequence backs founders with bold, unreasonable ambition to solve major global challenges. Working in partnership with CSIRO, the firm invests in and helps create companies across a set of defined challenge areas, supporting deep-technology and science-driven ventures aiming to achieve outcomes that seem impossible. It emphasizes building companies from the ground up as well as backing existing teams solving hard problems.

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Growth
HQ
Sydney, New South Wales, AU
Leads rounds
Follows
Instruments
Equity
Founded
2017
AUM
$1B
Tracked investments
61

Team · 25 people

from the firm's website & public directories
Alison Deans· Investment Committee
Ben Hansky· Senior Legal Counselin
Jack Steele· Investment Committee
Jen Baxter· Chief Operating Officer
Peter Chen· Head of Creative Ops
Sarah Pearson· Investment Committee
Danielle Haj Moussa· Analystin𝕏

What they invest in

from 20 of 61 portfolio companies

AI & Machine Learning ×7Deep Tech ×6Cleantech ×5Hardware ×5AgTech ×3Climate Tech ×3New Materials ×3SaaS ×3

HQs:Australia×9Germany×1United States×1

Investments · 61 tracked

founders shown can be your intro path
Advanced Navigationadvancednavigation.comin

Advanced Navigation develops navigation and positioning systems using inertial, photonic, and quantum sensing technologies for autonomous systems across defense, space, climate science, and commercial applications.

AI & Machine LearningDeep TechDefense TechIoTRoboticsSpace Tech

Chris Shaw(Founder & CEO)in

Amber Electric
Andromeda
Arkeus AI
Arlulaarlula.comin

Arlula builds infrastructure for Earth Observation, providing automated, secure systems that move satellite data through organizations at scale.

Data & InfrastructureSaaSSpace Tech

Avarniavarni.coin𝕏

Avarni provides AI-powered software that helps finance, compliance and sustainability teams measure supply-chain carbon emissions and meet sustainability reporting regulations.

CleantechClimate TechEnterprise SoftwareSaaSAustralia, AU

Misha(Co-founder)Anuj(Co-founder)

Barajabaraja.comin

Baraja manufactures LiDAR sensors using Spectrum-Scan technology for autonomous vehicles and self-driving applications.

AI & Machine LearningDeep TechHardwareMobility & Transportation

PartnerBill Bartee· led

Breakerbreaker.audioin𝕏

Breaker is an app for discovering and listening to podcasts, with plans to offer exclusive premium audio content on a paid subscription basis to listeners and provide publishers with analytics and community engagement tools.

ConsumerMedia & EntertainmentSan Francisco, US

Leah Culver(Founder/CTO)in

Castlepoint
Castlepoint Systems
Cauldron
Cortisonic
Coviu
Currus
Currus Biologics
Cylite
DeteQT
Eden Brewedenbrew.com.auin𝕏

Eden Brew has developed DeepForte™, a programmable casein micelle platform for nutrient delivery that replicates natural slow-release digestion principles.

BiotechDeep TechFoodTech

Jim Fader(CEO)

Electralithelectralith.comin

Electralith develops Direct Lithium Extraction and Refining (DLE-R) technology that produces battery-grade lithium hydroxide without water or chemicals, powered by renewable energy.

CleantechEnergyNew Materials

Emesent
Endua
EVERY
Fivecastfivecast.comin

Fivecast provides security and intelligence technology for public and private sector organizations to identify and combat terrorism and other global threats.

CybersecurityDefense TechGovTechAustralia, AU

Gilmour Space
Inventiainventia.lifein

Inventia Life Science provides advanced 3D cell culture platforms and reproducible 3D cell models for drug discovery, cancer research, and toxicology assessment.

AI & Machine LearningBiotechMedical Devices

JDoodle
Kapiche
Kasadakasada.ioin𝕏

Kasada provides a bot defense and fraud prevention platform that detects and blocks automated bot attacks, account takeover, scraping, and human fraud without relying on CAPTCHAs.

CybersecurityEnterprise SoftwareSaaS

Sam Crowther(Founder)

Levur
Loam
Loam Bio
Lumachainlumachain.io

Lumachain provides software for real-time visibility and quality data analytics to optimize the management and quality of perishable goods for the food service industry.

Advanced ManufacturingAI & Machine LearningData & InfrastructureFoodTechSydney, AU

MGA Thermal
Millibeammillibeam.comin

Millibeam develops RF and millimeter-wave chipsets for 5G/6G networks and non-terrestrial connectivity applications.

HardwareSemiconductorsNot stated, AU

Morse Micromorsemicro.comin𝕏
Myriotamyriota.comin

Myriota provides satellite connectivity infrastructure for IoT devices, enabling partners to develop solutions across industries.

AgTechHardwareIoTSpace Tech

Dr David Haley(CTO & Co-Founder)

Nourish
Nourish Ingredients
Number8number8.bioin

Number8 develops BetterFeed, a livestock bolus supplement designed to improve animal nutrition and farm resilience while reducing pasture waste.

AgTechClimate TechImpact & Social Good

Pending AI
Plotlogicplotlogic.com

Plotlogic develops OreSense®, a sensing and AI platform that provides real-time, quantitative mineral data to help mining operators make extraction decisions.

AI & Machine LearningCleantechDeep TechHardwareRed Hill, AU

Steve Lennard(CEO)Andrew Job(Executive Officer, Director)Saman Farid(Director)Grant Allen(Director)Samantha Smith-Eppsteiner(Director)Alireza Tahmasebzadeh(Director)

Practera
Presienpresien.comin
Prospection

PartnerBill Bartee· led

Q-CTRLq-ctrl.comin𝕏

Q-CTRL builds AI-powered control software for quantum computing systems, enabling manipulation and optimization of quantum computers without destroying quantum states.

AI & Machine LearningDeep TechQuantum Computing

Michael J. Biercuk(Founder & Chief Executive Officer)

PartnerBill Bartee· led

Quantum Brilliancequantumbrilliance.comin

Quantum Brilliance designs and manufactures diamond-based quantum chips and products that operate at room temperature, targeting deployment across data centers, edge computing, and field applications.

Deep TechHardwareQuantum ComputingStuttgart, DE

Quasar Satellite Technologies
QuintessenceLabs
Rainstick
Regrowregrow.ag

Regrow provides software and services to help farmers and agricultural businesses adopt regenerative practices that reduce land-based emissions.

AgTechAI & Machine LearningClimate TechImpact & Social Good

Anastasia Volkova(CEO and Co-Founder)

RIOS
Samsara Ecosamsaraeco.com
Skykraft
SunDrive
Terria
Trellis Data
ULUUuluu.com.auin

Uluu develops plastic alternatives made from sustainable materials as a replacement for fossil fuel-based plastics, addressing plastic pollution at its source.

Circular EconomyCleantechNew Materials

Dr Julia Reisser(Co-founder)Michael Kingsbury(Co-founder)

v2food
Varden
Xefcoxefco.comin

Xefco develops sustainable textile production technologies designed to reduce water, energy, and chemical consumption in manufacturing while maintaining fabric quality.

Advanced ManufacturingCleantechNew Materials

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Main Sequence Ventures invest at?
Main Sequence Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth stages.
What sectors does Main Sequence Ventures focus on?
Main Sequence Ventures focuses on Advanced Manufacturing, AgTech, Cleantech, Consumer, Data & Infrastructure, Deep Tech, Defense Tech, Energy, Enterprise Software, FoodTech, Hardware, Healthtech, Media & Entertainment, Medical Devices, New Materials, SaaS.
Where is Main Sequence Ventures located?
Main Sequence Ventures is headquartered in Sydney, AU.
Does Main Sequence Ventures lead rounds?
Main Sequence Ventures typically participates in rounds rather than leading them.

Media · Podcasts & interviews

featuring the team

Wayfinder: Phil Morle, Main Sequence Ventures

M.J. Bale Menswear · Phil Morle

Robotics Australia interview with Main Sequence Ventures' Mike Zimmerman

Robotics Australia Group · Mike Zimmerman

Images

Main Sequence Ventures photo

Co-investors · 20

DCVC (Data Collective)

DCVC (Data Collective) is a venture capital firm that backs founders building companies which apply technology to major challenges across areas such as energy, biotech, agriculture, and machine learning.

Both backed · 3
PlotlogicQ-CTRLSamsara Eco
$5M – $25M
Bessemer Venture Partners

Bessemer Venture Partners is a venture capital firm that partners with entrepreneurs from early stages through every stage of growth, publishing investment roadmaps across multiple technology sectors.

Both backed · 2
$5M – $100M
Blackbird Ventures

Blackbird Ventures is a venture capital firm backing ambitious founders across Australia and New Zealand, having invested in over 130 companies.

Both backed · 2
BarajaMorse Micro
Possible Ventures

Possible Ventures is an early-stage technology investor backing founders working on major global challenges, with a focus on using technology as a force for good.

Both backed · 2
$100K – $5M
Ten Eleven

Ten Eleven Ventures is a venture capital firm focused on cybersecurity, providing capital, connections, and expertise to security technology entrepreneurs.

Both backed · 2
$3M – $15M
Alumni Ventures

Alumni Ventures (AV) is a venture firm that gives accredited individual investors access to professionally managed, diversified venture portfolios by co-investing alongside leading lead VC firms. It offers annual funds, syndicate deal-by-deal investing, and various investor clubs.

Both backed · 1
$100K – $10M
Innovation Endeavors

Innovation Endeavors is an early-stage venture fund that invests in founders and supports venture creation through pre-team and pre-idea programs. The firm provides portfolio companies with access to mentors, advisors, and an entrepreneur ecosystem.

Both backed · 1
$1M – $15M
Sierra Ventures

Sierra Ventures is an early-stage venture capital firm that invests in first-principles founders, backing companies from inception through Series A across AI infrastructure, applied/vertical AI, deep tech, and physical/embodied AI.

Both backed · 1
$10M
Space Capital

Space Capital is a venture capital firm investing in the space economy, focusing on GPS, geospatial intelligence, and satellite communications technologies.

Both backed · 1
AirTree Ventures

AirTree Ventures runs the Pioneers community, a program supporting women and gender-diverse operators, founders and aspiring founders working in high-growth startups, offering mentorship, events and access to the AirTree team.

Both backed · 1
$132K – $16.5M
Brick Mortar Ventures

Brick & Mortar Ventures is a venture capital firm founded in 2015 that invests in early-stage startups building technology for the architecture, engineering, construction (AEC) and facilities management industries.

Both backed · 1
Sequoia Capital

Sequoia Capital is a venture capital firm that partners with founders to build technology companies, with a strong current focus on artificial intelligence.

$4.4M – $214M
8 more co-investors

Lightspeed Venture PartnersSOSV500 StartupsSalesforce Japan Co.,Ltd.Costanoa VenturesGiant Ventures Global LlpAstanor VenturesAirbus Ventures

Firms observed investing alongside Main Sequence Ventures, from public investor directories. Shared companies are the overlap with Main Sequence Ventures's recorded portfolio.

Similar investors

Featured in lists