Main Sequence Ventures
Venture capitalSydney · Pre-Seed–Growth · 25 people tracked
Investment thesis
Main Sequence backs founders with bold, unreasonable ambition to solve major global challenges. Working in partnership with CSIRO, the firm invests in and helps create companies across a set of defined challenge areas, supporting deep-technology and science-driven ventures aiming to achieve outcomes that seem impossible. It emphasizes building companies from the ground up as well as backing existing teams solving hard problems.
Source: firm website, verified Aug 3, 2026.
Team · 25 people
from the firm's website & public directoriesWhat they invest in
from 20 of 61 portfolio companiesAI & Machine Learning ×7Deep Tech ×6Cleantech ×5Hardware ×5AgTech ×3Climate Tech ×3New Materials ×3SaaS ×3
HQs:Australia×9Germany×1United States×1
Investments · 61 tracked
founders shown can be your intro pathAdvanced Navigation develops navigation and positioning systems using inertial, photonic, and quantum sensing technologies for autonomous systems across defense, space, climate science, and commercial applications.
AI & Machine LearningDeep TechDefense TechIoTRoboticsSpace Tech
Chris Shaw(Founder & CEO)in
Baraja manufactures LiDAR sensors using Spectrum-Scan technology for autonomous vehicles and self-driving applications.
AI & Machine LearningDeep TechHardwareMobility & Transportation
PartnerBill Bartee· led
Breaker is an app for discovering and listening to podcasts, with plans to offer exclusive premium audio content on a paid subscription basis to listeners and provide publishers with analytics and community engagement tools.
ConsumerMedia & EntertainmentSan Francisco, US
Leah Culver(Founder/CTO)in
Electralith develops Direct Lithium Extraction and Refining (DLE-R) technology that produces battery-grade lithium hydroxide without water or chemicals, powered by renewable energy.
CleantechEnergyNew Materials
Lumachain provides software for real-time visibility and quality data analytics to optimize the management and quality of perishable goods for the food service industry.
Advanced ManufacturingAI & Machine LearningData & InfrastructureFoodTechSydney, AU
Plotlogic develops OreSense®, a sensing and AI platform that provides real-time, quantitative mineral data to help mining operators make extraction decisions.
AI & Machine LearningCleantechDeep TechHardwareRed Hill, AU
Steve Lennard(CEO)Andrew Job(Executive Officer, Director)Saman Farid(Director)Grant Allen(Director)Samantha Smith-Eppsteiner(Director)Alireza Tahmasebzadeh(Director)
PartnerBill Bartee· led
Q-CTRL builds AI-powered control software for quantum computing systems, enabling manipulation and optimization of quantum computers without destroying quantum states.
AI & Machine LearningDeep TechQuantum Computing
Michael J. Biercuk(Founder & Chief Executive Officer)
PartnerBill Bartee· led
Quantum Brilliance designs and manufactures diamond-based quantum chips and products that operate at room temperature, targeting deployment across data centers, edge computing, and field applications.
Deep TechHardwareQuantum ComputingStuttgart, DE
Regrow provides software and services to help farmers and agricultural businesses adopt regenerative practices that reduce land-based emissions.
AgTechAI & Machine LearningClimate TechImpact & Social Good
Anastasia Volkova(CEO and Co-Founder)
Portfolio news
latest coverage across their companiesMyriota · natlawreview.com · Jun 30, 2026
Advanced Navigation · forbes.com.au · Jun 29, 2026
Breaker · pulse2.com · Jun 24, 2026
ULUU · smartcompany.com.au · Apr 15, 2026
Q-CTRL · salestools.io · Oct 26, 2025
Regrow · scroll.media · Mar 31, 2025
Frequently asked questions
- What stage does Main Sequence Ventures invest at?
- Main Sequence Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth stages.
- What sectors does Main Sequence Ventures focus on?
- Main Sequence Ventures focuses on Advanced Manufacturing, AgTech, Cleantech, Consumer, Data & Infrastructure, Deep Tech, Defense Tech, Energy, Enterprise Software, FoodTech, Hardware, Healthtech, Media & Entertainment, Medical Devices, New Materials, SaaS.
- Where is Main Sequence Ventures located?
- Main Sequence Ventures is headquartered in Sydney, AU.
- Does Main Sequence Ventures lead rounds?
- Main Sequence Ventures typically participates in rounds rather than leading them.
Media · Podcasts & interviews
featuring the teamWayfinder: Phil Morle, Main Sequence Ventures
M.J. Bale Menswear · Phil Morle
Robotics Australia interview with Main Sequence Ventures' Mike Zimmerman
Robotics Australia Group · Mike Zimmerman
Images
Co-investors · 20
DCVC (Data Collective) is a venture capital firm that backs founders building companies which apply technology to major challenges across areas such as energy, biotech, agriculture, and machine learning.
Bessemer Venture Partners is a venture capital firm that partners with entrepreneurs from early stages through every stage of growth, publishing investment roadmaps across multiple technology sectors.
Blackbird Ventures is a venture capital firm backing ambitious founders across Australia and New Zealand, having invested in over 130 companies.
Possible Ventures is an early-stage technology investor backing founders working on major global challenges, with a focus on using technology as a force for good.
Ten Eleven Ventures is a venture capital firm focused on cybersecurity, providing capital, connections, and expertise to security technology entrepreneurs.
Alumni Ventures (AV) is a venture firm that gives accredited individual investors access to professionally managed, diversified venture portfolios by co-investing alongside leading lead VC firms. It offers annual funds, syndicate deal-by-deal investing, and various investor clubs.
Innovation Endeavors is an early-stage venture fund that invests in founders and supports venture creation through pre-team and pre-idea programs. The firm provides portfolio companies with access to mentors, advisors, and an entrepreneur ecosystem.
Sierra Ventures is an early-stage venture capital firm that invests in first-principles founders, backing companies from inception through Series A across AI infrastructure, applied/vertical AI, deep tech, and physical/embodied AI.
Space Capital is a venture capital firm investing in the space economy, focusing on GPS, geospatial intelligence, and satellite communications technologies.
AirTree Ventures runs the Pioneers community, a program supporting women and gender-diverse operators, founders and aspiring founders working in high-growth startups, offering mentorship, events and access to the AirTree team.
Brick & Mortar Ventures is a venture capital firm founded in 2015 that invests in early-stage startups building technology for the architecture, engineering, construction (AEC) and facilities management industries.
Sequoia Capital is a venture capital firm that partners with founders to build technology companies, with a strong current focus on artificial intelligence.
▶8 more co-investors
Lightspeed Venture PartnersSOSV500 StartupsSalesforce Japan Co.,Ltd.Costanoa VenturesGiant Ventures Global LlpAstanor VenturesAirbus Ventures
Firms observed investing alongside Main Sequence Ventures, from public investor directories. Shared companies are the overlap with Main Sequence Ventures's recorded portfolio.
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