Main Sequence Ventures
Venture capitalSydney · Pre-Seed–Growth · 27 people tracked
Investment thesis
Main Sequence backs founders with bold, unreasonable ambition to solve major global challenges. Working in partnership with CSIRO, the firm invests in and helps create companies across a set of defined challenge areas, supporting deep-technology and science-driven ventures aiming to achieve outcomes that seem impossible. It emphasizes building companies from the ground up as well as backing existing teams solving hard problems.
Source: firm website, verified Aug 3, 2026.
Team · 27 people
from the firm's website & curated & public directories
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Founder mafia
2 people who came through Main Sequence Ventures went on to found or lead other companies.
What they invest in
from 41 of 65 portfolio companiesAI & Machine Learning ×17Deep Tech ×16Hardware ×11SaaS ×8AgTech ×7Biotech ×7Cleantech ×7Enterprise Software ×7
HQs:Australia×23United States×4Germany×1France×1
Who they back
founder profiles across 20 portfolio companiesFounding team size:solo founder×102 founders×73 founders×24+ founders×1
Investments · 65 tracked
founders shown can be your intro pathBy year:2026 · 12025 · 12024 · 12023 · 14 dated
Cauldron is an Australian biotech company using precision fermentation to produce alternative proteins.
Advanced ManufacturingAgTechBiotechDeep TechFoodTechOrange, AU
Michele Stansfield(Co-founder & CEO)David Kestenbaum(Co-founder)in
Co-investorsIn-Q-TelHorizons Ventures
Morse Micro designs Wi-Fi HaLow (IEEE 802.11ah) system-on-chip semiconductors that provide long-range, low-power sub-1 GHz wireless connectivity for IoT devices such as security cameras, dongles, and access points.
HardwareIoTSemiconductorsSydney, AU
Andrew Terry(Co-founder & CTO)inMichael De Nil(Co-founder & CEO)inJoe Bedewi(Chief Financial Officer)in
Co-investorsBlackbird VenturesRight Click CapitalSpringCapital InvestmentStoic VCVirescent VenturesStartmate+1 more
Advanced Navigation develops navigation and positioning systems using inertial, photonic, and quantum sensing technologies for autonomous systems across defense, space, climate science, and commercial applications.
AI & Machine LearningDeep TechDefense TechIoTRoboticsSpace Tech
Chris Shaw(Founder & CEO)in
Co-investorsAirTree VenturesAlpha Intelligence CapitalBrick Mortar VenturesIn-Q-TelKohlberg Kravis RobertsOIF Ventures+2 more
Australian electricity retailer passing through wholesale prices with smart-home integration for cheaper, greener power.
Co-investorsBlack Sheep CapitalMighty PartnersTripple
Arkeus builds AI-powered sensing systems that combine advanced sensors with onboard AI to give autonomous platforms real-time situational awareness at the edge.
AI & Machine LearningDeep TechDefense TechHardwareRobotics
Co-investorsFolklore VenturesSalus VenturesQIC VenturesR+ VC
Arlula builds infrastructure for Earth Observation, providing automated, secure systems that move satellite data through organizations at scale.
Data & InfrastructureSaaSSpace Tech
Co-investorsBlack Nova VCCroc PitchLockheed Martin Ventures
Avarni provides AI-powered software that helps finance, compliance and sustainability teams measure supply-chain carbon emissions and meet sustainability reporting regulations.
CleantechClimate TechEnterprise SoftwareSaaSAustralia, AU
Misha(Co-founder)inAnuj(Co-founder)in
Co-investorsAfterWork VenturesCommon Sense VenturesVulpes Ventures
Baraja manufactures LiDAR sensors using Spectrum-Scan technology for autonomous vehicles and self-driving applications.
AI & Machine LearningDeep TechHardwareMobility & Transportation
PartnerBill Bartee· led
Co-investorsBlackbird VenturesInterValley Ventures
Breaker is an app for discovering and listening to podcasts, with plans to offer exclusive premium audio content on a paid subscription basis to listeners and provide publishers with analytics and community engagement tools.
ConsumerMedia & EntertainmentSan Francisco, US
Leah Culver(Founder/CTO)in
Co-investorsBessemer Venture PartnersY CombinatorACE & CompanySE Ventures
Castlepoint provides AI-powered data governance solutions that help corporate clients manage cybersecurity risks and ensure secure information management across complex networks.
AI & Machine LearningCybersecurityData & InfrastructureEnterprise SoftwareGovTech
Rachael Greaves(Founder and CEO)
Co-investorsFlying Fox Ventures
Eden Brew develops food and supplementation products designed to deliver nutrition in natural forms that align with how the human body processes nutrients, with a focus on sustainable scaling and long-term health support.
BiotechDeep TechFoodTechHealthtechImpact & Social Good
Jim Fader(CEO)
Co-investorsBreakthrough VictoriaDigitalis Ventures
ElectraLith develops electrochemical and material-science technologies for lithium production and battery recycling in the renewable energy and mining sectors.
CleantechDeep TechEnergyNew Materials
Charlie McGill(CEO)SJ Oosthuizen(CTO)
Co-investorsBreakthrough VictoriaVX VenturesFathom
Emesent builds AI-powered mobile LiDAR scanners and autonomous mapping technology, including the GX1 handheld scanner and the Hovermap drone platform, that use SLAM to map GPS-denied and hard-to-reach environments.
AI & Machine LearningHardwareRobotics
Co-investorsArchangel VenturesPerennial Partners
Next-generation clean energy storage to power communities, remote industries, and off-grid infrastructure.
Co-investors77 PartnersMelt Ventures
Fivecast provides AI-enabled open-source intelligence software that collects and analyzes online data to surface security risks and actionable insights.
AI & Machine LearningCybersecurityDefense TechGovTechAustralia, AU
Dr Brenton Cooper(CEO & Director, Co-founder)Duane Rivett(VP Strategic Growth, Co-founder)Ross Buglak(VP Product Development, Co-founder)David Blockow(VP Engineering, Co-founder)
Co-investorsArtesianSouth Australian Venture Capital FundTen Eleven
A launch services company that develops vehicles and satellite systems for space missions.
Deep TechDefense TechHardwareSpace TechGold Coast, AU
James Gilmour(Co-Founder, Head of Launch Site Operations)Adam Gilmour(Co-Founder, Chief Executive Officer)
Gilmour Space is an Australian space technology company developing an integrated launch capability, including its Eris launch vehicles, ElaraSat satellite platform, and a licensed spaceport in North Queensland.
Deep TechDefense TechMobility & TransportationSpace TechGold Coast, AU
Adam Gilmour(Founder)inJames GilmourinMichelle Gilmourin
Co-investors500 GlobalBlackbird VenturesFine Structures Ventures
Inventia Life Science provides RASTRUM Workflow Paths, tools for generating reproducible 3D cell models for research and drug discovery.
AI & Machine LearningBiotechDeep TechMedical Devices
Co-investorsTenmileVU Venture Partners
Kapiche is an AI-powered conversation intelligence platform that analyzes customer interactions across all channels to identify patterns, predict churn, and measure customer experience ROI.
AI & Machine LearningEnterprise SoftwareSaaS
RyanKris
Co-investorsFlying Fox VenturesMoxxie VenturesSydney AngelsTransition Level Investments
Kasada provides a bot defense and fraud prevention platform that detects and blocks automated bot attacks, account takeover, scraping, and human fraud without relying on CAPTCHAs.
CybersecurityEnterprise SoftwareSaaS
Sam Crowther(Founder)
Co-investorsIn-Q-TelOIF VenturesOur Innovation FundTen ElevenReinventure Group
Using microbes to draw down carbon into soils at scale.
Co-investorsAcre Venture PartnersArtesianHAWKTAILHorizons VenturesLOWERCARBONLowercarbon Capital+2 more
Lumachain provides software for real-time visibility and quality data analytics to optimize the management and quality of perishable goods for the food service industry.
Advanced ManufacturingAI & Machine LearningData & InfrastructureFoodTechSydney, AU
Jamila Gordon(Founder)in
Co-investorsBessemer Venture Partners
MGA Thermal develops thermal energy storage materials and systems based on patented Miscibility Gap Alloy technology for renewable energy applications.
CleantechClimate TechEnergyNew MaterialsNewcastle, AU
Alexander Post(Chief Technology Officer & Co-Founder)Erich Kisi(Executive Chair, Chief Scientist, & Co-Founder)
Co-investorsAlberts Impact VenturesClimate Venture Capital FundCP VenturesMelt Ventures
Millibeam develops PHASEBEAM, a low-cost 5G transceiver platform for FR1 applications in the 3.3–4.1 GHz band, supporting 2x2 MIMO configurations for handsets and fixed wireless access devices.
Deep TechHardwareSemiconductorsNot stated, AU
Co-investorsArchangel VenturesBreakthrough Victoria
Myriota provides satellite connectivity infrastructure for IoT devices, enabling partners to develop solutions across industries.
AgTechHardwareIoTSpace Tech
Dr David Haley(CTO & Co-Founder)
Co-investorsArtesianBoeing HorizonX VenturesIn-Q-TelInterValley VenturesRight Click CapitalSouth Australian Venture Capital Fund+1 more
Nourish Ingredients develops animal-free fats and lipids using precision fermentation, including Tastilux (a fungal-fermentation phospholipid for meaty flavour) and Creamilux (a short-chain lipid emulsifier for dairy mouthfeel).
BiotechFoodTechNew Materials
Co-investorsHorizons Ventures
Number8 develops solutions to increase productivity and reduce emissions in grass-fed cattle operations and their retail supply chain.
AgTechBiotechClimate TechFoodTechImpact & Social GoodAustralia, AU
Tom Williams(Co-founder)Alex Carpenter(Co-founder)
Co-investorsBreakthrough VictoriaIcehouse VenturesPossible VenturesThe March Group
Pending AI develops a drug discovery and development platform using quantum mechanics and artificial intelligence to enable pharmaceutical companies to develop medicines for any disease.
AI & Machine LearningBiotechDeep TechBoston, US
Pennylane is a financial and accounting management platform.
Enterprise SoftwareFintechSaaSParis, FR
Arthur Waller(Founder)inEdouard MascréFélix BlossierinQuentin de Metz(Founder)Tancrède Besnard(Founder)Thierry Déo
Co-investorsCapitalGKima VenturesSequoia CapitalTCVAngel InvestAtomico+16 more
Plotlogic develops OreSense®, a sensing and AI platform that provides real-time, quantitative mineral data to help mining operators make extraction decisions.
AI & Machine LearningCleantechDeep TechHardwareRed Hill, AU
Andrew Job(Executive Officer, Director)Steve Lennard(CEO)
BoardSaman Farid(Director)Grant Allen(Director)Samantha Smith-Eppsteiner(Director)inAlireza Tahmasebzadeh(Director)
Co-investorsCerity Partners VenturesDCVC (Data Collective)SE VenturesGalvanize Climate SolutionsInnovation Endeavors
Practera is an AI-driven experiential learning company that connects university students with real industry projects and work experiences through a combination of technology platform and managed program delivery.
AI & Machine LearningB2B MarketplacesEdTechFuture of WorkSaaSSan Francisco, US
Beau Leese(Co-Founder and Co-CEO)inWes Sonnenreich(Co-Founder and Co-CEO)inSuzy Watson(Co-Founder and CFO)in
Presien develops plug-and-play computer vision and on-machine AI ("physical AI") solutions that heavy industry OEMs and technology providers integrate into machines to enable real-time operational insights.
AI & Machine LearningConstruction TechRoboticsSydney, AU
Co-investorsFlying Fox VenturesIn-Q-Tel
PartnerBill Bartee· led
Q-CTRL builds AI-powered control software for quantum computing systems, enabling manipulation and optimization of quantum computers without destroying quantum states.
AI & Machine LearningDeep TechQuantum Computing
Michael J. Biercuk(Founder & Chief Executive Officer)
PartnerBill Bartee· led
Co-investorsAlpha EdisonDCVC (Data Collective)Grit VenturesIn-Q-TelSalus VenturesSierra Ventures+10 more
Quantum Brilliance develops integrated quantum microchips based on diamond nitrogen-vacancy centers for sensing and computing applications.
Deep TechHardwareQuantum ComputingSemiconductorsStuttgart, DE
Marcus Doherty(Chief Technology Officer)Mark Luo(Chief Executive Officer)
Co-investorsBreakthrough VictoriaCP VenturesInterValley VenturesInvestible Climate Tech FundR&D Tax IncentiveRampersand
QuintessenceLabs provides post-quantum cryptography tools and quantum key distribution solutions to protect data encryption against threats from quantum computers.
CybersecurityEnterprise SoftwareQuantum ComputingCanberra, AU
Thomas Symul(Founder)
Co-investorsIn-Q-TelInterValley Ventures
RapidAIM develops IoT sensor hardware and mobile software for real-time pest detection and monitoring in orchards and farms.
AgTechIoTSaaS
Co-investorsAlberts Impact VenturesTenacious Ventures
Regrow provides software and services to help farmers and agricultural businesses adopt regenerative practices that reduce land-based emissions.
AgTechAI & Machine LearningClimate TechImpact & Social Good
Anastasia Volkova(CEO and Co-Founder)Anastasia Volkova, PhD(Founder)in
Co-investorsArtesianHAWKTAILRethink ImpactSE VenturesSpace CapitalTenacious Ventures+1 more
Co-investorsBreakthrough VictoriaDCVC (Data Collective)Fourward VenturesGreycroftHitachi VenturesTitanium Ventures+1 more
Solar technology replacing silver with copper to improve efficiency and reduce costs.
Co-investorsVirescent Ventures
Swoop operates global drone transport networks and aircraft to provide seamless aerial access in remote and inaccessible areas, with a focus on reducing carbon emissions and enabling delivery services.
HardwareLogistics & Supply ChainMobility & Transportation
Co-investorsFolklore VenturesIn-Q-TelRight Click CapitalArtesianGiant Leap
Terria develops open-source geospatial mapping and visualization technology, enabling government agencies, organizations, and the public to access, visualize, and analyze geographic data at scale.
AgTechAI & Machine LearningData & InfrastructureDeep TechGovTechPropTechSaaSMelbourne, AU
Ana Belgun(Co-founder / Chief Executive Officer)Amber Standley(Co-founder / Chief Experience Officer)
Trellis Data provides an AI platform that ingests data from multiple sources, supports various AI model types (generative, speech, vision), and chains models together to solve complex workflows.
AI & Machine LearningData & InfrastructureDefense TechEnterprise SoftwareGovTech
Uluu develops plastic alternatives made from sustainable materials as a replacement for fossil fuel-based plastics, addressing plastic pollution at its source.
Circular EconomyCleantechNew Materials
Dr Julia Reisser(Co-founder)Michael Kingsbury(Co-founder)Julia Reisser(Founder)in
Co-investorsAlberts Impact VenturesBurda Principal InvestmentsStartmatePossible VenturesTrinity Ventures
Plant-based meat that's good for you and for the planet
Surry Hills
Gareth William Sprainger(Chief Financial Officer)Chris Shi Chai Liu(Director)Philip David Morle(Director)Michael John Buchanan(Director)John James Cowin(Director)
BoardHendrik Van Asbroeck(Director)
Co-investorsAstanor Ventures
Xefco develops advanced materials and manufacturing solutions for the textile industry, with a focus on sustainable dyeing and finishing technologies.
Advanced ManufacturingCleantechNew MaterialsGeelong, AU
Co-investorsBreakthrough VictoriaPacific ChannelVirescent Ventures
Portfolio news
latest coverage across their companiesEmesent · canadianminingjournal.com · Aug 12, 2026
Castlepoint · bournemouthecho.co.uk · Aug 4, 2026
Myriota · natlawreview.com · Jun 30, 2026
Advanced Navigation · forbes.com.au · Jun 29, 2026
Breaker · pulse2.com · Jun 24, 2026
Arkeus · optica-opn.org · May 29, 2026
Gilmour Space Technologies · forbes.com.au · May 27, 2026
ULUU · smartcompany.com.au · Apr 15, 2026
Frequently asked questions
- How many investments has Main Sequence Ventures made?
- Main Sequence Ventures has 60 tracked investments, 1 of which have exited via acquisition or IPO, including 2 dated in the last 24 months.
- What stage does Main Sequence Ventures invest at?
- Main Sequence Ventures invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth stages.
- What sectors does Main Sequence Ventures focus on?
- Main Sequence Ventures focuses on Advanced Manufacturing, AgTech, Cleantech, Consumer, Data & Infrastructure, Deep Tech, Defense Tech, Energy, Enterprise Software, FoodTech, Hardware, Healthtech, Media & Entertainment, Medical Devices, New Materials, SaaS.
- Where is Main Sequence Ventures located?
- Main Sequence Ventures is headquartered in Sydney, AU.
- Does Main Sequence Ventures lead rounds?
- Main Sequence Ventures typically participates in rounds rather than leading them.
- Who does Main Sequence Ventures co-invest with?
- Main Sequence Ventures most often shares deals with Breakthrough Victoria, In-Q-Tel, Virescent Ventures, among 72 tracked co-investors.
Media · Podcasts & interviews
featuring the teamWayfinder: Phil Morle, Main Sequence Ventures
M.J. Bale Menswear · Phil Morle
Robotics Australia interview with Main Sequence Ventures' Mike Zimmerman
Robotics Australia Group · Mike Zimmerman
Images
Co-investors · 20
DCVC (Data Collective) is a deep tech venture capital firm that backs entrepreneurs using computational approaches to solve large-scale real-world problems across many industries.
Blackbird Ventures is an early-stage venture capital firm that backs ambitious founders with bold ideas from the very beginning.
Bessemer Venture Partners is a global venture capital firm that partners with entrepreneurs across enterprise, consumer, and healthcare sectors from early stages through growth.
Possible Ventures is an early-stage technology investor backing founders working on major global challenges, with a focus on using technology as a force for good.
Ten Eleven Ventures invests in cybersecurity companies across all stages and geographies. The firm provides capital and operational support to portfolio companies in the digital security sector.
Sequoia Capital is a venture capital firm that partners with founders to build technology companies.
Lightspeed is a global venture capital firm that has spent over two decades backing innovative companies as an early and first investor.
Alumni Ventures (AV) is a venture capital firm that co-invests alongside lead VCs in startups, backing founders with capital and access to a large investor and operator community.
Innovation Endeavors is an early-stage venture fund that invests in founders and supports venture creation through pre-team and pre-idea programs. The firm provides portfolio companies with access to mentors, advisors, and an entrepreneur ecosystem.
Sierra Ventures is an early-stage venture capital firm that invests in first-principles founders, backing companies from inception through Series A across AI infrastructure, applied/vertical AI, deep tech, and physical/embodied AI.
500 Global (formerly 500 Startups) is a venture capital firm whose flagship Silicon Valley strategy backs promising technology companies from pre-seed onward across a range of sectors and geographies.
Astanor Ventures is an impact-focused investment firm dedicated to transforming the agrifood system by backing innovation across the value chain from 'soil and sea to gut'.
▶8 more co-investors
Space CapitalAirTree VenturesAirbus VenturesBrick Mortar VenturesSOSVSalesforce Japan Co.,Ltd.Costanoa VenturesGiant Ventures Global Llp
Firms observed investing alongside Main Sequence Ventures, from public investor directories. Shared companies are the overlap with Main Sequence Ventures's recorded portfolio.
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