ACORN BIOVENTURES
Crossover fundNew York · Seed–Late Stage · 3 people tracked
Also known as ACORN CAPITAL ADVISORS, LLC
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Investment thesis
Acorn Bioventures seeks paradigm-changing medical therapies backed by exceptional management teams, focusing on undiscovered or underappreciated assets in the biotech and medtech spaces. The firm leverages over 35 years of investment experience and structures flexible capital to support companies from seed stage through public markets, with a track record of supporting companies that have achieved IPOs, major acquisitions, and multi-billion-dollar valuations.
Source: firm website, verified Sep 15, 2026.
Team · 3 people
from public directoriesWhat they invest in
from 15 of 15 portfolio companiesBiotech ×7AI & Machine Learning ×4Enterprise Software ×3Healthtech ×3SaaS ×3Creator Economy ×2Data & Infrastructure ×2Deep Tech ×2
HQs:United States×5Australia×4
Investments · 15 tracked
founders shown can be your intro pathBy year:2024 · 32023 · 12022 · 32021 · 411 dated
Addex Therapeutics is a clinical-stage pharmaceutical company that develops orally available small molecule drugs known as allosteric modulators for neurological disorders.
BiotechHealthtechGeneva
Roger Mills(Executive Officer, Director)inMikhail Kalinichev(Executive Officer)inJean-Philippe Rocher(Executive Officer)inRobert Lutjens(Executive Officer)inTimothy Dyer(Executive Officer, Director)Vincent Lawton(Director)
Board seatIsaac Manke· per SEC Form D · $5.9M raise · filed Dec 2021
Co-investorsNew Enterprise Associates (NEA)Sofinnova PartnersSR One Capital Management
OnKure Therapeutics is a clinical-stage biopharmaceutical company developing PI3Kα pan-mutant selective inhibitor medicines for the treatment of breast cancer and vascular anomalies.
BiotechDigital HealthHealthtechMedical DevicesBoulder, US
Jason Leverone(Executive Officer)inSamuel Agresta(Executive Officer)inDylan Hartley(Executive Officer)inNicholas Saccomano(Executive Officer, Director)Wendy Johnson(Executive Officer)
Board seatIsaac Manke· per SEC Form D · $65M raise · filed Oct 2024
Co-investorsAccess BiotechnologyBoulder VenturesRiverVest Venture PartnersAbingworthNew Enterprise Associates (NEA)
CG Oncology develops an investigational oncolytic immunotherapy for urologic cancer patients, specifically targeting BCG-unresponsive non-muscle invasive bladder cancer.
BiotechHealthtechMedical Devices
Co-investorsDecheng CapitalForesite CapitalLongitude CapitalPalm Drive CapitalRA CapitalTCG Crossover+2 more
BiotechWilmington, US
Valerie Morisset(Executive Officer)inErin Lavelle(Executive Officer)inRobert Azelby(Executive Officer, Director)James Bucher(Executive Officer)Leone Patterson(Director)
BoardAdam Rosenberg(Director)
Co-investorsManta Ray VenturesAccess BiotechnologyRA Capital
Complexica provides AI software for optimizing sales, marketing, and supply chain decisions for enterprise customers.
AI & Machine LearningEnterprise SoftwareLogistics & Supply ChainSaaSAdelaide, AU
Dr. Zbigniew Michalewicz(Chief Scientist)Matt Michalewicz(Chief Executive Officer)in
Co-investorsPerennial Partners
Engaged in discovery and development of targeted small molecule therapies for cancer treatment, including selective mutant-specific PI3K inhibitors.
BiotechBoulder, US
Anthony D. Piscopio(Executive Officer, Director)Nicholas Saccomano(Director)Duncan Walker(Executive Officer)James Winkler(Executive Officer)Jason Leverone(Executive Officer)Keith M. Olivia(Executive Officer)in
Board seatIsaac Manke· per SEC Form D
Co-investorsSamsara BioCapitalBlackRock
Additive provides a GenAI tool that extracts tax data from K-1, K-3, and related forms (including state forms, 199A, 926, and others), converting PDF tax packages into Excel workpapers or JSON via a web app, Excel add-in, or API.
AI & Machine LearningFintechSaaS
Venky Iyer(Founder)in
Co-investorsMantis CapitalAM VenturesBreakthrough VictoriaNordic Alpha Partners
Conflu-X Technology manufactures thermal management products including cold plates, intercoolers, and liquid cooling solutions for automotive, aviation, data center, defense, and industrial applications.
Advanced ManufacturingData & InfrastructureHardware
Co-investorsAM VenturesBreakthrough Victoria
Genero is a platform that connects marketers with independent creative talent and production partners on demand.
B2B MarketplacesCreator EconomyMarketing TechMelbourne, AU
Andrew Lane(Founder)in
Co-investorsBrick Capital VenturesEllerston Capital
Liquid Instruments develops Moku, a reconfigurable integrated test system for complex research and development applications.
Deep TechDeveloper ToolsEnterprise SoftwareHardware
Daniel Shaddock(CEO)inDanielle Wuchenich(Chief Operating Officer)in
Co-investorsAnzu PartnersBreakthrough VictoriaSignificant VenturesLockheed Martin VenturesMA Growth Ventures
Moku creates Moki, a collection of 8887 hand-assembled NFT characters built from 900+ traits, and develops games around them including an AI Fantasy Arena, a snack-combining puzzler, and an async autobattler.
AI & Machine LearningCrypto & Web3Gaming
Bruce Wasicsko(Founder)in
Co-investorsArca FundsBankless VenturesBig Brain HoldingsBlocktower CapitalContango Digital AssetsFormless Capital+4 more
mx51 provides a white-labelled, bank-grade Payment-as-a-Service platform that offers multi-channel payments and point-of-sale integrations for banks, merchant acquirers, and payment facilitators to serve their merchants.
Data & InfrastructureEnterprise SoftwareFintechRetail TechSaaS
Victor Zheng(Chief Executive Officer and Co-Founder)inMagnus Hsu(Chief Operating Officer and Co-Founder)inVarghese Mathew(Chief Customer Officer)in
Co-investorsArtesianCultivation CapitalReinventure GroupSixThirty Ventures
Neuron23 is a biotech company using data science, human genetics, and functional genomics to develop precision medicines and companion diagnostics for neurodegenerative diseases, starting with an LRRK2 program for Parkinson's disease.
AI & Machine LearningBiotechDeep TechDigital HealthSouth San Francisco, US
Nancy Stagliano(CEO)in
Co-investorsKleiner PerkinsSoftBank GroupSoftBank Vision FundWestlake Village BioPartnersCowen Healthcare InvestmentsHBM Partners+1 more
Redbubble is an online marketplace where independent artists sell their designs printed on products such as apparel and other merchandise.
Creator EconomyE-commerceMarketplaces
Martin Hosking(Founder)in
Co-investorsBlackbird VenturesPiton Capital
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 5
IPOs and acquisitions across the tracked portfolioAddex TherapeuticsNASDAQ: ADXNOnkure Therapeutics IncNASDAQ: OKURCG OncologyNASDAQ: CGONEliem TherapeuticsNASDAQ: CLYMTrovageneNASDAQ: CRDF
Portfolio news
latest coverage across their companiesEliem Therapeutics · tickerreport.com · Jun 30, 2026
Addex Therapeutics · stocktitan.net · Jun 25, 2026
Liquid Instruments · thequantuminsider.com · May 2, 2026
Neuron23 · finsmes.com · Jun 25, 2025
Frequently asked questions
- What stage does ACORN BIOVENTURES invest at?
- ACORN BIOVENTURES invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does ACORN BIOVENTURES focus on?
- ACORN BIOVENTURES focuses on Biotech, Medical Devices.
- Where is ACORN BIOVENTURES located?
- ACORN BIOVENTURES is headquartered in New York, US.
Co-investors · 8
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.
US Venture Partners (USVP) is an early-stage venture capital firm investing in information technology and healthcare companies, with four decades of investing experience.
OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.
Flagship Pioneering is a firm that creates and builds companies to pioneer breakthroughs in science and technology for people and the planet, active for over 25 years.
Sofinnova is an investment firm focused on the life sciences and biotechnology sector, partnering with companies from inception through drug development, regulatory approval, company building, and IPO.
Aisling Capital is an investment firm focused on companies developing and commercializing innovative healthcare products, services, and technologies.
Aberdare Ventures is a venture capital firm based in Menlo Park, California. It invests exclusively in companies working to make healthcare more efficient, lower cost, and smarter.
Firms observed investing alongside ACORN BIOVENTURES, from public investor directories. Shared companies are the overlap with ACORN BIOVENTURES's recorded portfolio.
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