ACORN BIOVENTURES
Crossover fundNew York · Seed–Late Stage · 4 people tracked
Also known as ACORN CAPITAL ADVISORS, LLC
Investment thesis
Acorn Bioventures seeks paradigm-changing medical therapies backed by exceptional management teams, focusing on undiscovered or underappreciated assets in the biotech and medtech spaces. The firm leverages over 35 years of investment experience and structures flexible capital to support companies from seed stage through public markets, with a track record of supporting companies that have achieved IPOs, major acquisitions, and multi-billion-dollar valuations.
Source: firm website, verified Aug 25, 2026.
Team · 4 people
from public directories
What they invest in
from 6 of 6 portfolio companiesBiotech ×4Healthtech ×3AI & Machine Learning ×1Creator Economy ×1Digital Health ×1E-commerce ×1Enterprise Software ×1Logistics & Supply Chain ×1
HQs:United States×2
Investments · 6 tracked
founders shown can be your intro pathBy year:2024 · 12021 · 23 dated
Addex Therapeutics is a clinical-stage pharmaceutical company that develops orally available small molecule drugs known as allosteric modulators for neurological disorders.
BiotechHealthtechGeneva
Roger Mills(Executive Officer, Director)Mikhail Kalinichev(Executive Officer)Jean-Philippe Rocher(Executive Officer)Robert Lutjens(Executive Officer)Timothy Dyer(Executive Officer, Director)Vincent Lawton(Director)
Board seatIsaac Manke· per SEC Form D · $5.9M raise · filed Dec 2021
Co-investorsNew Enterprise Associates (NEA)Sofinnova PartnersSR One Capital Management
OnKure Therapeutics is a clinical-stage biopharmaceutical company developing PI3Kα pan-mutant selective inhibitor medicines for the treatment of breast cancer and vascular anomalies.
BiotechDigital HealthHealthtechMedical DevicesBoulder, US
Jason Leverone(Executive Officer)Samuel Agresta(Executive Officer)Dylan Hartley(Executive Officer)Nicholas Saccomano(Executive Officer, Director)Wendy Johnson(Executive Officer)
Board seatIsaac Manke· per SEC Form D · $65M raise · filed Oct 2024
Co-investorsAccess BiotechnologyRiverVest Venture PartnersAbingworthBoulder VenturesNew Enterprise Associates (NEA)
CG Oncology is a clinical-stage biotechnology company developing bladder-sparing oncolytic immunotherapies for patients with bladder cancer.
BiotechHealthtech
Co-investorsDecheng CapitalForesite CapitalLongitude CapitalPalm Drive CapitalRA CapitalTCG Crossover+2 more
Engaged in discovery and development of targeted small molecule therapies for cancer treatment, including selective mutant-specific PI3K inhibitors.
BiotechBoulder, US
Anthony D. Piscopio(Executive Officer, Director)Nicholas Saccomano(Director)Duncan Walker(Executive Officer)James Winkler(Executive Officer)Jason Leverone(Executive Officer)Keith M. Olivia(Executive Officer)
Board seatIsaac Manke· per SEC Form D · $56.6M raise · filed Mar 2022
Co-investorsSamsara BioCapital
Complexica provides artificial intelligence software for supply and demand optimisation, including its Decision Cloud platform and "Larry, the Digital Analyst" engine for promotional planning, pricing, demand forecasting, supply chain scheduling, and sales optimisation.
AI & Machine LearningEnterprise SoftwareLogistics & Supply Chain
Co-investorsPerennial Partners
Redbubble is an online marketplace where independent artists sell their designs printed on products such as apparel and other merchandise.
Creator EconomyE-commerceMarketplaces
Martin Hosking(Founder)in
Co-investorsBlackbird VenturesPiton Capital
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 3
IPOs and acquisitions across the tracked portfolioAddex TherapeuticsNASDAQ: ADXNOnkure Therapeutics IncNASDAQ: OKURCG OncologyNASDAQ: CGON
Portfolio news
latest coverage across their companiesCG Oncology · investing.com · Aug 19, 2026
Addex Therapeutics · stocktitan.net · Jun 25, 2026
Frequently asked questions
- What stage does ACORN BIOVENTURES invest at?
- ACORN BIOVENTURES invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does ACORN BIOVENTURES focus on?
- ACORN BIOVENTURES focuses on Biotech, Medical Devices.
- Where is ACORN BIOVENTURES located?
- ACORN BIOVENTURES is headquartered in New York, US.
Co-investors · 8
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.
US Venture Partners (USVP) is an early-stage venture capital firm investing in information technology and healthcare companies, with four decades of investing experience.
OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.
Flagship Pioneering is a firm that creates and builds companies to pioneer breakthroughs in science and technology for people and the planet, active for over 25 years.
Sofinnova is an investment firm that partners with biotech companies from inception through growth, supporting drug development, the regulatory process, company building, and IPO.
Aisling Capital is an investment firm focused on companies developing and commercializing innovative healthcare products, services, and technologies.
Aberdare Ventures is a venture capital firm based in Menlo Park, California. It invests exclusively in companies working to make healthcare more efficient, lower cost, and smarter.
Firms observed investing alongside ACORN BIOVENTURES, from public investor directories. Shared companies are the overlap with ACORN BIOVENTURES's recorded portfolio.
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