ACORN BIOVENTURES
Crossover fundNew York · Seed–Late Stage · 4 people tracked
Investment thesis
Acorn Bioventures seeks paradigm-changing medical therapies backed by exceptional management teams, focusing on undiscovered or underappreciated assets in the biotech and medtech spaces. The firm leverages over 35 years of investment experience and structures flexible capital to support companies from seed stage through public markets, with a track record of supporting companies that have achieved IPOs, major acquisitions, and multi-billion-dollar valuations.
Source: firm website, verified Aug 5, 2026.
Team · 4 people
from public directoriesWhat they invest in
from 3 of 3 portfolio companiesBiotech ×3Digital Health ×1Medical Devices ×1
HQs:United States×2
Investments · 3 tracked
founders shown can be your intro pathBiotechGeneva
Roger Mills(Executive Officer, Director)Mikhail Kalinichev(Executive Officer)Isaac Manke(Director)Jean-Philippe Rocher(Executive Officer)Vincent Lawton(Director)Jake Nunn(Director)
Board seatIsaac Manke· per SEC Form D · $5.9M raise · filed Dec 2021
OnKure discovers and develops precision medicines targeting specific cancer drivers and vascular anomalies using structure-based drug design.
BiotechDigital HealthMedical DevicesBoulder, US
Jason Leverone(Executive Officer)Samuel Agresta(Executive Officer)Dylan Hartley(Executive Officer)Nicholas Saccomano(Executive Officer, Director)Scott Weiner(Director)Wendy Johnson(Executive Officer)
Board seatIsaac Manke· per SEC Form D · $65M raise · filed Oct 2024
Engaged in discovery and development of targeted small molecule therapies for cancer treatment, including selective mutant-specific PI3K inhibitors.
BiotechBoulder, US
Anthony D. Piscopio(Executive Officer, Director)R. Michael Carruthers(Director)Andrew J. Phillips(Director)Isaac Manke(Director)Nicholas Saccomano(Director)Duncan Walker(Executive Officer)
Board seatIsaac Manke· per SEC Form D · $56.6M raise · filed Mar 2022
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does ACORN BIOVENTURES invest at?
- ACORN BIOVENTURES invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does ACORN BIOVENTURES focus on?
- ACORN BIOVENTURES focuses on Biotech, Medical Devices.
- Where is ACORN BIOVENTURES located?
- ACORN BIOVENTURES is headquartered in New York, US.
Co-investors · 8
Polaris Partners is a venture capital firm that partners with biotech and healthcare entrepreneurs to build transformational companies.
Atlas Venture is a life sciences venture capital firm with three decades of experience investing in and building biotech and medical innovation companies, including startups launched from its own incubator.
US Venture Partners (USVP) is an early-stage venture capital firm investing in information technology and healthcare companies, with four decades of investing experience.
OrbiMed is a global healthcare-focused investment firm providing financing and operational support to companies across biopharmaceuticals, medical devices, digital health, diagnostics, and healthcare services.
Flagship Pioneering is a firm that creates and builds companies to pioneer breakthroughs in science and technology for people and the planet, active for over 25 years.
Sofinnova is an investment firm that partners with biotech companies from inception through growth, supporting drug development, the regulatory process, company building, and IPO.
Aisling Capital is an investment firm focused on companies developing and commercializing innovative healthcare products, services, and technologies.
Aberdare Ventures is a venture capital firm based in Menlo Park, California. It invests exclusively in companies working to make healthcare more efficient, lower cost, and smarter.
Firms observed investing alongside ACORN BIOVENTURES, from public investor directories.
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