Oxford · Pre-Seed–Growth · 83 people tracked
Investment thesis
OSE partners with researchers and innovators across Oxford, Harwell and Culham to explore the commercial potential of cutting-edge science, co-create ventures and build companies. It backs Oxford's spinouts from pre-seed to growth, raising capital from global investors keen to access world-leading science and partnering with specialist co-investors to fund and scale portfolio companies. The firm focuses on deep tech, life sciences and healthtech, and has raised over £850m, with more than £3bn invested alongside co-investors.
Source: firm website, verified Aug 27, 2026.
Team · 83 people
from the firm's website & curated & public directories
What they invest in
from 42 of 92 portfolio companiesDeep Tech ×23Biotech ×15AI & Machine Learning ×12Hardware ×11Healthtech ×11Cleantech ×8Quantum Computing ×6Enterprise Software ×4
HQs:United Kingdom×15United States×2
Who they back
founder profiles across 14 portfolio companiesFounding team size:solo founder×82 founders×43 founders×14+ founders×1
Investments · 92 tracked
founders shown can be your intro pathBy year:2026 · 22025 · 22024 · 15 dated
PepGen develops disease-modifying therapeutics aimed at the underlying causes of serious genetic neuromuscular and neurological diseases.
BiotechHealthtechBoston, US
Joshua Resnick(Director)James McArthur(Executive Officer, Director)Heidi Henson(Director)
BoardRamin Farzaneh-Far(Director)Christopher Ashton(Director)
Co-investorsRA Capital
Oxford Quantum Circuits (OQC) develops and operates superconducting quantum computers for commercial and strategic applications, offering Quantum-Compute-as-a-Service and integrating quantum systems directly into commercial data centres.
Deep TechEnterprise SoftwareHardwareQuantum ComputingOxford, GB
Peter Leek(Founder & CSO)inGerald Mullally(CEO)Simon Phillips(CTO)Nikki Cooper(CLO)Robert Coutts(CFO)
BoardJack Boyer(Chairman of the Board)
Co-investorsBritish Business BankOxfordOxford Investment Consultants LLPUTEC
Seloxium develops a metal recovery and refining technology (branded "Selectal") used for tailings reprocessing, wastewater treatment, bulk metal recovery, and high-purity refining.
Circular EconomyCleantechDeep TechNew MaterialsTeesside, GB
Dr Christian Peters(CEO & Director)Christian Peters(CEO & Co-founder)inSteve Colley(Co-founder, Technical Advisor & Director)Nick Hankins(Co-founder, Scientific Advisor & Director)Steve van Zutphen(Co-founder, CEO Advisor)Dr Richard Dixon(CCO)
Co-investorsOxford Investment Opportunity Network (OION)
Sitryx is a biotechnology company, founded in 2018, developing therapeutics with a focus on immunometabolism.
BiotechDeep TechHealthtech
Co-investorsLongwood FundSofinnova PartnersSV Health Investors
Theolytics develops systemically deliverable immunotherapies based on oncolytic adenoviruses designed to target solid tumours and their supporting microenvironment.
BiotechHealthtech
Co-investorsEpidarex CapitalSound BioventuresTaiho Ventures, LLCM Ventures
Redefining treatment of incurable blood cancers by targeting the cells that drive them.
Amber Therapeutics develops medical technology focused on treating mixed urinary incontinence, advancing toward pivotal clinical trials in the US with expanded feasibility studies in Europe.
Medical Devices
Co-investorsF-Prime CapitalIntuitive VenturesLightstone VenturesNew Enterprise Associates (NEA)
Archangel builds laser (optical) communication systems that connect satellite networks in space with terrestrial networks, offering an alternative to radio frequency and subsea cable infrastructure.
Deep TechHardwareSpace Tech
Co-investorsBlackfinch VenturesOxford
Co-investorsAdvent Life Sciences
BibliU is a digital learning platform that partners with publishers to provide students affordable, instant access to course content, and offers institutions workflow automation to reduce administrative burden.
EdTechSaaS
Dave Sherwood(Co-Founder & CEO)in
Co-investorsBrick Capital VenturesGreen Shores CapitalGuinness VenturesParkwalk AdvisorsEmerge Education
Co-investorsCreative Destruction Lab (CDL)Longwall Venture Partners LLPOxford Investment Consultants LLP
Dark Blue Therapeutics is a drug discovery company developing a pipeline of first-in-class precision medicine cancer drugs targeting high unmet medical needs.
BiotechHealthtech
Alastair MacKinnonin
Diffblue builds an autonomous testing agent that generates regression unit tests at scale for enterprise codebases, working with existing AI coding platforms like GitHub Copilot and Claude Code to produce verified tests for Java and Python.
AI & Machine LearningDeveloper ToolsEnterprise Software
Co-investorsAlbionVCPerivoli Innovations
Endlyz develops small-molecule disease-modifying therapeutics targeting the ATP13A2 and ATP10B lysosomal transporters to restore endo-lysosomal function and counter neurodegeneration.
BiotechDeep TechBoston, US
Joanna Wolak(Executive Officer, Director)Jonathan Behr(Director)John Gustofson(Director)Damian Crowther(Director)Zaven Kaprielian(Executive Officer, Director)
BoardLaurence Barker(Director)
Co-investorsDementia Discovery Fund
Co-investorsPerivoli Innovations
Evox Therapeutics develops exosome-based gene editing therapies using its ExoEdit platform, which combines exosome delivery with a proprietary CRISPR-based editor to treat severe neurodegenerative and other genetically-driven diseases.
BiotechDeep Tech
Co-investorsOrbiMedPanacea VentureCowen Healthcare InvestmentsGV (Google Ventures)REDMILE
First Light Fusion develops an inertial fusion energy architecture called FLARE that separates compression and fast ignition to lower the peak power needed for fusion, aiming for a simpler and lower-cost path to commercial fusion power.
CleantechDeep TechEnergy
Co-investorsSalica Investments
FluoRok, a spin-out of the University of Oxford, develops patented fluorinating technologies to produce fluorochemicals such as Li-ion battery electrolytes, agrochemicals, and pharmaceutical ingredients without generating toxic hydrofluoric acid.
CleantechDeep TechNew Materials
Gabriele Pupo(CEO & Founder)inVéronique Gouverneur(Founder)
Co-investorsExcellis HoldingGGFGreen Generation Fund
Fractile designs processors for AI acceleration, offering the next generation of computing hardware.
AI & Machine LearningDeep TechHardwareSemiconductorsBristol, GB
Walter Goodwin(Founder & CEO)in
Co-investorsAccelFactorial FundsFelicis VenturesGigascale CapitalInovia Capital01 Advisors+3 more
Greywolf is a clinical-stage biotech developing antigen modulation therapies, including oral small molecules in Phase 1/2 trials, for people with cancers and autoimmune disorders.
BiotechDigital HealthHealthtechMedical DevicesOxford, GB
Peter Joyce(Co-founder)Tom McCarthy(Co-founder)
Co-investorsAndera PartnersCanaan PartnersPfizer Venture InvestmentsBritish Patient CapitalEarlybird Venture CapitalPfizer Ventures
Co-investorsFuture Planet CapitalOxford Investment Opportunity Network (OION)
Living Optics builds a handheld snapshot hyperspectral imaging camera and accompanying software that capture and analyze hyperspectral data at video rate.
AI & Machine LearningDeep TechHardwareOxford, GB
Co-investorsOctopus Ventures
Marley Health is a clinical health platform for pets that combines at-home and in-clinic health data with AI to provide predictive insights and proactive care recommendations.
AI & Machine LearningConsumerHealthtech
Mind Foundry develops deployed AI and machine learning systems for high-risk, high-complexity operational domains, including defense applications such as multi-sensor data fusion for battlespace situational awareness and threat-signature analysis.
AI & Machine LearningDeep TechDefense Tech
Stephen Roberts(Co-founder)Michael Osborne(Co-founder)
A therapeutics company developing checkpoint agonist antibodies for autoimmune disease treatment based on Oxford University research (exited August 2022).
Co-investorsAdvent Life SciencesMedicxiMonograph Capital PartnersSamsara BioCapital
Mixergy makes patented smart hot water cylinders that heat only the water needed, helping reduce energy bills, improve EPC scores, and support compliance for social housing, new builds, and commercial buildings.
CleantechEnergyHardware
Co-investorsKiko Ventures
Portfolio company that raised a £22.2m Series C funding round
Co-investorsParkwalk Advisors
NavLive makes the Radius, a handheld LiDAR and SLAM-based scanner with AI processing that captures 2D floor plans and 3D point clouds of building sites in a single walk-through and exports them to BIM tools like Revit, AutoCAD, and ArchiCAD.
AI & Machine LearningConstruction TechHardware
David Wisth(Founder)in
Co-investorsClearance Venture PartnersOxford
Nucleome develops 3D genomics technology to map genetic variants in the non-coding genome to the genes they dysregulate, with applications in understanding inflammatory diseases and discovering therapeutic targets.
AI & Machine LearningBiotechDeep Tech
Co-investorsM VenturesPfizer Venture InvestmentsBritish Patient CapitalJJDCPfizer Ventures
OMass uses native mass spectrometry, proprietary biochemistry and custom chemistry to study drug targets and their interactions with their native biological environment outside the confounding complexity of the cell.
BiotechDeep TechHealthtech
Ros Deeganin
Co-investorsGV (Google Ventures)Sanofi Ventures
Opsydia is a laser technology company, spun out of the University of Oxford, that uses adaptive optic beam shaping to write features and optical waveguides in transparent materials such as glass.
Deep TechNew MaterialsSemiconductors
Co-investorsForesight GroupParkwalk Advisors
Orbit Discovery is a drug discovery company that participates in industry conferences focused on peptide therapeutics and GPCR-targeted drug discovery.
BiotechHealthtech
Neil Butt(CEO)
Co-investorsFuture Planet CapitalOxford Technology ManagementPerivoli Innovations
ORCA Computing develops full-stack photonic quantum computers, including its rack-mounted, air-cooled PT Series systems that use fibre-interconnected telecom and optical components for quantum-accelerated generative AI and optimisation.
AI & Machine LearningDeep TechQuantum ComputingLondon, GB
Ian Walmsley(Co-founder)Richard Murray(Co-founder, CEO)Josh Nunn(Co-founder, Chief Science Officer)
Co-investorsInnovating CapitalOctopus VenturesPerscitus LLPQuantonationVerve Ventures
Oxford Flow designs and manufactures industrial flow control valves, pressure regulators, and pilot valves using precision engineering and fluid dynamics.
Advanced ManufacturingCleantechHardware
Co-investorsEnergy Impact PartnersFuture Planet Capitalbp ventures
Oxford Ionics develops trapped-ion quantum computers using Electronic Qubit Control to integrate qubit trapping and control onto standard semiconductor chips.
Deep TechHardwareQuantum Computing
Co-investorsOxford University Innovation2xNLansdowne PartnersProsus Ventures
Oxford Semantic Technologies develops RDFox, an in-memory knowledge graph and semantic reasoning engine that uses logic-based inference to deduce new facts and deliver explainable, auditable results for AI applications.
AI & Machine LearningData & InfrastructureDeep TechOxford, GB
Ian Horrocks(Co-founder)Peter Crocker(Founder)in
PQShield develops quantum-resistant cryptography in hardware and software, including post-quantum cryptography (PQC) solutions for chips, applications, and cloud environments.
CybersecurityDeep TechQuantum Computing
Co-investorsBY Venture PartnersCrane Venture PartnersKindred CapitalAdditionChevron Technology Ventures
Prolific connects researchers, AI developers, and product teams with vetted participants for collecting high-quality human data for AI training, surveys, and behavioral research.
AI & Machine LearningData & InfrastructureEnterprise SoftwareMarketplacesSaaSLondon, GB
Phelim Bradley(Founder)in
Co-investors10xvaluepartnersY Combinator
Quantum Motion develops utility-scale quantum computers using silicon spin-qubit architecture compatible with standard semiconductor manufacturing processes and existing foundry supply chains.
Deep TechQuantum ComputingSemiconductors
Co-investorsBosch VenturesDCVC (Data Collective)Octopus VenturesRobert Bosch Venture CapitalSony Ventures CorporationBritish Business Bank+1 more
Refeyn develops mass photometers that measure the mass of individual molecules directly in solution using label-free single-molecule light scattering, providing rapid assessment of sample purity, molecular interactions, and heterogeneity.
BiotechDeep TechHardwareOxford, GB
Co-investorsHorizons VenturesOxford Technology Management
Company co-founded by Johannes Feldmann and Vaysh Kewada.
Spin-out from the Universities of Oxford and Munster developing a novel semiconductor chip.
Vaysh Kewada(Founder)in
Co-investorsCambridge Innovation CapitalPerivoli InnovationsSilicon Catalyst
Scenic Biotech develops disease-modifying therapies for patients with neurological and metabolic genetic disorders using its Cell-Seq discovery platform to identify modifier genes.
BiotechDeep TechHealthtech
Co-investorsBioMedPartnersEIR VenturesBioGeneration VenturesInkef
Snowfox Discovery is a natural hydrogen exploration company developing technology to locate and unlock naturally occurring hydrogen in the geological subsurface.
CleantechClimate TechEnergy
Daniel McMahonin
Co-investorsAP VenturesOxfordbp ventures
SpyBiotech is a clinical-stage biotech company developing vaccines against infectious diseases and cancer using its proprietary SpyTag/SpyCatcher protein "superglue" platform.
BiotechDeep TechHealthtech
Co-investorsGV (Google Ventures)
Co-investorsAmadeus Capital PartnersOxford University Innovation
T-Cypher develops drugs against novel disease-specific targets to treat patients with cancer and autoimmune diseases, focusing on immune-system-engaging medicines.
AI & Machine LearningBiotechDeep Tech
Co-investorsFuture Planet CapitalLifeArc VenturesPerivoli Innovations
Tidal Cyber develops tools and services that help enterprises adopt MITRE ATT&CK framework for threat-informed defense.
CybersecurityEnterprise Software
Rick Gordonin
Co-investorsAccess Venture PartnersBright Pixel CapitalDreamit VenturesGlasswing VenturesStoneMill VenturesTFX Capital+8 more
Ultromics develops FDA-cleared AI software (EchoGo Heart Failure and EchoGo Amyloidosis) that analyzes routine echocardiograms to help clinicians identify patients with HFpEF and screen for cardiac amyloidosis.
AI & Machine LearningDigital HealthMedical Devices
Ross Upton(CEO & Founder)
Co-investorsFuture Planet CapitalGV (Google Ventures)Nina CapitalNovaCapitalOptum VenturesALLEGIS CAPITAL
YASA develops axial flux electric motors ('eMotors') and control systems for electric vehicles and other electrification applications, using a proprietary Yokeless And Segmented Armature design that reduces motor size and weight while increasing power and torque density.
CleantechHardwareMobility & TransportationOxford, GB
Tim Woolmer(CTO & Founder)
Co-investors24 HaymarketParkwalk AdvisorsInovia Capital
Exits · 3
IPOs and acquisitions across the tracked portfolioBarinthus BiotherapeuticsNASDAQ: BRNSPepGenNASDAQ: PEPGYasaacq. by Mercedes Benz
Portfolio news
latest coverage across their companies
Archangel · startupdaily.net · Aug 17, 2026
First Light Fusion · stockpil.com · Aug 16, 2026
PepGen · tickerreport.com · Aug 8, 2026
Amber Therapeutics · foodsommelier.com · Jul 24, 2026
PQShield · pulse2.com · Jul 22, 2026
Fractile · datacenterdynamics.com · Jun 18, 2026
Tidal · esgtoday.com · May 29, 2026
Frequently asked questions
- How many investments has Oxford Science Enterprises made?
- Oxford Science Enterprises has 91 tracked investments, 1 of which have exited via acquisition or IPO, including 2 dated in the last 24 months.
- What stage does Oxford Science Enterprises invest at?
- Oxford Science Enterprises invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth stages.
- What is Oxford Science Enterprises's typical check size?
- Oxford Science Enterprises typically writes checks of $63.5K – $31.8M.
- What sectors does Oxford Science Enterprises focus on?
- Oxford Science Enterprises focuses on AgTech, AI & Machine Learning, Biotech, Cleantech, Climate Tech, Deep Tech, Energy, Healthtech, Medical Devices, Quantum Computing, Robotics, Sector Agnostic.
- Where is Oxford Science Enterprises located?
- Oxford Science Enterprises is headquartered in Oxford, GB.
- Does Oxford Science Enterprises lead rounds?
- Yes, Oxford Science Enterprises leads investment rounds.
- Who does Oxford Science Enterprises co-invest with?
- Oxford Science Enterprises most often shares deals with Future Planet Capital, Perivoli Innovations, Oxford, among 76 tracked co-investors.
Media · Podcasts & interviews
featuring the teamFII9: Ed Bussey – CEO, Oxford Science Enterprises
FII Institute · Ed Bussey
Ed Bussey, CEO of Oxford Science Enterprises, on the need for talent in the UK's spinout ecosystem.
Global Corporate Venturing · Ed Bussey
Ed Bussey, CEO, Oxford Science Enterprises
American European Business Association - AEBA · Ed Bussey
Bloomberg Talks: Oxford Science Enterprises CEO Ed Bussey | Bloomberg Talks
Bloomberg Podcasts · Ed Bussey
Images
Co-investors · 4
GV (Google Ventures) is a venture capital firm that has invested in artificial intelligence and machine learning since its early days, building a global portfolio of more than 100 AI companies across infrastructure, life sciences, and applications.
Parkwalk Advisors is a UK-based investment manager focused on backing deeptech companies spun out of UK universities, bridging the gap between academic research and commercial success. It operates as part of IP Group plc and is a leading EIS fund manager.
Apollo Health Ventures is a biotech-focused investor that combines traditional funding with venture building to back transformative healthcare and longevity companies in Europe and the US.
Borealis Ventures is a venture capital firm focused on building and backing healthcare companies.
Firms observed investing alongside Oxford Science Enterprises, from public investor directories. Shared companies are the overlap with Oxford Science Enterprises's recorded portfolio.
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