Fundraising FoxNew Haven · Seed–Series A · 15 people tracked
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Investment thesis
Elm Street Ventures invests at seed and early stage in companies built on great science and led by strong teams, with a focus on Yale-connected startups commercializing university research. It primarily targets companies whose technology was developed at and licensed from Yale, and also invests in the greater New Haven area, with occasional exceptions where the team has strong personal connections or can add substantial value. In evaluating deals, the firm weighs team strength — creativity, intelligence, passion, and commitment — as heavily as or more than the technology or market. Its focus areas include therapeutics, advanced industrial tools and materials, and climate interventions, aiming for great impact.
Source: firm website, verified Sep 27, 2026.
Team · 15 people
from the firm's websiteAdvisory board member; founder and executive director of the Yale Carbon Containment Lab.
Founder and managing partner of Elm Street Ventures, with experience as a venture capitalist, engineer, and entrepreneur.
A CEO, entrepreneur, and investor with broad experience spanning software and life sciences.
Partner at Elm Street Ventures with extensive experience working with early-stage teams across various sectors.
Former start-up CEO and pharma executive with experience commercializing academic technology; holds a PhD.
A retired US Navy Captain (2021) and vascular surgeon whose military roles included Chief of Vascular Surgery at Walter Reed and Chief Medical Officer for Innovation at the Defense Health Agency, later serving as CMO of dialysis-monitoring company Alio. He advises biotech entrepreneurs and consults at the intersection of life sciences and national security.
A physician executive with 25 years of experience evaluating and implementing healthcare technology, devices, and services. He serves as a limited partner and Venture Partner at Elm Street Ventures, held senior executive roles at Yale New Haven Health System, and is board certified in general surgery and plastic and reconstructive surgery.
Advisory board member; partner at Domain Ventures.
Advisory board member listed in memoriam, formerly of Venrock.
Advisory board member listed in memoriam, formerly of Evolution Life Sciences Partners.
Advisory board member; managing director at Eos BioInnovation.
Advisory board member; managing director at Sutter Hill Ventures.
Advisory board member; Chief Investment Officer of the Yale Investments Office.
Advisory board member; CEO of Connecticut Innovations.
Director of Yale University's Center for Green Chemistry and Green Engineering, holding the Heinz chair in Chemistry for the Environment. Widely known as the 'Father of Green Chemistry,' he previously served as Science Advisor and Assistant Administrator for Research and Development at the US EPA.
What they invest in
from 19 of 33 portfolio companiesBiotech ×13Healthtech ×6Deep Tech ×5Hardware ×4Medical Devices ×3SaaS ×3AgTech ×1AI & Machine Learning ×1
HQs:United States×19Hong Kong×1
Who they back
founder profiles across 11 portfolio companiesFounding team size:solo founder×42 founders×54+ founders×2
Where their founders worked beforefrom 11 founders with career history
Georgia Institute of Technology ×2Yale University ×2
Investments · 33 tracked
founders shown can be your intro pathBy year:2026 · 12021 · 12019 · 12017 · 12015 · 12014 · 12012 · 28 dated
Arvinas is a biopharmaceutical company developing PROTAC protein degrader therapies, with a pipeline focused on oncology and neurology.
BiotechHealthtechNew Haven, US
Sean Cassidy(Executive Officer)inManuel Litchman(Executive Officer, Director)inRandy Teel(President and Chief Executive Officer; Director)inCraig Crews(Founder)
BoardStephen Squinto(Director)inLiam Ratcliffe(Director)in
Co-investors5AM VenturesAccess BiotechnologyCanaan PartnersConnecticut InnovationsNextech InvestRA Capital+3 more
Allyx Therapeutics is a clinical-stage biopharmaceutical company developing therapies to preserve and protect synapses in people with neurodegenerative diseases.
BiotechDigital HealthHealthtechNew Haven, US
Paul Fonteyne(Co-Founder)inStephen Strittmatter(Scientific Founder)inStephen Bloch(CEO & Co-Founder)inTimothy Siegert(COO, Co-Founder)inTim Siegert, PhD(COO & Co-Founder)Jennifer Gabler(Executive Officer)in
Co-investorsSpring Mountain CapitalConnecticut InnovationsHighCape CapitalWHIN
AbbraTech develops a platform technology for the discovery, engineering, and validation of antibodies, targeting disease-relevant proteins that are difficult to address with conventional approaches.
BiotechDeep TechBranford, US
Michael Weiner(Founder)in
Co-investorsConnecticut Innovations
Ancera develops a software platform for food production that combines analytics, diagnostics, and automation to monitor, predict, and prevent risks such as pathogens and disease.
AgTechAI & Machine LearningFoodTechSaaSBranford, US
Arjun Ganesan(CEO)inHur Koser(Executive Officer, Director)in
BoardUgo DeBlasi(Director)McLeod Christopher(Director)Thomas Livingston(Director)
Co-investorsIAG Capital PartnersLaunchCapitalConnecticut Innovations
AtlasXomics develops spatial epigenomics tools, spanning chip fabrication, hardware, and bioinformatics, for researchers studying areas such as cancer and systems biology.
BiotechDeep TechHealthtechNew Haven, US
Gregory Ho(Director)Richard Andersson(Director)
BoardKenneth Wang(Investor and entrepreneur (board member))
Co-investorsConnecticut Innovations
CellFE develops microfluidics technology and instrumentation for cell therapy manufacturing, serving biotech researchers and clinical teams.
BiotechDeep TechHardwareMedical DevicesAtlanta, US
Alla Zamarayeva(CEO & Co-founder)inTodd Sulchek, PhD(CSO & Co-founder)Alex Alexeev, PhD(Co-founder)Todd Sulchek(CSO & Co-founder)inAlex Alexeev(Co-founder)in
Co-investorsDynamk CapitalCota CapitalCreative Destruction Lab (CDL)Embark VenturesGreatPoint VenturesM Ventures+1 more
San Francisco, US
Eli Luberoff(Executive Officer, Director, Promoter)inVan Dyke Billings, III(Executive Officer)
Co-investorsGV (Google Ventures)Kapor Capital
Device42 provides IT asset management and operations software that gives organizations visibility and control over their data center and cloud infrastructure.
Cloud ComputingData & InfrastructureEnterprise SoftwareIoTSaaSTrumbull, US
Rajneesh Jalan(Executive Officer, Director)Raj Jalan(Founder & CEO)in
BoardSteven P. Shwartz(Executive Officer, Director)John Kole(Director)Chris Penner(Director)
Co-investorsAlpine MeridianConnecticut Innovations
Enrich HK supports migrant domestic workers in Hong Kong through financial education, wellness programs, and community initiatives.
FintechHR TechImpact & Social GoodWellness & FitnessHong Kong, HK
Suzanne Gendron(Executive Director)inTynna Mendoza(Interim Executive Director)in
Co-investorsAVPN
Enrich Biosystems develops TROVO, a fluidics-free benchtop instrument that compartmentalizes standard culture plates into thousands of hydrogel microwells for high-throughput functional screening, imaging, and live recovery of cells.
BiotechHardwareHealthtechBranford, US
Qi Zhao(Executive Officer, Director)Dong Wang(Executive Officer, Director)Cynthia Green(Director)
BoardDaniel Wagner(Director)Christopher McLeod(Director)Jay Teich(Director)
Co-investorsConnecticut Innovations
EvolveImmune develops immunotherapy treatments for cancer patients.
BiotechHealthtechMedical DevicesBranford, US
Stephen Bloch(Co-founder and Chief Executive Officer)inDonmienne Leung(Manager)Ian Taylor(Manager)Jay Fine(President, Research and Development)
BoardDerek Yoon(Manager)inJasmina Marjanovic(Manager)in
Co-investorsSolasta VenturesPfizer VenturesPfizer Venture InvestmentsTakeda Ventures
BiotechMedical DevicesNew Haven, US
Scott Phillips(Executive Officer)in
BoardTim Shannon(Manager)inLiam Ratcliffe(Manager)in
Co-investorsAccess BiotechnologyCanaan PartnersConnecticut InnovationsFrazier Life SciencesRA CapitalTaiho Ventures, LLC+1 more
Osmol Therapeutics is a preclinical-stage biotech developing OSM-0205, an intravenous drug intended to prevent chemotherapy-induced peripheral neuropathy (CIPN) and chemotherapy-induced cognitive impairment (CICI) in cancer patients receiving taxane-based therapy.
BiotechHealthtechNew Haven, US
Brian Dixon(Executive Officer, Director)Bob Linke(President & CEO)inRon Weitzman(Chief Medical Officer)
BoardBarbara Ehrlich(Chief Scientific Advisor)
P2 Science develops green chemistry platform technologies (including its PIOz ozonolysis and PICE polymerization processes) that convert renewable, plant-based oils into functional intermediates, specialty ingredients, and polymers.
BiotechCircular EconomyCleantechNew MaterialsWoodbridge, US
Paul Anastas(Co-founder)Patrick Foley(Co-founder & President)inNeil A. Burns(Executive Officer, Director)Oihana Elizalde(Chief Executive Officer)inBrian Chan(Chief Financial Officer)inKevin Gallagher(Director)
Co-investorsXeraya CapitalCircular Innovation FundConnecticut InnovationsEmerald Technology Ventures AgHG VenturesSafer Made+2 more
Samara Aerospace designs and builds high-performance satellite platforms featuring the Hummingbird satellite bus, which combines pointing stability, agility, and power generation in a compact form for commercial, civil, and national security missions.
Deep TechHardwareSpace TechSuperior, US
Patrick Haddox(Co-founder)inVedant(Founder)in
Co-investorsBalerion Space VenturesGaingelsGeneral CatalystIllinois VenturesMana VenturesTamiami Angel+5 more
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Saphlux develops monolithic full-color micro-LED display technology and quantum dot COB display panels for AR smart glasses, sports intelligence glasses, and large-format business and home theater screens.
Deep TechHardwareSemiconductorsBranford, US
Chen Chen(CEO)
BoardHan Jung(Director)
Co-investorsNXT Ventures
SeeClickFix 311 CRM by CivicPlus is a 311 platform that lets residents report local issues, request repairs, and send feedback or questions to their local government.
GovTechSaaSNew Haven, US
Charles Kampmann Lasater(Executive Officer, Director)Ben Berkowitz(Executive Officer, Director)Miles Lasater(Director)in
BoardMark Jacobsen(Director)
Co-investorsConnecticut InnovationsLaunchCapitalPurpose Built Ventures
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Accelerated Orthopedic TechnologiesAffomix CorporationArtizan BiosciencesAxioMx, Inc.BiorelixCybrexa TherapeuticsIconic TherapeuticsKolltanMetagenomixOccam SciencesRetail Optimization Inc.Scribe BiosciencesScrollmotionSharegroveSiduma TherapeuticsStradefy Biosciences
Exits · 1
1 IPOsArvinas Holding Co. LLCNASDAQ: ARVN
Portfolio news
latest coverage across their companiesSamara Aerospace · spacetimespod.com · Jun 23, 2026
P2 Science, Inc · prnewswire.com · Jun 3, 2026
Frequently asked questions
- How many investments has Elm Street Ventures made?
- Elm Street Ventures has 33 tracked investments, 1 of which have exited, including 1 dated in the last 24 months.
- What stage does Elm Street Ventures invest at?
- Elm Street Ventures invests at the Seed, Series A stages.
- What is Elm Street Ventures's typical check size?
- Elm Street Ventures typically writes checks of $250K – $1M.
- What sectors does Elm Street Ventures focus on?
- Elm Street Ventures focuses on Biotech, Cleantech, Climate Tech, Cloud Computing, Deep Tech, Digital Health, Healthtech, IoT, Medical Devices, New Materials, SaaS.
- Where is Elm Street Ventures located?
- Elm Street Ventures is headquartered in New Haven, US.
- Does Elm Street Ventures lead rounds?
- Yes, Elm Street Ventures leads investment rounds.
- Who does Elm Street Ventures co-invest with?
- Elm Street Ventures most often shares deals with Connecticut Innovations, Canaan Partners, OUP (Osage University Partners), among 42 tracked co-investors.
Media · Podcasts & interviews
featuring the teamRob Bettigole (Elm Street Ventures) - Seed and Early Stage Venture Capital
Startup Grind Local · Rob Bettigole
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