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Avalon BioVentures

Venture capital

La Jolla · Pre-Seed–Seed · 18 people tracked

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Investment thesis

Avalon BioVentures backs first-in-class scientific innovation at the earliest stages, deliberately pursuing white-space opportunities other investors consider too early and embracing scientific risk. Its integrated ABV Accelerator model creates and builds companies, giving them immediate access to experienced C-level executives, R&D resources, lab space, and back-office functions such as finance, HR, and IT to accelerate development timelines and maximize capital efficiency. The team takes a hands-on role in portfolio companies, often taking leadership positions and driving strategy, with the aim of translating cutting-edge academic research into breakthrough therapies for patients with unmet needs.

Source: firm website, verified Sep 29, 2026.

Stage
Pre-Seed–Seed
HQ
La Jolla, California, US
Leads rounds
Leads
Instruments
Equity
Founded
1983
AUM
$135M
VC funds
1
Tracked investments
25
Acquisitions
9

Team · 18 people

from the firm's website & public directories

Founder mafia

3 people who came through Avalon BioVentures went on to found or lead other companies.

What they invest in

from 13 of 25 portfolio companies

Biotech ×12Healthtech ×7Deep Tech ×3Medical Devices ×2AI & Machine Learning ×1Digital Health ×1Enterprise Software ×1SaaS ×1

HQs:United States×13

Investments · 25 tracked

founders shown can be your intro path

By year:2025 · 22024 · 12023 · 12021 · 12020 · 12016 · 32014 · 110 dated

Arialysarialysrx.comin𝕏Sep 2023 · $58M✓ verified

Arialys Therapeutics develops precision medicines designed to block pathogenic autoantibodies that target brain receptors such as the NMDA receptor, aiming to treat neuropsychiatric disorders driven by autoimmune disease.

BiotechHealthtechLa Jolla, US

Peter Flynn, Ph.D.(Executive Officer, Director)

BoardJay Lichter, Ph.D.(Director)Brian Slingsby, M.D., Ph.D., M.P.H.(Director)Ed Hurwitz(Director)inAshish Xavier, Ph.D.(Director)Tighe Reardon(Executive Officer)

Co-investorsCatalys PacificMPM BioImpact

Valora Therapeuticsvaloratherapeutics.cominJul 2024 · $30M✓ verified

Valora Therapeutics is a biotech company developing antibody-lectin chimera (AbLec) therapeutics that target cell-surface glycans for immuno-oncology and immunotherapy applications.

BiotechHealthtechLa Jolla, US

Miguel Garcia-Guzman(Co-Founder, CEO & Director)inCarolyn Bertozzi(Scientific Co-Founder)Jessica Stark(Scientific Co-Founder)inJames Lee(VP, Business Development)in

BoardStefan Heller(Director)Sanford Madigan(Director)in

Co-investorsCorrelation VenturesAlexandria

Arista MDaristamd.comin𝕏Mar 2016SEC filingmedium confidence

AristaMD is a technology-enabled clinical services provider that connects primary care physicians with board-certified specialists through eConsults to improve access to specialty care and reduce costs.

Digital HealthEnterprise SoftwareHealthtechSaaSSan Diego, US

Keith Pinter(Chief Executive Officer)inJulia Jezmir(President and Chief Medical Officer)inBrooke LeVasseur(Executive Officer, Director)inDouglas Downs(Executive Officer, Director)Rebecca Cofinas(Executive Officer, Director)

BoardJohn Kuelper(Director)in

Board seatJay B. Lichter· per SEC Form D · $1.4M raise · filed Mar 2016

Co-investorsAscension Ventures.406 VenturesCobalt VenturesCU Healthcare Innovation FundHomebrewMemorialCare Innovation Fund+2 more

Enlaza Therapeuticsenlazatx.cominAug 2025

Enlaza Therapeutics develops covalent protein therapeutics using its War-Lock technology, which incorporates proprietary unnatural amino acids into protein drugs so they form irreversible covalent bonds with disease-related targets.

BiotechDeep TechSan Diego, US

Sergio Duron(Co-Founder & Chief Executive Officer)inSanford Madigan(Co-Founder, President & Chief Business Officer)inAnaleah Heidt(Chief Scientific Officer)in

BoardMarcos Milla(Director)inJay Lichter(Director)inTighe Reardon(Executive Officer)

Board seatJay B. Lichter· per SEC Form D

Co-investorsFrazier Life SciencesLightspeed Venture PartnersSamsara BioCapitalPappas CapitalPfizer Venture InvestmentsJ.P. Morgan Asset Management+1 more

Jnana Therapeuticsjnanatx.comin𝕏Aug 2021acquired by Otsuka

Jnana has developed RAPID, a next-generation chemoproteomics platform that enables rapid discovery of small molecule drugs targeting previously inaccessible disease targets by identifying novel binding sites on complex proteins.

AI & Machine LearningBiotechDeep TechAustin, US

Joel Barrish(Chief Scientific Officer)Donald W. Nicholson(Director)Matthew Hammond(Director)Caroline Stark Beer(Chief Business Officer)Carlo Rizzuto(Director)Annie C. Chen(Director)

Board seatKevin J. Kinsella· per SEC Form D

Co-investorsBain Capital Life SciencesPfizer Venture InvestmentsRA CapitalPfizer VenturesPolaris PartnersVersant Ventures

Actimisboehringer-ingelheim.comacquired by Boehringer Ingelheim

Co-investorsLifeX VenturesSanderling Ventures

AeroRx Therapeuticsaerorxtx.cominSep 2025

AeroRx is a clinical-stage biopharmaceutical company developing nebulized fixed-dose combination therapies (LABA/LAMA and triple LABA/LAMA/ICS) for moderate-to-severe COPD patients who are underserved by inhalers.

BiotechHealthtechLa Jolla, US

Ahmet Tutuncu(CEO and Co-founder)inAhmet Tutuncu, M.D., Ph.D.(Executive Officer, Director)

BoardTighe Reardon(Executive Officer)Heather Preston, M.D.(Director)Jay B. Lichter, Ph.D.(Director)Sanford Madigan, Ph.D.(Director)

Co-investorsAlexandriaCorrelation Ventures

Fibrogenfibrogen.comin𝕏Nov 2014

Kyntra Bio (formerly FibroGen) is a clinical-stage biopharmaceutical company developing therapies for oncology and rare diseases, including serious and life-threatening conditions.

BiotechHealthtechSan Francisco, US

Thomas B. Neff(Executive Officer, Director)Frank H. Valone(Executive Officer)inK. Peony Yu(Executive Officer)inPat Cotroneo(Executive Officer)inRory Riggs(Founder)

BoardRory B. Riggs(Director)

Co-investorsForesite CapitalRidgeback CapitalScientia VenturesMaverick Ventures

Fortis Therapeuticsfortistx.com

Fortis Therapeutics develops therapeutic treatments based on technology licensed from UCSF, with a focus on oncology and other disease areas.

BiotechHealthtechMedical DevicesSan Diego, US

Marc Nasoff(Chief Scientific Officer)

BoardJay B. Lichter(Ph.D.)in

Co-investorsVivo CapitalLilly Asia VenturesOUP (Osage University Partners)

Janux Therapeuticsjanuxrx.comin𝕏

Janux Therapeutics is a clinical-stage biotech company developing precision-engineered immunotherapies for the treatment of cancer and autoimmune diseases.

BiotechDeep TechHealthtechMedical DevicesLa Jolla, US

David Campbell, Ph.D.(Executive Officer, Director)inTighe Reardon(Executive Officer)

BoardJay Lichter, Ph.D.(Director)Jake Simson, Ph.D.(Director)Peter Thompson, M.D.(Director)inStefan Heller(Director)

Co-investorsOrbiMedSamsara BioCapital

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Cellular ApproachesCullinan MicaSynthorxAratana TherapeuticsArialys Therapeutics, Inc.CalportaCalporta TherapeuticsJanuxKorsa TherapeuticsNerio TherapeuticsPDI TherapeuticsProtalys TherapeuticsRQx PharmaRQx PharmaceuticalsSitari Pharmaceuticals

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 9

9 acquisitions

Jnana Therapeuticsacq. by OtsukaSynthorxacq. by SanofiActimisacq. by Boehringer IngelheimAratana Therapeuticsacq. by Elanco Animal HealthCalportaacq. by MerckCalporta Therapeuticsacq. by MerckNerio Therapeuticsacq. by Boehringer IngelheimPDI Therapeuticsacq. by Cullinan TherapeuticsSitari Pharmaceuticalsacq. by GSK

Frequently asked questions

How many investments has Avalon BioVentures made?
Avalon BioVentures has 25 tracked investments, 9 of which have exited, including 2 dated in the last 24 months.
What stage does Avalon BioVentures invest at?
Avalon BioVentures invests at the Pre-Seed, Seed stages.
What sectors does Avalon BioVentures focus on?
Avalon BioVentures focuses on Biotech, Healthtech, Medical Devices.
Where is Avalon BioVentures located?
Avalon BioVentures is headquartered in La Jolla, US.
Does Avalon BioVentures lead rounds?
Yes, Avalon BioVentures leads investment rounds.
Who does Avalon BioVentures co-invest with?
Avalon BioVentures most often shares deals with RA Capital, Correlation Ventures, OUP (Osage University Partners), among 20 tracked co-investors.

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Avalon BioVentures photo

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