APERTURE Venture Partners
Venture capitalBoston · Seed–Series C · 4 people tracked
Also known as APERTURE MANAGEMENT LLC
Investment thesis
Aperture Venture Partners focuses on healthcare investing, partnering with entrepreneurs to build innovative companies across medical devices, pharmaceuticals, healthcare IT and services, and diagnostics. The firm emphasizes its partners' deep industry knowledge and track record of helping companies reach their potential, pointing to several portfolio companies that have surpassed $1 billion valuations.
Source: firm website, verified Aug 25, 2026.
Team · 4 people
from the firm's website & public directories
What they invest in
from 26 of 34 portfolio companiesHealthtech ×24Medical Devices ×20Biotech ×12Hardware ×6Digital Health ×5Deep Tech ×2SaaS ×2Developer Tools ×1
HQs:United States×22Israel×1
Who they back
founder profiles across 10 portfolio companiesFounding team size:solo founder×62 founders×23 founders×2
Investments · 34 tracked
founders shown can be your intro pathBy year:2025 · 12024 · 22022 · 12020 · 12016 · 27 dated
Aclaris develops investigational monoclonal antibodies and small-molecule inhibitors targeting immune pathways for the treatment of atopic, autoimmune, and respiratory diseases.
BiotechHealthtechMedical DevicesWayne, US
Neal Walker(Executive Officer, Director)Kamil Ali-Jackson(Executive Officer)Stuart D. Shanler(Executive Officer)Joseph Monahan(Executive Officer)Hugh Davis(Executive Officer, Director)James Loerop(Executive Officer)
Co-investorsAisling CapitalF-Prime CapitalForesite CapitalRA CapitalSofinnova VenturesSofinnova Venture Partners+1 more
Collegium Pharmaceutical is a biopharmaceutical company developing a portfolio of medications to treat serious medical conditions.
BiotechCanton, US
Michael Heffernan(Executive Officer, Director)Paul Brannelly(Executive Officer)
BoardEran Nadav(Director)John Freund(Director)Patrick Heron(Director)inDavid Hirsch(Director)
Co-investorsEcoR1 CapitalFrazier Life SciencesLongitude Capital
Shoulder Innovations develops InSet® glenoid technology for shoulder joint implants that reduce the rocking horse effect and provide mechanical stability, serving patients with severe shoulder arthritis.
HardwareHealthtechMedical DevicesNorthern California, US
Robert Ball(CEO & Executive Chairman)Matthew Ahearn(Chief Operating Officer)Jeff Points(Executive Officer)David Blue(Executive Officer)Don Running(Manager and Chief Executive Officer)Jeff Ondrla(Chief Technology Officer)
Co-investorsArboretum VenturesGenesis Innovation GroupGlobal BrainInvest MichiganLightstone VenturesUS Venture Partners+2 more
Tarsus Rx is a pharmaceutical company developing treatments for diseases with high unmet need, with a lead product XDEMVY (lotilaner ophthalmic solution) approved by the FDA for Demodex blepharitis.
BiotechHealthtechMedical Devices
Bobak Azamian, MD, PhD(Founder)in
Co-investorsFlying L PartnersFrazier Life SciencesVisionary VenturesVivo CapitalBain Capital Life SciencesRTW Investments L.P.
Trevi Therapeutics is a clinical-stage biopharmaceutical company developing Haduvio (oral nalbuphine ER), an investigational therapy for chronic cough that targets the central and peripheral cough reflex arc.
BiotechHealthtechNew Haven, US
Jennifer L. Good(Executive Officer, Director)Thomas Sciascia(Executive Officer)Jennifer Good(Co-Founder, President & CEO)Lisa Delfini(Executive Officer)William Forbes(Executive Officer)Michael Heffernan(Director)
Co-investorsFrazier Life SciencesNew Enterprise Associates (NEA)
VS3 Medical is a medical device company developing the VS3 Medical Stent System, an investigational neurovascular implant designed to treat symptomatic venous sinus stenosis within the dural venous sinus anatomy.
HardwareHealthtechMedical Devices
Co-investorsGilde HealthcareUS Venture Partners
BiotechHealthtechMedical DevicesWaltham, US
David F. Muller(Executive Officer, Director)Brian J. Roberts(Executive Officer)Rhonda J. Bracey(Executive Officer)
BoardJason Hong(Director)Jeff Dykan(Director)inAnthony Natale(Director)in
Co-investorsLAVLilly Asia VenturesSCP Vitalife PartnersThird Point VenturesHealthQuest CapitalOrbiMed
BardyDx develops the Carnation Ambulatory Monitor (CAM), a lightweight cardiac patch monitor designed for extended-wear ambulatory ECG monitoring that emphasizes P-wave signal clarity.
Digital HealthHealthtechMedical DevicesSeattle, US
Gust H. Bardy(Executive Officer, Director, Promoter)Mark Querry(Executive Officer)Kevin Nelson, III(Executive Officer)Rik Vandevenne(Director)Alan Levy(Director)Mark Handfelt(Executive Officer, Promoter)
Co-investorsAphelion CapitalAscension VenturesLumira VenturesRC CapitalRex Health VenturesSV Health Investors+1 more
Biohaven is a biopharmaceutical company that discovers, develops, and commercializes treatments across immunology, obesity, neuroscience, and oncology, targeting rare and common diseases with limited treatment options.
BiotechHealthtech
Vlad Coric(Chairman & Chief Executive Officer)
Co-investorsAisling CapitalConnecticut InnovationsOUP (Osage University Partners)
Cardiac Dimensions develops medical technology to treat heart failure caused by functional mitral regurgitation (FMR), aiming to address underlying causes rather than symptoms.
BiotechHealthtechMedical DevicesKirkland, US
Frederick A. Stewart(Executive Officer, Director)Rick Wypych(Executive Officer)
BoardKurt Wheeler(Director)Nathan Every(Director)Douglas C. Fisher(Director)Gerry Brunk(Director)
Co-investorsLumira VenturesRedbus VenturesAlly Bridge GroupClaret Capital PartnersM.H. Carnegie & Co.
Co-investorsThird Point VenturesOsage Venture Partners
HealthtechEmeryville, US
Daniel Burnett(Director)Ulric Cote(Executive Officer, Director)Carter Meyer(Director)Bill Malecki(Executive Officer)
BoardDr. Jason Hong(Director)Anthony Natale(Director)in
Co-investorsGreen Park & Golf VenturesScientific Health DevelopmentThird Point VenturesLongwood FundVHM
Developer of drug-eluting stents for coronary artery disease; IPO'd in 2004 and acquired by J&J in 2007.
Co-investorsEaston Capital
Cortica provides in-home, in-clinic, and telehealth neurological therapies for children with autism and developmental differences, integrating neurological, biomedical, behavioral, speech-language, and sensorimotor treatments.
Digital HealthHealthtechMedical DevicesSan Diego, US
Dr. Suzanne Goh(Founder)Neil Hattangadi(Executive Officer, Director)Briana Elvaiah(Executive Officer)
BoardRyan Drant(Director)inStephen Anastos(Director)Justin Brock(Director)in
Co-investors.406 VenturesAIFCVS Health VenturesEcho Health VenturesLongitude CapitalOptum Ventures+4 more
Devoro Medical developed the WOLF Thrombectomy Platform, a non-console, lytic-free medical device that uses finger-like prongs to capture and remove blood clots (thrombi) from the arterial and venous systems.
HardwareHealthtechMedical DevicesFremont, US
BoardErik Engelson(Director)Michael Wallace(Executive Officer, Director)Skott Greenhalgh(Director)
Co-investorsShangBay Capital LLCNorwest Venture Partners
Inspire Medical Systems develops an FDA-approved implantable device that treats obstructive sleep apnea (OSA) by working with the patient's natural breathing, controlled via a small remote and intended for patients for whom CPAP is not effective.
Digital HealthHealthtechMedical DevicesGolden Valley, US
Timothy Herbert(Executive Officer, Director)Tim Herbert(Founder)inGlen Nelson(Director)Benjamin Pless(Director)Mark Fletcher(Director)Edward Shuck(Director)
Co-investorsAmzak HealthUS Venture PartnersOrbiMed
Miach Orthopaedics develops implants that help the body restore its own connective tissue, with an initial focus on treating ACL tears.
HealthtechMedical DevicesWestborough, US
Martha Murray(Founder)Chris Joyce(Executive Officer)Patrick McBrayer(Executive Officer, Director)Sean Sansiveri(Director)Pieter Wolters(Director)
BoardMarc-Andre Marcotte(Director)
Co-investorsAmzak HealthEndeavour VisionSV Health Investors
Nalu Medical develops a non-integrated neurostimulation system that uses electrical impulses to interrupt pain signals for patients with intractable chronic nerve pain.
HardwareHealthtechMedical DevicesCarlsbad, US
Earl Fender(President & CEO)Lee Hartley(Executive Officer)Allen Meacham(Executive Officer)Bick Sellers(Executive Officer)Thomas A. West(Executive Officer, Director)Jeffrey Swiecki(Executive Officer)
Co-investorsB Capital GroupB4 CapitalDecheng CapitalEndeavour VisionLongitude CapitalRunway Growth Capital+1 more
Neuros Medical develops the Altius Direct Electrical Nerve Stimulation System, an FDA-approved implantable device that delivers patient-controlled electrical stimulation to treat chronic post-amputation pain in adult lower limb amputees.
BiotechHealthtechMedical DevicesAliso Viejo, US
David Veino(President and CEO)Zach Stassen(Chief Financial Officer)Robert J. Centa(Chief Financial Officer)Jon J. Snyder(Director, President, Secretary and CEO)
BoardJoyce Erony(Director)inWilliam Harrington(Director)
Co-investorsAmzak HealthCWRU Technology VenturesiSelect FundJobsOhio VenturesJumpstart VenturesRiverVest Venture Partners+5 more
NuXcel is a global medical device accelerator that founds and incubates bioelectronics and neuromodulation startups addressing large unmet clinical needs, using a lean innovation model.
Deep TechHealthtechMedical Devices
Co-investorsTreo Ventures, LlcAmzak HealthNorwest Venture PartnersOSF VenturesU.S. Venture Partners
Developer ToolsE-commerceSaaS
ShiraTronics is a medical device company developing an implantable device to treat chronic migraine disease.
BiotechHardwareHealthtechMedical DevicesBrooklyn Park, US
Robert Binney(Executive Officer, Director)
BoardJoyce Erony(Director)inZack Scott(Director)Brad Vale(Director)inCasey Tansey(Director)Mudit Jain(Executive Officer, Director)
Co-investorsAmzak HealthBreakout VenturesGlobal BioAccess FundNorwest Venture PartnersOSF VenturesSeroba Life Sciences+3 more
Menlo Park, US
Duke Rohlen(Chief Executive Officer)
BoardCamille Samuels(Director)Anthony Natale(Director)inReed Gaither(Director)Aftab Kherani(Director)Ron Kuppersmith(Director)
Co-investorsAisling CapitalCorrelation VenturesVenrockHealthQuest CapitalVenrock AssociatesWestern Technology Investment
Co-investorsProspect Venture Partners
uLab Systems builds digital orthodontics tools, including software (uDesign, uAssist) and uSmile clear aligners manufactured in the USA, for dental professionals and orthodontic practices.
BiotechDigital HealthHealthtechMedical DevicesSaaSMemphis, US
AmirAli Talasaz(Director)Mark Foley(Director)David Thrower(Executive Officer)Tim Dumore(Director)Rita O'Connor(Director)Robert Doty(Executive Officer)
Co-investors7 Gate VenturesCivilization Ventures Management, LlcTachles VC
V-Wave develops the Ventura Interatrial Shunt, an hourglass-shaped percutaneous implantable device that reduces left atrial pressure by offloading volume from the left atrium to the right atrium in patients with chronic heart failure.
BiotechHealthtechMedical Devices
Co-investorsBRM CapitalPontifax Venture CapitalTriventures
Venus develops non-invasive, energy-based medical aesthetic devices for body, face, skin, and hair treatments, integrating robotics, AI, and IoT technologies.
BiotechHardwareHealthtechMedical DevicesToronto, US
Domenic Serafino(Executive Officer, Director)Kirk Gunhus(Executive Officer)Ross Portaro(Executive Officer)Anna Georgiadis(Executive Officer)Melissa Kang(Executive Officer)Michael Mandarello(Executive Officer)
Co-investorsEssex Woodlands Healthcare PartnersLongitude CapitalClarusHealthQuest Capital
XII Medical develops neuromodulation therapies for treating obstructive sleep apnea, focusing on simplifying treatment options and improving patient outcomes.
Deep TechDigital HealthHealthtechMedical DevicesUnion City, US
Garrett Schwab(Chief Executive Officer)Shane Kreidel(Secretary and Chief Financial Officer)inZachary Eisen(Director)
BoardDuke Rohlen(Director)inJD Friedland(Director)Saoussen Ben Halima(Director)
Co-investorsBroadview VenturesCincyTechIntuitive VenturesJobsOhio VenturesAjax HealthOmega Funds
HealthtechMountain View, US
Kenneth Binmoeller, M.D.(Executive Officer, Director)Greg Patterson(Executive Officer, Director)
BoardA. Barr Dolan(Director)Eric Sillman(Director)Anthony Natale, M.D.(Director)Avi Kometz(Director)
Co-investorsThird Point VenturesAscent Biomedical VenturesThird Point
Exits · 7
IPOs and acquisitions across the tracked portfolioAclaris TherapeuticsNASDAQ: ACRSCollegium PharmaceuticalNASDAQ: COLLShoulder InnovationsNYSE: SITarsus PharmaceuticalsNASDAQ: TARSTrevi TherapeuticsNASDAQ: TRVIAvedroacq. by GlaukosConor Medsystemsacq. by Johnson & Johnson
Portfolio news
latest coverage across their companiesTarsus Pharmaceuticals · americanbankingnews.com · Aug 28, 2026
Inspire Medical · themarketsdaily.com · Aug 19, 2026
Collegium Pharmaceutical · kalkinemedia.com · Aug 13, 2026
Trevi Therapeutics · investing.com · Aug 7, 2026
Shoulder Innovations · investing.com · Jun 29, 2026
Aclaris Therapeutics · investing.com · May 8, 2026
Frequently asked questions
- How many investments has APERTURE Venture Partners made?
- APERTURE Venture Partners has 32 tracked investments, 2 of which have exited via acquisition or IPO, including 2 dated in the last 24 months.
- What stage does APERTURE Venture Partners invest at?
- APERTURE Venture Partners invests at the Seed, Series A, Series B, Series C stages.
- What is APERTURE Venture Partners's typical check size?
- APERTURE Venture Partners typically writes checks of $1M – $5M.
- What sectors does APERTURE Venture Partners focus on?
- APERTURE Venture Partners focuses on Biotech, Digital Health, Healthtech, Medical Devices.
- Where is APERTURE Venture Partners located?
- APERTURE Venture Partners is headquartered in Boston, US.
- Who does APERTURE Venture Partners co-invest with?
- APERTURE Venture Partners most often shares deals with Amzak Health, Longitude Capital, Third Point Ventures, among 72 tracked co-investors.
Media · Podcasts & interviews
featuring the teamTony Natale, MD, Aperture Venture Partners, Intro: 2nd Annual PE/VC Conference
CFA Society New York · Tony Natale
Co-investors · 5
US Venture Partners (USVP) is an early-stage venture capital firm investing in information technology and healthcare companies, with four decades of investing experience.
EQT Life Sciences, formerly LSP, is one of Europe's largest and most experienced life sciences investors, backing companies developing therapeutics, medical devices, diagnostics and healthtech globally. It is part of EQT Group.
OUP (Osage University Partners) is a venture firm that invests in science-driven startups commercializing deep technology innovations emerging from university and breakthrough research.
Signet Healthcare Partners provides growth capital to commercial-stage healthcare companies worldwide, focusing on pharmaceutical and medical device businesses that are revenue-generating or preparing for commercial launch.
Deerfield Management is a healthcare-focused investment firm that supports companies across the healthcare ecosystem through flexible funding, market intelligence, and philanthropic initiatives.
Firms observed investing alongside APERTURE Venture Partners, from public investor directories. Shared companies are the overlap with APERTURE Venture Partners's recorded portfolio.
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