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CLI Ventures

Venture capital

Palo Alto · Seed–Late Stage · 6 people tracked

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Investment thesis

CLI Ventures backs strong founders building toward the future, supporting companies across early to late stages of growth. Its selected portfolio spans technology-driven real estate, gene-editing biopharmaceuticals, and genomic cancer diagnostics, reflecting a broad interest in transformative, high-growth businesses that can reach public-market or acquisition outcomes.

Source: firm website, verified Oct 3, 2026.

Stage
Seed–Late Stage
HQ
Palo Alto, US
Tracked investments
22
Unicorns
2
IPOs
3
Acquisitions
1

Team · 6 people

from the firm's website & public directories
Jeffrey, Zhi Li· Managing Partnerin

What they invest in

from 19 of 22 portfolio companies

Biotech ×7Healthtech ×7Medical Devices ×6Deep Tech ×4SaaS ×4AI & Machine Learning ×3Digital Health ×3PropTech ×3

HQs:United States×14Switzerland×1Vietnam×1

Who they back

founder profiles across 11 portfolio companies
36%
solo founders
4 of 11 mapped founding teams
36%
repeat founders
of 11 founders with career history

Founding team size:solo founder×42 founders×33 founders×34+ founders×1

Where their founders studiedfrom 11 founders with education data

Stanford University ×3Columbia Business School ×2Harvard University ×2University of California, Berkeley ×2

What their founders studiedfrom 10 founders with field-of-study data

Engineering ×5Physics ×3Computer Science ×2Finance & Accounting ×2

Where their founders worked beforefrom 11 founders with career history

LS9, Inc. ×2MAKO Surgical Corp. ×2Stanford Genome Technology Center ×2

Accelerator rootsportfolio companies that came through a program

Y Combinator ×2

Investments · 22 tracked

founders shown can be your intro path

By year:2016 · 22015 · 24 dated

Compasscompass.com𝕏NYSE: COMP

Compass is a real estate brokerage that uses technology to help consumers find homes.

B2B MarketplacesEnterprise SoftwareMarketplacesPropTechSaaSManhattan, US

Robert Reffkin(Founder)inOri Allon(Founder)Brad Serwin(Executive Officer)Kalani Reelitz(Executive Officer)Ethan Glass(Executive Officer)inScott Wahlers(Executive Officer)

Co-investors.406 VenturesAdvance Venture PartnersAlpaca VCAlumni VenturesAtomicoCorigin Ventures+12 more

Guardant Healthguardanthealth.comin𝕏NASDAQ: GH

Guardant Health develops blood-based testing (liquid biopsy) for cancer detection and monitoring across all stages of the disease.

BiotechDigital HealthHealthtechMedical DevicesRedwood City, US

AmirAli Talasaz(Founder)inHelmy Eltoukhy(Founder)inMichael Wiley(Executive Officer)inMichael Bell(Chief Financial Officer)Darya Chudova(Chief Technology Officer)inCraig Eagle(Chief Medical Officer)in

Co-investors8VCAUTHENTIC VENTURESCota CapitalFelicis VenturesKhosla VenturesKnockout Capital+10 more

Synlogicsynlogictx.comin𝕏OTC: SYBX

Synlogic develops synthetic biology-based biotherapeutics that use engineered living organisms to treat diseases.

BiotechDeep TechMedical DevicesCambridge, US

Bharatt Chowrira(Executive Officer)inMichael Sheahan(Executive Officer)Jose Carlos Gutierrez-Ramos(Executive Officer, Director)inPaul Miller(Executive Officer)inAoife Brennan(Executive Officer)inTodd Shegog(Executive Officer)in

Co-investorsAtlas VentureNew Enterprise Associates (NEA)NSG VenturesPfizer Venture InvestmentsSofinnova VenturesSolasta Ventures+1 more

Arthenaarthena.com𝕏SeedAcquired

Arthena operates a financial fund that enables high-net-worth individuals to invest in art by using statistical models trained on auction data to identify and purchase artworks expected to appreciate with low correlation to traditional asset classes.

FintechNew York City, US

Madelaine D'Angelo(Founder)inMichael DAngelo(Founder)in

Co-investorsAnya CapitalClick VenturesFirstrock CapitalY Combinator1984 Ventures Management, Llc2020 Ventures+10 more

Civil Mapscivilmaps.com

Civil Maps develops artificial intelligence for autonomous vehicle perception, creating continental-scale HD 3D maps and centimeter-level localization systems.

AI & Machine LearningDeep TechMobility & TransportationSilicon Valley, US

Co-investorsElev8.vcReshapeScrum VenturesTSVCAME Cloud VenturesMotus Ventures, Llc+1 more

CRISPRcrisprtx.comin𝕏Oct 2016

CRISPR Therapeutics is a biotechnology company developing gene-based medicines using CRISPR/Cas9 gene-editing technology.

BiotechDeep TechHealthtechZug, CH

Emmanuelle Charpentier(Founder)Samarth Kulkarni(Chief Executive Officer and Chairman of the Board)inJames R. Kasinger(General Counsel and Secretary)inStephen Kennedy(Head of Technical Operations)inMegan Wherry Menner(Head of Human Resources)inNaimish Patel(Chief Medical Officer)in

Co-investorsAvoro Capital AdvisorsKhosla VenturesNew Enterprise Associates (NEA)SR One Capital ManagementVersant VenturesWellington Management+2 more

CStoreProcstorepro.com

CStorePro provides cloud-based back-office software for convenience store operators.

Cloud ComputingData & Infrastructure

Arif Momin(Founder)in

Co-investors500 GlobalForefront VentureLaunchCapitalSandalphon CapitalSilicon Badia

Flirteyflirtey.comin𝕏

Xoilac TV is a Vietnamese website for streaming live football matches with free Vietnamese-language commentary, covering leagues such as the Premier League, La Liga, Serie A, Bundesliga, V-League and World Cup.

ConsumerMedia & EntertainmentSports TechĐà Nẵng, VN

Ahmed Haider(Founder)Matthew Sweeny(Founder)inTom Bass(Founder)Võ Hà Chiến(Founder)

Co-investorsZillionizeLowercase CapitalMenlo VenturesQualcomm VenturesWorld Innovation Lab (WiL)

Flirtey (SkyDrop)𝕏Seed

Flirtey operates a drone delivery network that transports goods directly to customers for last-mile logistics.

Advanced ManufacturingRoboticsBlountville, US

Matthew Sweeny(Founder/CEO)in

Co-investorsY CombinatorACE & CompanyAmasiaBessemer Venture PartnersDHVCElysium Venture Capital+13 more

Genalytegenalyte.comin𝕏

Genalyte develops Merlin, a real-time diagnostic system that performs laboratory testing directly in clinical settings and integrates results with electronic health records.

Digital HealthHardwareHealthtechMedical DevicesSan Diego, US

Cary Gunn(Founder)in

Co-investorsBioBritBoutique Venture PartnersClaremont Creek VenturesFusionX VenturesHBM Healthcare InvestmentsHBM Partners+7 more

Hiretualhiretual.com

Hiretual offers an AI agent-driven recruiting platform that handles the full hiring pipeline — candidate sourcing across 45+ platforms, branded career pages, ATS/CRM enrichment, applicant review, conversational screening, interview scheduling, and hiring analytics — directed from a single interface.

AI & Machine LearningHR TechSaaS

Immune-Onc Therapeuticsimmune-onc.cominJul 2016

Immune Onc is a biotechnology company developing medicines to treat patients with hard-to-treat cancers and autoimmune diseases, with expertise in translational medicine and clinical development.

BiotechMedical DevicesPalo Alto, US

Xiaoling Charlene Liao(Executive Officer, Director)

BoardGuo-Liang Yu(Director)Liqun Luo(Director)

Co-investorsNorthern Light Venture CapitalShangBay Capital LLCStartXVivo CapitalTriWise Capital

Industrial Microbesimicrobes.comin𝕏Seed

iMicrobes uses synthetic biology to develop cost-effective sustainable materials and replace conventional manufacturing processes.

BiotechCircular EconomyCleantechClimate TechHealthtechNew MaterialsSan Francisco, US

Derek Greenfield(Founder)inLiz Clarke(Founder)inNoah Helman(Founder)in

Co-investorsFirst Bight VenturesJude GomilaJuniperPoint Reyes ManagementStartXY Combinator+8 more

Inside Mapsinsidemaps.comin𝕏

InsideMaps provides 3D property documentation and virtual tour technology for real estate professionals, vacation rentals, hotels, and event spaces.

PropTechSaaS

Co-investorsColopl NextGFR FundRET VenturesUlu Ventures

Leaf Healthcareleafhealthcare.cominAug 2015

Leaf Healthcare makes the LEAF Patient Monitoring System, a wearable sensor and software interface that helps hospital nurses create and follow patient turning protocols to prevent hospital-acquired pressure injuries.

Digital HealthHealthtechMedical DevicesPleasanton, US

Mark V. Weckwerth(Executive Officer, Director)in

BoardDonald R. Scifres(Director)Ronald L. Chez(Director)James Holtz(Director)

Neocisneocis.comin𝕏

Neocis develops Yomi, a robotic surgical platform that assists clinicians during dental implant surgery with planning, surgical, and restorative software features.

HealthtechMedical DevicesRoboticsMiami, US

Alon Mozes(Founder)inJuan Salcedo(Founder)inDennis Moses(Chief Technical Officer)inAndres Carrillo(VP of Product)inJorge Fernandes(VP of Quality & Regulatory)inGabe Goldberg(VP of Marketing)in

Co-investorsIntuitive VenturesNorwest Venture PartnersVivo CapitalFlorida Opportunity FundMithril Capital ManagementB Capital Group+4 more

Sentieon Inc.sentieon.comin𝕏

Sentieon develops optimized bioinformatics algorithms for genomic data processing, particularly for precision medicine applications.

AI & Machine LearningBiotechData & InfrastructureDeep TechHealthtechSan Jose, US

Jun Yein

Co-investorsGRC SinogreenMission BiocapitalTen Coves Capital

Twoxartwoxar.comOct 2015

BiotechPalo Alto, US

Andrew Radin(President, Treasurer, Secretary and Sole Director)

Waypointwaypointbuilding.com

Waypoint offers a platform for commercial real estate teams that centralizes financial, leasing, operational, and strategic data into a single hub, with workflow automation, reporting templates, task management, and collaboration tools.

Enterprise SoftwarePropTechSaaS

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

CENTRILLION BIOSCIENCES, INC.GeliSmarking

Exits · 4

3 IPOs · 1 acquisitions · showing 3

CompassNYSE: COMPGuardant HealthNASDAQ: GHSynlogicOTC: SYBX

Portfolio news

latest coverage across their companies
CRISPR Therapeutics, Inc. - MassBio

CRISPR · massbio.org · Sep 6, 2026

Frequently asked questions

How many investments has CLI Ventures made?
CLI Ventures has 22 tracked investments, 4 of which have exited.
What stage does CLI Ventures invest at?
CLI Ventures invests at the Seed, Series A, Series B, Series C, Growth, Late Stage stages.
What sectors does CLI Ventures focus on?
CLI Ventures focuses on AI & Machine Learning, Biotech, Digital Health, Healthtech, PropTech, SaaS.
Where is CLI Ventures located?
CLI Ventures is headquartered in Palo Alto, US.
Who does CLI Ventures co-invest with?
CLI Ventures most often shares deals with Khosla Ventures, New Enterprise Associates (NEA), SoftBank Vision Fund, among 83 tracked co-investors.

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