Fundraising Fox

Medicxi

Venture capital

London · Pre-Seed–Late Stage · 39 people tracked

Also known as MEDICXI VENTURES MANAGEMENT (JERSEY) LIMITED

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Investment thesis

Medicxi invests in life sciences companies focused on drug discovery and development of therapeutics addressing unmet medical needs. The firm leverages deep domain expertise from its founders' 20+ year track record in the sector and manages a portfolio of investments alongside its institutional capital base, which includes support from major pharmaceutical and life sciences companies including GlaxoSmithKline, Johnson & Johnson, Novartis, and Verily.

Source: firm website, verified Sep 15, 2026.

Stage
Pre-Seed–Late Stage
HQ
London, GB
Leads rounds
Follows
Instruments
Equity
Founded
2016
Last 12 months
2 investments
AUM
$1.1B
VC funds
6
Tracked investments
38

Team · 39 people

from the firm's website & curated & public directories
Louisa Blanchet· Director

Founder mafia

2 people who came through Medicxi went on to found or lead other companies.

What they invest in

from 24 of 38 portfolio companies

Biotech ×24Healthtech ×17Medical Devices ×9AI & Machine Learning ×2Digital Health ×2Deep Tech ×1

HQs:United States×15United Kingdom×2Canada×1France×1

Investments · 38 tracked

founders shown can be your intro path

By year:2026 · 22025 · 42024 · 12020 · 32015 · 111 dated

Minerva Neurosciencesminervaneurosciences.comNASDAQ: NERVMar 2015SEC filingmedium confidence

Minerva Neurosciences is a clinical-stage biopharmaceutical company developing product candidates for central nervous system disorders.

BiotechHealthtechWaltham, US

Joseph Reilly(Executive Officer)Geoff Race(Executive Officer)inFred Ahlholm(Executive Officer)inRemy Luthringer(Executive Officer, Director)Mark Levine(Executive Officer)

BoardMichele Ollier(Director)in

Board seatFrancesco De Rubertis· per SEC Form D · $31M raise · filed Mar 2015

Co-investorsVivo CapitalCare CapitalIndex Ventures

SutroVaxNASDAQ: PCVXMar 2020

BiotechSouth San Francisco, US

Grant E Pickering(Executive Officer, Director, Promoter)Ashish Khanna(Executive Officer)Jeff Fairman(Executive Officer)

BoardTracy Saxton(Director)William Newell(Director)Kurt von Emster(Director)in

Board seatMoncef Slaoui· per SEC Form D

Co-investorsAbingworthCTI Life Sciences Fund L.P.Foresite CapitalFrazier Life SciencesJanus Henderson InvestorsLongitude Capital+4 more

Aura Biosciencesaurabiosciences.comin𝕏NASDAQ: AURA

Aura Biosciences develops Virus-Like Drug Conjugates (VDCs), a platform using Virus-Like Particles conjugated with drugs or loaded with nucleic acids to target solid tumors.

BiotechHealthtechMedical DevicesCambridge, US

Elisabet de los Pinos, Ph.D.(Executive Officer, Director)Elisabet de los Pinos(Founder)inMichael Wyzga(Executive Officer)Dale Pfost, Ph.D.(Director)Alan E. Walts, Ph.D.(Director)Lewis Geffen(Executive Officer)

Co-investorsAdvent Life SciencesChiesi VenturesDroia VenturesForesite CapitalJazzya InvestmentsMyelin VC+4 more

Vaxcytevaxcyte.comNASDAQ: PCVX

Vaxcyte develops broad-spectrum vaccines to prevent bacterial infections, using a cell-free protein synthesis platform and synthetic chemistry techniques.

BiotechHealthtech

Grant Pickering(Founder)in

Co-investorsBioRock VenturesCTI Life Sciences Fund L.P.Foresite CapitalFrazier Life SciencesLongitude CapitalRA Capital+2 more

Rivus Pharmaceuticals, Inc.rivuspharma.comin𝕏Jan 2025✓ verified

Rivus Pharmaceuticals develops mitochondrial-targeted therapies to treat cardiometabolic diseases.

BiotechDigital HealthHealthtechMedical DevicesCharlottesville, US

Francisco Portell(Co-founder & Vice President, Pharmaceutical Development)Allen Cunningham(Co-founder & Chief Operating Officer)inNancy Hargreaves(Executive Officer)Jayson Dallas(Executive Officer, Director)inShaharyar Khan(Co-founder & Chief Scientific Officer)in

Board seatFrancesco De Rubertis· per SEC Form D

Co-investorsLongitude CapitalRA Capital

Dalriadatxdalriadatx.comin✓ verified

Dalriada is a contract research organization providing integrated small molecule drug discovery services for global biotech and pharmaceutical companies.

BiotechDeep TechMedical DevicesToronto, CA

Diana(Co-founder and Chief Executive Officer)Patrick(Co-founder and Chief Scientific Director)

Co-investorsToronto Innovation Acceleration Partners

Ethyrealbioethyrealbio.comin✓ verified

Ethyreal Bio is a biopharmaceutical company developing medicines for people with Thyroid Eye Disease and Graves' Disease.

BiotechHealthtechCambridge, US

Niranjan Kameswaran(Chief Executive Officer)inJessica Stromme(Chief Development Officer)inKelly Foster(Chief Scientific Officer)inStephen Huang(Senior Vice President, Head of Clinical Development)in

BoardSimon Read(Chairman of the Board and Independent Board Member)

Co-investorsAtlas VentureAvoro Capital Advisors

visit www.levicept.comlevicept.com✓ verified

Levicept is a company in the life sciences sector with backing from prominent healthcare and pharmaceutical investors including Medicxi, Pfizer Ventures, Gilde Healthcare, and Advent Life Sciences.

BiotechHealthtechMedical Devices

Simon Westbrook(Founder and CSO)

Co-investorsAdvent Life SciencesGilde HealthcareIndex VenturesPfizer VenturesPfizer Venture Investments

Altesa BioSciencesaltesabio.comFeb 2026

Altesa BioSciences is a clinical-stage pharmaceutical company developing vapendavir, an orally administered antiviral targeting rhinovirus infections in patients with chronic lung diseases such as COPD and asthma.

BiotechHealthtechCollege Park, US

John Clerici(Executive Officer)inAndrew Drechsler(Executive Officer)Brett Giroir(Executive Officer, Director)

BoardNicholas Williams(Director)Jon Edwards(Director)

Board seatMoncef Slaoui· per SEC Form D

Co-investorsGRA VentureForbionPitango

CurevoMar 2025acquired by Eli Lilly and Company · May 2026 · $1.5B

Curevo Vaccine was a clinical-stage biotech developing non-mRNA subunit vaccines, including a shingles/varicella candidate targeting VZV glycoprotein E.

Bothell, US

Board seatGiovanni MariggiMoncef Slaoui· per SEC Form D

FORE US BioMay 2025SEC filingmedium confidence

BiotechPhiladelphia, US

William Hinshaw(Executive Officer, Director)inJeff Sacher(Chief Financial Officer)Matthew Ros(Chief Executive Officer, President and Secretary)

BoardErez Chimovits(Director)inMatthew Foy(Director)

Board seatGiovanni Mariggi· per SEC Form D · $46M raise · filed May 2025

Co-investors3B Future Health FundOrbiMed

Illexcor TherapeuticsMay 2026SEC filingmedium confidence

BiotechHenrico, US

Timothy E Ladin(Executive Officer)Andrew N Fleischman(Executive Officer, Director)in

BoardManeka Mirchandaney(Director)Ted Love(Director)

Board seatGiovanni Mariggi· per SEC Form D · $69M raise · filed May 2026

Co-investorsZynext Ventures

Zephyr AIzephyrai.bioin𝕏Mar 2024SEC filingmedium confidence

Zephyr AI is a healthcare technology company.

AI & Machine LearningBiotechDigital HealthDallas, US

Grant Verstandig(Director)inYisroel Brumer(Director)Jeff Sherman(Executive Officer)David Morgan(Executive Officer)Ken Samet(Director)Sol Barer(Director)

Board seatMoncef Slaoui· per SEC Form D · $120.7M raise · filed Mar 2024

Co-investorsRevolution

Abivaxabivax.comin𝕏

Abivax develops obefazimod, an orally administered small molecule drug candidate with a novel mechanism of action targeting microRNA biology to treat chronic inflammatory diseases including ulcerative colitis and Crohn's disease.

BiotechHealthtechMedical DevicesParis, FR

Marc de Garidel(CEO)in

Co-investorsAndera PartnersClaret Capital PartnersSamsara BioCapitalSofinnova PartnersTruffle CapitalMorgan Stanley

Breakpoint Therapeutics
Centessa Pharmaceuticalscentessa.com

Centessa is a biopharmaceutical company developing an Orexin Receptor 2 Agonist program aimed at treating sleep-wake, neurological, neurodegenerative, and neuropsychiatric disorders.

BiotechHealthtech

Co-investorsAdvent Life SciencesEcoR1 CapitalForesite CapitalOberland CapitalScion Life SciencesVida Ventures+1 more

Cosmyc Therapeutics
Curevo Vaccinecurevovaccine.cominMar 2025 · $110M

Curevo Vaccine is a biotech company developing next-generation non-mRNA vaccines, with a focus on infectious diseases.

BiotechHealthtech

George Simeon(CEO)inGregory S. Curhan(CFO)Guy De La Rosa(CMO)in

Co-investorsAdjuvant CapitalOrbiMedRA CapitalSanofi VenturesHBM Healthcare InvestmentsJanus Henderson Investors

Diasomediasome.comin

Diasome develops metabolic therapies using its HDV platform to enable targeted drug delivery for treating diabetes, obesity, and metabolic diseases.

BiotechHealthtechMedical Devices

Robert Geho(Co-Founder, Chief Executive Officer)inW. Blair Geho(Co-Founder, Chief Scientific Officer)in

Co-investorsJDRF T1D Fund

Diasome Pharmaceuticals

BiotechHealthtechCleveland, US

Robert Geho(Executive Officer, Director)W. Blair Geho(Executive Officer, Director)Helga Kautsky(Executive Officer)

BoardMichele Ollier(Director)Guiseppe Zocco(Director)Richard Caruso(Director)

Co-investorsJDRF T1D Fund

Ethyreal Bio
Fore Biotherapeuticsfore.bioin𝕏

Fore Biotherapeutics is a clinical-stage oncology company developing targeted cancer therapies, including its lead plixorafenib program.

BiotechHealthtechMedical DevicesPhiladelphia, US

Co-investorsLG Technology VenturesNovartis Venture FundOrbiMedPontifax Venture CapitalSR One Capital ManagementWindham Capital Partners+1 more

ForeBio
Imhoteximhotex.com

Imhotex is a biotech company focused on drug development, managed by experienced professionals in therapeutic discovery and clinical advancement.

BiotechHealthtechCambridge, GB

Robert W. Schroff(Chief Operating Officer)

BoardDavid J. Grainger(Chairman)

MiroBio

A therapeutics company developing checkpoint agonist antibodies for autoimmune disease treatment based on Oxford University research (exited August 2022).

Co-investorsAdvent Life SciencesMonograph Capital PartnersOxford Science EnterprisesSamsara BioCapital

My-T Bio
Neurommune
New Amsterdam
Palladio BiosciencesSep 2020

BiotechHorsham, US

Lorenzo Pellegrini(Executive Officer, Director)Marella Thorell(Executive Officer)John Alexander Martin(Executive Officer, Director)Sanford Zweifach(Director)Frank Condella(Director)

BoardFrancesco DeRubertis(Director)

Co-investorsOUP (Osage University Partners)Roche Venture FundSamsara BioCapital

Pandeia Therapeutics
Perfect Balance
Petalion Therapeutics
RAPT Therapeuticsacquired by GSK · Jan 2026 · $2.2B

RAPT Therapeutics was a clinical-stage biopharmaceutical company developing oral small-molecule and antibody therapies for inflammatory, immunologic, and oncologic diseases, including the anti-IgE antibody ozureprubart.

Co-investorsForesite Capital

SynOx Therapeutics Ltdsynoxtherapeutics.comin𝕏Nov 2020

SynOx Therapeutics develops emactuzumab, a monoclonal antibody treatment for tenosynovial giant cell tumours (TGCT) and macrophage-mediated diseases.

BiotechHealthtechMedical Devices

Ray Barlow(Chief Executive Officer)in

Co-investorsHealthCapBioqube VenturesForbionGimv

Synthorxacquired by Sanofi

Clinical-stage biotech expanding the genetic alphabet with synthetic nucleotides; acquired by Sanofi for $2.5B in 2020.

BiotechLa Jolla, US

Floyd Romesberg(Director)Douglas Downs(Executive Officer)

BoardJay Lichter(Director)Court Turner(Executive Officer, Director)

Co-investorsAvalon BioVenturesBoutique Venture PartnersCorrelation VenturesOUP (Osage University Partners)RA CapitalvenBio Partners+1 more

Tactix Bio
Vaderis Therapeuticsvaderis.comin

Vaderis develops a first-of-its-kind oral therapy for hereditary hemorrhagic telangiectasia (HHT), a rare vascular disease with no existing approved treatments.

BiotechHealthtechMedical Devices

Co-investorsDroia VenturesEQT Life SciencesGoldman Sachs

Vicebiovicebio.comin𝕏acquired by Sanofi

AI & Machine LearningBiotechHealthtech

PartnerGiovanni Mariggi· led

Co-investorsAvoro Capital AdvisorsTCG CrossoverUniQuest Extension Fund (UEF)venBio Partners

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.

Exits · 8

IPOs and acquisitions across the tracked portfolio

Minerva NeurosciencesNASDAQ: NERVSutroVaxNASDAQ: PCVXAura BiosciencesNASDAQ: AURAVaxcyteNASDAQ: PCVXCurevoacq. by Eli Lilly and CompanyRAPT Therapeuticsacq. by GSKSynthorxacq. by SanofiVicebioacq. by Sanofi

Portfolio news

latest coverage across their companies

IPO stake values · per SEC filings · 3

Value of this firm's stake in each portfolio company at its IPO price, from the prospectus principal-stockholder table.

CompanyOwnedIPO priceAt IPOStake value
Aura Biosciences8.2%$14.00Nov 2021$32.6M
SutroVax3.9%$16.00Jun 2020$30.2M
Vaxcyte3.9%$16.00Jun 2020$30.2M

Source: SEC S-1 / 424B prospectus filings. Stake value = shares beneficially owned × the initial public offering price, as disclosed — a market value at IPO, not a return multiple (the firm's original cost is not disclosed).

Public market activity · per SEC filings

what is this? ⓘ

11 insider ownership filings (Forms 3/4/5)

at Centessa Pharmaceuticals plc (CNTA), RAPT Therapeutics, Inc. (RAPT), Phathom Pharmaceuticals, Inc. (PHAT)

Files 13F institutional holdings reports · latest Aug 2026

From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.

Frequently asked questions

How many investments has Medicxi made?
Medicxi has 20 tracked investments, 3 of which have exited via acquisition or IPO, including 1 dated in the last 24 months.
What stage does Medicxi invest at?
Medicxi invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth, Late Stage stages.
What sectors does Medicxi focus on?
Medicxi focuses on Biotech, Digital Health, Medical Devices.
Where is Medicxi located?
Medicxi is headquartered in London, GB.
Does Medicxi lead rounds?
Medicxi typically participates in rounds rather than leading them.
Who does Medicxi co-invest with?
Medicxi most often shares deals with Advent Life Sciences, Foresite Capital, Droia Ventures, among 23 tracked co-investors.

Media · Podcasts & interviews

featuring the team

Gateway to Translation Webinar: Dr Francesco De Rubertis - Medicxi

Translation Manchester · Francesco De Rubertis

Fireside Chat Francesco de Rubertis, Co-Founder & Partner of Medicxi and Mike Ward, Clarivate

Optimum Strategic Communications · Francesco De Rubertis

How risky is it to invest in biotech? Where are the opportunities? - Francesco De Rubertis, Medicxi

SuperReturnTV · Francesco De Rubertis

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