Medicxi
Venture capitalLondon · Pre-Seed–Late Stage · 38 people tracked
Also known as MEDICXI VENTURES MANAGEMENT (JERSEY) LIMITED
Find your way into Medicxi
1,557 people in our graph share verified history with the Medicxi team — schools, employers, funds. One of them is your warm intro.
Investment thesis
Medicxi invests in life sciences companies focused on drug discovery and development of therapeutics addressing unmet medical needs. The firm leverages deep domain expertise from its founders' 20+ year track record in the sector and manages a portfolio of investments alongside its institutional capital base, which includes support from major pharmaceutical and life sciences companies including GlaxoSmithKline, Johnson & Johnson, Novartis, and Verily.
Source: firm website, verified Sep 22, 2026.
Team · 38 people
from the firm's website & curated & public directoriesFounder mafia
2 people who came through Medicxi went on to found or lead other companies.
What they invest in
from 28 of 42 portfolio companiesBiotech ×28Healthtech ×21Medical Devices ×10AI & Machine Learning ×2Digital Health ×2Deep Tech ×1
HQs:United States×16United Kingdom×2Canada×1France×1
Investments · 42 tracked
founders shown can be your intro pathBy year:2026 · 22025 · 42024 · 12021 · 12020 · 32019 · 12018 · 22017 · 22015 · 117 dated
Minerva Neurosciences is a clinical-stage biopharmaceutical company developing product candidates for central nervous system disorders.
BiotechHealthtechWaltham, US
Joseph Reilly(Executive Officer)Geoff Race(Executive Officer)inFred Ahlholm(Executive Officer)inRemy Luthringer(Executive Officer, Director)Mark Levine(Executive Officer)
BoardMichele Ollier(Director)in
Board seatFrancesco De Rubertis· per SEC Form D · $31M raise · filed Mar 2015
Co-investorsVivo CapitalCare CapitalIndex Ventures
BiotechSouth San Francisco, US
Grant E. Pickering(Chief Executive Officer)Ashish Khanna(Executive Officer)Jeff Fairman(Executive Officer)
BoardTracy Saxton(Director)William Newell(Director)Kurt von Emster(Director)in
Board seatMoncef Slaoui· per SEC Form D
Co-investorsAbingworthCTI Life Sciences Fund L.P.Foresite CapitalFrazier Life SciencesJanus Henderson InvestorsLongitude Capital+4 more
Aura Biosciences develops Virus-Like Drug Conjugates (VDCs), a platform using Virus-Like Particles conjugated with drugs or loaded with nucleic acids to target solid tumors.
BiotechHealthtechMedical DevicesCambridge, US
Elisabet de los Pinos, Ph.D.(Executive Officer, Director)Elisabet de los Pinos(Founder)inMichael Wyzga(Executive Officer)Dale Pfost, Ph.D.(Director)Alan E. Walts, Ph.D.(Director)Lewis Geffen(Executive Officer)
Co-investorsAdvent Life SciencesChiesi VenturesDroia VenturesForesite CapitalJazzya InvestmentsMyelin VC+4 more
Vaxcyte develops broad-spectrum vaccines to prevent bacterial infections, using a cell-free protein synthesis platform and synthetic chemistry techniques.
BiotechHealthtech
Grant Pickering(Founder)inGrant E. Pickering(Chief Executive Officer and Director)in
Co-investorsBioRock VenturesCTI Life Sciences Fund L.P.Foresite CapitalFrazier Life SciencesLongitude CapitalPivotal Life Sciences+2 more
Rivus Pharmaceuticals develops mitochondrial-targeted therapies to treat cardiometabolic diseases.
BiotechDigital HealthHealthtechMedical DevicesCharlottesville, US
Francisco Portell(Co-founder & Vice President, Pharmaceutical Development)Allen Cunningham(Co-founder & Chief Operating Officer)inNancy Hargreaves(Executive Officer)Jayson Dallas(Executive Officer, Director)inShaharyar Khan(Co-founder & Chief Scientific Officer)in
Board seatFrancesco De Rubertis· per SEC Form D
Co-investorsBain Capital Life SciencesLongitude CapitalRA Capital
Breakpoint Therapeutics is a biotech company focused on oncology drug discovery and development centered on DNA damage response (DDR) mechanisms.
BiotechHealthtechMedical Devices
Daniel Speidel(Co-founder & Managing Director)Jon Hollick(Co-founder & Managing Director)
Co-investorsTaiho Ventures, LLCBiotechnology Value Fund
Dalriada is a contract research organization providing integrated small molecule drug discovery services for global biotech and pharmaceutical companies.
BiotechDeep TechMedical DevicesToronto, CA
Diana(Co-founder and Chief Executive Officer)Patrick(Co-founder and Chief Scientific Director)
Co-investorsToronto Innovation Acceleration Partners
Ethyreal Bio is a biopharmaceutical company developing medicines for people with Thyroid Eye Disease and Graves' Disease.
BiotechHealthtechCambridge, US
Niranjan Kameswaran(Chief Executive Officer)inJessica Stromme(Chief Development Officer)inKelly Foster(Chief Scientific Officer)inStephen Huang(Senior Vice President, Head of Clinical Development)in
BoardSimon Read(Chairman of the Board and Independent Board Member)in
Co-investorsAtlas VentureAvoro Capital Advisors
Levicept is a company in the life sciences sector with backing from prominent healthcare and pharmaceutical investors including Medicxi, Pfizer Ventures, Gilde Healthcare, and Advent Life Sciences.
BiotechHealthtechMedical Devices
Simon Westbrook(Founder and CSO)
Co-investorsAdvent Life SciencesGilde HealthcareIndex VenturesPfizer VenturesPfizer Venture Investments
Altesa BioSciences is a clinical-stage pharmaceutical company developing vapendavir, an orally administered antiviral targeting rhinovirus infections in patients with chronic lung diseases such as COPD and asthma.
BiotechHealthtechCollege Park, US
John Clerici(Executive Officer)inAndrew Drechsler(Executive Officer)Brett Giroir(Executive Officer, Director)
BoardNicholas Williams(Director)Jon Edwards(Director)in
Board seatMoncef Slaoui· per SEC Form D
Co-investorsGRA VentureForbionPitango
Zephyr AI is a healthcare technology company.
AI & Machine LearningBiotechDigital HealthDallas, US
Grant Verstandig(Director)inYisroel Brumer(Director)Jeff Sherman(Executive Officer)David Morgan(Executive Officer)Ken Samet(Director)Sol Barer(Director)
Board seatMoncef Slaoui· per SEC Form D · $120.7M raise · filed Mar 2024
Co-investorsRevolution
Abivax develops obefazimod, an orally administered small molecule drug candidate with a novel mechanism of action targeting microRNA biology to treat chronic inflammatory diseases including ulcerative colitis and Crohn's disease.
BiotechHealthtechMedical DevicesParis, FR
Marc de Garidel(CEO)in
Co-investorsAndera PartnersClaret Capital PartnersSamsara BioCapitalSofinnova PartnersTruffle CapitalMorgan Stanley
Centessa is a biopharmaceutical company developing an Orexin Receptor 2 Agonist program aimed at treating sleep-wake, neurological, neurodegenerative, and neuropsychiatric disorders.
BiotechHealthtech
Co-investorsAdvent Life SciencesEcoR1 CapitalForesite CapitalOberland CapitalScion Life SciencesVida Ventures+1 more
Curevo Vaccine is a biotech company developing next-generation non-mRNA vaccines, with a focus on infectious diseases.
BiotechHealthtech
George Simeon(CEO)inGregory S. Curhan(CFO)Guy De La Rosa(CMO)in
Co-investorsAdjuvant CapitalOrbiMedRA CapitalSanofi VenturesHBM Healthcare InvestmentsJanus Henderson Investors
Diasome develops metabolic therapies using its HDV platform to enable targeted drug delivery for treating diabetes, obesity, and metabolic diseases.
BiotechHealthtechMedical Devices
Robert Geho(Co-Founder, Chief Executive Officer)inW. Blair Geho(Co-Founder, Chief Scientific Officer)in
Co-investorsJDRF T1D Fund
Fore Biotherapeutics is a clinical-stage oncology company developing targeted cancer therapies, including its lead plixorafenib program.
BiotechHealthtechMedical DevicesPhiladelphia, US
Co-investorsLG Technology VenturesNovartis Venture FundOrbiMedPontifax Venture CapitalSR One Capital ManagementWindham Capital Partners+1 more
Imhotex is a biotech company focused on drug development, managed by experienced professionals in therapeutic discovery and clinical advancement.
BiotechHealthtechCambridge, GB
Robert W. Schroff(Chief Operating Officer)
BoardDavid J. Grainger(Chairman)in
Therapeutics company with an active clinical development program.
Co-investorsAngel Physicians FundCincyTech
Phathom Pharmaceuticals is a pharmaceutical company that develops and markets prescription treatments, including VOQUEZNA (vonoprazan) for gastrointestinal conditions, in the U.S. market.
BiotechHealthtech
Mr. Basta(CEO)
Co-investorsCatalys PacificFrazier Life SciencesNew Enterprise Associates (NEA)
RAPT Therapeutics is a clinical-stage biopharmaceutical company developing therapeutics that target the immune system to treat inflammatory and immunologic diseases.
BiotechHealthtech
Co-investorsForesite CapitalFrazier Life SciencesKleiner PerkinsSolasta VenturesThe Column GroupOrbiMed
SynOx Therapeutics develops emactuzumab, a monoclonal antibody treatment for tenosynovial giant cell tumours (TGCT) and macrophage-mediated diseases.
BiotechHealthtechMedical Devices
Ray Barlow(Chief Executive Officer)in
Co-investorsHealthCapBioqube VenturesForbionGimv
Vaderis develops a first-of-its-kind oral therapy for hereditary hemorrhagic telangiectasia (HHT), a rare vascular disease with no existing approved treatments.
BiotechHealthtechMedical Devices
Co-investorsDroia VenturesEQT Life SciencesGoldman Sachs
AI & Machine LearningBiotechHealthtech
PartnerGiovanni Mariggi· led
Co-investorsAvoro Capital AdvisorsTCG CrossoverUniQuest Extension Fund (UEF)venBio Partners
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
CurevoFORE US BioIllexcor TherapeuticsBreakpoint TherapeuticsCosmyc TherapeuticsDiasome PharmaceuticalsEthyreal BioForeBioMiroBioMy-T BioNeurommuneNew AmsterdamPalladio BiosciencesPandeia TherapeuticsPerfect BalancePetalion TherapeuticsSynthorxTactix Bio
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Exits · 8
4 IPOs · 4 acquisitionsMinerva NeurosciencesNASDAQ: NERVSutroVaxNASDAQ: PCVXAura BiosciencesNASDAQ: AURAVaxcyteNASDAQ: PCVXCurevoacq. by Eli Lilly and CompanyRAPT Therapeuticsacq. by GSKSynthorxacq. by SanofiVicebioacq. by Sanofi
IPO stake values · per SEC filings · 3
Value of this firm's stake in each portfolio company at its IPO price, from the prospectus principal-stockholder table.
| Company | Owned | IPO price | At IPO | Stake value |
|---|---|---|---|---|
| Aura Biosciences | 8.2% | $14.00 | Nov 2021 | $32.6M |
| SutroVax | 3.9% | $16.00 | Jun 2020 | $30.2M |
| Vaxcyte | 3.9% | $16.00 | Jun 2020 | $30.2M |
Source: SEC S-1 / 424B prospectus filings. Stake value = shares beneficially owned × the initial public offering price, as disclosed — a market value at IPO, not a return multiple (the firm's original cost is not disclosed).
Public market activity · per SEC filings
what is this? ⓘ11 insider ownership filings (Forms 3/4/5)
at Centessa Pharmaceuticals plc (CNTA), RAPT Therapeutics, Inc. (RAPT), Phathom Pharmaceuticals, Inc. (PHAT)
Files 13F institutional holdings reports · latest Aug 2026
From the firm's own SEC EDGAR filings — stakes and insider roles in public companies, typically portfolio companies after an IPO. Not a portfolio list published by the firm.
Frequently asked questions
- How many investments has Medicxi made?
- Medicxi has 42 tracked investments, 8 of which have exited, including 6 dated in the last 24 months.
- What stage does Medicxi invest at?
- Medicxi invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth, Late Stage stages.
- What sectors does Medicxi focus on?
- Medicxi focuses on Biotech, Digital Health, Medical Devices.
- Where is Medicxi located?
- Medicxi is headquartered in London, GB.
- Does Medicxi lead rounds?
- Medicxi typically participates in rounds rather than leading them.
- Who does Medicxi co-invest with?
- Medicxi most often shares deals with Advent Life Sciences, Foresite Capital, Droia Ventures, among 27 tracked co-investors.
Media · Podcasts & interviews
featuring the teamGateway to Translation Webinar: Dr Francesco De Rubertis - Medicxi
Translation Manchester · Francesco De Rubertis
Fireside Chat Francesco de Rubertis, Co-Founder & Partner of Medicxi and Mike Ward, Clarivate
Optimum Strategic Communications · Francesco De Rubertis
How risky is it to invest in biotech? Where are the opportunities? - Francesco De Rubertis, Medicxi
SuperReturnTV · Francesco De Rubertis
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