/Investor DB

Twenty Two Ventures

Venture capitalActively deploying

Palo Alto · Pre-Seed–Seed · 2 people tracked

Also known as 22nd Street Ventures · Katey Caldwell · TwentyTwo VC

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Investment thesis

Twenty Two Ventures focuses on early-stage investments, often committing before companies publicly launch. The firm writes smaller check sizes than larger funds, enabling fast decisions and efficient execution that appeals to founders who want to focus on building. It targets SaaS, fintech, open source, marketplaces and developer tools, and seeks magnetic, tenacious, adaptable founders willing to pursue big ideas and ship great products.

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Seed
Check
$50K – $250K
HQ
Palo Alto, CA, US
Leads rounds
Follows
Instruments
Equity
Founded
2018
Last 12 months
11 investments
AUM
$20M
Tracked investments
286
Unicorns
2
Acquisitions
35

Team · 2 people

from the firm's website

What they invest in

from 282 of 286 portfolio companies

Enterprise Software ×205AI & Machine Learning ×166SaaS ×125Developer Tools ×87Fintech ×62Data & Infrastructure ×42Healthtech ×29Cloud Computing ×20

HQs:United States×237United Kingdom×12Mexico×6France×4Brazil×2Germany×2

Who they back

founder profiles across 16 portfolio companies
6%
solo founders
1 of 16 mapped founding teams
24%
repeat founders
of 33 founders with career history

Founding team size:solo founder×12 founders×83 founders×44+ founders×3

Where their founders studiedfrom 29 founders with education data

Massachusetts Institute of Technology ×5University of California, Berkeley ×4Harvard Business School ×3Carnegie Mellon University ×2Columbia University ×2Cornell ×2Texas McCombs School of Business ×2The University of Texas at Austin ×2

What their founders studiedfrom 28 founders with field-of-study data

Computer Science ×11Economics ×6Engineering ×5Business & Management ×2Finance & Accounting ×2

Where their founders worked beforefrom 33 founders with career history

Dover ×3Google ×3Affirm ×2Airbnb ×2Arachnys ×2Contrary ×2CuriosityStream ×2GoDaddy ×2

Accelerator rootsportfolio companies that came through a program

Y Combinator ×16

2 hold an MBA (of 33 with degree data)

Investments · 286 tracked

founders shown can be your intro path

By year:2026 · 52025 · 72024 · 42023 · 32022 · 72021 · 62020 · 32019 · 22017 · 12014 · 139 dated

Crimsoncrimson.lawinSeed · May 2026 · $2.5M✓ verified

Crimson uses AI to automate document review, evidence sorting, and case file organization for litigation and arbitration teams.

AI & Machine LearningEnterprise SoftwareLegalTechSaaSLondon, GB

Mark Feldner(CEO)inDavid Strömbäck(CTO)inAmine Amor

Co-investorsY CombinatorEight CapitalAcquisition.comAmino CapitalEight CapitalProgressive Ventures+4 more

Relarirelari.aiin𝕏Seed✓ verified

Relari builds an AI development platform called Nuvi that enables developers to define intelligent agents in plain English without prompt engineering or visual programming.

Advanced ManufacturingAI & Machine LearningDeveloper ToolsEnterprise SoftwareRoboticsSan Francisco, US

Yi Zhang(Founder)inPasquale Antonante(Founder)in

Co-investorsSoma CapitalY CombinatorAmino CapitalGeneral CatalystSBXiThe E14 Fund+5 more

99minutos99minutos.comin𝕏Seed

99minutos is an integrated logistics operator serving companies across Latin America, offering services from last-mile delivery to full supply chain management including warehousing, customs clearance, and international logistics.

Enterprise SoftwareLogistics & Supply ChainMexico City, MX

Alexis Patjane(Founder)inJose SalomoninEduardo Guzman(CFO)

Co-investors500 GlobalKaszek VenturesOak HC/FTPioneerSoma CapitalSommet AB+13 more

AccessOwlaccessowl.ioin𝕏Seed

AccessOwl is an access governance and identity management platform that automates SaaS access administration tasks like employee onboarding, offboarding, and access reviews.

CybersecurityData & InfrastructureEnterprise SoftwareSaaSBerlin, DE

Philip Eller(Founder)inMathias Nestler(Founder)inPhilip Eller Mathias Nestler(Founder)Jlo Cala(Hiring Manager)Bee Briones(Hiring Manager)

Co-investorsE Nugget Ventures UG (Haftungsbeschränkt)Maiora Rebel VenturesRebel FundY CombinatorSandhill (ex Stonks)TA Ventures+2 more

Aeraercompliance.com𝕏Seedacquired by StarCompliance

Aer Compliance offers a platform that consolidates compliance functions—including code of ethics management, marketing review, calendars, regulatory filings, and workflows—into one system to help firms meet SEC obligations.

Enterprise SoftwareFintechSaaSNew York City, US

Omar AmjadOwen RapaportRachel Weems(Head of Engineering)

Co-investorsVertex Ventures IsraelY CombinatorCharles DelingpoleCRV (Charles River Ventures)Diogo MónicaLeonis Investissement+3 more

Aestheticaesthetic.comin𝕏Seed · Apr 2020 · $3M

Aesthetic uses AI to generate images based on a user's personal visual style, producing results in seconds.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareNew York City, US

Nate Smith(CEO)inMatthew Trost(Software Engineer)inAndrew Look(CPO)inJohn Milinovich(CEO)Sumon Sadhu(CRO)inJames Lawrence Turner(Senior Software Engineer)

Co-investorsSoma CapitalY CombinatorA.Capital VenturesFoundation CapitalHaystackSignalFire+1 more

AiPriseaiprise.comin𝕏Seed

AiPrise provides AI-powered compliance and risk management software for KYB/KYC processes, covering fraud prevention and regulatory compliance.

AI & Machine LearningEnterprise SoftwareFintechSan Francisco, US

Chaitanya Sarda(CEO)inRushabh Shah(Founder/Co-CEO)inVarun Sharda(Product Designer)Nigel Braganza(Customer Success \u0026 Marketing lead)Hariom Tiwari(Infra Lead)Martin Lauria(Head of Sales)

Co-investorsCorrelation VenturesFinancial Venture StudioRestive VenturesY CombinatorGoodFin VenturesHard Yaka+6 more

Airbyteairbyte.comin𝕏Seed · May 2021

Airbyte provides a context layer for agents and pipelines, enabling data connectivity and integration solutions.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US

Michel Tricot(CEO)inJean Lafleur(COO)inJean (John) Lafleur(Founder)inJohn Lafleur(Founder)Brian Cannon(Lead Recruiter)Ron Miguel(Senior Recruiter)

Co-investors8VCAccelCoatue ManagementFlex Capital PartnersKima VenturesRebel Fund+11 more

Alephgetaleph.comin𝕏Seed

Aleph is a financial planning and analysis (FP&A) tool built with a spreadsheet-first approach that integrates company-wide data.

AI & Machine LearningEnterprise SoftwareFintechSaaSNew York City, US

Albert Gozzi(Founder)inSantiago Perez De Rosso(Founder)inAlberto Gozzi(Executive Officer, Director)Dylan McGuire(Founder)Craig Thompson(GTM)Paula Videla(Data)

Co-investorsBain Capital VenturesKhosla VenturesPICUS CAPITALSoma CapitalVentureSouqY Combinator+5 more

Alkalialkali.engineeringinSeed

Alkali provides AI-powered takeoff and estimation software for structural steel projects, automatically detecting and quantifying steel members, calculating tonnage, and generating nesting plans.

AI & Machine LearningConstruction TechDeveloper ToolsEnterprise SoftwareHouston, US

Emmett Goodman(CEO)inVictor Miller(CTO)in

Co-investorsGigascale CapitalY CombinatorUnpopular Ventures

Amborasamboras.comin𝕏Seed

Amboras builds autonomous AI systems for modern e-commerce platforms.

AI & Machine LearningE-commerceEnterprise SoftwareSaaSSan Francisco, US

Imad Mokadem(CEO)inAmin Mokadem(CTO)in

Co-investorsY Combinator12X VCA*Cherry VenturesFounder CapitalLiquid Ventures+3 more

Ancanaancana.coin𝕏Seed

Ancana operates a fractional co-ownership marketplace for vacation homes in Mexico and the United States, allowing multiple owners to share luxury properties.

B2B MarketplacesConsumerMarketplacesPropTechTravel & HospitalityMérida, MX

Andres Barrios(Founder)inRyan Black(Founder)in

Co-investorsY Combinator0BSCapria VenturesSoma CapitalStartupsVARIV+9 more

Archilarchil.comin𝕏Seed · Jun 2025

Archil provides a file system that virtualizes cloud storage buckets to offer local disk-like access with higher performance, allowing AI applications and analytics workloads to query large datasets without transferring data.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US

Hunter Leath(CEO)inReagan Matthews(Founder)

Co-investorsFelicis VenturesLombardstreet VenturesStandard CapitalY Combinator0 ADAnurag Goel LP+5 more

Arpariarpari.cominSeed

Arpari provides a unified treasury management platform that consolidates cash and account management across multiple banks for finance teams.

Enterprise SoftwareFintechSaaSNew York City, US

Alexandra Zwiener(CEO)inToby Edward(Founder)inTobias Milligan(Director)Grant Ross(Director)

Co-investorsPioneerY CombinatorGoodFin VenturesLiquid Ventures

Assembly HOAassemblyhoa.comin𝕏Seed

Assembly provides software and management services for homeowners associations (HOAs), addressing operational inefficiencies through transparency and accountability.

AI & Machine LearningFintechPropTechSaaSSan Francisco, US

Allen Liou(Founder)inShreyas Bharadwaj(Founder)in

Co-investorsEight CapitalPioneerStartXY CombinatorCapitalize VCFjor Founders+6 more

Atlasatlascard.comin𝕏Series B

Atlas is a membership card and app that provides access to reservations at high-end restaurants, luxury hotels, sold-out concerts, and sporting events for members.

ConsumerDirect to ConsumerFintechSan Francisco, US

Patrick Mrozowski(Founder)inSid Parihar(Founder)Kenan Pulak(Founder)inClio Harper(Backend engineer intern)Andrew Harrington(Head of Operations)Sophie Jasinski(Senior Technical Recruiter)

Co-investors01 AdvisorsAccelARA NEA Ventures (Brand: Dmz.Xyz)Chapter OneEvolution VC PartnersFinancial Venture Studio+42 more

Attuneattunehq.comin𝕏Seed

Attune provides software supply chain security by enabling traceability of code back to its author, device, and keystroke to prevent CI/CD pipeline attacks and secure the build process.

CybersecurityDeveloper ToolsEnterprise SoftwareSan Francisco, US

Xin Ding(CEO)inJack Ryan(Founder)inEliza Zhang

Co-investorsTranspose Platform ManagementY Combinator0 ADInitialized Capital

Atum Worksatum.worksin𝕏Seed

Atum Works develops scalable 3D lithography technology capable of printing metal structures with submicron resolution for advanced manufacturing applications.

Advanced ManufacturingDeep TechHardwareRoboticsMountain View, US

Lucas Pabarcius(CEO)inMatteo Kimura(CRO)inMalcolm Tisdale(COO)inArun Nagpal(CTO)

Co-investorsHummingbird VenturesOceans VenturesPioneerSaga VenturesSoma CapitalTranspose Platform Management+17 more

Avocadoavocadopos.cominSeed

Avocado is a point-of-sale platform designed for food trucks, coffee shops, and restaurants, offering features including QR code ordering, handheld POS, AI-powered order taking and reporting, and payment processing.

AI & Machine LearningEnterprise SoftwareFintechRetail TechSaaSSan Francisco, US

Nick Evans(Founder)inShayan Guha(Founder)inThomas GarrisonJimmy Watson(Head of Restaurant Growth)Richard Velasco(Head of Business Development)

Co-investorsY CombinatorGlobal Founders Capital

Avoiceavoice.coinSeed

Avoice provides administrative and workflow management software for architecture and engineering practices, handling specification writing, submittal tracking, RFI coordination, and drawing markup.

Construction TechEnterprise SoftwareSan Francisco, US

Chawin Asavasaetakul(CEO)inChawit Asavasaetakul(CTO)in

Co-investorsY CombinatorAlecla7Blast.ClubSandwith Ventures, LLCSpot VC

b12 Labsb12-labs.comin𝕏Seed

b12 develops AI agents and lab automation software to help chemists plan, optimize, and execute the synthesis of complex molecules.

AI & Machine LearningBiotechDeep TechEnterprise SoftwareHealthtechRoboticsSan Francisco, US

Zlatko Jončev(CEO)inAndres Bran(CTO)inAdriana Faraone(Research Scientist)

Co-investorsY CombinatorTranspose Platform ManagementZAKA VCC Square CapitalMyAsiaVCOurCrowd+2 more

Baudbaudlabs.aiinSeed

Baud Labs designs specialized AI chips that reduce the computational cost and power consumption of training and serving large language models by replacing multiplication-based arithmetic with addition-based operations.

Advanced ManufacturingAI & Machine LearningHardwareSemiconductorsSan Francisco, US

Sarang Zambare(CEO)inEric Taylor(Founder \u0026 Chief Hardware Architect)in

Co-investorsEight CapitalLightspeed Venture PartnersPioneerTranspose Platform ManagementY CombinatorAgrolimen Ventures+9 more

Beambeam.cloudin𝕏Seed

Beam is a cloud platform for developers to build and ship AI products without managing infrastructure, servers, or containers.

AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareNew York City, US

Eli Mernit(Founder)inLuke Lombardi(Founder)inAdam Eagle(Founder)Chinakrit Piamchon(Founder)Dan Mottice(Founder)Nattapat Chaimanowong(Founder)

Co-investorsAlumni VenturesSoma CapitalUncorrelated VenturesY CombinatorAbacus Capital GroupAC Ventures+24 more

Beeperbeeper.comin𝕏SeedAcquired

Beeper is a unified messaging app that consolidates popular messaging services into a single cross-platform interface.

ConsumerSaaSSan Francisco, US

Eric Migicovsky(Founder)inBrad Murray(Founder)inTulir Asokan(Founder)inCaroline Frishman(Chief of Staff)Sarah Mason(Technical Recruiter)Jonathan Lee(Head of Product and Design)

Co-investorsInitialized CapitalY CombinatorAutomatticLiquid VenturesSamsung NextShrug Capital+1 more

BeGobego.aiin𝕏Seed

BeGo is a platform that connects cargo shipments with available transportation, serving freight companies and logistics operators in Mexico.

AI & Machine LearningB2B MarketplacesEnterprise SoftwareLogistics & Supply ChainSan Francisco, US

Ivan Cardenas(Founder)inJasiel Cardenas(Founder)in

Co-investorsFundersClubMantis CapitalSoma CapitalStartupsY CombinatorHack VC+4 more

Belugatrybeluga.aiin𝕏Seed

Beluga provides tools for measuring and executing creator marketing campaigns with automation similar to paid advertising platforms.

AI & Machine LearningCreator EconomyEnterprise SoftwareMarketing TechSan Francisco, US

Fernando Young(CEO)inJack Swisher(CTO)in

Co-investorsBlast.ClubY CombinatorAgrolimen VenturesAnagram VenturesGoodwater CapitalProCap Velocity

Berbixberbix.comin𝕏SeedAcquired

Berbix provides identity verification and fraud detection technology that online platforms integrate via SDKs to confirm users' identities and prevent fraudulent accounts.

Developer ToolsEnterprise SoftwareSaaSSan Francisco, US

Eric Levine(Founder)inSteve Kirkham(Founder)inKelsey Wolf(Recruiter)Jay Omar(Vice President of Sales)Jonathan Unikowski(Vice President of Engineering)Jason Goodman(Vice President of Product)

Co-investorsDream MachineFikaY CombinatorAirAngelsFika VenturesIndex Ventures+3 more

Bild AIbild.aiin𝕏Seed

Bild.ai extracts door schedules, frames, and hardware specifications from building plans and construction documents.

AI & Machine LearningConstruction TechDeveloper ToolsPropTechSan Francisco, US

Roop Pal(Founder)inPuneet Sukhija(Founder)inAvinash Kunaparaju(Founder)inOwen Boyd(Founding Engineer)Eric Chen(Founding Engineer)Aditya Byju(Intern)

Co-investorsPioneerY CombinatorKhosla VenturesMission Street Capital

BioStack Platformsgetbiostack.com𝕏Seed

BioStack provides a platform for bioinformatics and experimental science that integrates biological insights with computational technology.

AI & Machine LearningBiotechData & InfrastructureHealthtechSan Francisco, US

Sanat Mishra(CEO)inParth Patwa(CTO)in

Co-investorsLobster CapitalStreamlined VenturesTranspose Platform ManagementY CombinatorYonder VC468 Capital+14 more

Blaxelblaxel.aiin𝕏SeedAcquired

Blaxel provides cloud infrastructure for autonomous agents, offering persistent sandboxes that boot in milliseconds and can stay idle indefinitely without cold-start penalties.

AI & Machine LearningCloud ComputingDeveloper ToolsEnterprise SoftwareSan Francisco, US

Paul Sinaï(CEO)inThomas Crochet(Founder)inCharles Drappier(Founder)inMathis Joffre(Founder)inNicolas Lecomte(Founder)inChristophe Ploujoux(CTO)in

Co-investorsBlast.ClubFirst Round CapitalKima VenturesPioneerTranspose Platform ManagementY Combinator+8 more

BootLoopbootloop.aiin𝕏Seed

BootLoop is an AI agent for firmware development that automates hardware understanding, code generation, testing, and debugging across multiple toolchains and embedded platforms.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareHardwareSan Francisco, US

Noah Pacik-Nelson(CEO)inChris Markus(CTO)inBill Lai(Recruiting Manager)

Co-investorsOlive Tree CapitalPioneerTranspose Platform ManagementY Combinator468 CapitalAndreessen Horowitz+10 more

Botonbotonapp.cominSeed

Boton provides an AI agent that generates real-time financial statements for small businesses in Latin America, with the option to connect with partner accountants for review and guidance.

AI & Machine LearningEnterprise SoftwareFintechSaaSPanama City, PA

Alvaro Sosa(Founder)inFernando Varela(Founder)in

Co-investorsY CombinatorLatam Venture Capital

Bottomlessbottomless.comin𝕏Seed

Bottomless operates a coffee subscription service powered by an IoT scale that automatically reorders coffee based on consumption patterns.

ConsumerE-commerceFoodTechIoTMarketplacesSeattle, US

Liana Herrera(Founder)inMichael Mayer(Founder)in

Co-investorsFJ LabsPioneerY CombinatorBragiel BrothersCraft VenturesGelt VC+6 more

Boundaryboundaryml.comin𝕏Seed

Boundary develops BAML, a programming language designed for building AI agents and integrating large language models into applications.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSeattle, US

Vaibhav Gupta(Founder)inAaron Villalpando Gonzalez(Founder)in

Co-investorsSoma CapitalY CombinatorAnthos CapitalAsymmetric Capital PartnersBasis Set VenturesDG Daiwa Ventures+2 more

Browser Usebrowser-use.comin𝕏Seed

Browser Use provides AI-powered browser automation infrastructure with anti-detection capabilities, CAPTCHA solving, and custom LLMs designed for web-based agent tasks at scale.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US

Magnus Müller(CEO)inGregor Zunic(CTO)inGregor Žunič(Founder)inMagnus Muller Gregor Zunic(Founder)

Co-investorsA.Capital VenturesEight CapitalFelicis VenturesFjor FoundersLombardstreet VenturesOrange Collective+16 more

Bubble Labbubblelab.aiin𝕏Seed

Bubble Lab provides a platform for managing online communities that consolidates applications, payments, member directories, events, and messaging into a single interface.

AI & Machine LearningB2B MarketplacesEnterprise SoftwareSaaSSan Francisco, US

Selina Li(CEO)inZach Zhong(CTO)in

Co-investorsY CombinatorFounder CapitalOUTBOUND CAPITAL

BuildBuddybuildbuddy.ioin𝕏Seed

BuildBuddy makes tools for developers to increase productivity.

AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US

Siggi Simonarson(Founder)inTyler Williams(Founder)inIain Macdonald(Software Engineer)George Li(Head of Sales)

Co-investorsavraScribble VenturesSwitch VenturesThe E14 FundVillage GlobalY Combinator+4 more

Bunting Labscodecanary.aiin𝕏Seed

CodeCanary provides an AI agent that automates code quality and product testing through browser-based session replay analysis and A/B testing.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US

Michael Egan(Founder)inBrendan Ashworth(Founder)in

Co-investorsY CombinatorFAST — by GETTYLABFriends Family Capital

Caddycaddy.appin𝕏Seed

Caddy is a personal AI assistant accessible via text messaging that helps users manage calendars, reminders, messages, and tasks.

AI & Machine LearningConsumerDeveloper ToolsEnterprise SoftwareFuture of WorkNew York City, US

Connor Waslo(CEO)inRajiv Sancheti(COO)inConnor Waslo Rajiv Sancheti(Founder)

Co-investorsY CombinatorBread And Butter Ventures, LlcDeVCKleiner PerkinsMatrixNurture Venture Partners+2 more

Caliicalii.cominSeries A

Cali is an e-commerce platform serving customers in a Spanish-speaking market, offering delivery services with promotional incentives.

ConsumerE-commerceFoodTechLogistics & Supply ChainMarketplacesMonterrey, MX

Maurizio Caló Caligaris(Founder)inDavid Arrambide(Founder)inEugenia González(Head of People Ops)

Co-investorsCM VenturesDalus CapitalMONASHEESSoma CapitalStreamlined VenturesY Combinator+7 more

Campfirecampfire.aiin𝕏Seed

Campfire is an AI-native ERP platform designed for accounting teams at mid-market and enterprise companies.

AI & Machine LearningEnterprise SoftwareFintechSaaSSan Francisco, US

John Glasgow(Founder)inTodd Ericksen(Executive Officer, Director)Steve Arntz(Executive Officer, Director)Paul Nichols(CTO)inFernando San MartininJustin Alvarado(Head of Implementations \u0026 CS)

Co-investorsAccelavraFoundation CapitalY CombinatorEast VenturesGlobal Brain+2 more

Cardinal Graycardinalgray.cominSeed

Cardinal Gray automates vehicle titling and DMV documentation workflows for lenders and financial institutions.

AI & Machine LearningEnterprise SoftwareFintechNew York City, US

Jack Chapman(Founder)inMuhammad Khattak(Founder)inGrant Pease(Founder)in

Co-investorsEight CapitalY CombinatorAlloy FundAndreessen HorowitzGeneral AdvanceKrew Capital Venture+2 more

Cascocasco.comin𝕏Seed

Casco provides autonomous security testing that continuously scans code for vulnerabilities, replacing traditional once-yearly penetration testing.

CybersecurityEnterprise Software

Rene Brandel(CEO)inIan Saultz(CTO)inPrakul Singh(Recruiter)

Co-investorsFundersClubMaiora Rebel VenturesRebel FundStandard CapitalY CombinatorBatch Ventures+4 more

Caseflood.aicaseflood.aiinSeed

Caseflood.ai provides intake software for high-end law firms, helping them manage client onboarding and case intake processes.

AI & Machine LearningEnterprise SoftwareLegalTechSan Francisco, US

Ethan Hilton(CEO)inTolen Schreid(CTO)inAyushman Srivastava(Founder)

Co-investorsEight CapitalMaiora Rebel VenturesPioneerRebel FundTranspose Platform ManagementValia Ventures+11 more

Catchcatch.coin𝕏SeedAcquired

Catch provides automated financial management and benefits solutions for independent workers and freelancers, handling tax withholding, retirement savings, and health insurance enrollment without relying on traditional employer-provided benefits.

FintechHealthtechInsurTechNew York City, US

Andrew Ambrosino(Founder)inKristen Anderson(Founder)Alexandra Smith(Director, Engineering)Carl Reyes(Lead, Apps)Jess Little(Director, Partnerships)Alvin Ohlenbusch(Lead, Platform)

Co-investorsArdent VentureCrosslink CapitalDeepwater Asset ManagementKube VCLoup VenturesPrehype+20 more

Cedarcedarcopilot.cominSeed

Cedar provides sales automation software that helps account executives reduce administrative work on CRM tasks and deal management, allowing them to focus on selling for high-growth companies.

Developer ToolsEnterprise SoftwareSan Francisco, US

Jesse Li(CEO)inIsabelle Ilyia(CTO)in

Co-investorsY CombinatorAndreessen HorowitzJP Morgan ChaseTranspose Platform Management

Cheerscheers.techin𝕏Seed

Cheers builds reputation management software for multi-location service businesses, optimizing how AI systems like ChatGPT and Gemini discover and recommend them.

AI & Machine LearningEnterprise SoftwareMarketing TechRetail TechSaaSSan Francisco, US

Dylan Allen-Arnegård(CEO)inAmadeus Peterson(Founder)Ernesto Valencia Arevalo

Co-investorsY CombinatorTranspose Platform ManagementALLEGIS CAPITALAmplify.LACommunity Phone CompanyFitz Gate Ventures+5 more

Cinapsecinapse.ioin𝕏Seedacquired by Wrapbook

Cinapse builds production scheduling software for film and television productions, helping filmmakers and production teams collaborate on schedules, budgets, and timelines.

Cloud ComputingEnterprise SoftwareFuture of WorkMedia & EntertainmentSaaSLos Angeles, US

Herman Phillips(Founder)inRoger Tran(Founder)inGreg KuferaVeronica Amundson(Chief Compliance Officer / VPE)Nick Pozoulakis(CTO)

Co-investorsY CombinatorAgrolimen VenturesFAST — by GETTYLABGaingelsUnpopular VenturesZillionize

Clearspaceclearspace.orgin𝕏Seed

Clearspace advocates for reduced screen time in childhood and promotes outdoor activity and unstructured play.

ConsumerImpact & Social GoodSan Francisco, US

Royce Branning(CEO)inOliver Hill(Founder)in

Co-investorsY CombinatorCaladanCapitalize VCCojourn CompaniesDream MachineElementum Ventures+10 more

cmuxcmux.comin𝕏Seed

A native macOS terminal application built on libghostty that features vertical tabs, split panes, notification alerts, and a programmable API for developers working with AI coding agents and terminal-based workflows.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US

Austin Wang(Founder)inLawrence Chen(Founder)inWesley Tjangnaka

Co-investorsScribble VenturesY CombinatorAmino CapitalAmplify PartnersAndreessen HorowitzFriale+2 more

Cocooncocoon.comin𝕏SeedAcquired

Cocoon provides technology to simplify leave management for employees and employers, handling leave compliance, insurance claims, and payroll administration in the United States.

ConsumerHR TechSaaSSocialSan Francisco, US

Alex Cornell(Founder)inSachin Monga(Founder)inMahima Chawla(Founder)inLauren Dai(Founder)Amber Feng(Founder)inEliot Brooks(Founder)

Co-investorsFirst Round CapitalIndex VenturesLerer HippeauMagnify VenturesSemperVirens Venture CapitalXYZ Venture Capital+16 more

Complifcomplif.comin𝕏Seed

Complif simplifies operational processes and reduces administrative burden for financial services institutions, enabling them to focus on growth and innovation.

Enterprise SoftwareFintechSaaSBuenos Aires, AR

Lucas Ranallo(Founder)inMathias Caramutti(Founder)in

Co-investorsFundersClubPioneerPrimary XY CombinatorCommerce VenturesPrimary Venture Partners+1 more

ComplyDocomplydo.ioinSeed

ComplyDo provides an AI-powered platform that automates enterprise compliance by analyzing regulations and contracts, mapping requirements to internal controls, and identifying compliance gaps for regulated organizations.

AI & Machine LearningCybersecurityEnterprise SoftwareLegalTechBerlin, DE

Leo Schuhmann(CEO)inMoritz Moser(CPO)inMatthias Schneider(CTO)inElizaveta Iakovleva(FA)

Co-investorsAdesso venturesEight CapitalY CombinatorAndreessen HorowitzBlast.Club

Comraderycomradery.com𝕏SeedDefunct

Comradery is a community platform that provides moderation, member profiles, and event management tools for building and managing online and offline communities.

Enterprise SoftwareFuture of WorkSaaSSocialSan Francisco, US

Rishab Hegde(Founder)in

Co-investorsY CombinatorAgrolimen VenturesCaffeinated CapitalPerret Capital LLCSequoia Capital

Confluence Labsconfluence.shin𝕏Seed

Confluence Labs is an AI research lab developing models that improve learning efficiency, enabling faster scientific discovery with minimal experimental data.

AI & Machine LearningBiotechDeep TechEnterprise SoftwareSan Francisco, US

Brent Burdick(CEO)inNiranjan Baskaran(CTO)in

Co-investorsTranspose Platform ManagementY CombinatorHaseeb QureshiMetsu CapitalScript CapitalZapier

Conta Simplescontasimples.comin𝕏Seed

Conta Simples is a financial platform for businesses that centralizes corporate payment management, including corporate card issuance, fund transfers, and bill payments, while providing real-time expense tracking and cost center organization.

Enterprise SoftwareFintechSaaSSão Paulo, BR

Rodrigo Tognini(Founder)inRicardo Gottschalk(Founder)inFernando Santos(Founder)inMarco Antonio(Head of Engineering)

Co-investorsABSeed Venturesbig_betsBVCCapria VenturesDOMO.VCFJ Labs+12 more

Context.devcontext.devin𝕏Seed

Context provides an API that extracts brand color palettes from any domain, returning structured color data with HEX values, RGB/HSL support, and usage weights for developers and product teams building dashboards and marketing tools.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US

Yahia Bakour(CEO)in

Co-investorsPioneerVela PartnersY CombinatorZero IndexBatch VenturesBlast.Club+10 more

Convergerunconverge.comin𝕏Seed

Converge is an AI-native growth platform for direct-to-consumer brands that automates media buying, attribution analysis, and reporting through agentic AI.

AdTechAI & Machine LearningDirect to ConsumerE-commerceEnterprise SoftwareSaaSNew York City, US

Jan-Henrik Lambrechts(Founder)inJerome Billiet(Founder)inThomas Holvoet(Founder)inJérôme Billiet(Founder)inGideon Farrell(Founder)Raph Scheps(Founder)

Co-investorsEntourage VenturesUncorrelated VenturesY CombinatorBessemer Venture PartnersCambridge Angels groupEMV Capital+7 more

CoreCarecorecare.aiinSeed

CoreCare builds AI-powered operations and billing management software for long-term care and skilled nursing facilities.

AI & Machine LearningEnterprise SoftwareHealthtechSaaSNew York City, US

Dennis Antonelos(CEO)inMehrdad Shafaie(COO)inGeoffrey Roguelon(CTO)inTravis DockterRobert Antonelos(Vice President of Operations)Ramon de Jonge(Frontend Engineer)

Co-investorsCathexis VenturesFundersClubHDS CapitalMaccabee VenturesPrimetime PartnersVentureSouq+8 more

Corelayercorelayer.comin𝕏Seed

Corelayer provides AI-powered incident detection and root-cause analysis for production environments, using agents to proactively identify and prevent infrastructure issues for engineering teams.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US

Mitch Radhuber(CEO)inShipra Jha(CTO)in

Co-investorsY CombinatorActive CapitalBlast.ClubFundersClubSandwith Ventures, LLCStratus Ventures

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

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▶86 more tracked companies

ProximittyPsychicPunchcardPyroscopeQuoRailbirdRationalRepaintReplicasRepoolResponseResquaredReverie LabsRGI LabsRoboflowRomeRoutableRumeRunLocal AIs2.devSableSafeBaseSaga AIScanwell HealthSealSendblueSendoSequinShiruSigmanticAISimSlapdashSmobiSocratix AISorenSourcebotStablestagewiseSTARK BANKStocklineStreamdalSunsetSupersetSymphonySynchTableFlowTandemTensrTintTitanTranchTreintaTrigger.devTrueNorthTryglooTwentyTwo DotsUbicloudUnsloth AIUnusualUpsolve AIVellumVelvetVerbiflowVerdict MachineVerse MedicalVesenceVista PowerVitauVoicepanelVooshVulcan TechnologiesWardstoneWhalyWhatnotWolfiaXTrafficYottaZBioticsZeon SystemsZeroDownZeroEntropyZeroframeZipZippiZynq

Exits · 35

35 acquisitions · showing 6

Aeracq. by StarComplianceCinapseacq. by WrapbookDashdiveacq. by RhombusHey Reviaacq. by OpenLoopHiroacq. by OpenAINovaflowacq. by Corob

Portfolio news

latest coverage across their companies

Frequently asked questions

How many investments has Twenty Two Ventures made?
Twenty Two Ventures has 286 tracked investments, 35 of which have exited, including 14 dated in the last 24 months.
What stage does Twenty Two Ventures invest at?
Twenty Two Ventures invests at the Pre-Seed, Seed stages.
What is Twenty Two Ventures's typical check size?
Twenty Two Ventures typically writes checks of $50K – $250K.
What sectors does Twenty Two Ventures focus on?
Twenty Two Ventures focuses on B2B Marketplaces, Developer Tools, Fintech, Marketplaces, SaaS.
Where is Twenty Two Ventures located?
Twenty Two Ventures is headquartered in Palo Alto, US.
Does Twenty Two Ventures lead rounds?
Twenty Two Ventures typically participates in rounds rather than leading them.
Who does Twenty Two Ventures co-invest with?
Twenty Two Ventures most often shares deals with Y Combinator, Standard Capital, BoxGroup, among 85 tracked co-investors.

Co-investors · 11

SV Angel

SV Angel is a San Francisco-based firm that invests long-term in founders, supporting them with advice, introductions, and network access at key business inflection points.

$150K – $20M
Standard Capital

Standard Capital is an AI-native venture firm that leads Series A rounds in post-product-market-fit startups through a fast application-and-interview process rather than traditional pitching, without taking board seats.

Hack VC

Hack VC is a venture capital firm investing in early-stage crypto, blockchain infrastructure, decentralized finance, and AI companies.

$3M
Kima Ventures

Kima Ventures is an early-stage investor associated with entrepreneur Xavier Niel, backing a large and diverse portfolio of startups worldwide.

$50K – $5M
Bain Capital Ventures

BCV Labs is the platform and hands-on support arm of Bain Capital Ventures, providing portfolio founders with go-to-market strategy, brand development, hiring assistance, and customer introductions.

$1M – $100M
Transmedia Capital

Transmedia Capital is an early-stage technology venture fund that backs founders with domain expertise, operating experience, and advisory support.

Both backed · 2
$250K – $5M
A.Capital Ventures

A.Capital Ventures is an early-stage venture firm that provides funding, network access, and hands-on support to entrepreneurs building forward-thinking technology companies.

Both backed · 2
Nine Four Ventures

Nine Four Ventures is an early-stage PropTech investor backing technologies that affect the people, processes, and ecosystems interacting with the built world.

Both backed · 1
Stealth Capital

A team of analytical investors, traders, and builders employing data-driven and first-principles approaches to identify market trends and solve complex problems across diverse segments.

Firms observed investing alongside Twenty Two Ventures, from public investor directories. Shared companies are the overlap with Twenty Two Ventures's recorded portfolio.

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