Twenty Two Ventures — Full Portfolio

Relari builds an AI development platform called Nuvi that enables developers to define intelligent agents in plain English without prompt engineering or visual programming.

Advanced ManufacturingAI & Machine LearningDeveloper ToolsEnterprise SoftwareRoboticsSan Francisco, US

YZYi Zhang(Founder)inPAPasquale Antonante(Founder)in

Co-investorsY Y CombinatorAMAmino CapitalGEGeneral CatalystSOSoma Capital46468 Capital

Airbyte provides a context layer for agents and pipelines, enabling data connectivity and integration solutions.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSan Francisco, US

MTMichel Tricot(Co-Founder & CEO)inJLJean Lafleur(Co-Founder & COO)inJ(Jean (John) Lafleur(Co-Founder and COO)in

BoardChetan Puttagunta(Benchmark partner and board member)

Co-investors8V8VCACAccelCOCoatue ManagementFLFlex Capital PartnersKIKima VenturesRERebel Fund+6 more

Berbix provides identity verification and fraud detection technology that online platforms integrate via SDKs to confirm users' identities and prevent fraudulent accounts.

Developer ToolsEnterprise SoftwareSaaSSan Francisco, US

ELEric Levine(Founder)inSKSteve Kirkham(Founder)in

Co-investorsDRDream MachineFIFikaY Y CombinatorFIFika VenturesINInitialized CapitalMAMayfield Fund

BuildBuddy makes tools for developers to increase productivity.

AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US

SSSiggi Simonarson(Founder)inTWTyler Williams(Founder)in

Co-investorsSCScribble VenturesSWSwitch VenturesTHThe E14 FundVIVillage GlobalY Y CombinatorADAddition

Cron is a next-generation calendar application designed for professionals and teams to manage their schedules and time.

Enterprise SoftwareFuture of WorkSaaSSan Francisco, US

RSRaphael Schaad(Founder CEO)in

Co-investorsCHChapter OneNENext Play VenturesY Y CombinatorYOYourNest Venture Capital

Dots is an API-first payouts platform that lets businesses onboard payees, send domestic and international payments across 300+ rails in 190+ countries, and handle tax form collection and filing.

Developer ToolsFintechSaaSSan Francisco, US

SHSahil Hasan(Founder)in

Co-investorsCLClocktower VenturesDCDCMY Y Combinator

Dropback provides a database and toolkit for college sports front offices to centralize personnel and financial data, enabling data-driven roster decisions and cap strategy management without spreadsheets.

Data & InfrastructureFintechSaaSSports Tech

LBLuke Bogus(Co-Founder)inNSNick Siscoe(Founder)in

Co-investorsY Y CombinatorREReach Capital

Finley provides software to banks and asset managers that automates debt capital management, due diligence, compliance, and reporting for asset-backed finance, private credit, and structured finance.

Enterprise SoftwareFintechSaaSSan Francisco, US

JTJeremy Tsui(Co-founder & CEO)inKSKevin Suh(Co-founder)inJTJosiah Tsui(Co-founder)in

BoardJGJames Green(Director)in

Co-investorsCRCRV (Charles River Ventures)UPUpper90Y Y CombinatorBABain Capital VenturesHAHaystack

A financial technology platform that enables fractional home ownership through partnerships with payment processors and banking services.

B2B MarketplacesFintechFuture of WorkPropTechSan Francisco, US

SHStella Han(Founder)inCTCarlos Treviño(Founder)in

Co-investorsCOContraryDRDreamers VCLELeft Lane CapitalOUOutbound VenturesPAPath VenturesY Y Combinator+7 more

Great Question is a UX research platform that combines participant recruitment, study management, mixed-method research capabilities, and AI-powered analysis in a single system.

Developer ToolsEnterprise SoftwareMarketing TechSaaSSan Francisco, US

NDNed Dwyer(Founder / CEO)inPMPJ Murray(Founder)in

Co-investorsFUFundersClubIMImmeasurableINInovia CapitalNONOMO VenturesY Y CombinatorAMAmplify.LA+16 more

Infisical is an all-in-one platform for managing application secrets, certificates, and privileged access across cloud, on-premises, and AI infrastructure, serving developer teams and organizations.

CybersecurityDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US

VMVlad Matsiiako(Founder)inTDTony Dang(Founder)inMIMaidul Islam(Founder)in

Co-investorsGRGradient VenturesY Y CombinatorAVavraELElad Gil

Double provides an AI-assisted platform for the accounting month-end close, integrating with ledgers and ERPs (QuickBooks Online, Xero, Sage, NetSuite) to automate transaction categorization, reconciliations, and journal entries.

AI & Machine LearningFintechSaaS

Co-investorsALAlbum VC

Loops builds an email platform designed for software companies to manage customer communication and engagement.

Developer ToolsEnterprise SoftwareMarketing TechSaaSWashington, US

CFChris Frantz(Founder)inAKAdam Kaczmarek(Founder)in

Co-investorsY Y CombinatorA1A16Z SpeedrunCACardumen CapitalSCScale Venture Partners

Lua is a free online PDF converter that enables users to convert PDF files to Word, Excel, JPG, PNG, PPT, and HTML formats without requiring downloads.

SaaSNew York City, US

Co-investorsTETechstars2020VCFLFlourish VenturesNONorrsken22P1P1 VenturesY Y Combinator

Magic provides managed virtual assistant teams for executives and growing businesses, handling administrative tasks like calendar management, email, travel planning, and operational coordination.

AI & Machine LearningConsumerEnterprise SoftwareFuture of WorkSaaSWashington, US

MCMike Chen(Founder/CEO)inAKAaron Kemmer(Founder)inDMDavid Merriman(Founder)inNNNic Novak(Founder)inMRMichael Rubin(Founder/CFO)in

Co-investorsALAltra VentureMVMVP VenturesSISilicon VenturesSPSprint VcY Y CombinatorBLBling Capital+4 more

Magic provides a bank-based payment solution that allows merchants to accept direct bank transfers at checkout, reducing processing fees and payment failures compared to traditional card payments.

E-commerceFintechSaaSNew York City, US

CKChetan Kulhari(Founder)inDavid Guo(Founder)in

Co-investorsY Y CombinatorBLBling CapitalESESSENCE VCFLFloodgateLELerer HippeauSTStandard Capital

Magic Patterns generates user interface designs that match existing product styling and enables rapid prototyping of new features.

Developer ToolsEnterprise SoftwareSaaSSan Francisco, US

ADAlex Danilowicz(Founder)inTNTeddy Ni(Founder)in

Co-investorsSTStandard CapitalY Y CombinatorESESSENCE VCESEssence Venture Capital

Newton builds a unified phone system platform for dental practices, integrating AI receptionist capabilities with traditional staff workflows to replace fragmented communication tools.

AI & Machine LearningEnterprise SoftwareHealthtechSaaSSan Francisco, US

RCRohit Chaparala(Founder)inSDSam Detjen(Founder)in

Co-investorsY Y Combinator

Newton is an onchain authorization layer that verifies and enforces programmable compliance, security, and risk policies on each transaction before it settles across multiple blockchains.

Crypto & Web3CybersecurityFintech

Co-investorsEAEarl Grey CapitalY Y Combinator

Newton is an innovation company that develops therapeutic optical lenses for treating eye-related conditions like headaches, motion sickness, and neck pain caused by eye misalignment.

Digital HealthHardwareHealthtechMedical Devices

Yuval B.(Founder)in

Co-investorsTUTullis Health InvestorsY Y Combinator

Palette Technology provides AI-powered native image and video generation tools for creative teams, enabling them to produce audience-ready content across formats (video, visuals, structured content) from a single source material without rebuilding assets for each output.

AI & Machine LearningCreator EconomyEnterprise SoftwareSan Francisco, US

JLJosephine Lee(Founder)inSPSerena Pei(Founder)in

Co-investorsY Y CombinatorBABain Capital VenturesKIKima VenturesLILiquid Ventures

Palette Desktop is a workspace application designed for non-engineering professionals to manage writing, research, planning, operations, and design tasks across shared folders using AI agents.

AI & Machine LearningEnterprise SoftwareSaaS

Co-investorsACAcadian Ventures Management, LlcBABain Capital VenturesEXExfinity VenturesKIKima VenturesLILiquid VenturesPIpi Ventures+1 more

Palette is a platform for sales leaders and managers to set short-term goals, track performance, and motivate teams through personalized incentives and coaching programs.

Enterprise SoftwareSaaSSales TechParis, FR

JLJean-Edern Lorillon(Founder)in

Co-investorsY Y CombinatorBABain Capital VenturesKIKima VenturesLILiquid Ventures

Patterns provides an AI-powered platform for financial analysis and reporting that allows users to perform data analysis using natural language instead of traditional spreadsheets.

Data & InfrastructureEnterprise SoftwareSan Francisco, US

KVKen Van Haren(Founder)inCSChris Stanley(Founder)in

Co-investorsRORoot Ventures Manager, LlcWAWayfinder VenturesY Y CombinatorESESSENCE VCSTStandard Capital

PoplarML provides tooling to deploy machine learning models to GPU infrastructure and expose them as scalable API endpoints with minimal configuration.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US

DLDanna Liu(Founder)inECEvan Chu(Founder)in

Co-investorsY Y Combinator

PostHog is a product analytics and data platform offering multiple integrated tools for product engineers, including analytics, experimentation, and customer data management.

Data & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US

JHJames Hawkins(Founder)inTGTim Glaser(Founder)in

Co-investors191984 Ventures Management, LlcFOFormus CapitalPEPeak XV PartnersSTStandard CapitalUNUnusual VenturesVAValkyrie Ventures Management, Llc+4 more

Platform that connects private data sources to LLM-powered applications.

Routable provides business payment infrastructure and automation for accounts payable teams, enabling instant payments through FedNow and Real-Time Payments to US bank accounts, and automating invoice processing with features like PO-matching and AI-powered bill coding.

AI & Machine LearningEnterprise SoftwareFintechSaaSSan Francisco, US

OMOmri Mor(Founder/CEO)inTHTom Harel(Founder)in

BoardCHRIS DEVORE(Director)in

Co-investorsGOGood FriendsY Y CombinatorFLFlexportFOFounders' Co-op

SafeBase (part of Drata) provides an AI-driven platform that automates security compliance, manages internal and third-party risk, and maintains a Trust Center to share always-current proof of an organization's security posture.

AI & Machine LearningCybersecurityEnterprise SoftwareSaaSSan Francisco, US

AYAl Yang(Founder)inAAAdar Arnon(Founder)in

Co-investorsANAnalog VenturesCOComcast VenturesCOContour Venture PartnersNENew Enterprise Associates (NEA)TITime Zero CapitalTOTouring Capital+3 more

Sim is an open-source AI workspace where teams build, deploy, and manage AI agents across their existing tool stack using 1,000+ integrations and every major LLM.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareSan Francisco, US

EKEmir Karabeg(Co-Founder / CEO)inWLWaleed Latif(Co-Founder & CTO)in

Co-investorsRIRitual CapitalY Y CombinatorFUFuel CapitalLILiquid VenturesSTStandard CapitalSVSV Angel

Slapdash builds a command bar interface that aggregates cloud applications and provides low-latency file-system access to accelerate workflows for knowledge workers.

Developer ToolsEnterprise SoftwareFuture of WorkSan Francisco, US

IKIvan Kanevski(Founder/CEO)inDKDmitry Koterov(Founder)in

Co-investorsY Y CombinatorQUQuiet CapitalS2S28 CapitalUPUP2398

Smobi is an AI-powered messaging platform that enables brands to send interactive RCS (Rich Communication Services) and SMS campaigns directly to customers' phones.

AI & Machine LearningEnterprise SoftwareMarketing TechSaaSNew York City, US

KPKunal Puri(Founder)in

Co-investorsY Y Combinator

Socratix provides AI agents for fraud detection and compliance investigations at financial institutions.

AI & Machine LearningEnterprise SoftwareFintechSaaSSan Francisco, US

RJRiya Jagetia(Co-Founder & CEO)inSVSatya Vasanth Tumati(Co-Founder & CTO)in

Co-investorsTRTranspose Platform ManagementY Y CombinatorPEPear VC

Treinta is a cloud-based business management system that enables small business owners to manage sales, inventory, customers, suppliers, and employees from mobile or web.

AI & Machine LearningCloud ComputingEnterprise SoftwareFuture of WorkRetail TechSaaSBogotá, CO

LCLluis Canadell(Founder and CEO)inMHMan Hei Lou(Founder)in

Co-investorsCOCommerce VenturesETEthos VCKUKube VCLOLoftyInc CapitalOUOutbound VenturesTETen13+7 more

Vellum builds AI development tools and platforms for teams building AI applications.

AI & Machine LearningDeveloper ToolsEnterprise SoftwareFuture of WorkNew York City, US

ASAkash Sharma(Founder)inSSSidd Seethepalli(Founder)inNFNoa Flaherty(Founder)in

Co-investorsEAEastlink Capital PartnersY Y CombinatorACAcrew CapitalFLFlourish VenturesLELeaders FundRERebel Fund+1 more

Voicepanel provides customer research tools to help companies understand their customers faster and more reliably than traditional research methods.

AI & Machine LearningData & InfrastructureEnterprise SoftwareMarketing TechSaaSSan Francisco, US

ASAsa Schachar(Co-Founder & CTO)inJPJohn Provine(Co-Founder & CEO)inDDavidin

Co-investorsY Y CombinatorAMAME Cloud Ventures

Whatnot is a live commerce marketplace that enables creators and entrepreneurs to build businesses by connecting with audiences through real-time streaming and shopping.

ConsumerCreator EconomyE-commerceMarketplacesSocialLos Angeles, US

GLGrant LaFontaine(Founder/CEO)inLHLogan Head(Founder)in

BoardDCDalton Caldwell(Director)inCCConnie Chan(Director)inLSLaela Sturdy(Director)inAnu Hariharan(Director)in

Co-investorsALAlkeon InnovationANAndreessen HorowitzBABackwards CapitalCACapitalGFIFirebolt Ventures Management Company, LlcGRGreycroft+12 more

Zip is an AI platform for enterprise procurement that automates and optimizes the B2B purchasing process from intake to payment.

AI & Machine LearningEnterprise SoftwareSaaSSan Francisco, US

RZRujul Zaparde(Founder)inLCLu Cheng(Founder)inLDLarry Diamond(Executive Officer, Director)inMartin Brooke(Executive Officer)Peter Gray(Executive Officer, Director)

BoardPhilip Crutchfield(Director)

Co-investorsY Y CombinatorTITiger Global ManagementALAlkeon InnovationCRCRV (Charles River Ventures)FJFjor FoundersNINight Capital+5 more