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Cambrian Ventures

Venture capitaloperating company · company profile

San Francisco · Pre-Seed–Seed · 1 people tracked

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Investment thesis

Cambrian invests in early-stage fintech startups, believing the next evolution of fintech will come from strong founders backed by strong networks. It writes $300k to $1mm+ checks at pre-seed and seed, acting as lead, co-lead, or participant. Beyond capital, the firm activates the Cambrian network of founders, investors, and operators to help portfolio companies with insights, funding, early hires, customers, channel partners, and infrastructure. Its interests span the breadth of fintech, including payments, banktech, supply chain, insurtech, accounting and tax, capital markets, healthtech-fintech, HR-fintech, consumer finance, lending, wealthtech, identity and fraud, regtech, blockchain and crypto, proptech, and retail/e-commerce.

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Seed
Check
$300K – $1M
HQ
San Francisco, CA, US
Leads rounds
Leads
Instruments
Equity
Founded
2000
Tracked investments
9

Team · 1 people

from the firm's website

What they invest in

from 8 of 9 portfolio companies

Fintech ×6SaaS ×6AI & Machine Learning ×3Enterprise Software ×3Healthtech ×2InsurTech ×2Data & Infrastructure ×1Future of Work ×1

HQs:United States×2Canada×1

Investments · 9 tracked

founders shown can be your intro path
32Health32health.careinNov 2024

Chestnut Hill, US

Shaju Puthussery(Executive Officer, Director)Deepak Ramaswamy(Executive Officer, Director)

BoardRohan Malhotra(Director)

PartnerRex Salisbury· solo GP

Anatomyanatomy.comin

Anatomy offers AI-based financial automation tools for healthcare organizations that bill insurance, including medical and dental practices, MSOs/DSOs, revenue cycle management companies, and digital health providers.

AI & Machine LearningFintechHealthtech

Everyevery.ioin𝕏

Every.io is a financial technology company that enables businesses to invest in U.S.

Enterprise SoftwareFintechFuture of WorkSaaSSan Francisco, US

Rajeev Behera(Founder)inBarry Peterson(Founder)in

Hellopaidhellopaid.comin𝕏

Paid provides no-cost core payroll software for business owners, including direct deposit, tax filing, compliance tracking, benefits/PTO, and W2 & 1099 generation.

FintechHR TechSaaS

Keeptrykeep.comin𝕏

Keep provides an all-in-one financial platform for Canadian businesses, offering business cards with higher credit limits, expense automation, global banking services, and growth capital financing.

Enterprise SoftwareFintechSaaSCanada, CA

Lightspunlightspun.comin

LightSpun offers an AI-powered healthcare administration platform with modular tools for claims adjudication, credentialing, provider network management, benefit administration, billing, contact center automation, and reporting.

AI & Machine LearningHealthtechInsurTech

OatFi New York, USAoatfi.com

OatFi provides payment infrastructure and embedded credit APIs that let B2B payment platforms offer working capital, early payments, net terms, and reconciliation within their existing flow of funds.

Data & InfrastructureFintechSaaS

Oysterwithoyster.comin𝕏

Oyster Technologies builds Cara, an AI-based "Agency Intelligence System" for insurance agencies, brokerages, and wholesalers.

AI & Machine LearningInsurTechSaaS

Salsasalsa.devin

Salsa builds modern payroll infrastructure for financial software platforms and businesses.

Enterprise SoftwareFintechSaaS

JohnJuan

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Cambrian Ventures invest at?
Cambrian Ventures invests at the Pre-Seed, Seed stages.
What is Cambrian Ventures's typical check size?
Cambrian Ventures typically writes checks of $300K – $1M.
What sectors does Cambrian Ventures focus on?
Cambrian Ventures focuses on Crypto & Web3, E-commerce, Fintech, Healthtech, HR Tech, InsurTech, PropTech, SaaS.
Where is Cambrian Ventures located?
Cambrian Ventures is headquartered in San Francisco, US.
Does Cambrian Ventures lead rounds?
Yes, Cambrian Ventures leads investment rounds.

Media · Podcasts & interviews

featuring the team

#411: Rex Salisbury of Cambrian Ventures

Peter Renton · Rex Salisbury

Building a Community-Driven VC with Rex Salisbury of Cambrian Ventures

Ripple Ventures · Rex Salisbury

Podcast 411: Rex Salisbury of Cambrian Ventures

Fintech Nexus · Rex Salisbury

America's #2 Neobank That Nobody Talks About

Rex Salisbury

⁠How AI Rewrote Ramp's Product Playbook

Rex Salisbury

Startup Ideas Are Boring Now (Ex-YC Partner Dalton Caldwell)

Rex Salisbury

Images

Cambrian Ventures photo

Co-investors · 34

Kleiner Perkins

Kleiner Perkins is a venture capital firm that backs founders across technology and life sciences, from early stage through growth.

Both backed · 1
$500K – $15M
PICUS CAPITAL

Picus Capital is an early-stage technology investment firm that partners closely with founders on strategic and operational challenges to help build global companies.

Both backed · 1
$100K – $300M
QED Investors

QED Investors is a venture capital firm focused on financial services and fintech, founded by former Capital One executives.

Both backed · 1
$30K – $25M
Andreessen Horowitz

The a16z Cultural Leadership Fund (CLF) is a venture fund within Andreessen Horowitz composed exclusively of Black cultural leaders and organizations, which coinvests in a16z portfolio companies and donates all management fees and carry to nonprofits advancing Black talent in technology.

$500K – $50M
GV (Google Ventures)

GV (Google Ventures) is a venture capital firm that has invested in artificial intelligence and machine learning since its early days, building a global portfolio of more than 100 AI companies across infrastructure, life sciences, and applications.

$250K – $50M
Insight Partners

Insight Partners is a software-focused venture and growth investor whose enterprise program connects executives with its portfolio companies, founders, research, and a network of peers through curated introductions, events, and programs.

$120M – $350M
BoxGroup

BoxGroup is an early-stage venture capital firm that invests in startups at their earliest stages.

$1M
Susa Ventures

Susa Ventures operates two early-stage technology funds that invest in companies leveraging data, network effects, and economies of scale.

$1M – $5M
Liquid Ventures

Liquid 2 is an early- and growth-stage venture capital firm that invests in founders across all sectors of technology, providing capital along with support from a network of operators.

$250K – $5M
Innovation Endeavors

Innovation Endeavors is an early-stage venture fund that invests in founders and supports venture creation through pre-team and pre-idea programs. The firm provides portfolio companies with access to mentors, advisors, and an entrepreneur ecosystem.

$1M – $15M
Lookout Ventures

Lookout Ventures provides seed-stage funding to enterprise technology companies outside Silicon Valley, with partner expertise in AI, cybersecurity, infrastructure software, and vertical SaaS.

$250K – $2M
Trajectory Ventures

Trajectory Ventures invests in and partners with innovative founders and companies driving digital transformation, while also providing advisory, growth marketing, financing strategy, and M&A support.

22 more co-investors

ParadigmBase10 PartnersWEEKENDBanana CapitalCowboy VenturesFootworkNextGen Venture PartnersNotion CapitalKearny JacksonMischiefEnsemble VCVera EquityConversion CapitalTTV CapitalJump CapitalTimespan VenturesFin CapitalM25MPG FundFlyover CapitalUpWestHoneyBook

Firms observed investing alongside Cambrian Ventures, from public investor directories. Shared companies are the overlap with Cambrian Ventures's recorded portfolio.

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