Mantis
YC W26New York City, US · Founded 2025 · 3 employees · Hiring · 7 known investors
Mantis builds predictive models of individual physiology and behavior by aggregating consented personal data streams (wearables, device telemetry, clinical records) to forecast health outcomes and enable personalized medical decisions. The company serves healthcare providers and researchers by operating as a data broker that delivers scoped, revocable predictions to authenticated applications without selling raw data.
Also known as Mantis Biotechnology · Mantis Biotech
Founders & leadership· Y Combinator alumni (W26)
Mantis was founded in 2025 by Georgia Witchel.
Investors · 7
Also in the syndicate · 3
Funding
SEC filings, press & company announcements- Undisclosed amountseed roundJan 2026
Decibel Partners (lead), Fenwick, Pioneer Fund, Spot VC, StoryHouse Ventures, Y Combinator
Source ↗
Source: company announcements and press reports — follow each round's link for the claim.
Company profile
researched Aug 2026Mantis (also referred to as Mantis Biotech) is a New York-based company building "digital twins" of individual humans: living, predictive models of a person's anatomy, physiology and behavior, forecast out to the horizon at which a decision must be made. The company positions itself as behavioral forecasting infrastructure and starts in healthcare, arguing that individual-level prediction is worth the most there and that permissions, privacy, validation and accountability standards are most clearly defined in medicine.
The platform ingests disparate data streams — device telemetry, wearable physiology, digital activity, clinical records, and, per press coverage, textbooks, motion-capture cameras, biometric sensors, training logs and medical imaging. An LLM-based system routes, validates and synthesizes those streams, and a physics engine grounds the synthetic data and produces high-fidelity renders used to train predictive models. Mantis frames this as addressing a data-availability bottleneck in biomedical research, where data on rare diseases, unusual conditions and other edge cases is scarce, unstructured, siloed, or restricted by ethical and regulatory constraints; the company says it can generate datasets for such cases by modifying the physics model (for example, regenerating hand-pose data for a person missing a finger).
The company describes a catalogue of application areas served from the same primitive — a scoped, consented prediction from the twin — including pre-symptomatic infection detection from wearable physiology, cognitive baseline monitoring, heart-failure decompensation and readmission forecasting, medication adherence prediction, post-operative recovery trajectories, psychiatric relapse early warning, and trial matching with counterfactual arms run against digital twins instead of placebo groups. Applications outside medicine include modeling athlete performance and injury risk.
Business model
Mantis describes itself as a neutral broker layer rather than a data seller: individuals grant data streams and hold the keys, Mantis assembles a unified record and predictive twin, and companies request scoped, revocable access to predictions from that twin, analogous to an application requesting access through OAuth. The company states it does not sell data, but sells the connection, with consent on the person's side.
Traction
As of the March 2026 TechCrunch report, Mantis had gained traction in professional sports, with an NBA team described as one of its main clients; the company creates digital representations of athletes tracking metrics such as jump characteristics over time against sleep and movement loads. Team size was listed as three on the Y Combinator profile.
Latest developments
In March 2026, TechCrunch reported that Mantis had raised $7.4 million in seed funding led by Decibel VC, with participation from Y Combinator, Liquid 2 and angel investors, to be used for hiring, advertising, marketing and go-to-market. Next steps described were continued technology development, expansion to pharmaceutical labs and FDA trial researchers, and an eventual public release focused on preventative healthcare.
▸Full profile — market position, technology, go-to-market, geography, history, risks & controversies
Market position
Mantis argues that Google, Apple and Meta each hold only a deep slice of the human record, see only their own products, and monetize through a single narrow business, leaving a holistic model of the individual structurally outside every incumbent's mandate. It compares its intended role to OAuth for identity, Plaid for banking and Stripe for payments — an intermediary that does not compete with either side of the exchange.
The company's stated differentiators are the physics-engine layer that grounds generated synthetic data in realistic anatomy and physiology — allowing datasets to be generated for edge cases with no public data — combined with an LLM layer for reconciling disparate, unstructured sources, and a consent architecture that delivers scoped, revocable predictions rather than raw data.
Technology
The system assembles a per-person record from continuously measured streams (device telemetry, wearable physiology, digital activity, clinical records) and applies an LLM-based layer to route, validate and synthesize heterogeneous inputs, then runs the data through a physics engine to produce high-fidelity, physically grounded renders and synthetic datasets used to train predictive models. The company's stated thesis is that raw human behavior is chaotic and unforecastable, but that correct coarse-grainings of it are not: stable aggregates (resting-heart-rate trends, sleep architecture, adherence rates, cognitive baseline drift) and stable routines (sleep location, commute, spending categories) are forecastable, while micro-chaos such as the next word typed remains a longer-term goal. Mantis cites published research as evidence for the achievable ceiling, including a 93% upper bound on the predictability of individual location (Song et al., Science, 2010), personality inference from ~300 Facebook Likes (Kosinski et al., PNAS, 2013 and 2015), and a finding that 81% of COVID-19 cases showed physiological warning signs at or before symptom onset, some nine days early, from a smartwatch alone (Mishra et al., Nature Biomedical Engineering, 2020).
Go-to-market
Mantis began with professional sports customers, including an NBA team, while planning to broaden to pharmaceutical labs and FDA trial researchers and, later, a general-public preventative-health product. The company said its March 2026 seed funding would go toward hiring, advertising, marketing and go-to-market functions. It was recruiting a founding engineer in New York and a part-time content creator/video editor as of the Y Combinator listing.
Builders and companies that need forecasts about individual people, initially in healthcare: care teams and providers, clinical researchers, pharmaceutical labs and researchers working on FDA trials. The company has also sold into professional sports, with an NBA team cited as one of its main clients, and says it eventually intends to release the platform to the general public for preventative healthcare.
Geography
Headquartered in New York City, New York, United States, with job listings for New York and remote (US) roles.
History
Mantis was founded in 2025 and is based in New York City. It participated in Y Combinator's Winter 2026 batch, with Gustaf Alstromer as primary partner, and had a team size of three as listed on its YC profile. In March 2026 it announced a $7.4 million seed round.
Risks & controversies
Mantis's model depends on aggregating sensitive personal physiological, behavioral and clinical data, an area subject to privacy expectations and regulatory constraints; the founder has stated that people's data should not be exploited and that access is scoped and revocable. The company also notes that ethical and regulatory constraints limit the availability of patient data for public datasets and AI training, which is the gap its synthetic-data approach targets.
Compiled by commissioned research from 7 cited public sources — announcements, filings, and press listed under research sources below.
Key figures
latest reportedCompany-reported or press-reported figures, each dated to when it was claimed — not independently audited.
Competitors · 2
by search overlapCompanies competing with Mantis for the same Google search keywords, organic and paid, via search-intersection analysis.
Timeline · 2
launches, deals, and filingsTechCrunch reported that Mantis had recently raised $7.4 million in seed funding led by Decibel VC, with participation from Y Combinator, Liquid 2 and several angel investors, to fund hiring, advertising, marketing and go-to-market.
$7.4M source ↗
Mantis is listed in Y Combinator's Winter 2026 batch with Gustaf Alstromer as primary partner.
Dated company events from announcements, filings, and press; legal rows summarize public dockets and regulator releases.
In the news
▸Research sources · 7
primary sources listed
- Mantismantisbiotech.com · web
7 public sources were cited for this profile; the first-party ones are listed here.
Frequently asked questions
- What does Mantis do?
- Mantis builds predictive "digital twins" of individual people, combining LLMs and physics simulation, starting in medicine.
- Who founded Mantis?
- Mantis was founded by Georgia Witchel in 2025.
- Who are Mantis's investors?
- Mantis's investors include Decibel Partners, Y Combinator, Spot VC, StoryHouse.
- Where is Mantis headquartered?
- Mantis is headquartered in New York City, US.


