2048 Ventures
Venture capitalActively deployingNew York · Pre-Seed–Seed · 11 people tracked
Also known as 2048 VENTURES, LLC
Investment thesis
2048 Ventures is a thesis-driven early-stage firm investing in the next generation of platforms with strong data moats — Systems of Record, infrastructure, and API companies across Vertical AI, Deep Tech, Health, and Bio. It leads Pre-Seed and Seed rounds with $500K-$3M checks, moving from first meeting to a lead commitment in 10-15 business days and offering a Pre-Seed Fast Track for smaller rounds funded in 10 days. The firm emphasizes long-term value and wealth creation by backing companies solving fundamental problems, aiming to partner with founders from day zero and be a highly helpful, low-friction investor.
Source: firm website, verified Aug 3, 2026.
Team · 11 people
from the firm's website & public directories
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What they invest in
from 35 of 90 portfolio companiesAI & Machine Learning ×20SaaS ×13Healthtech ×11Enterprise Software ×9Medical Devices ×6Biotech ×5Digital Health ×5Cleantech ×4
HQs:United States×26Canada×3Denmark×1
Investments · 90 tracked
founders shown can be your intro pathGenerable develops statistical and computational models for drug development and healthcare decision-making, leveraging Bayesian methods and probabilistic modeling.
AI & Machine LearningBiotechCloud ComputingDeep TechHealthtechMedical DevicesNew York City, US
EricJacqueline
New York, US
Kevin Flyangolts(Executive Officer, Director, Promoter)Alex Iskold(Director)
Board seatAlex Iskold· per SEC Form D
CybersecurityBelmont, US
Kevin O'Brien(Executive Officer, Director)Raymond Wallace(Executive Officer, Director)
Board seatAlex Iskold· per SEC Form D · $2.5M raise · filed Mar 2016
Kennebunk, US
George Matelich(Executive Officer, Director, Promoter)David LoBosco(Executive Officer, Director, Promoter)
PartnerZann Ali· quoted
Board seatAlex Iskold· per SEC Form D
New York, US
Lawrence Fish(Executive Officer, Director)Alex Iskold(Director)Cem Kozinoglu(Executive Officer, Director)
Board seatAlex Iskold· per SEC Form D · $2.2M raise · filed Aug 2016
Acorn Finance is a platform that enables contractors to offer financing to customers for home improvement and repair projects.
B2B MarketplacesConstruction TechFintech
New York, US
Heather Widman(Director)Sheida Shahi(Executive Officer, Director, Promoter)Aida Mollaei(Executive Officer, Director, Promoter)
Airspace Link provides a unified platform (AirHub Portal) for airspace security, drone operations management, and air traffic coordination, serving government agencies, defense organizations, and commercial enterprises operating unmanned aircraft systems.
Defense TechGovTechIoTNorthville, US
Jonathan Struhl(Director)Michael Healander(Executive Officer, Director)Dillon Krasnigor(Director)Daniel Bradshaw(Executive Officer, Director)
ApertureDB is a multimodal AI data platform that unifies diverse data types into a searchable database for building and deploying generative AI applications, agents, and RAG workflows.
AI & Machine LearningData & Infrastructure
Aviary Health provides an AI-powered platform that combines intelligent automation with expert clinical teams to deliver end-to-end rehabilitation and care management services to health systems.
AI & Machine LearningDigital HealthHealthtech
Basis Health offers Ready Practice, an all-in-one platform for healthcare providers that combines EHR, scheduling, telehealth, payments, memberships, and marketing tools with a clinical AI assistant that reads labs, builds protocols, and suggests billing codes.
AI & Machine LearningDigital HealthSaaS
Citruslabs is a clinical research organization that designs and runs consumer perception studies, clinical trials, and randomized controlled trials for health and wellness brands including supplements, skincare, pet health, biotech, and functional foods.
BiotechHealthtechMedical DevicesSaaSWellness & FitnessSanta Monica, US
Susanne Mitschke(CEO & Co-Founder)Patrick Renner(COO & Co-Founder)Roger Arellano(CTO & Co-Founder)
Cobalt maps networks of beneficial owners and entity relationships to identify fraud rings, shell structures, and coordinated schemes that evade detection.
AI & Machine LearningEnterprise SoftwareFintech
ConverseNow provides customizable voice AI for hospitality and service businesses to automate customer interactions, improve satisfaction, and reduce staffing needs.
AI & Machine LearningEnterprise Software
CoolrAI is an AI-powered SaaS platform that analyzes cooler and freezer images to provide commercial intelligence for Food & Beverage brands and distributors.
AI & Machine LearningRetail TechSaaSChantilly, US
Durlabh Jain(Director)David Gearhart(Director)Atul Jain(Director)Roy Mehta(Executive Officer, Director)
Fazeshift provides enterprise-grade AI agents that automate accounts receivable processes for organizations, handling transaction processing, cash application, payment communications, and customer experience tasks.
AI & Machine LearningEnterprise SoftwareFintechSan Francisco, US
An AI-powered returns management portal for Shopify merchants that automates returns processing, prevents fraud, and optimizes exchange and refund decisions to reduce costs and boost customer retention in ecommerce.
AI & Machine LearningE-commerceSaaSAustin, US
Bailey Newton(Executive Officer, Director)
BoardYenn Lei(Director)Ryan Broshar(Director)
GlossGenius provides employee management software designed for beauty, wellness, and health businesses.
ConsumerEnterprise SoftwareHR TechMarketing TechSaaSWellness & FitnessNew York City, US
Danielle Cohen-ShohetLeah Cohen-ShohetIan Friedman(Director)Kent Bennett(Director)
Humane Genomics develops oncolytic viral therapies designed to selectively target and kill cancer cells using engineered RNA viruses, particularly Vesicular Stomatitis Virus.
BiotechDeep TechHealthtechMedical DevicesNew York City, US
New York, US
NATASHA TRUEMAN(Executive Officer, Director)DAVID WAXMAN(Director)LISA-MARIE ASSENZA(Executive Officer, Director)
Nextmv provides a decision automation and optimization platform for developers, delivering optimization and scheduling solutions for logistics, delivery, and similar operational challenges.
AI & Machine LearningDeveloper ToolsEnterprise SoftwareLogistics & Supply ChainSaaSPhiladelphia, US
Nimbus acquires and consolidates pulmonary care practices across the United States, unifying them under standardized clinical protocols and connecting patients to care through its own technology platform.
HealthtechMedical DevicesPhoenix, US
Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.
Frequently asked questions
- What stage does 2048 Ventures invest at?
- 2048 Ventures invests at the Pre-Seed, Seed stages.
- What is 2048 Ventures's typical check size?
- 2048 Ventures typically writes checks of $500K – $3M.
- What sectors does 2048 Ventures focus on?
- 2048 Ventures focuses on AI & Machine Learning, Biotech, Deep Tech, Digital Health, FemTech, Healthtech, Longevity.
- Where is 2048 Ventures located?
- 2048 Ventures is headquartered in New York, US.
- Does 2048 Ventures lead rounds?
- Yes, 2048 Ventures leads investment rounds.
From the blog
visit blog ↗2048 Ventures recently closed Fund III and backed Rely Intelligence, an AI-native diligence automation platform for multifamily real estate. The firm also launched a VC Fellowship program for Boston students to source exceptional founders across campus and explore venture careers. AI summary
Media · Podcasts & interviews
featuring the teamStartups Corner Series - Alex Iskold, 2048 Ventures - 2.The Founding Team
ideasvoice · Alex Iskold
Startups Corner Series - Alex Iskold, 2048 Ventures - 1.Business Plan
ideasvoice · Alex Iskold
Let's Build Live: App Building in Interfaces
Airtable
Get Started in Airtable
Airtable
Rejuvenation: Scaling Product Copy with AI Agents to Drive Revenue Growth
Airtable
Live Build: Deploying a Real AI Agent for People, Inc. — On Stage, Start to Finish
Airtable
Images
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Co-investors · 118
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Afore Capital is a $500M pre-seed venture fund that invests in pre-traction, early-stage companies, leveraging product and investment expertise to support founders from day zero.
One Way Ventures is a venture capital firm that backs exceptional immigrant founders building high-impact global companies.
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The Venture Collective (TVC) is a venture capital firm that invests in and supports a portfolio of startups across sectors such as energy and consumer products.
First Star Ventures is a pre-seed fund that backs technical, research-driven founders building companies at the intersection of computing, robotics, biology, and AI.
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▶106 more co-investors
AccelBain Capital VenturesBoxGroupRRE VenturesTrajectory VenturesSocial StartsNext Play VenturesPreston-Werner VenturesOrigin VenturesRTP GlobalUnderscore VCIndicator VenturesAntiImaginary Venture CapitalSterling RoadPanache VenturesAvanta VenturesGV (Google Ventures)Alumni VenturesLong Journey VenturesFounder CollectiveFirst Round CapitalKleiner PerkinsEverywhere VenturesB Capital GroupSound VenturesIVP (Institutional Venture Partners)Norwest Venture PartnersPlug and Play VenturesQuiet CapitalSusa VenturesACME CapitalFirstMarkLiquid VenturesBling CapitalGreycroftPioneerC2 InvestmentsForerunner VenturesFlybridge Capital PartnersCota CapitalBowery CapitalPractical Venture CapitalBullpen CapitalRibbit CapitalHack VCSocial LeverageM13Banana CapitalUncorrelated VenturesPareto HoldingsGaingelsCyberstartsAngelPadEntree CapitalMS&AD VenturesCowboy VenturesStandard CapitalNextGen Venture Partnersboldstart venturesBrainchild HoldingsAugust CapitalTeamworthy VenturesTransmedia CapitalDecibel PartnersAnthemis VentureFf Venture CapitalBlackbird Venturesxfactor venturesCapital FactoryMarcy Venture PartnersMulticoin CapitalNotation CapitalBoost VCDrive CapitalEnsemble VCRally Ventures Management, LlcScout VenturesBECO CapitalCurious CapitalCorrelation Ventures14WCyfrinAlpaca VCTA VenturesDimension CapitalForgePoint CapitalFactorial CapitalBread And Butter Ventures, LlcRichmond Global VenturesSyngenta Group VenturesNKM CapitalAsymmetric Capital PartnersLooking Glass CapitalDynamo VenturesWaverley CapitalSupernode VenturesC2 VenturesLaconiaTechAviv Founder PartnersNavitas CapitalSandalphon CapitalEveningGamegroove CapitalAvant BioNetwork Society Ventures
Firms observed investing alongside 2048 Ventures, from public investor directories. Shared companies are the overlap with 2048 Ventures's recorded portfolio.
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