/Companies

Cofactor Genomics

YC S15

St. Louis, US · Founded 2015 · Delaware corporation · 13 employees · 18 known investors

Find your way into Cofactor Genomics

Sign up to see every warm intro you have to Cofactor Genomics

  • Paths you didn't know you had: your email and LinkedIn already hold routes to the Cofactor Genomics team. We find them for you
  • 2nd- and 3rd-degree connections: the friend-of-a-friend routes that take hours to manually find through your inbox or LinkedIn
  • Answers now, not in days: momentum is everything in a raise. Skip asking around whether someone knows someone

Days of research, done the moment you sign in, with every route ranked by how warm it is.

Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response. The company serves oncology and precision medicine markets by enabling more accurate patient-to-therapy matching.

AI & Machine LearningBiotechHealthtechMedical DevicesDiagnosticsUnited States of AmericaAmerica / CanadaPartly Remote

Founders & leadership· Y Combinator alumni (S15)

Cofactor Genomics was founded in 2015 by Dave Messina, Jarret Glasscock, Jarret Glassock, and Jon Armstrong.

DMDave Messina
Dave MessinaFounder and Chief Operating Officer2016–2024Dave Messina founded Cofactor Genomics, an RNA and machine learning company that achieved Medicare reimbursement, and has over 25 years of experience in healthcare including prior work on the Human Genome Project. Since 2019, he has led healthcare investments at Pioneer Fund.
JGJarret Glasscock
Jarret GlasscockCo-founder · President & CTOJarret Glasscock is a computational biologist and geneticist who co-founded Cofactor Genomics after serving as faculty in the Department of Genetics at Washington University and at The Genome Institute, where he contributed to early human genome sequencing work and led the Computational Biology Group.
JG
Jarret GlassockCo-founder
JAJon Armstrong
Jon ArmstrongCo-Founder and Chief Scientific Officer2014–2021Jon Armstrong helped establish transcriptomic diagnostics and machine learning approaches for precision oncology at Cofactor Genomics, and previously developed next-generation sequencing technologies at Jumpcode Genomics. He is now co-founder and chief scientific officer of Amptiv Bio, focused on RNA therapeutics combining molecular biology, chemistry, and computational methods.
JW
Jonathan WaldSoftware Engineering Intern2009–2009

Board

MAMatthew A. Ocko
Matthew A. OckoBoard directorFounder and Managing Partner at DCVC (Data Collective)
MSMark Siegel
Mark SiegelBoard directorPartner Emeritus at Menlo Ventures

Investors · 18

Ascension Ventureslisted by Ascension VenturesSaint Louis · $10M – $20M

How we know: a partner's Signal profile · funding news · press coverage · Not right? Tell us

Fifty Yearslisted by Fifty YearsSan Francisco · $250K – $2M

How we know: Fifty Years's portfolio page · the VCSheet dataset · Y Combinator's founder network · Not right? Tell us

Menlo Ventureslisted by Menlo VenturesSan Francisco · $1M – $20Mvia Mark Siegel · board

How we know: Menlo Ventures's portfolio page · board seat on SEC Form D · funding news · press coverage · the VCSheet dataset · Y Combinator's founder network · Not right? Tell us

Growbig Venturesreported

How we know: Y Combinator's founder network · Not right? Tell us

Millennium ManagementreportedNew York

How we know: Y Combinator's founder network · Not right? Tell us

Sapphire VenturesreportedAustin · $5M – $20M

How we know: Y Combinator's founder network · Not right? Tell us

Stanford UniversityreportedStanford

How we know: Y Combinator's founder network · Not right? Tell us

Sv Tech Ventures, Inc.reportedPalo Alto

How we know: Y Combinator's founder network · Not right? Tell us

TenOneTen VenturesreportedLos Angeles · $500K – $5M

How we know: the VCSheet dataset · Y Combinator's founder network · Not right? Tell us

Venture Investment AssociatesreportedPeapack

How we know: Y Combinator's founder network · Not right? Tell us

Reported raises · per SEC filings

Form D private placements

$18.8M disclosed across 3 rounds · 2017–2023

▶$1.2MraisedAug 2023 · 2 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • William HagstromDirector
  • David MessinaExecutive Officer
  • John KuelperExecutive Officer, Director
  • Jarret GlasscockExecutive Officer, Director
  • Mark SiegelDirector
Offering amount
$2M
Amount sold
$1.2M
First sale
Jul 2023
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$6.9MraisedDec 2021 · 9 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Jarret GlasscockExecutive Officer, Director
  • David MessinaDirector
  • John KuelperExecutive Officer, Director
  • William HagstromDirector
  • Armen VidianDirector
  • Mark SiegelDirector
  • Jon ArmstrongDirector
Offering amount
$7.1M
Amount sold
$6.9M
First sale
Dec 2021
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$10.7MraisedJun 2017 · 23 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Jarret GlassockExecutive Officer, Director
  • Matthew A. OckoDirector
  • Jon ArmstrongDirector
  • Mark SiegelDirector
Offering amount
$15.1M
Amount sold
$10.7M
First sale
Jun 2017
Incorporated
Corporation, Delaware, 2015
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

Founder mafia

4 people who came through Cofactor Genomics went on to found or lead other companies.

Related companies · 9

DeleeDEWI11 is an online gaming platform that provides information and articles about online games, including game updates, seasonal changes, new features, and strategies for players.
Luminist LabsLuminist Labs provided a non-invasive test to identify and assess the progression of liver fibrosis and NASH in patients. The company was acquired by DiscernDx in 2020.
NumenNumen develops at-home cancer diagnostics and health data collection infrastructure using machine learning models to enable earlier intervention and improve patient outcomes.
BiocartesianBiocartesian provides optical pooled screening services for functional genomics research. The company uses its proprietary ARADIA technology to link microscopy-based cellular phenotypes with genetic perturbations, enabling researchers to conduct large-scale CRISPR screens and other genomic studies with visual, spatial, and live-cell readouts.
Pando BiosciencePando develops enzyme design and optimization using machine learning to accelerate the design-build-test-learn cycle for biotechnology applications.
OupOxford University Press (OUP) provides dictionary data, language datasets, and lexical content in over 60 languages to power digital literacy tools, educational software, gaming platforms, and media experiences. The company works across reading apps, word games, quiz shows, and broadcast media to expand access to language learning and comprehension.
IDbyDNAScalable, high throughput DNA sequencing platforms.
Massive BioMassive Bio operates an AI-based platform that matches cancer patients with oncology clinical trials and provides concierge support throughout the trial process. It serves patients across the U.S., Canada, Latin America, and Europe, and works with pharma and CRO customers, patient advocacy organizations, and the National Cancer Institute's network of cancer centers.
AbcamSupplier of protein research tools to life scientists. Publicly listed on the LSE following an IPO.

Companies working in the same space as Cofactor Genomics.

Non-dilutive funding · 2 SBIR/STTR awards

Federal grants — no equity taken
AgencyPhaseYearAmount
National Institutes of Health (NIH)National Institutes of HealthPhase II2015$1.4M
National Institutes of Health (NIH)National Institutes of HealthPhase I2014$161.5K

Source: SBIR.gov award data (U.S. Small Business Administration). SBIR/STTR awards are competitive federal R&D grants and contracts — non-dilutive capital alongside any venture rounds above.

Legal entities · 2

corporate structure
Cofactor Genomics
Cofactor Genomics, Inc.

In the news

Frequently asked questions

What does Cofactor Genomics do?
Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response. The company serves oncology and precision medicine markets by enabling more accurate patient-to-therapy matching.
Who founded Cofactor Genomics?
Cofactor Genomics was founded by Dave Messina, Jarret Glasscock, Jarret Glassock, Jon Armstrong in 2015.
Who are Cofactor Genomics's investors?
Cofactor Genomics's investors include Argonautic Ventures, Ascension Ventures, DCVC (Data Collective), Fifty Years, iSelect Fund, Jude Gomila, Menlo Ventures, Mission and Market and 10 more.
How much funding has Cofactor Genomics raised?
Cofactor Genomics has disclosed $18.8M raised across 3 rounds.
Where is Cofactor Genomics headquartered?
Cofactor Genomics is headquartered in St. Louis, US.