Cofactor Genomics
YC S15St. Louis, US · Founded 2015 · Delaware corporation · 13 employees · 18 known investors
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Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response. The company serves oncology and precision medicine markets by enabling more accurate patient-to-therapy matching.
Founders & leadership· Y Combinator alumni (S15)
Cofactor Genomics was founded in 2015 by Dave Messina, Jarret Glasscock, Jarret Glassock, and Jon Armstrong.



Board


Investors · 18
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How we know: iSelect Fund's portfolio page · Y Combinator's founder network · Not right? Tell us
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How we know: Menlo Ventures's portfolio page · board seat on SEC Form D · funding news · press coverage · the VCSheet dataset · Y Combinator's founder network · Not right? Tell us
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Reported raises · per SEC filings
Form D private placements$18.8M disclosed across 3 rounds · 2017–2023
▶$1.2MraisedAug 2023 · 2 investors · BiotechnologyRule 506(b)
- William HagstromDirector
- David MessinaExecutive Officer
- John KuelperExecutive Officer, Director
- Jarret GlasscockExecutive Officer, Director
- Mark SiegelDirector
- Offering amount
- $2M
- Amount sold
- $1.2M
- First sale
- Jul 2023
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$6.9MraisedDec 2021 · 9 investors · BiotechnologyRule 506(b)
- Jarret GlasscockExecutive Officer, Director
- David MessinaDirector
- John KuelperExecutive Officer, Director
- William HagstromDirector
- Armen VidianDirector
- Mark SiegelDirector
- Jon ArmstrongDirector
- Offering amount
- $7.1M
- Amount sold
- $6.9M
- First sale
- Dec 2021
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$10.7MraisedJun 2017 · 23 investors · BiotechnologyRule 506(b)
- Jarret GlassockExecutive Officer, Director
- Matthew A. OckoDirector
- Jon ArmstrongDirector
- Mark SiegelDirector
- Offering amount
- $15.1M
- Amount sold
- $10.7M
- First sale
- Jun 2017
- Incorporated
- Corporation, Delaware, 2015
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
Founder mafia
4 people who came through Cofactor Genomics went on to found or lead other companies.
Related companies · 9
Companies working in the same space as Cofactor Genomics.
Non-dilutive funding · 2 SBIR/STTR awards
Federal grants — no equity taken| Agency | Phase | Year | Amount |
|---|---|---|---|
| National Institutes of Health (NIH)National Institutes of Health | Phase II | 2015 | $1.4M |
| National Institutes of Health (NIH)National Institutes of Health | Phase I | 2014 | $161.5K |
Source: SBIR.gov award data (U.S. Small Business Administration). SBIR/STTR awards are competitive federal R&D grants and contracts — non-dilutive capital alongside any venture rounds above.
Legal entities · 2
corporate structureIn the news
Frequently asked questions
- What does Cofactor Genomics do?
- Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response. The company serves oncology and precision medicine markets by enabling more accurate patient-to-therapy matching.
- Who founded Cofactor Genomics?
- Cofactor Genomics was founded by Dave Messina, Jarret Glasscock, Jarret Glassock, Jon Armstrong in 2015.
- Who are Cofactor Genomics's investors?
- Cofactor Genomics's investors include Argonautic Ventures, Ascension Ventures, DCVC (Data Collective), Fifty Years, iSelect Fund, Jude Gomila, Menlo Ventures, Mission and Market and 10 more.
- How much funding has Cofactor Genomics raised?
- Cofactor Genomics has disclosed $18.8M raised across 3 rounds.
- Where is Cofactor Genomics headquartered?
- Cofactor Genomics is headquartered in St. Louis, US.

















