Cofactor Genomics
YC S15 ↗St. Louis, US · Founded 2015 · Delaware corporation · 13 employees · 8 known investors
Cofactor Genomics develops predictive diagnostics for cancer immunotherapy using RNA-expression models to characterize tumor microenvironments and predict patient response. The company serves oncology and precision medicine markets by enabling more accurate patient-to-therapy matching.
AI & Machine LearningBiotechHealthtechMedical DevicesDiagnosticsin /cofactorgenomics/@cofactorgenomicycombinator.com ↗

Founders & leadership· Y Combinator alumni (S15)
DM
Dave Messinain𝕏Founder/COO
JG
Jarret GlasscockinFounder/CTO
JG
Jarret GlassockExecutive Officer, Director
MA
Matthew A. OckoDirector
JA
Jon ArmstrongDirector
MS

Mark SiegelDirector
Investors · 8
Argonautic VenturesNew York · $5M
Ascension VenturesSaint Louis · $10M – $20M
DCVC (Data Collective)Palo Alto · $5M – $25M
Fifty YearsSan Francisco · $250K – $2M
iSelect FundSt. Louis · $250K – $2M
Menlo VenturesSan Francisco · $1M – $20Mvia Mark Siegel · board
Y CombinatorSan Francisco · $500K
TenOneTen VenturesreportedLos Angeles · $500K – $5M
Reported raises · per SEC filings
Form D private placements▶$1.2MraisedAug 2023 · 2 investors · BiotechnologyRule 506(b)
▶$1.2MraisedAug 2023 · 2 investors · Biotechnology
Rule 506(b)Officers, directors & promoters on the filing
- William HagstromDirector
- David MessinaExecutive Officer
- John KuelperExecutive Officer, Director
- Jarret GlasscockExecutive Officer, Director
- Mark SiegelDirector
- Offering amount
- $2M
- Amount sold
- $1.2M
- First sale
- Jul 2023
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$6.9MraisedDec 2021 · 9 investors · BiotechnologyRule 506(b)
▶$6.9MraisedDec 2021 · 9 investors · Biotechnology
Rule 506(b)Officers, directors & promoters on the filing
- Jarret GlasscockExecutive Officer, Director
- David MessinaDirector
- John KuelperExecutive Officer, Director
- William HagstromDirector
- Armen VidianDirector
- Mark SiegelDirector
- Jon ArmstrongDirector
- Offering amount
- $7.1M
- Amount sold
- $6.9M
- First sale
- Dec 2021
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$10.7MraisedJun 2017 · 23 investors · BiotechnologyRule 506(b)
▶$10.7MraisedJun 2017 · 23 investors · Biotechnology
Rule 506(b)Officers, directors & promoters on the filing
- Jarret GlassockExecutive Officer, Director
- Matthew A. OckoDirector
- Jon ArmstrongDirector
- Mark SiegelDirector
- Offering amount
- $15.1M
- Amount sold
- $10.7M
- First sale
- Jun 2017
- Incorporated
- Corporation, Delaware, 2015
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
In the news
- In Brief This Week: Cofactor Genomics, Biocartis, Caris Life Sciences, More | GenomeWebgenomeweb.com · 2025
- Cofactor Genomics Receives Investment from Labcorp and Ascension Venturesfinsmes.com · 2025
- Investors – Cofactor Genomicscofactorgenomics.com · 2019
- Cofactor Genomics Announces $18 Million Funding In An Oversubscribed Series-A Round To Bring RNA To Precision Medicine - BioSpacebiospace.com · 2017
- Cofactor Genomics Awarded $1.5M NIH Grant for Circular RNA Enrichment Tech | GenomeWebgenomeweb.com · 2015
