Fundraising Fox
20 people tracked
Also known as Palo Santo
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Investment thesis
Palo Santo backs next-generation neuroscience companies advancing breakthrough therapeutics and technologies for mental health, spanning discovery through clinical translation. Its portfolio concentrates on drug discovery platforms, psychedelic and serotonergic pharmaceuticals, neurotechnology, and mental health treatment services aimed at neurological and psychiatric disorders.
Source: firm website, verified Sep 27, 2026.
Team · 20 people
from the firm's website & public directories
Founder mafia
3 people who came through Palo Santo VC went on to found or lead other companies.
What they invest in
from 21 of 30 portfolio companiesBiotech ×19Digital Health ×14Healthtech ×10Mental Health ×8Deep Tech ×7Medical Devices ×6AI & Machine Learning ×4EdTech ×1
HQs:United States×10Australia×1Canada×1
Who they back
founder profiles across 14 portfolio companiesFounding team size:solo founder×32 founders×83 founders×14+ founders×2
What their founders studiedfrom 16 founders with field-of-study data
Chemistry ×5Economics ×3Life Sciences ×3Business & Management ×2Mathematics & Statistics ×2
Where their founders worked beforefrom 16 founders with career history
Columbia University in the City of New York ×2Entheos Labs ×2Gilgamesh Pharma ×2Harvard Medical School ×2Massachusetts General Hospital ×2Neurogen Corporation ×2
Investments · 30 tracked
founders shown can be your intro pathBy year:2024 · 12022 · 12021 · 42019 · 17 dated
2AB BioscienceS develops first-in-class small molecule therapeutics targeting the 5-HT2A receptor for ophthalmology and central nervous system disorders.
BiotechDeep TechDigital HealthEdTechHealthtechMedical DevicesSanta Monica, US
Alex Speiser(Co-Founder & Chief Executive Officer)inCharles Nichols, PhD(Co-Founder & Chief Science Officer)David Nichols, PhD(Co-Founder & Head of Chemistry)Tim Foster, PhD(Co-Founder & Head of Translational Discovery)
BoardGopal Das(Director)
Co-investorsLIONHEART VENTURESTabula Rasa VenturesWhat If Ventures
AtaiBeckley develops rapid-acting and durable mental health treatments for patients with difficult-to-treat mental health conditions.
BiotechMedical DevicesMental Health
Christian AngermayerCosmo Feilding Mellen(Founder)inSrinivas Rao
Co-investorsBailey Venture PartnersFJ LabsIter InvestmentsLeafy TunnelMaiora Rebel VenturesNoetic+4 more
BRC Therapeutics develops and manufactures botanically-derived pharmaceutical products, with expertise spanning drug development and manufacturing for pharmaceutical applications.
BiotechDigital HealthHealthtechMedical Devices
George Hodgin(Founder and CEO)inCharles Schumacher
Co-investorsDelta Emerald Ventures
Bright Minds Biosciences develops selective serotonin receptor agonists (5-HT2A and 5-HT2C) without 5-HT2B activity, built on a proprietary chemistry platform.
BiotechDeep TechHealthtechNew York, US
Alan Kozikowski(Executive Officer, Director)inIan McDonaldRyan Cheung(Chief Financial Officer)JAN PEDERSEN(Chief Science Officer)Gideon Shapiro(Executive Officer)Revati Sheeniwas(Executive Officer)
Co-investorsLifeSci Venture PartnersPsyMed Ventures
Delix Therapeutics develops third-generation, non-hallucinogenic neuroplastogens for people with neurological conditions, using a discovery platform to identify novel compounds.
BiotechDigital HealthMedical Devices
David Olson(Founder)David Olson Nick Haft(Founder)Nick Haft(Founder)
Co-investorsArtis VenturesBailey Venture PartnersCasa Verde CapitalDolby Family VenturesNoeticOMX Ventures+7 more
Diamond Therapeutics is a preclinical biotechnology company developing drug treatments for psychiatric and neurological disorders, with a focus on the pharmacology and therapeutic use of psychedelic compounds.
BiotechHealthtechMental HealthToronto, CA
Judy Blumstock(Chief Executive Officer, Founder, Director)inMichael B. McDonnell(Chief Medical Officer)Grant McCutcheon(Chief Financial Officer)in
Co-investorsJLSNoeticNew Enterprise Associates (NEA)Nextech InvestRA Capital
Fauna Bio applies AI and computational analysis to its proprietary biobank of data from extreme mammals such as hibernating species to identify drug targets that are conserved across species including humans.
AI & Machine LearningBiotechDeep TechHealthtechEmeryville, US
Linda Goodman(Founder)inAshley(CEO)
Co-investorsage1Farvatn VentureGRIDS CapitalLifeforce CapitalLifespan Vision VenturesMetaplanet+7 more
Gilgamesh Pharmaceutical develops novel chemical entities for psychiatric disorders using medicinal chemistry and AI-powered translational platforms to design rapid-acting therapies targeting neurobiological mechanisms rather than symptom management.
AI & Machine LearningBiotechDigital HealthHealthtechNew York City, US
Jonathan Sporn(Founder)inAndrew Kruegel(Founder)inDalibor Sames(Founder)inAndrew Kruegel, Ph.D.(Executive Officer)Thomas Kevin Murphy, Ph.D.(Executive Officer)JONATHAN SPORN(Founder)in
Co-investorsAera VCAlumni VenturesAwareness VentureFrontera Technology VenturesFrontier Path VCJames Beshara Fund+26 more
Journey Clinical provides ketamine-assisted psychotherapy (KAP) for depression, anxiety, and PTSD, partnering patients with licensed therapists and medical teams while coordinating with major insurance providers.
Digital HealthMedical DevicesMental Health
Jonathan Sabbagh(Founder)inMyriam Barthes(Founder)in
Co-investorsAble PartnersAlleyCorpCoalition OperatorsFifty YearsFJ LabsMantis Capital+9 more
Kadence Bio is a clinical-stage life sciences company developing therapeutics for conditions in sexual and mental health.
BiotechDigital HealthMental Health
Active seed-stage healthcare company
Eugene, US
Nicholas Allen(Chief Executive Officer)Phillip Scripa(Chief Financial Officer and Secretary)William Shortt(Chief Operating Officer)Jan Hardorp(Director)in
Co-investorsBIP VenturesJLSWPSS Investmentsre.Mind Capital
Modulate Bio develops small-molecule GABAA positive allosteric modulators to treat neurological disorders including Essential Tremor, epilepsy, and anxiety.
BiotechDeep TechHealthtechAllston, US
Dario Doller(Co-founder)inKevin Hodgetts(Founding Lab / Co-founder)inAndrew Thomson(Executive Officer, Director, Promoter)in
Co-investorsPillar VCHealthspan Capital
MycoMedica Life Sciences is a biopharmaceutical company developing psilocybin-based treatments for mental health and neurodegenerative disorders.
BiotechDigital HealthMental HealthShelton, US
Co-investorsLauder PartnersObvious VenturesTrue Ventures
Pangea Bio develops therapies targeting central nervous system and mental health disorders by activating the TrkB receptor pathway to promote neuronal survival and synaptic plasticity.
BiotechDeep TechDigital Health
Co-investorsMetaplanetNO LABEL VENTURESSeaside VenturesVox CapitalXEIA Venture Partners
Reunion Neuroscience is a clinical-stage biopharmaceutical company developing serotonergic psychedelic therapies for mental health conditions such as postpartum depression, adjustment disorder, and generalized anxiety disorder.
BiotechDigital HealthMental HealthMorristown, US
Sahil V. Kirpekar(President and CEO)inGregory Mayes(Executive Officer, Director)Ellen Lubman(Director)Mark Pollack(Executive Officer)inNathan Bryson(Executive Officer)inMark Theeuwes(Executive Officer)in
Co-investorsFemHealth VenturesMitsui Global InvestmentMPM BioImpactNovo Holdings
Sensorium Therapeutics is a clinical-stage biotech company developing novel CNS therapies for anxiety, epilepsy, and cognitive dysfunction using its SensAI platform, which integrates AI, chemistry, and curated natural product data to identify therapeutic patterns from over 50 million biological relationships.
AI & Machine LearningBiotechDigital HealthMedford, US
Jerrold Rosenbaum(Director)inJacob Hooker(Executive Officer, Director)inPranav Tadi(Executive Officer)
BoardRyan Katz(Director)inKevin Lalande(Director)inRichard Simon(Director)
Co-investorsBonaventure Equity, LLCHatteras Venture PartnersIter InvestmentsMission BiocapitalRoute 66 VenturesService Provider Capital+3 more
Syndeio Biosciences is a synapse-focused biotech developing precision neurotherapeutics for neuropsychiatric, mental health, and cognitive disorders such as depression and Alzheimer's.
AI & Machine LearningBiotechDigital Health
Co-investorsEvolution VC PartnersTenmileCatalio Capital Management
Tactogen develops patented new chemical entities, including benzofuran-based compositions, and conducts preclinical research and publishes data on these compounds.
BiotechDeep TechHealthtech
Matthew Baggott(CEO)in
Co-investorsLeafy TunnelNoeticPsyMed Ventures10X CapitalWefunder
Transcend Therapeutics develops rapid-acting pharmaceutical treatments for neuropsychiatric diseases, including PTSD and depression, targeting patients unresponsive to current psychiatric medications.
BiotechDigital HealthMedical DevicesMental Health
Blake Mandell(Co-Founder & CEO)in
Co-investorsAlleyCorpAlpha Wave GlobalAlumni VenturesEmerald Development ManagersFJ LabsAlley Robotics Ventures
Wavepaths develops adaptive therapeutic music designed to support mental health and wellness practitioners in their sessions.
Digital HealthMental HealthWellness & Fitness
Mendel Kaelen(Founder & CEO)in
Co-investorsMITONReflex CapitalTabula Rasa VenturesEmpath VenturesLIONHEART VENTURESNeo Kuma Ventures
Xylo develops mechanism-based drug therapies targeting psychiatric and neurological disorders using computational and rational drug design approaches.
BiotechDeep TechDigital HealthHealthtechSydney, AU
Joshua Ismin(Co-founder, President)inDr. Sam Banister(Co-founder, Chief Scientific Officer)
Co-investorsRadar VenturesTenmileXEIA Venture PartnersCapitalTCommon MagicSure Valley Ventures
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
<UNKNOWNatai Life SciencesBeacon BiosignalsBionomicsBlackbox BioCybinFluenceneurocarePsy Therapeutics
Portfolio news
latest coverage across their companiesKsana Health · prnewswire.com · May 14, 2026
Frequently asked questions
- How many investments has Palo Santo VC made?
- Palo Santo VC has 30 tracked investments.
- What sectors does Palo Santo VC focus on?
- Palo Santo VC focuses on AI & Machine Learning, Biotech, Deep Tech, Digital Health, Healthtech, Mental Health.
- Who does Palo Santo VC co-invest with?
- Palo Santo VC most often shares deals with Noetic, PsyMed Ventures, WPSS Investments, among 75 tracked co-investors.
Co-investors · 9
Pioneer Fund is an investment fund backed by 540+ Y Combinator alumni that invests in and supports top startups coming out of Y Combinator.
Fifty Years (50Y) is a pre-seed and seed-focused venture capital firm that backs founders using technology to solve major global problems, and also helps start companies.
500 Global (formerly 500 Startups) is a venture capital firm whose flagship Silicon Valley strategy backs promising technology companies from pre-seed onward across a range of sectors and geographies.
Dawn Capital is a European venture capital firm backing companies with global ambitions.
Avalanche is a private investment firm led by Katelyn Donnelly that invests early in technology companies at structural inflection points, pairing capital with operational experience in complex markets like government, energy, and critical infrastructure.
Amino Collective is an early-stage venture firm that backs bold, unconventional founders willing to explore uncharted territory.
Blueyard is a small equal partnership with offices in the US and Europe, investing in early-stage companies.
Cerulean Ventures is a venture capital firm that backs founders using AI to digitize and transform traditionally under-digitized physical-world industries such as manufacturing, supply chains, maritime, food and agriculture, and energy.
Cambridge Angels is a UK business angel network that has been providing capital and operational support to entrepreneurs since 2001, backing more than 150 companies.
Firms observed investing alongside Palo Santo VC, from public investor directories. Shared companies are the overlap with Palo Santo VC's recorded portfolio.
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