15 people tracked
Investment thesis
Mental health represents a generational challenge affecting over one billion people globally, with depression and anxiety alone costing the economy over $1 trillion annually despite largely unchanged standards of care over 50 years. Novel therapeutics, particularly next-generation psychedelics, are advancing through late-stage clinical trials with unprecedented efficacy data and FDA Breakthrough Therapy Designations. Palo Santo invests across the neuroscience and mental health landscape to accelerate precision neuroscience through CNS therapeutics and brain health technologies with the potential to transform patient outcomes.
Source: firm website, verified Aug 6, 2026.
Team · 15 people
from the firm's website & public directories
Founder mafia
2 people who came through Palo Santo VC went on to found or lead other companies.
Investments · 1 tracked
founders shown can be your intro pathHarnessing the serotonin system to combat inflammatory diseases
Frequently asked questions
- What sectors does Palo Santo VC focus on?
- Palo Santo VC focuses on Biotech, Deep Tech, Healthtech, Mental Health.
Co-investors · 9
Pioneer Fund is a venture capital firm investing in the top Y Combinator startups.
500 Global (formerly 500 Startups) is a venture capital firm whose flagship Silicon Valley strategy backs promising technology companies from pre-seed onward across a range of sectors and geographies.
Dawn Capital is a European venture capital firm backing companies with global ambitions.
Fifty Years (50Y) is a pre-seed and seed-focused venture capital firm that backs founders using technology to solve major global problems, and also helps start companies.
Avalanche is a private investment firm led by Katelyn Donnelly that invests early in technology companies at structural inflection points, pairing capital with operational experience in complex markets like government, energy, and critical infrastructure.
Amino Collective is an early-stage venture firm that backs bold, unconventional founders willing to explore uncharted territory.
Blueyard is a small equal partnership with offices in the US and Europe, investing in early-stage companies.
Cerulean Ventures is a venture capital firm that backs founders using AI to digitize and transform traditionally under-digitized physical-world industries such as manufacturing, supply chains, maritime, food and agriculture, and energy.
Cambridge Angels is a UK business angel network that has been providing capital and operational support to entrepreneurs since 2001, backing more than 150 companies.
Firms observed investing alongside Palo Santo VC, from public investor directories. Shared companies are the overlap with Palo Santo VC's recorded portfolio.
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