Fundraising Fox
Big Brain Holdings
Venture capitalLos Angeles · Seed–Growth · 4 people tracked
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Investment thesis
Big Brain Holdings applies first-principles thinking to back founders redefining the intersection of intelligence, autonomy, and infrastructure. Rooted in a cypherpunk ethos, the firm supports conviction-driven visionaries pursuing radical ideas. It takes concentrated, long-term positions in companies with the potential to reshape industries, spanning artificial intelligence (foundation models, inference infrastructure, AI-native applications, agentic systems), robotics (humanoid robots, autonomous and industrial systems, embodied AI), decentralized infrastructure (blockchain protocols, decentralized compute networks, Web3 primitives), and consumer and deep-technology companies solving fundamental problems. As a multi-strategy, multi-stage global firm, it invests both directly in startups and in other funds.
Source: firm website, verified Sep 26, 2026.
Team · 4 people
from public directoriesFounder mafia
2 people who came through Big Brain Holdings went on to found or lead other companies.
What they invest in
from 97 of 114 portfolio companiesCrypto & Web3 ×61Fintech ×38AI & Machine Learning ×37Data & Infrastructure ×33Developer Tools ×22Deep Tech ×15Cloud Computing ×11Hardware ×9
HQs:United States×29United Arab Emirates×1Canada×1Estonia×1United Kingdom×1Singapore×1
Who they back
founder profiles across 43 portfolio companiesFounding team size:solo founder×212 founders×103 founders×74+ founders×5
Where their founders studiedfrom 55 founders with education data
Massachusetts Institute of Technology ×5Stanford University ×4Princeton University ×3University of California, Berkeley ×3Harvard Business School ×2Purdue University ×2Queen's University ×2UCLA ×2
What their founders studiedfrom 58 founders with field-of-study data
Computer Science ×26Engineering ×18Business & Management ×4Economics ×3Mathematics & Statistics ×3Design & Architecture ×2
Where their founders worked beforefrom 64 founders with career history
Meta ×4Intel ×3McKinsey & Company ×3Protocol Labs ×3Stanford University ×3Carnegie Mellon University ×2Cisco ×2Dorm Room ×2
Accelerator rootsportfolio companies that came through a program
15 founders hold a PhD · 4 hold an MBA (of 62 with degree data)
Investments · 114 tracked
founders shown can be your intro pathBy year:2026 · 32025 · 62024 · 82023 · 52022 · 82021 · 22019 · 12016 · 235 dated
A digital asset treasury company that acquires and holds Solana tokens to maximize SOL per share through treasury management and staking activities, while maintaining a secondary focus on neurotechnology for neurological wellness.
BiotechHealthtechNewtown, US
Antonella Favit-Von Pelt(Executive Officer)Jeffrey S. Mathiesen(Executive Officer, Director)Jonathan Sackier(Executive Officer)Amanda Tseng(Executive Officer)Philippe Deschamps(Executive Officer, Director)Joyce LaViscount(Director)
Co-investorsAnimoca BrandsArrington CapitalAspen DigitalAvenirColumbus CapitalHashkey Capital+3 more
Upexi is a Solana-focused treasury company that acquires, holds, and stakes SOL tokens to give investors digital asset exposure through a publicly traded equity security (UPXI).
Crypto & Web3FintechTampa, US
Andrew Nordstrud(Chief Financial Officer)Allan Marshall(Chief Executive Officer)inRobert Hackett(Executive Officer, Director)
BoardGene Salkind(Director)Lawrence H. Dugan(Director)Thomas C. Williams(Director)
Co-investorsWhite Star CapitalGSR
CrossCurve is a cross-chain DeFi protocol built around its Cross-chain Data Protocol (CDP), a messaging and transport layer for transferring data and liquidity between blockchains, supporting products such as a cross-chain bridge, liquidity protocol, and DEX.
Crypto & Web3Developer ToolsFintech
Boris Povar(Founder)in
Co-investorsDraper AssociatesFenbushi CapitalGBV CapitalMarshland CapitalBitDAOMantle Network+1 more
decent.land builds onchain data infrastructure — an "onchain data center" for storing, verifying, and computing with blockchain data at scale, secured by Arweave and HyperBEAM.
Crypto & Web3Data & InfrastructureDeveloper Tools
Co-investorsLD CapitalDeep VenturesForesight VenturesNarwhal VenturesTsingTech VenturesY Combinator
Eywa provides a MetaLayer and API for building in DeFi, offering a single integration for cross-chain routing, deep liquidity access, and automated on-chain operations across EVM and non-EVM networks with gasless execution.
Crypto & Web3Developer ToolsFintech
Co-investorsFenbushi CapitalGBV CapitalMarshland CapitalAfford.CapitalG1 VenturesMulana Capital
Fairside provides membership-based insurance coverage that reimburses crypto holders for losses from theft, hacks, and scams such as malicious transactions, malware, and address poisoning.
Crypto & Web3FintechInsurTech
Co-investorsTRGCDominance VenturesFigment CapitalJump CapitalKosmos VenturesLaser Digital+3 more
Helika builds Helika Evolve, a brand-safe AI character platform that lets IP owners deploy interactive characters trained on their approved content to engage fans in real time across Discord, web, social, and community channels.
AI & Machine LearningGamingMarketing Tech
Anton(Founder & CEO)Ilya(CPO)
Co-investorsDiagramPantera CapitalBuilder CapitalFenbushi CapitalSparkle VenturesFermion
Aethir operates a distributed cloud compute platform providing enterprise-grade GPU resources for AI model training, fine-tuning, inference, and low-latency cloud gaming.
AI & Machine LearningCloud ComputingCrypto & Web3
Mark Rydon(Founder)in
Co-investorsAndromeda CapitalAnimoca BrandsBeamBuilder CapitalCVP NoLimitGTS Ventures+13 more
Agility Robotics develops and deploys humanoid robots for warehouse automation and logistics operations.
AI & Machine LearningHardwareLogistics & Supply ChainRoboticsSalem, US
Jonathan Hurst(Co-founder & Chief Robot Officer)inDamion Shelton(Co-Founder & Chairman of the Board)in
BoardBruce Leak(Director)inMatthew Ocko(Director)in
Co-investorsDCVC (Data Collective)HARPER COURT VENTURESManhattan Venture PartnersMFV PartnersNVenturesNVIDIA+8 more
AheadComputing develops high-performance 64-bit RISC-V application processor cores designed to maximize per-core CPU performance for AI, cloud, client, mobile, and edge workloads.
AI & Machine LearningDeep TechSemiconductorsBeaverton, US
Debbie Marr(Founder)inJonathan Pearce(Founder)inSrikanth Srinivasan(Founder)
BoardGreg Reichow(Director)inJim Keller(Director)
Co-investorsCambium CapitalEclipse VenturesMESHTrousdale VenturesFundomoMaverick Capital+1 more
Akave provides isolated, persistent object storage for AI and machine learning workloads, enabling customers to store datasets, model weights, and training artifacts with tenant-level data isolation and compliance capabilities.
AI & Machine LearningCloud ComputingData & InfrastructureDeep Tech
Stefaan Vervaet(Founder)inAngelo Schalley(Founder)inDaniel León(Founder)in
Co-investorsCVP NoLimitNo Limit Holdings (NLH)
Ambient builds an open, decentralized network for AI inference that ensures every answer can be verified and no single provider can control model delivery.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper Tools
Co-investorsAllegion Ventures
Apptronik builds humanoid robots designed to perform repetitive, physically taxing, and dangerous tasks in warehousing and manufacturing environments, aiming to free workers for higher-value activities.
Advanced ManufacturingAI & Machine LearningHardwareRoboticsAustin, US
Jeff Cardenas(Co-founder & CEO)inNicholas Arden Paine(Executive Officer, Director)
BoardClarence Gordon Daugherty, IV(Director)Howard Lee Morgan(Director)inGeorge Samuel Rose(Director)
Co-investors1435 CapitalAssembly VenturesAtinum Investment Co. Ltd.B Capital GroupB4 CapitalBaseTwo+34 more
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Arch is a Bitcoin-native chain and execution environment (ArchVM) that lets institutions and users borrow, lend, earn yield, swap, and build financial applications that settle directly to Bitcoin without bridging, wrapping, or leaving self-custody.
Crypto & Web3Data & InfrastructureFintech
Amine ElQaraoui(Founder)in
Co-investorsABCDE CapitalAsymmetricMulticoin CapitalPantera CapitalCartaCiti Ventures+5 more
Argument builds systems for verifiable computing by combining zero-knowledge cryptography, formal verification, and distributed consensus technologies.
Crypto & Web3Deep TechDeveloper ToolsEnterprise SoftwareBoston, US
John Burnham(Founder)inGabriel Barreto(Founder)inSamuel Burnham(Founder)in
Co-investorsSamsung NextVarys CapitalY CombinatorDWeb3 CapitalIOSG VenturesLombardstreet Ventures+6 more
Arweave is a decentralized ecosystem that offers grants and investment opportunities through various organizations including non-profits, DAOs, and venture studios to support projects and developers building on its network.
Cloud ComputingCrypto & Web3Data & InfrastructureFintechLondon, GB
Sam Williams(Founder & CEO)in
Co-investors1k(x)1kxa16z cryptoAdvanced BlockchainAndreessen HorowitzArrington Capital+25 more
The Avalanche Foundation is a non-profit organization that supports innovation and growth in the Avalanche ecosystem through grants, programs, and strategic support for developers, entrepreneurs, and communities building on the Avalanche blockchain platform.
Crypto & Web3Data & InfrastructureDeveloper ToolsEnterprise SoftwareFintech
Emin Gun Sirer(Founder)in
Co-investorsa16z cryptoAegis VentuesAndreessen HorowitzAndromeda CapitalBaseTwoBig Candle Capital+32 more
Avnu is a decentralized exchange interface on the Starknet blockchain that lets users connect a crypto wallet to swap, bridge, and set up recurring or limit buys of tokens.
Crypto & Web3Fintech
Bio Protocol is a decentralized science (DeSci) platform where people can fund, develop and govern tokenized early-stage scientific research from universities, companies and researchers.
AI & Machine LearningBiotechCrypto & Web3
Co-investorsBinance LabsPfizer VenturesPolymorphic CapitalSerafundSignature VenturesSMAPE Capital+3 more
Bitflow is a decentralized exchange and DEX aggregator built on the Stacks/Bitcoin ecosystem, letting users trade BTC, sBTC, SIP10 tokens and Runes, provide liquidity, and set up recurring swaps.
Crypto & Web3Fintech
Dylan Floyd(Founder)inNicholas Thompsonin
Co-investorsMarin Digital VenturesBitcoin Startup LabGenblock CapitalNewman CapitalPortal VenturesTykhe Block Ventures
BitRobot is a decentralized network that coordinates researchers, hardware operators, and compute providers to advance embodied AI and robotics R&D.
AI & Machine LearningCrypto & Web3Robotics
Michael Cho
Co-investorsTioga Capital PartnersFabric VenturesProtocol LabsZee Prime Capital
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Bulk is a decentralized trading platform that aims to combine the decentralized custody of a DEX with the execution performance of a centralized exchange.
Crypto & Web3
Co-investors6th Man VenturesChapter OneWintermuteMirana VenturesRobot VenturesStride Ventures
Collective Memory aggregates crowd-sourced photos, videos, and reports from citizen journalists worldwide, automatically detecting events when multiple independent sources report from the same location and time.
AI & Machine LearningMedia & Entertainment
Co-investorsNode Capital
Pump.fun is a platform that lets anyone create and trade coins, with open access to buy and sell from launch.
Crypto & Web3
Co-investors6th Man VenturesD1 VenturesLattice CapitalLattice CapitalWintermute
ZAR is a financial app that lets people in countries with volatile local currencies send, hold, and spend US dollars.
ConsumerCrypto & Web3Fintech
Cookie3 uses blockchain and analytics to turn on-chain user behavior into marketing insights for brands while maintaining data privacy.
AdTechCrypto & Web3Data & InfrastructureMarketing TechTallinn, EE
Wojciech Piechociński(Founder)inFilip Wielanier(Founder)in
Co-investorsAweh VenturesBitDAOBlock54 CapitalCastrum CapitalDigital Finance GroupFounderheads,+11 more
Crossmint builds developer tools that let companies, AI agents, and users work with blockchain and stablecoin rails without dealing with the underlying complexity.
Crypto & Web3Developer ToolsEnterprise SoftwareFintechSaaSNew York, US
Alfonso Gómez-Jordana Mañas(Founder)inRodri Fernández Touza(Founder)in
Co-investors6th Man VenturesAbstract VenturesCommerce VenturesFactionFinancial Venture StudioFirst Round Capital+14 more
Raiku develops a lightweight Solana validator client that provides ahead-of-time compute reservations and just-in-time MEV bundle processing, enabling financial institutions and market makers to achieve enterprise-grade execution reliability and performance in cryptocurrency markets.
Crypto & Web3Data & InfrastructureFintech
Robin A. Nordnes(Founder & CEO)Konrad Stepniak(Head of Engineering)Waleed Al Zuhair(Head of Growth)Saikat Das(Chief Marketing Officer)
Co-investorsFigmentReciprocal Ventures
Utexo develops infrastructure for bringing USD Tether (USDT) to Bitcoin, leveraging RGB and Lightning Network technologies to enable Bitcoin-native stablecoin payments.
Crypto & Web3Data & InfrastructureFintech
Viktor Ihnatiuk(Co-founder)Chris Hutchinson(Co-founder)Renat Skitsan(Co-founder)
Co-investorsFulgur VenturesMaven 11Paper Ventures
Daxo Robotics develops a highly dexterous, tendon-driven robotic hand with 120 tendens and high degrees of freedom, offered with a Python-first API, ROS wrapper, and simulation assets.
Deep TechHardwareRobotics
Tom Zhang Jiahao(Founder)in
Co-investorsDeep FutureNextFab Ventures
Dymension is a decentralized layer-1 protocol that lets creators launch tokens and convert them into full blockchains called RollApps, with built-in DEX and rollup-as-a-service tooling.
Crypto & Web3Data & InfrastructureDeveloper Tools
Co-investorsCogitent VenturesContinue CapitalTPC Club (The presale club)TPC Ventures
Dyna develops general-purpose robots powered by foundation models that adapt across environments and learn new skills rapidly, with deployment across a fleet that continuously improves.
AI & Machine LearningDeep TechRobotics
Lindon Gao(Founder)inJason Ma(Founder)inYork Yang(Founder)in
Co-investorsAlumni VenturesCRV (Charles River Ventures)FellowsHCVCINCE CapitalLG Technology Ventures+7 more
Enhanced develops a scientific platform that combines sports performance analysis with human potential optimization.
AI & Machine LearningConsumerDigital HealthHealthtechSports TechWellness & Fitness
Maximilian Martin(Co-Founder & CEO)inChristian Angermayer(Co-Founder & Executive Chairman)Dr Aron D'Souza(Founder)
Co-investorsDCVC (Data Collective)Decisive PointFlowdeskGSRInitialized CapitalPresight Capital+2 more
Entangle is a Web3 interoperability layer providing cross-chain messaging, data feeds and a universal token standard for dApps.
Dubai, AE
Faisal Mehrban(Founder)
Co-investorsBitDAOCastrum CapitalCogitent VenturesLBANK LabsMantle NetworkRana Capital+4 more
Exabits provides AI compute infrastructure by refining GPU assets (such as GB200s, H100s, H200s, and RTX5090s) from leading manufacturers to support AI workloads.
AI & Machine LearningCloud ComputingData & Infrastructure
Co-investorsBloccelerate VCEdessa CapitalFOMO VenturesGenerative VenturesLBANK LabsMoonhill Capital+5 more
exo connects Macs and workstations into a single local inference cluster, automatically discovering devices, mapping network topology, and splitting AI models across device memory to run frontier models on-premises.
AI & Machine LearningDeep TechDeveloper Tools
Co-investorsArchetypeBreedPragma VenturesRobot Ventures
Flashbots is a research and development organization that mitigates negative externalities from Maximal Extractable Value (MEV) on blockchains, primarily Ethereum, through infrastructure and tools for block building, transaction protection, and MEV distribution.
Crypto & Web3Data & InfrastructureDeveloper ToolsGrand Cayman
Alejo Salles(Director)Philip Alexander Daian(Director)Tianhong Zhen(Director)Robert Miller(Director)
Co-investorsBlueYard CapitalDragonflyEthereal Ventures Management Ltd.Fabric VenturesFactionFenbushi Capital+15 more
Fortytwo operates a sovereign, participant-owned AI network that uses swarm inference to combine heterogeneous AI models into a single networked intelligence.
AI & Machine LearningCloud ComputingDeep Tech
Alex Firsov(Founder)in
Co-investorsEv3 Ventures Llc
FrodoBots turns tele-operation of robots into a game, using gamers' actions as training data to develop embodied foundational AI models.
AI & Machine LearningGamingRobotics
Co-investorsFabric VenturesFABRICTioga Capital PartnersZee Prime Capital
Secures the modern app-driven lifestyle across banking, email, shopping, and browsing.
Co-investorsBright Pixel CapitalChamaeleonCogitent VenturesSonae IMVertex VenturesArrington Capital+2 more
GLIF provides DeFi and liquid staking infrastructure for the Filecoin network, including staking pools and a loyalty rewards program tied to its $GLF token.
Crypto & Web3Data & InfrastructureFintech
Jonathan Schwartz(Founder)
Co-investorsMulticoin CapitalZee Prime CapitalStruck CapitalFinTech CollectiveProtocol Labs
Grass operates a network that lets users share their unused internet bandwidth with verified institutions in exchange for rewards paid as points, Grass Tokens, or USDC.
ConsumerCrypto & Web3Data & Infrastructure
Co-investorsChronos VenturesCogitent VenturesCVP NoLimitLattice CapitalNo Limit Holdings (NLH)Hack VC
GTE is a decentralized exchange platform that enables trading of stocks, crypto, and commodities from a single account on a blockchain-based system, offering centralized-exchange-level speed and performance with decentralized properties.
Crypto & Web3FintechNew York City, US
Matteo Lunghi(Founder)
Co-investorsParadigmRobot VenturesMaven 11MITONMitonCWintermute
Hawksight collects trading signals submitted by a distributed community of contributors and runs analytics over them to rank and filter the results.
Crypto & Web3FintechSingapore, SG
Bradian Muliadi(CEO)inLorenzo Ampil(CTO)in
Co-investorsEntrepreneur FirstSkyVision CapitalSolar Eco FundByBitCherubic VenturesCSP DAO+8 more
Helius is Solana's leading infrastructure provider offering high-performance RPC nodes, transaction sending services, and data streaming tools for developers, traders, and applications.
Crypto & Web3Data & InfrastructureDeveloper ToolsToronto, CA
Rifat Mert Mumtaz(Executive Officer, Director)Nicolas Pennie(Founder)inLiam Vovk(Founder)inMert M(Founder)
BoardSteve Vassallo(Director)inCraig Burel(Director)in
Co-investorsFoundation CapitalHaun VenturesFounders Fund6th Man VenturesChapter OnePropel Venture Partners+13 more
Hemi is a dual-layer Bitcoin protocol that enables smart contract execution and programmability by combining Bitcoin's Proof-of-Work security with Ethereum-level functionality.
Crypto & Web3Data & InfrastructureDeveloper ToolsFintech
Matthew Roszak(Co-Founder, Hemi Labs)Jeff Garzik(Principal Engineering, Hemi Labs)Max Sanchez(Lead Architect, Hemi Labs)
Co-investorsGate VenturesHyperchain CapitalImpossible FinanceOptic CapitalTRGCWeb3com Ventures+1 more
Hyperbolic operates an AI cloud platform that provides developers and researchers with affordable access to GPU compute and open-source AI models by tapping underutilized hardware.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper ToolsNew York, US
Jasper Zhang(Co-founder and CEO)inYuchen Jin(CTO and Co-Founder)inYue Zhang(Executive Officer, Director)
Co-investorsAlumni VenturesAmbush CapitalBankless VenturesChapter OneFactionGSR+7 more
Ika is a decentralized MPC network on Solana that introduces "dWallets," a primitive splitting signing authority between users and Solana programs to control native assets on other blockchains without bridges or centralized custody.
AI & Machine LearningCrypto & Web3Data & Infrastructure
Omer Sadika(Founder)in
Co-investorsCollider VenturesCVP NoLimitFlowdeskLvna CapitalNo Limit Holdings (NLH)Node Capital+3 more
Inco provides a privacy layer for blockchain networks, enabling privacy solutions that adapt to different chains, use cases, and regulatory requirements.
AI & Machine LearningCrypto & Web3CybersecurityDeveloper Tools
Remi
Co-investorsAlliance DAO (ex DeFi Alliance)Coinbase VenturesGSRSymbolic CapitalZero Knowledge Validator (ZKV)1kx+8 more
Inference Labs develops cryptographic verification systems for autonomous AI agents, robots, and other autonomous systems, enabling auditable and trustworthy decision-making through zero-knowledge proofs and verifiable computing.
AI & Machine LearningCrypto & Web3Deep Tech
Colin Gagich(Founder)inRon Chan(Founder)in
Co-investorsEdessa CapitalLvna CapitalArche Capital VentureDigital Asset CapitalMechanism Capital
Initia provides blockchain infrastructure that connects full-stack applications through integrated protocols and aligned economic incentives.
Crypto & Web3Data & Infrastructure
Co-investorsA.Capital VenturesFigmentHack VCNascentTheory Ventures
Kash operates a mobile payment system that processes transactions directly from bank accounts to merchants, bypassing credit card networks and intermediaries to reduce transaction fees.
FintechSan Francisco, US
Geoff Flarity(Founder/COO)in
Co-investorsY CombinatorBDC Venture CapitalCoinbase VenturesDraper AssociatesFabric VCGreen Visor Capital+6 more
Kash is a social prediction market platform that combines betting mechanics with blockchain technology to enable trustless peer-to-peer wagering.
AI & Machine LearningConsumerCrypto & Web3FintechMarketplaces
Lucas Martin Calderon(Founder & CEO)in
Co-investorsCoinbase VenturesDraper AssociatesFabric VCGreen Visor CapitalKosmos VenturesMoonrock Capital+1 more
Kima Finance is a distributed settlement protocol that provides a single atomic rail for cross-ecosystem transfers across fiat, stablecoins, CBDCs, and tokenized assets, without bridges or smart contracts.
Crypto & Web3Data & InfrastructureFintech
Co-investorsCastrum CapitalMaven CapitalOutlier Ventures
Legend is a social trading platform where users copy trades from other traders, follow live alerts, and trade with up to 50x leverage.
Crypto & Web3FintechSocial
Co-investorsElectric CapitalMitonCAndreessen HorowitzCoinbase Ventures
Mach Industries designs and manufactures defense systems including unmanned aerial systems, precision munitions, high-altitude surveillance platforms, and propulsion testing capabilities for military applications.
Deep TechDefense TechHardwareHuntington Beach, US
Ethan Thornton(Executive Officer, Director)inBrendan Cooney(Executive Officer)in
BoardKeith Rabois(Director)inGeoff Lewis(Director)inLewis Geoff(Director)
Co-investorsAloft VCBedrockBoxGroupChampion Hill VenturesCoalitionDefense Angels+18 more
Magna is an all-in-one platform for crypto companies to launch, manage, and scale tokens, offering token operations, treasury management, stablecoin management, and distribution across a global web3 ecosystem.
Crypto & Web3Developer ToolsEnterprise SoftwareFintechSaaSNew York City, US
Bruno Faviero(Founder)inArun Kirubarajan(Founder)in
Co-investorsAlumni VenturesAsymmetricBehind Genius VenturesDorm RoomJude GomilaMarin Digital Ventures+14 more
MatchboxDAO is a blockchain gaming DAO building and incubating on-chain games and developer tooling on StarkNet.
Co-investorsBitkraft Esports VenturesLemniscap1kxC Squared VenturesFabric VenturesFormless Capital+6 more
MeanFi provides DeFi infrastructure and a treasury toolkit for businesses and individuals to manage crypto assets on the Solana blockchain, offering features such as multisig wallets, real-time token streaming, payroll, vesting, lending, and payment collection.
Crypto & Web3Data & InfrastructureFintech
Co-investorsOpen Opportunity FundSolaniumSolar Eco FundDeFiance CapitalGerstenbrot CapitalMEXC+2 more
MegaETH is a blockchain platform offering high-throughput transaction processing with real-time capabilities, settling on Ethereum.
Crypto & Web3Data & InfrastructureFintech
Shuyao Kong (孔姝尧)(Founder)in
Co-investorsDragonflyFigmentInception CapitalMarin Digital VenturesMetastableMITON+3 more
Merge Labs is a research lab developing brain-computer interfaces that connect with neurons using molecules instead of electrodes and non-invasive modalities like ultrasound, integrated with AI.
AI & Machine LearningBiotechDeep TechSan Antonio, US
Andrew Trickett(Executive Officer, Director)Franklin Lyons(Executive Officer, Director)
BoardLew Moorman(Director)in
Co-investorsAntiInterface FundSaga VenturesSciFi VCStarship VenturesTransform Investments+4 more
Minteo provides stablecoin infrastructure backed by liquid reserves, enabling cross-border money transfers in emerging markets, particularly Latin America.
Crypto & Web3Fintech
William Duran(Founder)in
Co-investorsFabric VenturesFJ LabsG20 VenturesVarys CapitalDune VenturesSevenX Ventures+1 more
Mitosis is a blockchain protocol that provides a cross-chain settlement and liquidity layer, letting users deposit capital once and access it across multiple chains without bridging.
Crypto & Web3Data & InfrastructureFintech
Co-investorsCitizenX Crypto VenturesTPC Club (The presale club)TPC VenturesAmber GroupForesight Ventures
Moku creates Moki, a collection of 8887 hand-assembled NFT characters built from 900+ traits, and develops games around them including an AI Fantasy Arena, a snack-combining puzzler, and an async autobattler.
AI & Machine LearningCrypto & Web3Gaming
Bruce Wasicsko(Founder)in
Co-investorsArca FundsBankless VenturesACORN BIOVENTURESBlocktower CapitalContango Digital AssetsFormless Capital+4 more
Monad is a high-performance EVM-compatible blockchain designed for fast, low-cost transactions.
Cloud ComputingCrypto & Web3Data & InfrastructureCalifon, US
Eunice Giarta Hon(Executive Officer)James Hunsaker(Director)Keone Hon(Founder & CEO)in
Co-investorsAlphaLab CapitalAmbush CapitalArchetypeBankless VenturesBloccelerate VCBODL+32 more
Mysten Labs builds infrastructure and tools for web3, focusing on making decentralized systems secure, reliable, and ready for mass adoption.
Cloud ComputingCrypto & Web3Deep TechDeveloper ToolsPalo Alto, US
Adeniyi Abiodun(Founder)inKostas Kryptos Chalkias(Founder)inSam Blackshear(Founder)inEvan Cheng(Founder)in
Co-investorsa16z cryptoAlumni VenturesAndreessen HorowitzArrington CapitalBasecamp FundChamaeleon+35 more
NEAR is an open blockchain infrastructure powering the agent economy, providing cross-chain execution, confidential settlement, and private inference capabilities.
AI & Machine LearningCloud ComputingCrypto & Web3Miami, US
Illia Polosukhin(Co-Founder)in
Co-investorsA.Capital Venturesa16z cryptoAccompliceAdvanced BlockchainAmbush CapitalAmplify Partners+40 more
Nillion is a decentralized secure computing network that uses privacy-enhancing technologies to store and process sensitive data by distributing trust across nodes.
AI & Machine LearningCrypto & Web3Data & Infrastructure
Andrew Yeoh(Founder)in
Co-investorsARKN venturesChapter OneFlowdeskFOMO VenturesG1 VenturesInception Capital+16 more
Nirvana Robotics builds humanoid robots and learning systems designed to operate in the physical world.
AI & Machine LearningHardwareRoboticsNew York City, US
Octra provides encrypted computation infrastructure for blockchain, AI, and applications.
AI & Machine LearningCrypto & Web3Data & Infrastructure
Co-investorsBuilder CapitalFinality Capital Partners
Open Forest Protocol builds data-backed financing and monitoring mechanisms for nature-based climate solutions, working with afforestation and reforestation projects tied to the voluntary carbon market.
Climate TechCrypto & Web3Impact & Social GoodZug, Canton Zug
Frederic Fournier(Executive Officer)inMichael David Kelly(Executive Officer)Olha Dyka(Executive Officer)Aureline Natacha Grange(Executive Officer)
BoardJeremy Daniel Epstein(Director)
Co-investorsCapria VenturesMercy Corps VenturesValor Capital GroupNot Boring CapitalShima CapitalÜbermorgen Ventures
Outdefine provides a governed decisioning and execution layer for clinical trial teams, using trial-trained AI inference and workflow agents to support site feasibility ranking, study risk monitoring, and real-world evidence analysis.
AI & Machine LearningBiotechHealthtech
Co-investorsVery Serious VenturesFormless CapitalJump Crypto
Panoptic is an onchain DeFi protocol for perpetual options — options without expiry dates — built on Uniswap liquidity, letting traders deploy leveraged options strategies and depositors earn yield through curator-managed vaults.
Crypto & Web3Fintech
Co-investorsAdvanced BlockchainCoinbase VenturesDivergencegumi IncVidenGreenfield+2 more
Parallel operates AI-driven simulation games and extraction shooter games set in the Parallel Universe.
AI & Machine LearningGaming
Parag Agrawal(Founder & CEO)
Co-investorsCoinbase VenturesCollab+CurrencyOSS CapitalParadigmWWVenturesYunt Capital
Parcl provides daily real estate market signals, ownership data, and tools for analyzing how housing markets move, including a portfolio-search tool for finding single-family rental portfolios and data/resolution services for housing-related prediction markets.
Data & InfrastructureFintechPropTechNew York City, US
Jason Lewris(Founder)in
Co-investorsArchetypeCoinbase VenturesDragonflyFJ LabsHack VCLAB Ventures+9 more
Perle provides expert-driven data services for AI teams, supplying credentialed specialists to handle data collection, labeling, quality assurance, evaluation, and RLHF/RLAIF for tasks that generic crowd-worker vendors can't judge.
AI & Machine LearningData & InfrastructureEnterprise SoftwareRoboticsSan Francisco, US
Ahmed Rashad(Founder)in
Co-investorsACTAI VenturesAlphaLab CapitalBreedCaladanCoinFundEnigma Fund+3 more
Persona AI develops modular industrial humanoid robots for skilled physical tasks such as welding, grinding, inspection, fabrication, and maintenance.
AI & Machine LearningHardwareRobotics
Nicolaus Radford(Co-Founder and CEO)inJide Akinyode(Co-Founder and COO)inJerry Pratt(Co-Founder and CTO)in
Co-investorsBaseTwoEmbedded VenturesGOOSE CapitalK50 VenturesOlive Hill VenturesOptic Capital+8 more
Personal AI builds user-owned personal language models and AI personas trained on an individual's own data and memories.
San Francisco, US
Sharon Zhang(Founder)
Co-investorsBBG VenturesBDev VenturesBeni Venture CapitalDifferential VenturesGood FriendsGrotech Ventures+6 more
PlayEmber develops and publishes casual mobile and console games across iOS, Android, Roblox, and Nintendo Switch, combining gameplay with consumer finance features that let users earn and save while playing.
ConsumerFintechGaming
Hugo Furneauxin
Co-investors2 Punks CapitalFermionFOMO VenturesHTX Ventures (ex Huobi Ventures)HyperithmShima Capital
Poseidon develops unmanned aerial vehicles for cargo logistics, specifically wave-skimming seagliders designed to reduce the cost per ton-mile of air freight.
Deep TechHardwareLogistics & Supply ChainSan Francisco, US
Parker Tenney(Cofounder)inDavid Zagaynov(Cofounder)in
Co-investorsCade VenturesDraper AssociatesGoAhead VenturesStarship VenturesTamarack GlobalTq Ventures Llc
Rain provides real-time financial guidance to employees by monitoring cash flow, analyzing spending patterns, and offering personalized financial advice.
AI & Machine LearningEnterprise SoftwareFintechHR TechSaaSLos Angeles, US
AJ Nelson(Founder)inGilberto Garcia(Co-Founder & CTO)inHR Tech SaaS AJ Nelson(Founder)Jen Terrell(Co-Founder)inAlex Bradford(Founder & CEO)in
Co-investors14Peaks CapitalAurum Venture PartnersClear Haven Capital ManagementCM VenturesDreamers VCEnsemble VC+20 more
Reflect Orbital is developing satellite-based mirrors that redirect natural sunlight from space to illuminate specific areas on Earth on demand, with adjustable brightness and scheduling.
CleantechEnergySpace TechHawthorne, US
Ben Nowack(Executive Officer, Director)inTristan Semmelhack(Executive Officer, Director)in
BoardShaun Maguire(Director)inJosh Wolfe(Director)in
Co-investorsAlumni VenturesLux CapitalSequoia CapitalStarship VenturesTIBAS VenturesWinklevoss Capital
Ritual is a research lab combining artificial intelligence, cryptography, algorithmic game theory, and distributed systems.
AI & Machine LearningCrypto & Web3Deep Tech
Niraj Pant(Co-Founder)Akilesh Potti(Co-Founder)
Co-investorsArchetypeBollinger Investment GroupEdessa CapitalHypersphere VenturesLvna CapitalMH Ventures+1 more
Sleektext is a news and information platform dedicated to World of Warcraft coverage, offering game updates, player guides, strategies, and tournament information to WoW players globally.
GamingMedia & Entertainment
Co-investorsBAM VenturesDorm RoomArkStream CapitalBinance LabsEmirates ConsortiumGenblock Capital+6 more
Solana is a blockchain network designed for high-performance internet capital markets, payments, and cryptocurrency applications.
Crypto & Web3Data & InfrastructureFintechSan Francisco, US
Anatoly Yakovenko(Solana Founder & Solana Labs CEO)inGregory Fitzgerald(Executive Officer)Rajiv Gokal(Executive Officer)Alan Yu
Co-investors1k(x)1kx500 Globala16z cryptoAbstract VenturesAegis Ventues+54 more
Solayer is a hardware-accelerated blockchain and financial platform that enables trading of crypto, equities, and commodities on a high-performance L1 blockchain, along with a crypto-native payment card for global spending.
Crypto & Web3Fintech
Co-investorsFOMO VenturesHack VCProtagonistPolychain Capital
Solayer operates a hardware-accelerated Solana validator that offers staking services through its sSOL liquid staking token, capturing maximum MEV rewards for depositors.
Crypto & Web3Data & InfrastructureFintech
Co-investorsBorderless VentureFOMO VenturesLvna CapitalMaelstromProtagonist
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Stacks is a blockchain platform that enables smart contracts and decentralized applications to leverage Bitcoin as a secure base layer through a Layer 2 solution, offering developer tools and a programming language called Clarity.
Crypto & Web3Developer ToolsNew York, US
Ryan Shea(Co-founder)inMuneeb Ali(Co-founder)in
BoardAlbert Wenger(Director)in
Co-investorsBitcoin FrontierBreyer CapitalCompoundContinue CapitalDigital Currency GroupDraper Associates+26 more
Stackup is a smart account platform that enables crypto companies to manage onchain financial operations through modern infrastructure for digital asset management.
Crypto & Web3Developer ToolsEnterprise SoftwareFintechSaaSLos Angeles, US
John Rising(Founder)inHazim Jumali(Founder & CTO)in
Co-investorsDigital Currency GroupY Combinator1kxAmino CapitalAsymmetry VenturesFour Cities+3 more
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Sweatcoin is a mobile health and fitness app that tracks users' steps and movement, converting physical activity into a virtual currency (sweatcoins) that can be redeemed for rewards such as gadgets, digital subscriptions, travel vouchers, and crypto.
ConsumerHealthtechWellness & Fitness
Egor Khmelev(Founder)inOleg Fomenko(Founder)in
Co-investorsImpossible FinanceRubyLightRuna CapitalChapter OneElectric CapitalGoodwater Capital+1 more
Teralink builds high-speed communication systems for satellites, drones, and other airborne platforms.
Deep TechHardwareSpace Tech
Ali Alqaraghuli(Founder)in
The Graph organizes and indexes blockchain data through a decentralized network, providing web3 developers with fast, cost-efficient access to smart contract data via subgraphs and GraphQL queries.
Crypto & Web3Data & InfrastructureDeveloper Tools
Co-investorsAGE CryptoAndromeda CapitalAngelONE CapitalBollinger Investment GroupBootNodeChapter One+31 more
Tsavorite designs and manufactures the Omni Processing Unit, a hardware and software architecture for AI workloads that scales from edge devices to datacenter and exascale systems.
AI & Machine LearningHardwareSemiconductors
Shalesh Thusoo(Founder, Chief Executive Officer)inSupriya Madan(Co-Founder, Chief Development Officer)inGuntram Wolski(Co-Founder, Chief Operating Officer)inSarvagya Kochak(Co-Founder, VP Business Development)inShirish Seetharam(Co-Founder, VP Software Development)inMike Uhler(Chief Technology Officer)in
Co-investorsPavestonePresidio Ventures
Ultrade is a non-custodial trading platform offering perps, spot, and lending with unified cross-chain margin that keeps assets native across nine chains without bridges or wrapped assets.
Crypto & Web3Fintech
Dan Goldman(Founder)in
Co-investorsCastrum CapitalStakez CapitalAlgorand FoundationSarson FundsStealth CapitalTess Ventures
USD.ai offers a stablecoin-based platform for financing AI compute infrastructure, letting users earn yield or borrow to fund the machines behind AI data centers.
AI & Machine LearningCrypto & Web3Fintech
Co-investorsAlliance DAO (ex DeFi Alliance)AlphaLab CapitalBreedCaladanCoinListDe Fi Alliance Holdings+2 more
Vulcan Elements manufactures rare earth magnets for critical applications in defense, semiconductors, satellites, data centers, and industrial equipment.
Advanced ManufacturingDefense TechNew MaterialsBenson, US
John Maslin(Executive Officer, Director)inScott Glover(Executive Officer)inJacob Bowles(Executive Officer)Jonah Glick-Unterman(Executive Officer)Bryan Van Demark(Executive Officer)Daniel Aronowitz(Executive Officer, Director)
Co-investorsBlindspot Ventures Management CoDorm RoomDuke Capital PartnersFifth Down CapitalFJ LabsGlynn Capital Management+10 more
Wormhole offers Native Token Transfers (NTT), an open framework for token issuers to create, transfer, and customize tokens across multiple blockchains without relying on pooled liquidity.
Crypto & Web3Data & InfrastructureDeveloper ToolsFintech
Robinson Burkey(Founder)in
Co-investorsBootNodeBorderless VentureDelta BlockchainFigmentGate VenturesMulticoin Capital+7 more
Creator platform with an MMOTPS core and dual-layer economy built by gaming industry veterans.
Jeffry Kim(Founder)in
Co-investorsTaisu VenturesHashedKraftonNeoclassic CapitalSpartan Ventures
XPLA is a blockchain mainnet, transitioning to a rebrand called CONX, focused on connecting value across culture, finance, and technology in the web3 space.
Crypto & Web3
Co-investorsGOAL VenturesPlay VenturesTRANSCENDFunPlusHashedIVC
YottaLabs provides on-demand, production-ready GPU cloud infrastructure for AI teams, offering GPU pods, virtual machines, serverless scaling, an AI gateway that routes across model providers, and model quantization for training and inference.
AI & Machine LearningCloud ComputingData & Infrastructure
Co-investorsGenerative VenturesKuCoin Labs
Co-investorsCollab+Currency
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
Consumer Collector Crypt TCG appConsumer LEVR Sports prediction marketConsumer Sphinx Commodities perpetualsNeomoonNubitPudgy PenguinsSphereTensorThird Time EntertainmentWayfinder PrivateWynd
Exits · 4
2 IPOs · 2 acquisitions · showing 2Helius Medical TechnologiesNASDAQ: HSDTUpexiNASDAQ: UPXI
Portfolio news
latest coverage across their companies
Persona AI · runtimewire.com · Sep 14, 2026
Mach Industries · prnewswire.com · Jun 2, 2026
Tsavorite · trysignalbase.com · May 4, 2026
Apptronik · finsmes.com · Feb 17, 2026
Merge Labs · merge.io · Jan 16, 2026
Bio Protocol · prnewswire.com · Sep 17, 2025
Vulcan Elements · finsmes.com · Aug 29, 2025
Frequently asked questions
- How many investments has Big Brain Holdings made?
- Big Brain Holdings has 114 tracked investments, 4 of which have exited, including 9 dated in the last 24 months.
- What stage does Big Brain Holdings invest at?
- Big Brain Holdings invests at the Seed, Series A, Series B, Growth stages.
- What sectors does Big Brain Holdings focus on?
- Big Brain Holdings focuses on AI & Machine Learning, Consumer, Crypto & Web3, Data & Infrastructure, Deep Tech, Fintech, Gaming, Robotics, Semiconductors.
- Where is Big Brain Holdings located?
- Big Brain Holdings is headquartered in Los Angeles, US.
- Who does Big Brain Holdings co-invest with?
- Big Brain Holdings most often shares deals with Coinbase Ventures, Lvna Capital, Figment, among 388 tracked co-investors.
- What size deals does Big Brain Holdings back?
- Across 5 deals with disclosed amounts, Big Brain Holdings has joined rounds of $2M – $500M (median $8M).
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