Big Brain Holdings
Venture capitalLos Angeles Β· Pre-SeedβGrowth Β· 4 people tracked
Investment thesis
Big Brain Holdings is a global, multi-stage firm rooted in cypherpunk values and first-principles thinking, backing visionary founders pursuing radical ideas at the intersection of intelligence, autonomy, and infrastructure. It takes concentrated, long-term positions in companies with the potential to reshape industries. Focus areas include AI (foundation models, inference infrastructure, AI-native applications, and agentic systems), robotics and autonomy (humanoid robots, autonomous and industrial automation systems, embodied AI), crypto (next-generation blockchain protocols, decentralized compute networks, and Web3 primitives), and consumer applications at scale alongside deep-technology companies solving fundamental problems. The firm invests in both funds and founders.
Source: firm website, verified Aug 7, 2026.
Team Β· 4 people
from public directories
What they invest in
from 38 of 75 portfolio companiesCrypto & Web3 Γ22AI & Machine Learning Γ17Data & Infrastructure Γ15Developer Tools Γ11Cloud Computing Γ8Deep Tech Γ8Fintech Γ8Hardware Γ5
HQs:United StatesΓ8United KingdomΓ1
Investments Β· 75 tracked
founders shown can be your intro pathCrossCurve is a cross-chain DeFi protocol built around its Cross-chain Data Protocol (CDP), a messaging and transport layer for transferring data and liquidity between blockchains, supporting products such as a cross-chain bridge, liquidity protocol, and DEX.
Crypto & Web3Developer ToolsFintech
Agility Robotics develops and deploys humanoid robots for warehouse automation and logistics operations.
AI & Machine LearningHardwareLogistics & Supply ChainRoboticsSalem, US
Jonathan Hurst(Co-founder & Chief Robot Officer)inDamion Shelton(Co-Founder & Chairman of the Board)inMatthew Ocko(Director)
BoardBruce Leak(Director)
AheadComputing develops high-performance 64-bit RISC-V application processor cores designed to maximize per-core CPU performance for AI, cloud, client, mobile, and edge workloads.
AI & Machine LearningDeep TechSemiconductors
Debbie Marr(Founder)
Akave provides an S3-compatible object storage cloud with usage-based pricing, zero egress fees, immutability, and cryptographic access controls, positioned as a lower-cost alternative to hyperscalers like AWS.
AI & Machine LearningCloud ComputingData & Infrastructure
Apptronik builds humanoid robots designed to perform repetitive, physically taxing, and dangerous tasks in warehousing and manufacturing environments, aiming to free workers for higher-value activities.
Advanced ManufacturingAI & Machine LearningHardwareRoboticsAustin, US
Jeff Cardenas(CEO)Jeffery Lee Cardenas(Executive Officer, Director)Nicholas Arden Paine(Executive Officer, Director)George Samuel Rose(Director)
BoardClarence Gordon Daugherty, IV(Director)Howard Lee Morgan(Director)
Argument builds zero-knowledge cryptography, formal verification, and distributed consensus systems for private and decentralized software.
AI & Machine LearningCrypto & Web3Developer ToolsEnterprise SoftwareBoston, US
John Burnham(Founder)inGabriel Barreto(Founder)inSamuel Burnham(Founder)in
Arweave is a decentralized ecosystem that offers grants and investment opportunities through various organizations including non-profits, DAOs, and venture studios to support projects and developers building on its network.
Cloud ComputingCrypto & Web3Data & InfrastructureFintechLondon, GB
Sam Williams(Founder & CEO)
The Avalanche Foundation is a non-profit organization that supports innovation and growth in the Avalanche ecosystem through grants, programs, and strategic support for developers, entrepreneurs, and communities building on the Avalanche blockchain platform.
Crypto & Web3Data & InfrastructureDeveloper ToolsEnterprise SoftwareFintech
Crossmint is a platform for integrating stablecoin infrastructure including wallets, onramps, and payment orchestration for enterprises and developers.
Crypto & Web3FintechSaaS
Arch is a Bitcoin-native chain and execution environment (ArchVM) that lets institutions and users borrow, lend, earn yield, swap, and build financial applications that settle directly to Bitcoin without bridging, wrapping, or leaving self-custody.
Crypto & Web3Data & InfrastructureFintech
Dyna develops general-purpose robots powered by foundation models that adapt across environments and learn new skills rapidly, with deployment across a fleet that continuously improves.
AI & Machine LearningDeep TechRobotics
Exabits provides AI compute infrastructure by refining GPU assets (such as GB200s, H100s, H200s, and RTX5090s) from leading manufacturers to support AI workloads.
AI & Machine LearningCloud ComputingData & Infrastructure
Flashbots is a research and development organization that mitigates negative externalities from Maximal Extractable Value (MEV) on blockchains, primarily Ethereum, through infrastructure and tools for block building, transaction protection, and MEV distribution.
Crypto & Web3Data & InfrastructureDeveloper Tools
Grass operates a network that lets users share their unused internet bandwidth with verified institutions in exchange for rewards paid as points, Grass Tokens, or USDC.
ConsumerCrypto & Web3Data & Infrastructure
Inference Labs develops cryptographic verification systems for autonomous AI agents, robots, and other autonomous systems, enabling auditable and trustworthy decision-making through zero-knowledge proofs and verifiable computing.
AI & Machine LearningCrypto & Web3Deep Tech
Mach Industries designs and manufactures defense systems including unmanned aerial systems, precision munitions, high-altitude surveillance platforms, and propulsion testing capabilities for military applications.
Defense TechHardwareHuntington Beach, US
Ethan Thornton(Executive Officer, Director)Brendan Cooney(Executive Officer)Lewis Geoff(Director)
BoardKeith Rabois(Director)Geoff Lewis(Director)
Magna is an all-in-one platform for crypto companies to launch, manage, and scale tokens, offering token operations, treasury management, stablecoin management, and distribution across a global web3 ecosystem.
Crypto & Web3Developer ToolsEnterprise SoftwareFintechSaaSNew York City, US
Bruno Faviero(Founder)inArun Kirubarajan(Founder)in
Merge Labs is a research lab developing brain-computer interfaces that connect with neurons using molecules instead of electrodes and non-invasive modalities like ultrasound, integrated with AI.
AI & Machine LearningBiotechDeep Tech
Mysten Labs builds infrastructure and tools for web3, focusing on making decentralized systems secure, reliable, and ready for mass adoption.
Cloud ComputingCrypto & Web3Deep TechDeveloper Tools
Adeniyi Abiodun(Founder)in
Parallel operates AI-driven simulation games and extraction shooter games set in the Parallel Universe.
AI & Machine LearningGaming
Building industrial-grade humanoid robots for Hyundai and others.
Poseidon develops unmanned aerial vehicles for cargo logistics, specifically wave-skimming seagliders designed to reduce the cost per ton-mile of air freight.
Deep TechHardwareLogistics & Supply Chain
Parker Tenney(Cofounder)David Zagaynov(Cofounder)
Portfolio news
latest coverage across their companiesMonad Β· crypto-economy.com Β· Jul 17, 2026
Dyna Robotics Β· citybiz.co Β· Jul 15, 2026
Avalanche Β· cryptonews.net Β· Jul 13, 2026
Helius Β· kalkine.ca Β· Jul 3, 2026
Solana Β· cryptobriefing.com Β· Jul 2, 2026
Apptronik Β· barchart.com Β· Jun 23, 2026
Tsavorite Β· m.economictimes.com Β· May 4, 2026
Parallel Private Β· finsmes.com Β· Apr 29, 2026
Frequently asked questions
- What stage does Big Brain Holdings invest at?
- Big Brain Holdings invests at the Pre-Seed, Seed, Series A, Series B, Series C, Growth stages.
- What sectors does Big Brain Holdings focus on?
- Big Brain Holdings focuses on AI & Machine Learning, Consumer, Crypto & Web3, Data & Infrastructure, Deep Tech, Gaming, Robotics.
- Where is Big Brain Holdings located?
- Big Brain Holdings is headquartered in Los Angeles, US.
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