Mindset Health

Mindset Health is a digital therapeutics company headquartered in Melbourne, Australia, with a commercial office in New York. It converts published behavioural and mind-body protocols — clinical hypnotherapy, pain reprocessing and autonomic regulation — into smartphone-delivered programs for chronic conditions where the company argues pharmacology under-performs, including irritable bowel syndrome, menopausal vasomotor symptoms, chronic pain, anxiety and depression.

The product portfolio comprises four programs described as available: Nerva, a six-week gut-brain program for IBS; Evia, a five-week hormone-free program for hot flashes, night sweats and disturbed sleep, built with Dr Gary Elkins of Baylor University's Mind-Body Medicine Research Laboratory; Claria, short daily sessions for anxiety, depression and stress, developed with Dr Michael Yapko; and Relio, a pain reprocessing program for chronic back pain developed with NeuRA. Each program is described as being built with the academic centre that authored the original protocol, tested in randomised trials, and delivered through an adaptive model that assesses symptoms, personalises audio sessions, lessons and exercises, and tracks outcomes over time. At the time of its 2023 Series A the company had three apps, covering medically diagnosed IBS, menopause and smoking cessation, and stated plans to launch programs for anxiety and depression, sleep and chronic pain.

Active research areas listed by the company include extending gut-directed hypnotherapy to other disorders of gut-brain interaction (bloating, distension, upper GI symptoms), comorbidity populations (IBS with endometriosis, interstitial cystitis, IBD), under-studied demographics (pregnancy, paediatrics, underserved cohorts), controlled studies within national health systems including NHS arms, wearable biometrics such as heart rate and sleep as response predictors, and predictive personalisation models.

Founding story

Company materials state that brothers Chris and Alex Naoumidis started Mindset Health because a category of medicine working through the brain rather than the bloodstream remained largely unaddressed while drug pipelines repeatedly failed the same conditions; their stated mission is to help a billion people improve their health with their mind. The company's About page gives the founding year as 2019, while press coverage reports the brothers founded the company in 2018 [6][7].

Business model

Mindset Health develops and distributes condition-specific digital therapeutic programs to consumers through the App Store and Google Play, and also distributes through health-plan partners. The company reports 30M+ covered lives and runs dedicated channels for providers (clinicians and practices) and health plans (payers and employers), including demo requests, indicating a mix of direct-to-consumer app distribution and institutional partnership distribution [0][2][3].

Traction

The company reports more than 350,000 patients helped, 20,000+ referring providers, 30M+ covered lives, 10+ published studies, and distribution to users in 70+ countries. At the March 2023 Series A its largest markets by users were the US (38%), Australia (19%) and the United Kingdom (15%) [0][5][7].

Latest developments

In 2025 the company published two peer-reviewed studies: an active-controlled trial of digitally delivered gut-directed hypnotherapy for IBS in the American Journal of Gastroenterology (Anderson et al., 120(2):440-448) and a retrospective analysis of app-delivered hypnosis for menopausal hot flashes in JMIR Formative Research (Scheffrahn et al., 2025;9:e63948). Its portfolio now lists four available programs, including Claria for mental health and Relio for chronic back pain, and it markets itself as an AI therapeutics company with an active pipeline spanning DGBI expansion, comorbidity and demographic research, health-system validation, biometrics and predictive personalisation [0][2][7].