a16z crypto

Freatic builds Murmur, a monetization layer for information goods based on decentralized mechanisms, cryptography, and game theory that enables trustless trading of valuable insights. The platform addresses market failures in information exchange by creating permissionless marketplaces for untapped opportunities and alpha, currently demonstrated through applications in the crypto trading and memecoin space.

AI & Machine LearningCrypto & Web3Data & Infrastructure

Kairos is a trading terminal that aggregates prediction markets from multiple venues including Kalshi, Polymarket, and Predict.fun, providing unified execution, real-time data, and analytics for professional traders. It serves serious and professional prediction market traders who need institutional-grade trading infrastructure.

Fintech

Manifold provides tools for creating, selling, and distributing digital goods on the Ethereum blockchain. The platform serves creators, artists, and brands seeking to mint and sell digital assets including art, memberships, and experiences without intermediaries.

B2B MarketplacesCreator EconomyCrypto & Web3

Rally Protocol provides a mobile SDK for React Native developers to build blockchain features and applications. The company targets mobile developers seeking to integrate blockchain functionality into their apps.

Crypto & Web3Developer Tools

Alchemy is a platform layer that enables developers to build applications on blockchain networks. The company provides infrastructure and APIs to simplify blockchain development for a global audience.

Cloud ComputingCrypto & Web3Developer ToolsFintechUnknown

Nikil Viswanathan(Co-Founder and CEO)Joe Lau(Co-Founder and President)

AminoChain builds decentralized infrastructure for biomedical research that connects biospecimens, participant consent, and research data through a network of biorepositories. The platform provides AI-powered search for biospecimens and participant management systems for prospective research studies.

BiotechData & InfrastructureHealthtech

Anchorage Digital is a global cryptocurrency platform providing institutions with custody, staking, trading, governance, and settlement services, along with security infrastructure. The company operates through federally chartered and internationally licensed entities serving institutional clients managing digital assets.

Crypto & Web3Enterprise SoftwareFintechNew York, US

Diogo Mónica(Co-founder)Nathan McCauley(Co-founder)

Angle was a cryptocurrency protocol that issued stablecoin tokens (USDA and EURA) that could be redeemed 1:1. The protocol is shutting down with a redemption deadline of March 1, 2027.

Crypto & Web3

Kits provides AI-powered audio tools for music production, including custom voice generation, vocal isolation, stem separation, and mastering features for creators and producers. The platform enables users to create studio-quality vocal tracks and manipulate audio without traditional recording sessions.

AI & Machine LearningCreator EconomyMedia & Entertainment

Arweave is a decentralized ecosystem that offers grants and investment opportunities through various organizations including non-profits, DAOs, and venture studios to support projects and developers building on its network.

Cloud ComputingCrypto & Web3Data & InfrastructureFintechLondon, GB

Autograph is a platform that facilitates branded digital collectibles and experiences, typically NFTs, featuring collaborations with celebrities, athletes, and influencers from sports, music, and entertainment sectors.

Creator EconomyCrypto & Web3

The Avalanche Foundation is a non-profit organization that supports innovation and growth in the Avalanche ecosystem through grants, programs, and strategic support for developers, entrepreneurs, and communities building on the Avalanche blockchain platform.

Crypto & Web3Data & InfrastructureDeveloper ToolsEnterprise SoftwareFintech

Azra is a video game developer that creates role-playing games for mobile platforms, leveraging proprietary AI technology to accelerate development and bring titles to market faster.

GamingSacramento, US

Mark Otero(CEO)

Aztec is a Layer 2 blockchain network on Ethereum that enables programmable privacy for decentralized applications through client-side zero-knowledge proofs and a dual state architecture. The network allows builders to code privacy at multiple layers—user, data, metadata, transaction, and code levels—while maintaining full decentralization in sequencing, proving, and governance.

Crypto & Web3Developer Tools

Zac

Babylon Labs develops trustless infrastructure that enables Bitcoin to be used as collateral in decentralized finance and through a Bitcoin staking protocol for blockchain validation. The platform allows users to lock native Bitcoin without wrapping or custodial risk.

Crypto & Web3

Babylon is a digital health company that develops prescription medications and treatments for specific health conditions. The company's portfolio includes Xiidra, an FDA-approved eye drop for treating dry eye disease in adults.

Digital HealthHealthtechMedical Devices

Michelle Arkin(PhD)

Bastion provides stablecoin issuance infrastructure with compliance and security features, enabling institutions to launch USD-backed stablecoins with customizable issuer models.

Crypto & Web3Fintech

Catena is building a financial institution purpose-built for AI agents, combining a technology platform with a national trust bank to provide regulated banking with deterministic policy enforcement and immutable audit trails. The company is pursuing OCC-regulated charter status to offer direct, governed banking services to AI agents operating at scale.

AI & Machine LearningEnterprise SoftwareFintech

Sean Neville(CEO)Matt Venables(CTO)

Fenris Creations develops and operates EVE Online, a massively multiplayer online game launched in 2003. The company has established itself as an innovator in interactive entertainment.

GamingReykjavik, IS

Fenris Creations

Celo is a blockchain network designed for stablecoin payments and global financial transactions, positioned as a Layer 2 solution built on Ethereum's ecosystem. It supports low-cost transactions, including gas payments with ERC20 tokens, and enables development of AI agents with real-world utility.

Crypto & Web3Fintech

Chia develops an open-source blockchain network using Proof of Space Time consensus, designed to significantly reduce energy consumption compared to traditional proof-of-work systems. The company provides infrastructure and technology for building secure, regulatory-compliant decentralized applications.

Crypto & Web3Data & InfrastructureFintech

Bram Cohen(Founder)Gene Hoffman(Chief Executive Officer and President)Misha Graboi(Chief Financial Officer)Vishal Kapoor(Chief Operating Officer)

Coinbase is a cryptocurrency exchange platform that offers trading, custody, and financial services for cryptocurrencies, stocks, derivatives, and prediction markets to consumers, institutions, and developers. The company operates a full-stack infrastructure including secure custody, liquidity services, stablecoin infrastructure, and global settlement rails.

Crypto & Web3FintechLos Angeles, US

Brian Armstrong(Founder/CEO)in

Digitoys is a platform for collecting and trading digital collectible toy characters available in tiered blind boxes (Adventurer, Elite, Hero). The project emphasizes community engagement and in-game rewards for collectors.

ConsumerCrypto & Web3Gaming

Onchain Studios is a digital studio creating content and products for collectors, with a focus on web3 and digital collectibles.

ConsumerCreator Economy

Dapper Labs is a venture studio building products and communities at the intersection of culture and emerging technology, focused on digital ownership, data control, and decentralized platforms for creators and collectors. The company operates as a studio where individuals serve as founders or founder-in-training, developing solutions that leverage blockchain and open-state technologies.

ConsumerCreator EconomyCrypto & Web3Sector Agnostic

Roham Gharegozlou(Founder)Dieter Shirley(Founder)

Daylight provides managed security services combining AI agents and human security experts to detect, investigate, and respond to threats for enterprise organizations. The company offers coordinated monitoring, threat hunting, and phishing response services powered by senior threat hunters and incident responders.

AI & Machine LearningCybersecurityEnterprise Software

DeSo is a layer-1 blockchain built to decentralize social media and power storage-heavy applications, enabling developers to build social networks, NFT marketplaces, and creator monetization tools with on-chain data and user-owned content.

Crypto & Web3Social

DFINITY builds the Internet Computer, a decentralized cloud network that enables applications to run directly on the blockchain with persistent state, native HTTP serving, and built-in security without requiring external databases or a dedicated operations team. The platform is powered by cryptography and distributed systems, and no single entity controls the network.

AI & Machine LearningCloud ComputingCrypto & Web3Developer Tools

District is a member-owned community network for founders, investors, and leaders in technology, offering exclusive events, peer groups, mentorship, and programming focused on scaling high-growth companies. The community curates members through a selective application process and provides access to a network of 300+ successful entrepreneurs and investors.

Future of WorkSaaS

Michael Ma(District)

dYdX is a decentralized exchange for trading perpetuals that uses zero-knowledge proofs to provide security and privacy. The platform targets traders globally who lack access to advanced trading tools and financial products.

Crypto & Web3Fintech

Dynamic provides wallet and payment infrastructure for applications and platforms, enabling integration of blockchain-based transactions. The platform serves fintech, payroll, HR, and crypto applications seeking to add wallet functionality and cryptocurrency payment capabilities.

Crypto & Web3Developer ToolsFintechSaaSNew York, US

Yoni GoldberginItai Turbahnin

Eco provides a developer platform for stablecoin companies to enable cross-chain money movement without building underlying infrastructure. The platform offers real-time settlement, simplified onchain user experience, and programmable orchestration for stablecoin transactions across multiple chains and assets.

Crypto & Web3Fintech

EigenCloud is a developer platform providing cryptographic trust primitives for applications and AI agents through verifiable computation, inference, and data availability backed by slashable stake on EigenLayer.

AI & Machine LearningCrypto & Web3Developer Tools

Espresso Systems builds Ethereum infrastructure and blockchain systems with a focus on practical solutions for developers and users within the crypto ecosystem.

Cloud ComputingCrypto & Web3Data & InfrastructureDeveloper Tools

<UNKNOWN>

Everyrealm develops infrastructure and deploys capital for crypto and community-driven projects, investing in and building across blockchain protocols and platforms to connect digital economies.

Cloud ComputingCrypto & Web3GamingSocial

<UNKNOWN>(Co-Founder)

Flow is a blockchain network designed for consumer decentralized finance applications, offering institutional-grade financial products, yield optimization, and automated strategies with features like prediction markets, home equity credit lines, and scheduled transactions that require no cryptocurrency knowledge.

ConsumerCrypto & Web3Fintech

Flowcarbon provides financing solutions including project finance, private credit, and transferable tax credits for infrastructure, waste-to-value, and niche energy sectors. The firm specializes in capital solutions for frontier industries.

CleantechClimate TechEnergyFintechImpact & Social Good

Forta provides onchain security and compliance monitoring through a firewall platform that detects and prevents malicious transactions, smart contract exploits, and compliance risks for teams building blockchain applications. The platform uses AI and simulations to identify threats in real-time with high accuracy.

AI & Machine LearningCrypto & Web3Cybersecurity

Foundation was a non-custodial platform for NFT trading and creator monetization. The platform is now offline and will not resume operations.

Creator EconomyCrypto & Web3

FWB is a members-only community and cultural organization for artists, technologists, and builders that organizes events, funds projects, and operates as a decentralized autonomous organization (DAO).

Creator EconomyCrypto & Web3Sector AgnosticSocialIdyllwild, US

Gensyn provides decentralized infrastructure for AI models to train, verify, trade, and evolve using cryptographic verification and on-chain identity mechanisms. The platform creates a market where AI models are rewarded for accurate predictions, with Delphi serving as an information market where humans and AI agents trade predictions with on-chain settlement.

AI & Machine LearningCrypto & Web3Data & Infrastructure

Golden builds a self-constructing knowledge graph that combines artificial and human intelligence to automatically map and reconcile human knowledge from millions of disparate sources. The platform serves organizations requiring accurate, up-to-date knowledge bases, including financial crime intelligence applications.

AI & Machine LearningData & InfrastructureEnterprise SoftwareSan Francisco, US

Jude Gomila(Founder)

Halliday builds a unified, cross-chain payments platform that enables users to onramp, swap, and execute on-chain actions across multiple blockchain networks. The platform serves developers and users in the decentralized finance ecosystem.

Crypto & Web3FintechSaaS

Improbable is a venture builder and technology company that creates and scales ventures in AI, Web3, and the metaverse, drawing on over a decade of experience in large-scale multiplayer technology and virtual worlds. The company builds new ventures from the ground up and spins out internal teams into independent companies, combining capital, technical expertise, and operational support.

AI & Machine LearningCrypto & Web3Deep TechCambridge, GB

Herman Narula(Founder)Rob Whitehead(Co-founder)

A fan community platform that recognizes and rewards user-generated content about films and entertainment franchises, connecting fans directly to studios. The platform launches with John Wick content for Lionsgate.

Creator EconomyMedia & Entertainment

Iron Fish is a zero-knowledge Layer-1 blockchain that provides optional privacy features for cryptocurrency assets across multiple chains. It enables private transactions and multi-asset support across 20+ EVM-compatible blockchains with compliance screening.

Crypto & Web3

IYK provides a platform for musicians to strengthen artist-fan relationships by embedding digital verification technology into merchandise and live shows. Fans collect verified proofs of merch ownership and concert attendance to unlock exclusive rewards and build a shareable digital identity.

Creator EconomySaaS

Jito optimizes transaction execution and MEV (maximal extractable value) rewards on the Solana blockchain network. The platform allows validators and stakers to earn additional rewards while improving network transparency and fairness through its TipRouter consensus mechanism.

Crypto & Web3

Kairos provides an applied AI layer that enables enterprises to build specialized agents trained on their proprietary data and workflows. The platform helps critical industries bridge the reliability gap in enterprise AI by embedding operator expertise into customized agents that work within messy real-world business environments.

AI & Machine LearningData & InfrastructureEnterprise SoftwareSaaSSan Francisco, US

Shivum Pandove(Founder)in