The Engine Ventures

Foundational Alloy develops engineering alloys through a solid-state process called MetalsFIRST, in which metal is produced without melting to create microstructures unreachable by conventional metallurgy while controlling oxygen and contaminants.

Advanced ManufacturingDeep TechNew Materials

Jasper Lienhard(Cofounder)Jake(Co-founder (company strategy, operations, financing, commercialization))

Co-investorsAlumni VenturesAmerica's Frontier FundBasecamp FundCastor Ventures (an Alumni Ventures Fund)El Cap EquityMaterial Impact+3 more

Addis Energy develops technology that combines oil and gas engineering expertise with advanced research to access energy and resources from subsurface geology.

CleantechDeep TechEnergySomerville, US

Michael Alexander(Founder)inCharlie Mitchell, P.E.(Founder)inIwnetim Iwnetu Abate(Director)Oliver Charles Mitchell(Director)

BoardLaurie Menoud(Director)Michael Kearney(Director)

Co-investorsAt One VenturesBlindspot Ventures Management CoPillar VCVoyager PartnersFounders FundKhosla Ventures

Rapid robotic synthesis of valuable peptides and protein structures that can't be manufactured with cells.

Amide is a peptide synthesis provider that manufactures hard-to-obtain peptides on demand, offering reliable linear synthesis up to 120 amino acids and large full-length proteins via ligation.

Advanced ManufacturingBiotechDeep Tech

Anthology develops designer and hybrid genomes by decoding genomic "language" to engineer microbes that convert feedstocks such as sugars, plastics, and agricultural waste into products like chemicals, materials, and food ingredients.

BiotechFoodTechNew Materials

Dr. Tzu-Chieh 'Zijay' Tang(CTO & Co-Founder)

Co-investorsJuniperThe E14 Fund

Marvell designs custom silicon and provides interconnect and network switch products for AI data center infrastructure, serving hyperscalers, enterprises, and telecom carriers.

AI & Machine LearningCloud ComputingData & InfrastructureSemiconductorsSan Jose, US

Phil Delansay(Co-Founder; President & CEO (2004-2009), later SVP Business Development)Ramin Farjadrad(Co-Founder; Chief Architect (2005-2012), later VP Technology Development)inRamin Shirani(Senior Vice President, Engineering; Director)Linda Reddick(Senior Vice President, Finance (previously Chief Financial Officer, Sept. 2009-Jan. 2016))Phillippe Delansay(Executive Officer)Mark Voll(Chief Financial Officer)

Co-investorsAllegisCyber CapitalAugust CapitalCelesta CapitalGLOBALFOUNDRIESICCP Venture PartnersLightspeed Venture Partners+10 more

Building scalable quantum computers with reduced complexity and cost to reach error correction at scale.

Cambridge, US

Bharath Kannan(Executive Officer)Simon Gustavsson(Director)

Co-investorsBlindspot Ventures Management CoChalmers Ventures ABMassVenturesNeotribe VenturesThe E14 FundGlasswing Ventures

AtmosZero builds modular electrified heat pump boilers that draw heat from ambient air to produce emissions-free industrial steam as a drop-in replacement for fuel-burning boilers.

CleantechClimate TechEnergy

Addison Stark(Founder)in

Co-investorsConstellation Technology VenturesEnergy Impact PartnersAENUMitsubishi Heavy IndustriesStarlight VenturesVXI Capital

Axiomatic AI makes Lemma, an AI co-explorer for scientific and engineering work that helps users validate, derive, and analyze equations and reasoning across mathematics, physics, and engineering with reproducible Python-based modeling.

AI & Machine LearningDeep TechDeveloper Tools

Co-investorsPropagator VenturesTwo Small Fish VenturesKleiner PerkinsG Vision Capital

Axoft is developing soft, tissue-mimicking neural implants and supporting bidirectional electronics that record and stimulate brain activity through a minimally-invasive burr-hole procedure.

AI & Machine LearningDeep TechMedical DevicesCambridge, US

Paul Le Floch(Executive Officer, Director)inTianyang Ye(Director)inRachel Sha(Director)

BoardChia An Lee(Director)Benjamin Pless(Director)

Co-investorsArcherman CapitalBlindspot Ventures Management CoCastor Ventures (an Alumni Ventures Fund)Creative Destruction Lab (CDL)Safar PartnersAlumni Ventures+2 more

Bexorg is a biotech platform for CNS drug discovery built on a whole-brain perfusion model that allows manipulation and recording of cellular activity in intact human brains.

AI & Machine LearningBiotechDigital HealthMedical DevicesNew Haven, US

BoardZvonimir VrseljainNenad Sestan

Co-investorsAmplify PartnersConnecticut InnovationsAmplify Partners CVE1 Ventures

Biobot pioneers wastewater epidemiology, monitoring pathogens and substances in sewage to provide real-time public health surveillance at the community level.

BiotechData & InfrastructureGovTechHealthtechBoston, US

Newsha Ghaeli(Cofounder & President)inMariana Matus(Founder)inMariana Guadalupe Matus Garcia(Executive Officer, Director)

BoardVivek Pattipati(Director)inAndrew Perlman(Director)in

Co-investorsAmerican Family Insurance Institute for Corporate and Social ImpactBlindspot Ventures Management CoDCVC (Data Collective)Dorm RoomHomebrewPathbreaker Ventures+5 more

Blue Energy develops scalable small modular reactor (SMR) technology to deliver nuclear power at scale.

CleantechClimate TechDeep TechEnergyHardwareWashington, US

JakeTomJacob Jurewicz(Executive Officer, Director)Thomas O'Neill(Executive Officer, Director)

BoardOrin Hoffman(Director)Michael Kearney(Director)in

Co-investorsAt One VenturesAngular VenturesNucleation CapitalTamarack GlobalFounders FundKhosla Ventures+3 more

Boston Metal develops Molten Oxide Electrolysis (MOE), an electrified process for producing steel and other metals from a range of oxide feedstocks without direct emissions.

Advanced ManufacturingCleantechClimate TechNew MaterialsWoburn, US

Donald Sadoway(Co-founder (MIT professor))Antoine Allanore(Co-founder (MIT professor))Tadeu Carneiro(CEO)in

Co-investorsBreakthrough Energy VenturesClimate InvestmentPrelude VenturesInternational Finance CorporationBMW i VenturesEnergy Impact Partners+7 more

The page describes Photonic Fabric, an optical interconnect technology platform for the scale-up interconnect market that enables high-bandwidth, power-efficient links for AI data center infrastructure.

AI & Machine LearningDeep TechSector AgnosticSemiconductorsSanta Clara, US

Preetinder Virk(Chief Operating Officer)David Lazovsky(President and Chief Executive Officer)inKelyn Brannon(Chief Financial Officer)Philip Winterbottom(Chief Technology Officer)in

BoardLip-Bu Tan(Director)Alonso Galvan(Director)

Co-investorsFitz Gate VenturesIAG Capital PartnersKoch Disruptive TechnologiesM VenturesSamsung Catalyst FundTyche Partners+2 more

Cellineobio develops cell engineering and bioprocess technology platforms.

AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, US

Nabiha Saklayen, PhD(Co-Founder & CEO)inMarinna Madrid, PhD(Co-Founder & Chief Product Officer)Nabiha Saklayen(Executive Officer, Director)Matthias Wagner(Executive Officer, Director)

BoardKatie Rae(Director)in

Co-investors8VCCota CapitalFelicis VenturesHAWKTAILKhosla VenturesHumboldt

Commonwealth Fusion Systems develops commercial fusion power plants using high-temperature superconducting magnet technology to provide grid-scale energy.

CleantechClimate TechDeep TechEnergyCambridge, US

Brandon Sorbom(Founder)inRobert Mumgaard(Executive Officer, Director)inDaniel Brunner(Executive Officer)inBob Mumgaard(Founder)in

BoardMassimiliano Pieri(Director)Katie Rae(Director)in

Co-investorsAdvection Growth CapitalArmada Investment AGBay Bridge Ventures ClimateBeni Venture CapitalBrainstorm VenturesBreakthrough Energy Ventures+38 more

Copernic develops catalysts for zero-carbon ammonia and e-fuels that are cost-competitive and compatible with existing industrial infrastructure.

CleantechClimate TechDeep TechEnergyCambridge, US

Aruna Ramkrishnan(Founder)inJacob Ebenstein Grose(Executive Officer, Director)

BoardLindy Fishburne(Director)inMichael Kearney(Director)inMichael LoCascio(Director)

Co-investorsBreakout VenturesFuture VenturesInnospark VenturesJuniperNew Climate Ventures

DBOS provides an open-source library that adds durable workflows and queues to applications and AI agents, making them fault-tolerant, observable, and reproducible by connecting to a Postgres database with no new infrastructure.

AI & Machine LearningData & InfrastructureDeveloper Tools

Peter Kraft(Founder)inQian Li, PhD(Founder)in

Co-investorsConstruct CapitalSINEWAVE VENTURESGutbrain Ventures

DG Matrix builds the Interport platform, a multi-port solid-state transformer (SST) system for software-defined power distribution and electrification.

CleantechEnergyHardwareCary, US

Haroon Inam(Executive Officer, Director)in

BoardVlatko Vlatkovic(Director)

Co-investorsClean Energy VenturesTech Square Ventures

Droplet Biosciences develops cancer diagnostics with a focus on liquid biopsy and precision oncology.

BiotechDigital HealthHealthtechMedical DevicesMelrose, US

Haluk Tezcan(Chief Medical Officer)Stanley Lapidus(Director)Theresa Tribble(Executive Officer, Director)Aadel Chaudhuri(Executive Officer, Director)Jose Zevallos(Director)

BoardAnn DeWitt(Director)in

Co-investorsSafar Partners

Startup cofounded by Emmanuel Kasseris.

Co-investorsMassVenturesVectors Angel

Engine Ventures is a venture capital firm that invests in early-stage deep technology companies addressing fundamental challenges in energy, materials, infrastructure, computing, and healthcare.

AI & Machine LearningCleantechDeep TechCambridge, US

Katie Rae(Managing Partner)inIsrael Ruiz(President & General Partner)in

Co-investorsClean Energy Ventures

Evoloh operates high-throughput factories that manufacture electrolyzer stacks, sold as its Nautilus stack module to EPCs and project developers building hydrogen plants.

Advanced ManufacturingCleantechEnergy

Jimmy Rojas(Founder)

Co-investorsBaruch Future VenturesJuniperSafar PartnersThird Sphere

Finwave Semiconductor develops GaN-on-Silicon RF technology and devices, including E-mode GaN power amplifiers and high-power broadband RF switches for radio front-end applications.

Deep TechHardwareSemiconductors

Tomas Palacios(Co-founder)in

Co-investorsCastor Ventures (an Alumni Ventures Fund)Citta CapitalFine Structures VenturesFoothill VenturesIn-Q-TelSafar Partners+2 more

Protecting and restoring natural ecosystems, one plant cell at a time.

BiotechCambridge, US

Ashley Beckwith(Executive Officer, Director)

Foray Bioscience uses single plant cells and AI-powered software (Pando) to direct how plant matter forms, producing plant materials, molecules, and seeds without growing whole plants.

AgTechAI & Machine LearningBiotech

Ashley Beckwith(Founder & CEO)

Co-investorsService Provider CapitalTet Ventures

Form Energy develops and manufactures low-cost, multi-day iron-air battery systems for long-duration energy storage on the electric grid, serving utilities and project developers primarily in the United States.

Advanced ManufacturingCleantechEnergyHardware

Mateo Jaramillo(Founder & CEO)inTed Wiley(Founder)inYet-Ming Chiang(Founder)inMarco Ferrara(Founder)inWilliam Woodford(Founder)in

Co-investors2045 VenturesBlindspot Ventures Management CoBreakthrough Energy VenturesCarbonCoatue ManagementCongruent Ventures+12 more

Genomines uses biological systems to extract battery-grade nickel from low-grade soils, producing critical metals at lower cost and environmental impact than traditional mining.

BiotechCleantechEnergyNew MaterialsParis, FR

Fabien Koutchekian(CEO)inDali Rashid(CTO)in

Co-investorsCarbonDeepTech & Climate FondsEntrepreneur FirstForbionLOWERCARBONLowercarbon Capital+4 more

Hyfé operates a refining process that extracts specialty ingredients and chemical building blocks from food-processing waste and biomass.

Circular EconomyFoodTechNew MaterialsChicago, US

Michelle Ruiz(Executive Officer, Director)inAndrea Schoen(Executive Officer)

Co-investorsOverwater Ventures LlcSynthesis CapitalChemistryCraft VenturesPace Capital

Repurposing wastewater into low-cost feedstock to enable biomanufacturing at scale.

Ultra-efficient optical circuits to de-bottleneck data centers and telecom networks.

HyperLight develops thin-film lithium niobate (TFLN) photonic integrated circuits for high-bandwidth, energy-efficient optical applications in data centers, telecommunications, quantum computing, and AI systems.

AI & Machine LearningDeep TechHardwareSemiconductorsCambridge, US

Co-investorsFoothill Ventures

Enabling precision-genomic editing with single-stranded DNA technology.

Kano Therapeutics develops circular single-stranded DNA (cssDNA) as a genetic payload for gene-editing and other DNA-based therapies, offering an alternative to viral vectors and double-stranded DNA.

BiotechDeep TechCambridge, US

Floris Engelhardt(Executive Officer, Director)John Vroom(Director)

BoardAnn DeWitt(Director)in

Co-investorsFifty YearsLaunchpad Venture GroupMetaplanetVsquared VenturesZAKA VC

Kytopen develops non-viral gene delivery technology called Flowfect that combines fluid flow with electric fields to deliver payloads such as mRNA, DNA, and CRISPR Cas9 RNP into cells for high-throughput transfection.

BiotechDeep TechHardwareCambridge, US

Cullen Buie(Director)inPaulo Garcia(Executive Officer, Director, Promoter)inMichael Chiu(Director, Executive Officer)in

BoardPaxton Major(Director)Ann DeWitt(Director)inPaul Wotton(Director)

Co-investorsBantam GroupHorizons VenturesMassVenturesSelvedge VentureTBD AngelsTelegraph Hill Partners+1 more

Lilac Solutions develops direct lithium extraction technology using ceramic ion exchange media, enabling fast, clean, and affordable lithium production from brines for the electric vehicle and battery industries.

CleantechClimate TechEnergyNew MaterialsOakland, US

David Snydacker(President & Chief Technology Officer)inNicholas Goldberg(Chief Legal Officer of Issuer)David Gelinas(Chief Financial Officer of Issuer)inRaef Sully(Chief Executive Officer of Issuer)in

BoardClay Dumas(Director)inDavid Danielson(Director)in

Co-investorsBreakthrough Energy VenturesLowercarbon CapitalAzolla VenturesBMW i VenturesMount Wilson VenturesPrelude Ventures+7 more

Mantel Capture, Inc. appears to operate in process engineering and commissioning, with roles referencing boilers, licensing, and research; the page itself provides no explicit statement of the company's product or market.

CleantechClimate TechNew MaterialsCambridge, US

Cameron Halliday(Co-founder & CEO)inDanielle Rapson(Co-founder & COO)inDanielle Colson(Cofounder)inSean Robertson(Co-founder & CTO)inHoosiweng Ow(Director)

BoardHooisweng Ow(Director)

Co-investorsEni NextNew Climate VenturesShell VenturesWaverley Capital

Matrisome Bio is an oncology biotech developing therapies based on extracellular matrix (ECM) biology, using a protein engineering platform to target the tumor microenvironment.

BiotechDeep TechHealthtech

Noor Jailkhani(Chief Executive Officer, Co-Founder & President)inRichard Hynes(Co-Founder / Professor, MIT & HHMI)Sangeeta Bhatia(Co-Founder / Professor, MIT & HHMI)inMonica Gostissa(Chief Science Officer)inEdward Tad Stewart(Chief Business Officer)in

Co-investorsBold Capital Partners

Mori makes a silk protein-based protective coating that extends the shelf life of fresh and packaged foods.

Co-investorsAcre Venture PartnersBlindspot Ventures Management CoBluestein VenturesCollaborative FundDns CapitalToba Capital+1 more

Osmoses develops a membrane technology for purifying and separating gas molecules, aimed at making industrial gas separation processes more energy-efficient.

CleantechClimate TechDeep TechNew MaterialsBoston, US

Francesco Benedetti(Co-Founder & CEO)Katherine Mizrahi Rodriguez(Co-Founder & Chief Implementation Officer)inZachary P. Smith(Co-Founder / Associate Professor, MIT)

Co-investorsBlindspot Ventures Management CoFine Structures VenturesMassVenturesNew Climate VenturesOrbia Ventures

Oso Semiconductor develops power-efficient, high-performance beamforming chipsets for wireless systems using phased-array (electrically steered) antennas, based on ultra-low-loss beamforming IP.

Defense TechHardwareSemiconductors

Co-investorsEntrada VenturesFitz Gate Ventures

Overview Energy develops space-based solar power systems that beam energy from space to Earth, drawing on expertise in aerospace, energy systems, and manufacturing.

CleantechEnergySpace TechCovina, US

Abdullah Al-ShakarchiinDr. Paul JaffeinDr. Patrick MockinHannah MacKayinSagi KfirinAndrew Cantino(Executive Officer, Director)in

Co-investorsAngel Collective Opportunity FundAurelia FoundryColle Capital PartnersJetstreamPrime Movers LabRice Investment Group+2 more

A materials breakthrough to eliminate the climate impact of cooling.

Co-investorsBlindspot Ventures Management Co

Pascal is developing solid refrigerants for the heating, ventilation, and air conditioning (HVAC) industry that operate in the same temperature and pressure ranges as gaseous refrigerants but with zero global warming potential.

CleantechClimate TechNew MaterialsCambridge, US

Adam SlavneyJinyoung SeoJarad Mason

Co-investorsBlindspot Ventures Management Co

Provides insights by analyzing data and content about brands on the internet.

Mcminnville, US

Dale Djerassi(Director)Brian Feucht(Executive Officer)

BoardRoger Lang(Executive Officer, Director)in

Co-investorsInspiration VenturesCerraCap VenturesIllumina Ventures

Using molecular diagnostics to transform the patient experience and unlock novel therapies.

Predicta Biosciences operates a molecular insights platform for blood cancer care, using whole genome sequencing of intact circulating tumor cells from a single blood sample combined with single-cell immune profiling to characterize disease biology and immune response.

BiotechDigital HealthMedical DevicesCambridge, US

Irene Ghobrial(Co-founder)Kenneth Anderson(Co-founder)Gad Getz(Co-founder)Romanos Sklavenitis-Pistofidis(Co-founder)Keith Flaherty(Co-founder)Brian McKernan(CEO)

Co-investorsIllumina Ventures

Quaise Energy develops ultra-deep geothermal drilling using gyrotron-powered millimeter-wave technology to reach depths up to 20 km and temperatures up to 500°C, aiming to build superhot geothermal power plants.

CleantechDeep TechEnergy

Carlos Araque(Founder)

Co-investorsHelium-3 Ventures

Quaise Energy develops superhot geothermal drilling technology using millimeter-wave powered drilling to access deep geothermal energy sources at unprecedented depths and temperatures for large-scale clean power generation globally.

CleantechDeep TechEnergyHouston, US

Carlos Araque(Executive Officer, Director)inMatt Houde(Founder)in

BoardColleen Calhoun(Director)inVinod Khosla(Director)William Restrepo(Director)Frohman Anderson(Director)

Co-investorsCollaborative FundFine Structures VenturesHelium-3 VenturesPrelude VenturesTechEnergy VenturesXplorer Capital+5 more

Resonant Link Inc. developed wireless power technology and is no longer operating as an active business, now managing and licensing its patent portfolio for non-medical wireless power.

Deep TechEnergyHardwareMedical DevicesShelburne, US

Grayson Zulauf(Executive Officer, Director)Aaron Stein(Director)

BoardOrin Hoffman(Director)Shilpi Kumar(Director)in

Co-investorsISVWIND VenturesScout VenturesThird Sphere

Applying a fundamental mathematical insight to the problem of turbulence.

Co-investorsThird Sphere

RISE Robotics develops RISE® Cylinder, a fluid-free electro-mechanical alternative to hydraulic cylinders for heavy equipment and machinery that uses belt technology to deliver hydraulic-like forces with significantly greater energy efficiency.

Advanced ManufacturingCleantechDeep TechHardwareRoboticsBoston, US

Arron Acosta(Co-Founder, VP of Business Development)Blake Sessions(Co-Founder & Chief Technology Officer)Toomas Sepp(Co-Founder & Chief Engineer)Kyle Dell'Aquila(Co-Founder & Head of Industrial Design & Customer Experience)inHiten Sonpal(Chief Executive Officer)

Co-investorsDecisive PointTechstars

Seaspire develops safe and sustainable suncare and skincare products using Xanthochrome®, a proprietary class of biomolecules inspired by oceanic compounds.

Advanced ManufacturingBiotechConsumerDirect to ConsumerWellness & FitnessCambridge, US

Camille A. Martin(CEO and co-founder)inLeila Deravi(Co-founder and scientific advisor)Camille Martin, PhD(Founder)in

Co-investorsHuntington Angels NetworkMassVenturesSafar PartnersTechstarsAlumni Ventures

Sora Fuel produces sustainable aviation fuel (SAF) and diesel using a proprietary closed-loop direct air capture and conversion process that draws carbon from air rather than biomass or industrial feedstocks.

CleantechClimate TechEnergyCambridge, US

Curtis BerlinguetteinGareth Ross(Executive Officer, Director)inCurtis Belinguete(Director)

BoardPatrick Sarver(Director)inMarc Tarpenning(Director)inMichael Kearney(Director)in

Co-investorsInnovation UBCInspired CapitalLeitmotifSpero VenturesWireframe Ventures

Sublime Systems develops an energy-saving, carbon-reducing process for manufacturing cement from previously inaccessible minerals.

CleantechClimate TechConstruction TechNew MaterialsBoston, US

Leah Ellis(Co-founder)inYet-Ming Chiang(Co-founder)in

Co-investorsAzolla VenturesCongruent VenturesEnergy Impact PartnersLOWERCARBONLowercarbon CapitalPrime Impact Fund+3 more