Cambridge · Pre-Seed–Series A · 25 people tracked
Also known as FWH MANAGEMENT COMPANY, LLC · The Engine
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Investment thesis
Engine Ventures invests in Tough Tech founders tackling problems at the edge of what is technically possible and economically essential, rebuilding foundational systems the world depends on across energy, materials, infrastructure, computing, and human health. It recognizes that such technologies face deep scientific risk, first-of-kind engineering, regulatory scrutiny, manufacturing scale-up, and long deployment timelines. The firm invests early and stays close from technical validation through industrial scale, working alongside founders to define milestones, structure durable capital, build leadership teams, and connect companies to partners, policymakers, and customers. Rooted near MIT, Harvard, and the Boston research community, it operates globally while drawing on one of the densest innovation ecosystems.
Source: firm website, verified Sep 29, 2026.
Team · 25 people
from the firm's website & curated & public directoriesWhat they invest in
from 84 of 113 portfolio companiesDeep Tech ×40Biotech ×29Cleantech ×27AI & Machine Learning ×22Energy ×20Hardware ×20Medical Devices ×17New Materials ×16
HQs:United States×62France×1United Kingdom×1New Zealand×1
Who they back
founder profiles across 39 portfolio companiesFounding team size:solo founder×82 founders×123 founders×74+ founders×12
Where their founders studiedfrom 54 founders with education data
Massachusetts Institute of Technology ×12Harvard University ×7Harvard Business School ×5Stanford University ×3Duke University ×2MIT Sloan School of Management ×2Northeastern University ×2UCLA ×2
What their founders studiedfrom 59 founders with field-of-study data
Engineering ×36Physics ×12Computer Science ×7Business & Management ×5Chemistry ×5Finance & Accounting ×2Life Sciences ×2Mathematics & Statistics ×2
Where their founders worked beforefrom 55 founders with career history
Massachusetts Institute of Technology ×12Google ×5Stanford University ×5Humatics ×3Massachusetts Institute of Technology (MIT) ×3Avila ×2Broad Institute of MIT and Harvard ×2Cornell ×2
Accelerator rootsportfolio companies that came through a program
35 founders hold a PhD · 9 hold an MBA (of 59 with degree data)
Investments · 113 tracked
founders shown can be your intro pathBy year:2026 · 12025 · 32024 · 22022 · 32021 · 32019 · 12017 · 114 dated
Amide develops technology to automate peptide synthesis, transitioning advanced manufacturing methods from research settings into practical commercial applications.
Advanced ManufacturingBiotechDeep Tech
Co-investorsKhosla Ventures
ISEE AI builds fully autonomous yard trucks for industrial supply chain and logistics operations, combining an AI platform with software and hardware engineering to automate yard operations.
AI & Machine LearningLogistics & Supply ChainRoboticsCambridge, US
Yibiao Zhao(Executive Officer, Director)inLe Yu(Director)
Board seatReed Sturtevant· per SEC Form D
Co-investorsBoston Seed CapitalEniac VenturesHyperplane Venture CapitalMaersk GrowthSafar PartnersSamsung Next+1 more
STRM.BIO develops technology to deliver gene therapies, aiming to improve how these treatments reach patients.
BiotechDeep TechHealthtechLongevityMedical Devices
Michael Luther(CEO)in
Co-investorsAscension VenturesBreakout LabsBreakout VenturesDelos CapitalNYBC VenturesBoehringer Ingelheim Venture Fund+1 more
Abselion develops measurement tools and a platform combining hardware, purpose-built assay formats, and software for biological measurements such as protein quantification.
BiotechDeep TechHardwareMedical DevicesCambridge, GB
Dr Ruizhi Wang(CEO)
Co-investorsCambridge Angels groupM VenturesBusiness Growth FundR42 GroupUniversity of Cambridge EnterpriseUntitled Ventures
Addis Energy develops technology that combines oil and gas engineering expertise with advanced research to access energy and resources from subsurface geology.
CleantechDeep TechEnergySomerville, US
Michael Alexander(Founder)inCharlie Mitchell, P.E.(Founder)inIwnetim Iwnetu Abate(Director)Oliver Charles Mitchell(Director)
BoardLaurie Menoud(Director)inMichael Kearney(Director)in
Co-investorsAt One VenturesBlindspot Ventures Management CoPillar VCVoyager PartnersFounders FundKhosla Ventures
Anthology develops designer and hybrid genomes by decoding genomic "language" to engineer microbes that convert feedstocks such as sugars, plastics, and agricultural waste into products like chemicals, materials, and food ingredients.
BiotechFoodTechNew Materials
Dr. Tzu-Chieh 'Zijay' Tang(CTO & Co-Founder)
Co-investorsAlumni VenturesCollaborative FundJuniperTaihill VentureThe E14 Fund
Apeiron Labs develops autonomous underwater vehicles and ocean technology for marine applications.
Climate TechDeep TechIoTRoboticsCambridge, US
Ravi Pappu(CEO / Board Member)in
BoardSanjeev Krishnan(Director)Jonathan Rosen(Director)David Douglas(Director)Kyle Teamey(Director)inMark Abbott(Director)
Co-investorsBay Bridge Ventures ClimateCoalitionS2G InvestmentsTFX CapitalBreakthrough Energy VenturesRA Capital
Marvell designs custom silicon and provides interconnect and network switch products for AI data center infrastructure, serving hyperscalers, enterprises, and telecom carriers.
AI & Machine LearningCloud ComputingData & InfrastructureSemiconductorsSan Jose, US
Phil Delansay(Co-Founder; President & CEO (2004-2009), later SVP Business Development)Ramin Farjadrad(Co-Founder; Chief Architect (2005-2012), later VP Technology Development)inRamin Shirani(Senior Vice President, Engineering; Director)Linda Reddick(Senior Vice President, Finance (previously Chief Financial Officer, Sept. 2009-Jan. 2016))Phillippe Delansay(Executive Officer)Mark Voll(Chief Financial Officer)
Co-investorsAllegisCyber CapitalAugust CapitalCelesta CapitalCisco InvestmentsGLOBALFOUNDRIESICCP Venture Partners+11 more
Building scalable quantum computers with reduced complexity and cost to reach error correction at scale.
Cambridge, US
Bharath Kannan(Executive Officer)inSimon Gustavsson(Director)in
Co-investorsBlindspot Ventures Management CoChalmers Ventures ABGlasswing VenturesMassVenturesNeotribe VenturesThe E14 Fund+2 more
AtmosZero builds modular electrified heat pump boilers that draw heat from ambient air to produce emissions-free industrial steam as a drop-in replacement for fuel-burning boilers.
CleantechClimate TechEnergy
Addison Stark(Founder)in
Co-investorsAENUConstellation Technology VenturesEnergy Impact PartnersMitsubishi Heavy IndustriesStarlight VenturesVXI Capital
Axiomatic AI makes Lemma, an AI co-explorer for scientific and engineering work that helps users validate, derive, and analyze equations and reasoning across mathematics, physics, and engineering with reproducible Python-based modeling.
AI & Machine LearningDeep TechDeveloper Tools
Co-investorsPropagator VenturesTwo Small Fish VenturesKleiner PerkinsG Vision Capital
Axoft is developing soft, tissue-mimicking neural implants and supporting bidirectional electronics that record and stimulate brain activity through a minimally-invasive burr-hole procedure.
AI & Machine LearningDeep TechMedical DevicesCambridge, US
Paul Le Floch(Executive Officer, Director)inTianyang Ye(Director)inRachel Sha(Director)in
BoardChia An Lee(Director)Benjamin Pless(Director)
Co-investorsAlumni VenturesAmino CapitalArcherman CapitalBlindspot Ventures Management CoCastor VenturesCreative Destruction Lab (CDL)+4 more
Bexorg is a biotech platform for CNS drug discovery built on a whole-brain perfusion model that allows manipulation and recording of cellular activity in intact human brains.
AI & Machine LearningBiotechDigital HealthMedical DevicesNew Haven, US
Zvonimir Vrselja Nenad Sestan(Founder)
BoardZvonimir Vrselja(Founder)inNenad Sestan(Founder)
Co-investorsAmplify PartnersConnecticut InnovationsE1 Ventures
Biobot pioneers wastewater epidemiology, monitoring pathogens and substances in sewage to provide real-time public health surveillance at the community level.
BiotechData & InfrastructureGovTechHealthtechBoston, US
Newsha Ghaeli(President)inMariana Matus(Founder)inMariana Guadalupe Matus Garcia(Executive Officer, Director)Ayo Omojola(Investor)in
BoardVivek Pattipati(Director)inAndrew Perlman(Director)in
Co-investorsAmerican Family Insurance Institute for Corporate and Social ImpactBlindspot Ventures Management CoDCVC (Data Collective)DesignXDorm RoomHomebrew+22 more
Blue Energy develops scalable small modular reactor (SMR) technology to deliver nuclear power at scale.
CleantechClimate TechDeep TechEnergyHardwareWashington, US
JakeTomJacob Jurewicz(Executive Officer, Director)Thomas O'Neill(Executive Officer, Director)Jake Jurewicz(CEO & Co-founder)
BoardOrin Hoffman(Director)
Co-investorsAt One VenturesAngular VenturesNeutron Power VenturesNucleation CapitalTamarack GlobalFounders Fund+4 more
Blueshift creates AI-driven solutions for customer engagement and marketing intelligence that enable consumer marketers to execute data-driven campaigns across multiple channels.
AI & Machine LearningMarketing TechSaaSSan Francisco, US
Subramanyam Mallela(Executive Officer, Director)Mehul Shah(Founder)inVijay Chittoor(Founder)inManyam Mallela(Founder)
BoardJishnu Bhattacharjee(Director)inAnshu Sharma(Director)
Co-investorsAvatar Growth Capital PartnersConductive VenturesGreat Oaks Venture CapitalMilliways VenturesNew Enterprise Associates (NEA)R136 Ventures+5 more
Boston Metal develops Molten Oxide Electrolysis (MOE), an electrified process for producing steel and other metals from a range of oxide feedstocks without direct emissions.
Advanced ManufacturingCleantechClimate TechNew MaterialsWoburn, US
Donald Sadoway(Founder)inAntoine Allanore(Founder)Tadeu Carneiro(CEO)inJames Yurko(Founder)
Co-investorsBreakthrough Energy VenturesClimate InvestmentPrelude VenturesInternational Finance CorporationBMW i VenturesEnergy Impact Partners+8 more
Butlr makes anonymous thermal sensors that measure occupancy and space utilization across offices, buildings, campuses, stores, and labs without cameras, badges, or Wi-Fi tracking.
AI & Machine LearningDigital HealthHardwareHealthtechIoTPropTechSan Francisco, US
Honghao Deng(Founder)inJiani Zeng(Founder)inHonghao Deng Jiani Zeng(Founder)
BoardRaymond Stuart Stata(Director)Seth Levine(Director)inNaimish Patel(Director)in
Co-investors1Flourish Capital500 GlobalFounder CollectiveFoundryGS FuturesHDS Capital+17 more
Hyperion Biosystems builds diagnostic devices that use computer vision and physics-based algorithms to improve the sensitivity and specificity of point-of-care and at-home tests.
AI & Machine LearningHealthtechMedical Devices
Co-investorsNewlin Investment Company LLCSafar PartnersBoston Millennia PartnersBreakout LabsCranberry CapitalPropel Venture Partners
The page describes Photonic Fabric, an optical interconnect technology platform for the scale-up interconnect market that enables high-bandwidth, power-efficient links for AI data center infrastructure.
AI & Machine LearningDeep TechSector AgnosticSemiconductorsSanta Clara, US
Preetinder Virk(Chief Operating Officer)David Lazovsky(Founder)inKelyn Brannon(Chief Financial Officer)Philip Winterbottom(Chief Technology Officer)inDave Lazovsky(Founder)Preet Virk(Founder)
Co-investorsFitz Gate VenturesIAG Capital Partnersimec.xpandKoch Disruptive TechnologiesM VenturesSamsung Catalyst Fund+11 more
Cellineobio develops cell engineering and bioprocess technology platforms.
AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, US
Nabiha Saklayen, PhD(Co-Founder & CEO)inMarinna Madrid, PhD(Co-Founder & Chief Product Officer)inNabiha Saklayen(Founder)inMatthias Wagner(Founder)inMarinna Madrid(Founder)Stan Wang(Founder)
Co-investors8VCCota CapitalFelicis VenturesHAWKTAILKhosla VenturesHumboldt+1 more
Commonwealth Fusion Systems develops commercial fusion power plants using high-temperature superconducting magnet technology to provide grid-scale energy.
CleantechClimate TechDeep TechEnergyCambridge, US
Brandon Sorbom(Founder)inRobert Mumgaard(Executive Officer, Director)inDaniel Brunner(Executive Officer)inBob Mumgaard(Founder)inDan Brunner(Founder)Dennis Whyte(Founder)
Co-investorsAdvection Growth CapitalArmada Investment AGBay Bridge Ventures ClimateBeni Venture CapitalBrainstorm VenturesBreakthrough Energy Ventures+45 more
Concerto Bio generates large-scale ecological datasets on microbial communities and uses them to develop microbe-based consumer health products for applications such as skincare, chronic disease, and nutrition.
AI & Machine LearningBiotechDeep TechCambridge, US
Jared Kehe(Executive Officer, Director)inCheri Ackerman(Executive Officer, Director)inBernardo Cervantes(Executive Officer, Director)inVera Schroeder(Director)in
BoardSarah Luppino(Director)in
Co-investorsAlumni VenturesExcelestar VenturesGolden SeedsHorizons VenturesISVM Ventures+4 more
Copernic develops catalysts for zero-carbon ammonia and e-fuels that are cost-competitive and compatible with existing industrial infrastructure.
CleantechClimate TechDeep TechEnergyCambridge, US
Aruna Ramkrishnan(Founder)inJacob Ebenstein Grose(Executive Officer, Director)
BoardLindy Fishburne(Director)inMichael Kearney(Director)inMichael LoCascio(Director)
Co-investorsBreakout VenturesFuture VenturesInnospark VenturesJuniperNew Climate Ventures
DBOS provides a durable workflow platform with observability and management tooling, letting developers view, cancel, resume, fork, and export application workflows through its Conductor console.
AI & Machine LearningCloud ComputingData & InfrastructureDeveloper Tools
Peter Kraft(Founder)inQian Li, PhD(Founder)inMike Stonebraker(Co-founder)
Co-investorsConstruct CapitalSINEWAVE VENTURESGutbrain Ventures
DG Matrix builds the Interport platform, a multi-port solid-state transformer (SST) system for software-defined power distribution and electrification.
CleantechEnergyHardwareCary, US
Haroon Inam(Executive Officer, Director)in
BoardVlatko Vlatkovic(Director)
Co-investorsat HulaCerberus VenturesClean Energy VenturesInnova Capital Partners, LLCTech Square VenturesThird Derivative
Droplet Biosciences develops cancer diagnostics with a focus on liquid biopsy and precision oncology.
BiotechDigital HealthHealthtechMedical DevicesMelrose, US
Haluk Tezcan(Chief Medical Officer)inStanley Lapidus(Director)inTheresa Tribble(Executive Officer, Director)Aadel Chaudhuri(Executive Officer, Director)Jose Zevallos(Director)
BoardAnn DeWitt(Director)in
Co-investorsIdeashipSafar Partners
Startup cofounded by Emmanuel Kasseris.
Co-investorsGOOSE CapitalMassVenturesVectors AngelVX Ventures
Encora Therapeutics makes the Encora X1, an FDA-cleared, prescription wrist-worn device that uses mechanical neurostimulation to relieve hand tremors in adults with essential tremor.
HardwareHealthtechMedical Devices
Daniel Carballo(Cofounder)inAllison Davanzo(Cofounder)Kyle Pina(Cofounder)in
Co-investorsGood Growth CapitalInnospark VenturesSafar PartnersSBXi
Evoloh operates high-throughput factories that manufacture electrolyzer stacks, sold as its Nautilus stack module to EPCs and project developers building hydrogen plants.
Advanced ManufacturingCleantechEnergy
Jimmy Rojas(Founder)
Co-investorsBaruch Future VenturesCollaborative FundJuniperSafar PartnersThird SphereGS Futures
Finwave Semiconductor develops GaN-on-Silicon RF technology and devices, including E-mode GaN power amplifiers and high-power broadband RF switches for radio front-end applications.
Deep TechHardwareSemiconductors
Tomas Palacios(Co-founder)in
Co-investorsAlumni VenturesCastor VenturesCitta CapitalFine Structures VenturesFoothill VenturesIn-Q-Tel+5 more
Foray Bioscience uses single plant cells and AI-powered software (Pando) to direct how plant matter forms, producing plant materials, molecules, and seeds without growing whole plants.
AgTechAI & Machine LearningBiotechCambridge, US
Ashley Beckwith(Founder & CEO)in
Co-investorsCollaborative FundMilemark Capital PartnersService Provider CapitalReGen VenturesTet Ventures
Form Energy develops and manufactures low-cost, multi-day iron-air battery systems for long-duration energy storage on the electric grid, serving utilities and project developers primarily in the United States.
Advanced ManufacturingCleantechEnergyHardware
Mateo Jaramillo(Founder)inTed Wiley(Founder)inYet-Ming Chiang(Founder)inMarco Ferrara(Founder)inWilliam Woodford(Founder)in
Co-investors2045 VenturesBlindspot Ventures Management CoBreakthrough Energy VenturesCarbonCoatue ManagementCongruent Ventures+12 more
Foundational Alloy develops engineering alloys through a solid-state process called MetalsFIRST, in which metal is produced without melting to create microstructures unreachable by conventional metallurgy while controlling oxygen and contaminants.
Advanced ManufacturingDeep TechNew Materials
Jasper Lienhard(Founder)Jake(Co-founder (company strategy, operations, financing, commercialization))Chris Schuh(Founder)Jake Guglin(Founder)Tim Rupert(Founder)
Co-investorsAlumni VenturesAmerica's Frontier FundBasecamp FundCastor VenturesEl Cap EquityMaterial Impact+6 more
Alex Gu(Founder)Zen Koh(Founder)
Co-investorsSoftBank Vision FundGeneral CatalystIDG CapitalInnospark VenturesTau Ventures
Genomines uses biological systems to extract battery-grade nickel from low-grade soils, producing critical metals at lower cost and environmental impact than traditional mining.
BiotechCleantechEnergyNew MaterialsParis, FR
Fabien Koutchekian(Founder)inDali Rashid(Founder)inDr. Dali Rashid(Founder)
Co-investorsCarbonDeepTech & Climate FondsEntrepreneur FirstForbionHEC Paris IncubatorLowercarbon Capital+7 more
Harton Therapeutics offers a GMP-ready platform for advanced 3D cell manufacturing, using a perfusion-based single-use cartridge system with automated process control to produce human cells at scale.
Advanced ManufacturingBiotechMedical Devices
Co-investorsDecheng Capital
Hyfé operates a refining process that extracts specialty ingredients and chemical building blocks from food-processing waste and biomass.
Circular EconomyFoodTechNew MaterialsChicago, US
Michelle Ruiz(Executive Officer, Director)inAndrea Schoen(Executive Officer)
Co-investorsOverwater Ventures LlcSynthesis CapitalChemistryCraft VenturesPace Capital
HyperLight develops thin-film lithium niobate (TFLN) photonic integrated circuits for high-bandwidth, energy-efficient optical applications in data centers, telecommunications, quantum computing, and AI systems.
AI & Machine LearningDeep TechHardwareSemiconductorsCambridge, US
Co-investorsFoothill VenturesXora
HyperSpectral develops a spectral sensing and AI layer for Physical AI that interprets matter through spectral data, molecular identification, and AI architecture.
AI & Machine LearningDeep TechDefense TechHardwareAlexandria, US
Matthew Theurer(Executive Officer, Director)Lauren Stack(Executive Officer, Director)inVincent Lubsey(Executive Officer)
BoardJuan Lopez(Director)inWilliam Porteous(Director)in
Co-investorsKibo VenturesRRE VenturesAngelini VenturesGlade Brook Capital PartnersHeal CapitalLifeX Ventures+1 more
Kano Therapeutics develops circular single-stranded DNA (cssDNA) as a genetic payload for gene-editing and other DNA-based therapies, offering an alternative to viral vectors and double-stranded DNA.
BiotechDeep TechCambridge, US
Floris Engelhardt(Executive Officer, Director)John Vroom(Director)
BoardAnn DeWitt(Director)in
Co-investorsFifty YearsLaunchpad Venture GroupMetaplanetVsquared VenturesZAKA VC
Kytopen develops non-viral gene delivery technology called Flowfect that combines fluid flow with electric fields to deliver payloads such as mRNA, DNA, and CRISPR Cas9 RNP into cells for high-throughput transfection.
BiotechDeep TechHardwareCambridge, US
Cullen Buie(Founder; Board Observer)inPaulo Garcia(Founder)inMichael Chiu(Chief Executive Officer)in
BoardPaxton Major(Director)inAnn DeWitt(Director)inPaul Wotton(Director)
Co-investorsBantam GroupHorizons VenturesMassVenturesSelvedge VentureTBD AngelsTelegraph Hill Partners+2 more
Lilac Solutions develops direct lithium extraction technology using ceramic ion exchange media, enabling fast, clean, and affordable lithium production from brines for the electric vehicle and battery industries.
CleantechClimate TechEnergyNew MaterialsOakland, US
David Snydacker(Founder)inNicholas Goldberg(Chief Legal Officer of Issuer)David Gelinas(Chief Financial Officer of Issuer)inRaef Sully(Chief Executive Officer of Issuer)inDave Snydacker(Founder)
BoardClay Dumas(Director)in
Co-investorsBreakthrough Energy VenturesLowercarbon CapitalAzolla VenturesBerkeley Angel NetworkBMW i VenturesE8 Angels+10 more
Martin Bazant(Founder)Mo Alkhadra(Founder)Mohammad Alkhadra(Founder)
Co-investorsClean Energy VenturesLowercarbon Capital
MacroCycle uses a proprietary chemical process called SolvoGenesis, based on solvent systems and macrocyclic chemistry, to convert textile waste into pure polyester resin at low cost.
Circular EconomyCleantechNew MaterialsCambridge, US
Stwart Peña Feliz(Executive Officer, Director)inJan-Georg Rosenboom(Executive Officer, Director)in
BoardCatia Cesari(Director)Temple Fennell(Director)in
Co-investorsCircular Innovation FundCollaborative FundNeotribe VenturesVolta CircleClean Energy VentureClean Energy Ventures+2 more
Mantel Capture, Inc. appears to operate in process engineering and commissioning, with roles referencing boilers, licensing, and research; the page itself provides no explicit statement of the company's product or market.
CleantechClimate TechNew MaterialsCambridge, US
Cameron Halliday(Founder)inDanielle Rapson(Founder)inDanielle Colson(Cofounder)inSean Robertson(Founder)inHoosiweng Ow(Director)
BoardHooisweng Ow(Director)
Co-investorsAlumni VenturesAOKI LABSEni NextNew Climate VenturesThird DerivativeArosa Ventures+9 more
Matrisome Bio is an oncology biotech developing therapies based on extracellular matrix (ECM) biology, using a protein engineering platform to target the tumor microenvironment.
BiotechDeep TechHealthtech
Noor Jailkhani(Chief Executive Officer, Co-Founder & President)inRichard Hynes(Co-Founder / Professor, MIT & HHMI)Sangeeta Bhatia(Co-Founder / Professor, MIT & HHMI)inMonica Gostissa(Chief Science Officer)inEdward Tad Stewart(Chief Business Officer)in
Co-investorsBold Capital Partners
MAV Unlimited develops volumetric 3D printing technology that manufactures objects in minutes rather than hours by printing the entire object simultaneously instead of layer-by-layer.
Advanced ManufacturingDeep TechHardwarePortland, US
Robert Shepherd(Co-founder)Thomas Wallin(Director)Aaron Pempel(Executive Officer, Director)
Co-investorsDeep FuturePortland Seed Fund
Merida is a biotherapeutics company developing a new class of drugs designed to selectively and durably eliminate the pathogenic antibodies that drive autoimmune and allergic diseases.
BiotechHealthtech
Pierre Bruhns(Co-founder; Director of Research, Pasteur Institute)Mark Shlomchik(Co-founder; Professor of Immunology, University of Pittsburgh)Michael Naill(Senior Vice President, Process and Product Development)in
Co-investorsBain Capital Life SciencesThird Rock VenturesGV (Google Ventures)Biotechnology Value Fund
Mori makes a silk protein-based protective coating that extends the shelf life of fresh and packaged foods.
Co-investorsAcre Venture PartnersBlindspot Ventures Management CoBluestein VenturesCollaborative FundDns CapitalToba Capital+1 more
Multiply Labs builds robotic systems that automate biologics manufacturing for pharmaceutical companies.
Advanced ManufacturingBiotechDeep TechRoboticsSan Francisco, US
Fred Parietti(CEO)inAlice Melocchi(CSO)inNaveen Jain(Investor)inJoe Wilson(COO)Tiffany Kuo(Head of Marketing and Operations)Zack Bright(Lead Robotics Engineer)
Co-investorsFifty YearsGarage CapitalJude GomilaLingottoP101 VenturesStrange Ventures+16 more
Northwood provides end-to-end ground infrastructure for space missions, from concept through deployment to live data delivery.
Deep TechHardwareSaaSSpace Tech
Shaurya Luthra(Founder)inBridgit Mendler(Founder)Griffin Cleverly(Founder)
Co-investorsAlpine Space VenturesAlso CapitalAlumni VenturesAndreessen HorowitzAurelia FoundryBalerion Space Ventures+13 more
Notch is an agentic AI operations platform that automates customer-facing, internal, and back-office workflows for regulated industries such as insurance, finance, and telecom.
AI & Machine LearningEnterprise SoftwareSaaSNew York City, US
Elool Jacoby(Founder)inRafael Broshi(Founder)Yuval Peled(Founder)
Co-investorsJibe VenturesLitquidity VenturesGolden VenturesHeadlineIlluminate FinancialLightspeed Venture Partners+2 more
OpenStar develops compact fusion energy technology using a levitated dipole approach and high-temperature superconducting systems, working toward commercial fusion.
CleantechDeep TechEnergyWellington, NZ
Ratu Mataira(Founder)inThomas Berry(Co-founder & Chief Product Officer)inDarren Garnier(Chief Science Officer)inRod Badcock(Chief Technology Officer)inNicole Ferguson(VP - Finance)inBen Taylor-Bryant(VP - Investor Relations)in
Co-investorsBlackbird VenturesIcehouse VenturesNZ Growth Capital PartnersOutset VenturesRadar Ventures
Osmoses develops a membrane technology for purifying and separating gas molecules, aimed at making industrial gas separation processes more energy-efficient.
CleantechClimate TechDeep TechNew MaterialsBoston, US
Francesco Benedetti(Co-Founder & CEO)inKatherine Mizrahi Rodriguez(Co-Founder & Chief Implementation Officer)inZachary P. Smith(Co-Founder / Associate Professor, MIT)
Co-investorsBlindspot Ventures Management CoCollaborative FundFine Structures VenturesMassVenturesNew Climate VenturesOrbia Ventures
Francesco Maria Benedetti(Founder)Holden Lai(Founder)Katherine Mizrahi Rodriguez(Founder)Zachary Smith(Founder)
Co-investorsBlindspot Ventures Management CoEnergy Capital Ventures
Oso Semiconductor develops power-efficient, high-performance beamforming chipsets for wireless systems using phased-array (electrically steered) antennas, based on ultra-low-loss beamforming IP.
Defense TechHardwareSemiconductors
Co-investorsCollaborative FundEntrada VenturesFitz Gate Ventures
Overview Energy develops space-based solar power systems that beam energy from space to Earth, drawing on expertise in aerospace, energy systems, and manufacturing.
CleantechEnergySpace TechCovina, US
Abdullah Al-Shakarchi(Co-CEO)inDr. Paul JaffeinDr. Patrick MockinHannah MacKayinSagi KfirinAndrew Cantino(Co-Founder of Overview Energy)in
Co-investorsAngel Collective Opportunity FundAurelia FoundryColle Capital PartnersDangerous VenturesEarthrise VenturesJetstream+4 more
Ivo Crnkovic-Rubsamen(Founder)Matthew Downey(Founder)
Co-investorsAntlerBlindspot Ventures Management CoSouth Park CommonsUnion Square Ventures (USV)
Pascal is developing solid refrigerants for the heating, ventilation, and air conditioning (HVAC) industry that operate in the same temperature and pressure ranges as gaseous refrigerants but with zero global warming potential.
CleantechClimate TechNew MaterialsCambridge, US
Adam SlavneyinJinyoung SeoinJarad Mason
Co-investorsBlindspot Ventures Management CoCollaborative FundLB Investment
Pearl Bio develops technologies for genome engineering, ribosome engineering, and biomanufacturing to enable production of novel proteins, chemicals, and materials for biotechnology and medicine.
BiotechDeep TechNew MaterialsStamford, US
Farren Isaacs(Founder)Michael Jewett(Founder)inAmy Cayne Schwartz(Founder)inMerton Gollaher(Executive Officer)
BoardGeorge Church(Science Advisor)Jesse Rinehart(Science Advisor)
Co-investorsKhosla Ventures
Predicta Biosciences operates a molecular insights platform for blood cancer care, using whole genome sequencing of intact circulating tumor cells from a single blood sample combined with single-cell immune profiling to characterize disease biology and immune response.
BiotechDigital HealthMedical DevicesCambridge, US
Irene Ghobrial(Co-founder)inKenneth Anderson(Co-founder)Gad Getz(Co-founder)Romanos Sklavenitis-Pistofidis(Co-founder)Keith Flaherty(Co-founder)Brian McKernan(CEO)in
Co-investorsIllumina Ventures
Quaise Energy develops ultra-deep geothermal drilling using gyrotron-powered millimeter-wave technology to reach depths up to 20 km and temperatures up to 500°C, aiming to build superhot geothermal power plants.
CleantechDeep TechEnergyHouston, US
Matt Houde(Founder)inCarlos Araque(Founder)inAaron Mandell(Founder)inPaul Woskov(Founder)
BoardColleen Calhoun(Director)inVinod Khosla(Director)
Co-investorsCollaborative FundFine Structures VenturesHelium-3 VenturesPrelude VenturesTechEnergy VenturesXplorer Capital+6 more
Quantum Machines builds Hybrid Control systems that integrate quantum control units with classical compute, including the Pulse Processing Unit (PPU) and a development platform based on the QUA language.
Deep TechHardwareQuantum ComputingClaymont, US
Nissim Ofek(Founder)Itamar Sivan(Founder)Yonatan Cohen(Founder)
Co-investorsAlumni VenturesBattery VenturesIntel CapitalMaor InvestmentsMeron CapitalOurCrowd+6 more
Radix Labs develops software systems that manage operations and workflows in biological research laboratories.
BiotechHealthtechMedical DevicesBoston, US
Dhasharath Shrivathsa(Founder)inIan Paul(Founder)in
Co-investorsY CombinatorBlindspot Ventures Management Cofirstminute capitalLiquid VenturesProtocol LabsSound Ventures
Resonant Link Inc. developed wireless power technology and is no longer operating as an active business, now managing and licensing its patent portfolio for non-medical wireless power.
Deep TechEnergyHardwareMedical DevicesShelburne, US
Grayson Zulauf(Chief Executive Officer, co-founder)Phyo Aung Kyaw, PhD(Chief Science Officer, co-founder)Charles Sullivan(Co-founder)inAaron Stein(Chief Technology Officer, co-founder)in
BoardOrin Hoffman(Director)Shilpi Kumar(Director)in
Co-investorsFreshTracks CapitalISVWIND VenturesIMPACT SCIENCE VENTURESScout VenturesThird Sphere
Applying a fundamental mathematical insight to the problem of turbulence.
Justin Beroz(Founder)
Co-investorsCollaborative FundDay One VenturesThird Sphere
RISE Robotics develops RISE® Cylinder, a fluid-free electro-mechanical alternative to hydraulic cylinders for heavy equipment and machinery that uses belt technology to deliver hydraulic-like forces with significantly greater energy efficiency.
Advanced ManufacturingCleantechDeep TechHardwareRoboticsBoston, US
Arron Acosta(Co-Founder, VP of Business Development)inBlake Sessions(Co-Founder & Chief Technology Officer)inToomas Sepp(Co-Founder & Chief Engineer)inKyle Dell'Aquila(Co-Founder & Head of Industrial Design & Customer Experience)inHiten Sonpal(Chief Executive Officer)in
Co-investorsD3VCDecisive PointTechstars
Robigo develops engineered microbial crop protection products for growers, including a biological solution targeting Sudden Death Syndrome in soybean.
AgTechBiotechFoodTech
Andee Wallace, PhD(Founder)in
Co-investorsCongruent VenturesEndeavor8First Star VenturesGood Growth CapitalSUPPLY CHANGE CAPITALSVG Ventures | THRIVE+4 more
Rock Zero is a technology company with chemistry, materials, and process engineering teams working on chemical and materials science-based technology.
CleantechDeep TechEnergyNew MaterialsCambridge, US
Camden Hunt(Co-Founder & CEO)inBenjamin Mowbray(Co-Founder & CTO)inYet-Ming Chiang(Co-Founder & CIO)in
Co-investorsAzolla VenturesBlindspot Ventures Management CoToyota Ventures
Seaspire develops safe and sustainable suncare and skincare products using Xanthochrome®, a proprietary class of biomolecules inspired by oceanic compounds.
Advanced ManufacturingBiotechConsumerDirect to ConsumerWellness & FitnessCambridge, US
Leila Deravi(Co-founder and scientific advisor)inCamille Martin, PhD(Founder)in
Co-investorsAlumni VenturesHuntington Angels NetworkMassVenturesSafar PartnersTechstars
SiTration develops silicon-based electro-extraction (SEE) and nano-filtration (SNF) technologies that recover metals and critical minerals from mining waste, leachate, and recycled material using electricity and no added chemicals.
CleantechDeep TechNew MaterialsCambridge, US
Brendan Smith(Co-founder & CEO)inJeffrey Grossman(Co-founder & Chief Scientist)
BoardJacob Bro(Director)inMatthew Nordan(Director)in
Co-investorsAzolla VenturesCarbonThe E14 FundWorking Capital FundBHP VenturesExtantia Capital+1 more
Sora Fuel produces sustainable aviation fuel (SAF) and diesel using a proprietary closed-loop direct air capture and conversion process that draws carbon from air rather than biomass or industrial feedstocks.
CleantechClimate TechEnergyCambridge, US
Curtis Berlinguette(Founder)inGareth Ross(Founder)inCurtis Belinguete(Director)
BoardPatrick Sarver(Founder)inMarc Tarpenning(Director)inMichael Kearney(Director)in
Co-investorsInnovation UBCInspired CapitalLeitmotifSpero VenturesWireframe Ventures
Sublime Systems develops an energy-saving, carbon-reducing process for manufacturing cement from previously inaccessible minerals.
CleantechClimate TechConstruction TechNew MaterialsBoston, US
Leah Ellis(Founder)inYet-Ming Chiang(Founder)inRob Davies(Chief Executive Officer)in
BoardKatie Rae(Director)inJohanna Wolfson(Director)in
Co-investorsAzolla VenturesCongruent VenturesCRH VenturesEnergy Impact PartnersKhosla VenturesLowercarbon Capital+4 more
Superlight builds a clean-sheet, aerospace-inspired electric truck for middle-mile cargo transport, using a lightweight aluminium monocoque, software-defined controls, and by-wire architecture to improve payload and operating economics versus diesel.
CleantechLogistics & Supply ChainMobility & Transportation
Co-investorsAvila
Optimizing the resources at the heart of every cloud computation.
Cambridge, US
Suraj Bramhavar(Director)inJeffery Chou(Executive Officer, Director)
Co-investorsCostanoa VenturesNational Grid Partners
Syzygy Plasmonics converts waste biogas and renewable electricity into sustainable aviation fuel using proprietary photocatalytic technology.
CleantechClimate TechEnergyHouston, US
Trevor Best(Executive Officer, Director)inSuman Khatiwada(Founder)in
BoardPatrick Poon(Director)Ann DeWitt(Director)Michael Biddle(Director)inMatthew Hill(Director)
Co-investorsClimate Impact CapitalEvok InnovationsGOOSE CapitalHorizons VenturesLotte VenturesNew Climate Ventures+5 more
TenSixty uses machine learning and cell biology expertise to identify novel antibody targets on cancer cells for the development of new cancer therapeutics.
AI & Machine LearningBiotechMedical DevicesCambridge, US
Daniel Montoro(Executive Officer, Director)inKarthik Jagadeesh(Executive Officer, Director)Christoph Muus(Director)
BoardDipchand Nishar(Director)Sara Choi(Director)in
Co-investorsCivilization Ventures Management, LlcGeneral CatalystWing
Teradar develops terahertz-based sensors for automotive safety, defense, and emerging applications.
Deep TechDefense TechHardwareMobility & TransportationBoston, US
Matthew Carey(CEO & Co-founder)inGregory Charvat(CTO & Co-founder)inNicholas Saiz(Chief Chip Architect & Co-founder)in
Co-investorsAlumni VenturesIbex InvestorsCapricorn Investment GroupLockheed Martin VenturesVXI Capital
Teragen Energy builds modular fuel cell systems for onsite power generation, offering fuel flexibility with optional energy storage and carbon capture.
CleantechEnergyHardware
Co-investorsUntroD CapitalAP VenturesEnergy Capital Ventures
Terragia develops consolidated bioprocessing technology using engineered thermophilic bacteria to convert cellulosic biomass, such as crop residues and perennial crops, into ethanol, other biofuels, and co-products at costs competitive with petroleum.
BiotechCleantechEnergy
Lee Lynd(Founder)inBill Brady(Founder)Chris Herring(Founder)
Co-investorsEnergy Impact PartnersGeneral Catalyst
Terrestrial is developing the Tacterra microarray patch (MAP) platform, which uses dissolvable tips made from biomaterials to deliver therapies such as GLP-1 through the skin without injections.
BiotechDeep TechMedical Devices
Rachel Sha(CEO)in
Co-investorsGlobal Health Investment CorporationRA CapitalUlu Ventures
The Routing Company builds a real-time routing algorithm and its Pingo platform for on-demand transit and logistics, reoptimizing routes to increase vehicle seat utilization while maintaining ETAs.
AI & Machine LearningLogistics & Supply ChainMobility & Transportation
Alex Wallar(Founder)inMenno van der Zee(Founder)
Co-investorsAlumni VenturesConvergeSystemiq CapitalGalvanize Climate SolutionsMenlo VenturesSYSTEMIQ
Acteris is an intelligence layer for industrial robots, including collaborative robots (cobots), built on physical AI to handle high-mix, low-volume production where variable, real-world conditions defeat rigid programming.
Advanced ManufacturingAI & Machine LearningRoboticsSan Jose, US
Asad Tirmizi(Founder)
Co-investorsFitz Gate VenturesGeodesic CapitalRadius Capital Ventures
Terrestrial develops the Tacterra microarray patch platform, a dissolvable skin-patch technology for delivering therapies including GLP-1 without injection.
BiotechHealthtechMedical Devices
Livio Valenti(Cofounder)Rachel Sha(CEO)
Co-investorsMission BiocapitalNorwich VenturesUlu Ventures
VEIR manufactures low- and medium-voltage superconducting systems that deliver electricity for high-performance AI data centers.
AI & Machine LearningDeep TechEnergyHardwareWoburn, US
Tim Heidel(CEO & Co-Founder)in
BoardDoug Stewart(Director)Adam Wallen(Executive Officer, Director)in
Co-investorsBreakthrough Energy VenturesCongruent VenturesPiva CapitalTyche PartnersNational Grid PartnersVXI Capital+5 more
Via Separations makes industrial membrane filtration systems that cut the energy used in thermal separation processes.
Cambridge, US
Brent Keller(Executive Officer, Director)inShreya Dave(Executive Officer, Director)in
BoardKatie Rae(Director)inArunas Chesonis(Director)in
Co-investorsATEL VenturesAzolla VenturesCapTableClimate InvestmentEmbark VenturesPrime Impact Fund+3 more
VioNano Innovations develops advanced materials and chemical solutions leveraging nanoscale technology and expertise from the semiconductor and materials science industries.
Advanced ManufacturingDeep TechNew MaterialsSemiconductorsCambridge, US
Chris Taylor(CEO and Founder)inPhil Hustad(CTO and Founder)in
Co-investorsRhapsody Venture Partners
Wild Microbes uses synthetic biology to engineer microbes sourced from diverse wild biomes into production hosts for biomanufacturing high-performance ingredients.
BiotechDeep TechNew Materials
Timothy Wannier(Founder)in
Co-investorsAgronomicsCoalitionCollaborative FundFREEFLOWJuniperSiddhi Capital+2 more
WoHo develops systems to change how buildings are designed and constructed, aligning the efforts of cities, developers, contractors, and designers to improve quality and reduce waste and inefficiency.
Construction TechPropTech
Antón García-Abril(Co-Founder & CEO)Débora Mesa(Co-Founder, President & CDO)Borja Soriano(Chief Operating Officer)inJavier Cuesta(Chief Technology Officer)Eduardo Cadorniga(Chief Financial Officer)
XGenomes develops genomic sequencing technology using fluorescent probes and machine learning to read genetic and epigenetic information at single-molecule resolution.
AI & Machine LearningBiotechDigital HealthHealthtechMedical DevicesBoston, US
Kalim Mir(CEO)inJaney Muñoz(Bio- and Systems Engineer)
Co-investorsFundersClubThink+ Ventures Management, LlcY CombinatorAmino CapitalCantos VenturesFCVC+2 more
Zag Bio develops thymus-targeted bifunctional antibodies designed to induce central tolerance for treating autoimmune diseases.
BiotechDeep TechHealthtechMedical DevicesCambridge, US
Alan Crane(Founder)Diane Mathis(Founder)Joanne Lim(Co-founder)Dr. Diane Mathis(Founder)Jo Viney(Founder)John Kulman(Founder)
Co-investorsLightspeed Venture PartnersMission BiocapitalPear VCSanofi VenturesPolaris Partners
Zapata Quantum is a publicly traded company (OTCQB: ZPTA) that develops quantum algorithms and applies agentic AI to automate quantum resource estimation workflows.
AI & Machine LearningDeep TechQuantum ComputingCambridge, US
Christopher Savoie(Executive Officer, Director)in
BoardReed Sturtevant(Director)inAlán Aspuru-Guzik(Director)inRuss Wilcox(Director)
Co-investorsBosch VenturesComcast VenturesCXO FundPropagator VenturesRaptor GroupWorldQuant Ventures+7 more
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
AmideAtlantic QcCopernicDropGenieDrūlGander RoboticsHyféHyfé FoodsHyperLightKanoLydianNanopathPredictaRheyoTrener RoboticsUbiceptVolunaWorld Economic Forum
Exits · 1
1 acquisitionsAquantiaacq. by Marvell Technology
Portfolio news
latest coverage across their companiesSyzygy Plasmonics · worldbiomarketinsights.com · Sep 1, 2026
Quaise Energy · citybiz.co · Aug 28, 2026

Form Energy · techcrunch.com · Aug 12, 2026
Superlight · finsmes.com · Jun 22, 2026
Boston Metal · globenewswire.com · May 20, 2026
Axoft · trysignalbase.com · Apr 30, 2026
Sora Fuel · finsmes.com · Apr 8, 2026
Kytopen · finsmes.com · Apr 7, 2026
Frequently asked questions
- How many investments has The Engine Ventures made?
- The Engine Ventures has 113 tracked investments, 1 of which have exited, including 4 dated in the last 24 months.
- What stage does The Engine Ventures invest at?
- The Engine Ventures invests at the Pre-Seed, Seed, Series A stages.
- What sectors does The Engine Ventures focus on?
- The Engine Ventures focuses on Advanced Manufacturing, AgTech, Biotech, Cleantech, Climate Tech, Consumer, Data & Infrastructure, Deep Tech, Energy, Enterprise Software, FoodTech, Hardware, New Materials, SaaS, Semiconductors.
- Where is The Engine Ventures located?
- The Engine Ventures is headquartered in Cambridge, US.
- Does The Engine Ventures lead rounds?
- The Engine Ventures typically participates in rounds rather than leading them.
- Who does The Engine Ventures co-invest with?
- The Engine Ventures most often shares deals with Collaborative Fund, Alumni Ventures, Blindspot Ventures Management Co, among 197 tracked co-investors.
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