San Francisco Bay Area · Pre-Seed–Series A · 10 people tracked
Also known as Z21 Ventures HEN Nozzles Dec 2024 · Z21 Ventures HEN Nozzles July 2025 · z21 Ventures ID Cafe March 2025
Find your way into Z21 Ventures
3,154 people in our graph share verified history with the Z21 Ventures team — schools, employers, funds. One of them is your warm intro.
Investment thesis
Z21 Ventures positions its 205+ member community of operators, investors, and advisors as a core value proposition, offering portfolio companies hands-on support beyond capital. The community engages with every portfolio company across the lifecycle — from sourcing through scaling — helping with areas such as go-to-market strategy and growth acceleration, and leveraging extensive industry connections. Testimonials reference expertise in healthcare and enterprise software, indicating relevant sector strengths. The firm emphasizes opening doors and providing an 'unfair advantage from day one' rather than acting solely as a source of funding.
Source: firm website, verified Aug 3, 2026.
Team · 10 people
from the firm's website & public directories
Founder mafia
5 people who came through Z21 Ventures went on to found or lead other companies.
What they invest in
from 18 of 49 portfolio companiesAI & Machine Learning ×12SaaS ×7Healthtech ×5Cloud Computing ×3Deep Tech ×3Digital Health ×3Enterprise Software ×3Data & Infrastructure ×2
HQs:United States×9India×1
Who they back
founder profiles across 9 portfolio companiesFounding team size:solo founder×42 founders×5
Accelerator rootsportfolio companies that came through a program
Investments · 49 tracked
founders shown can be your intro pathBy year:2026 · 22025 · 32024 · 12023 · 17 dated
FOXO Technologies is a healthcare services and technology company operating three divisions: epigenetic diagnostics and interpretation, rural hospitals, and mental and behavioral health facilities.
Digital HealthHealthtechMental HealthMinneapolis, US
Jon Sabes(Executive Officer, Director)Steve Sabes(Executive Officer)Martin Ward(Interim Chief Financial Officer)Mark White(Interim Chief Executive Officer)Brian Chen(Chief Science Officer)Tyler Danielson(Interim Chief Executive Officer and Chief Technology Officer)
HEN Technologies builds an integrated fire defense platform combining re-engineered suppression hardware (nozzles, monitors, pump controls), a data layer, and real-time AI incident-command software (FLUID-IQ and STAR-IQ).
AI & Machine LearningDefense TechGovTechHardwareSaaS
Sunny Sethi(Founder)in
Co-investorsNivesha Ventures
Adaption Labs builds adaptive AI systems that continually learn and adjust to specific industries, languages, and use cases, positioning itself against large monolithic, one-size-fits-all models.
AI & Machine LearningDeep Tech
Co-investorsAlpha Intelligence CapitalEmergence Capital PartnersFifty YearsMozilla VenturesThe E14 FundThreshold Ventures
Babblebots provides AI-powered phone interview software that automates candidate screening through conversational voice calls, eliminating manual recruiter screening tasks and enabling high-volume hiring at scale.
AI & Machine LearningHR TechSaaS
Roli Gupta(Founder)in
Basepair is a SaaS bioinformatics platform that provisions in a customer's own AWS account to store and analyze genomic and next-generation sequencing (NGS) data without moving it, offering point-and-click and API-driven workflows plus interactive visualization.
BiotechCloud ComputingData & InfrastructureNew York, US
Amit U Sinha(Founder)in
Co-investors37 AngelsCarbon SiliconDraper AssociatesEntrepreneurs Roundtable Accelerator (ERA)Fresco CapitalMetaplanet
Breakout offers an AI SDR platform that identifies website visitors and buyer intent signals, engages them in real time through AI chat, and automates follow-ups, campaigns, and CRM updates.
AI & Machine LearningMarketing TechSales TechSan Jose, US
Hitesh A(Founder)Sachin Gupta(Founder)in
Co-investorsRecall CapitalVillage Global
Conifer designs and manufactures powertrains and motors for drones, robots, data centers, and mobility applications using proprietary axial-flux architecture that reduces material costs and increases performance.
Advanced ManufacturingDeep TechHardware
Ankit Somani(Founder)in
Co-investorsMaC Venture CapitalMFV PartnersTrue VenturesVoyager Partners
CoverSelf offers a healthcare payment integrity platform that helps payers detect and prevent claims inaccuracies and payment leakage while reducing administrative costs.
FintechHealthtechSaaSSan Francisco, US
Rajasekhar Maddireddy(Executive Officer, Director, Promoter)Raghavendra Pawar(Executive Officer, Director, Promoter)in
Co-investorsSaison Capital3one4 CapitalBEENEXT
Develo builds an AI-native, FHIR-conformant software platform for independent pediatric practices that combines charting, billing, practice management, and family engagement in one system.
AI & Machine LearningDigital HealthHealthtechMedical DevicesSaaSLos Angeles, US
Han Ke(Founder)in
Co-investorsBlueprint EquityFractal SoftwareBienville Capital
Gloroots operates a centralized platform that enables distributed companies to offer localized benefits packages, including health insurance, life and disability coverage, pension plans, and co-working access, compliant with labor laws across 140+ countries.
Enterprise SoftwareFuture of WorkHR TechSaaS
Abhirup Nath(Founder)in
Co-investorsFoster VenturesUpsparks Capital
hosted·ai is a turnkey platform for GPU orchestration, monetization and neocloud operations, using software-defined GPU multi-tenancy, overcommit and elastic GPUaaS to raise GPU utilization and margin.
AI & Machine LearningCloud ComputingData & InfrastructureSan Jose, US
Ditlev Bredahl(Executive Officer, Director)Narendar (Naren) S(Founder)Ditlev B.inNarendar Shankar(Executive Officer, Director)
BoardCarl Fritjofsson(Director)inJames Withall(Director)
Co-investorsCreandumGolden Sparrow Ventures, LlcPeople VenturesRepeat VC
Inito provides fertility and reproductive health services, advised by reproductive endocrinologists and infertility specialists.
FemTechHealthtechWellness & FitnessBengaluru, IN
Varun AV(Founder)inAayush Rai(Founder)in
Co-investorsBetter CapitalFireside Ventures Advisory LlpOwl CapitalY CombinatorBertelsmann India Investments
Lighthouz AI provides AI-powered back-office automation for freight brokers, automating freight bill audits, accounts receivable, and collections.
AI & Machine LearningEnterprise SoftwareLogistics & Supply ChainSaaSAtlanta, US
Srijan Kumar(CEO & Co-founder)inSonali Pattnaik(COO & Co-founder)in
Co-investorsY Combinator
Myolab develops MyoSapiens, an embodied AI system designed to understand and learn from human full-body movements, behaviors, and interactions by combining embodied behavior data with environmental context and world knowledge.
AI & Machine LearningDeep TechRobotics
Co-investorsAllianz Life VenturesGolden Sparrow Ventures, Llc
Risa Labs provides automated prior authorization and revenue-cycle workflows for oncology practices, handling Part B and Part D drug authorizations, eligibility and benefit verification, claims status tracking, and denial management.
AI & Machine LearningDigital HealthHealthtech
Co-investorsBetter CapitalCencora VenturesOncology VenturesOptum VenturesAlpha PartnersGeneral Catalyst
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TrueFoundry provides a unified platform for deploying, governing, scaling, and tracing agentic AI and LLM workloads, including an AI gateway, model hosting, fine-tuning, and observability.
AI & Machine LearningCloud ComputingDeveloper ToolsSan Francisco, US
Nikunj Bajaj(Founder)inAbhishek Choudhary(Founder)in
Co-investorsEniac VenturesIntel CapitalMyAsiaVCPeak XV PartnersTrajectory VenturesAIX Ventures+2 more
vHub.ai is an AI-based influencer marketing intelligence platform that helps brands and marketing teams discover creators, analyze audience demographics and authenticity, study content, and track campaign performance.
AI & Machine LearningCreator EconomyMarketing Tech
Rajesh Jagasia
Co-investorsStartup India Seed Fund Scheme
Zime provides a GTM Context Model exposed through MCP that allows multiple in-house AI agents (forecasting, RFP, deal desk, content) to access unified buyer language, deal context, and sales strategy.
AI & Machine LearningEnterprise SoftwareSaaSSales Tech
Co-investorsAUM Venturespeercheque
Other
Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.
CignaraConifer SystemsDeviceThreadDmandEarkartExplorexFlashaidFurnishkaGaana AIGimbal SpaceGreenjetsHarness CareHarness InsuranceHumigentIncertoKid ExKim CCLivSytMatterfactMeomindMighty AIMoneyClubNaïveOptiwiseOriginPerceptyne RobotsRapidflareRefold AIRexeraShifu HealthThe Energy Company
Exits · 1
1 IPOsFoxo TechnologiesOTC: FOXO
Portfolio news
latest coverage across their companiesTrueFoundry · simplywall.st · Sep 11, 2026
Naïve · techcrunch.com · Aug 10, 2026
Breakout · breakoutprop.com · Jul 31, 2026
Develo · latimes.com · Jun 29, 2026
Gloroots · trysignalbase.com · Mar 25, 2026
Risa Labs · biospace.com · Jan 14, 2026
Frequently asked questions
- How many investments has Z21 Ventures made?
- Z21 Ventures has 49 tracked investments, 1 of which have exited, including 5 dated in the last 24 months.
- What stage does Z21 Ventures invest at?
- Z21 Ventures invests at the Pre-Seed, Seed, Series A stages.
- What is Z21 Ventures's typical check size?
- Z21 Ventures typically writes checks of $500K – $1M.
- What sectors does Z21 Ventures focus on?
- Z21 Ventures focuses on AI & Machine Learning, Consumer, Data & Infrastructure, Deep Tech, Enterprise Software, Healthtech, SaaS.
- Where is Z21 Ventures located?
- Z21 Ventures is headquartered in San Francisco Bay Area, US.
- Does Z21 Ventures lead rounds?
- Z21 Ventures typically participates in rounds rather than leading them.
- Who does Z21 Ventures co-invest with?
- Z21 Ventures most often shares deals with Better Capital, Golden Sparrow Ventures, Llc, Y Combinator, among 26 tracked co-investors.
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