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Z21 Ventures

Venture capitalActively deploying

San Francisco Bay Area · Pre-Seed–Series A · 11 people tracked

Also known as Z21 Ventures HEN Nozzles Dec 2024 · Z21 Ventures HEN Nozzles July 2025 · z21 Ventures ID Cafe March 2025

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Investment thesis

Z21 Ventures positions its 205+ member community of operators, investors, and advisors as a core value proposition, offering portfolio companies hands-on support beyond capital. The community engages with every portfolio company across the lifecycle — from sourcing through scaling — helping with areas such as go-to-market strategy and growth acceleration, and leveraging extensive industry connections. Testimonials reference expertise in healthcare and enterprise software, indicating relevant sector strengths. The firm emphasizes opening doors and providing an 'unfair advantage from day one' rather than acting solely as a source of funding.

Invests inAI & Machine LearningConsumerData & InfrastructureDeep TechEnterprise SoftwareHealthtechSaaSBerkeleyGlobalIndiaNorth AmericaSan FranciscoSan Francisco Bay AreaUnited States

Source: firm website, verified Aug 3, 2026.

Stage
Pre-Seed–Series A
Check
$500K – $1M
HQ
San Francisco Bay Area, California, US
Leads rounds
Follows
Instruments
Equity
Founded
2022
Tracked investments
48

Team · 11 people

from the firm's website & public directories

What they invest in

from 6 of 48 portfolio companies

AI & Machine Learning ×5SaaS ×3Cloud Computing ×2Data & Infrastructure ×1Deep Tech ×1Defense Tech ×1Developer Tools ×1Enterprise Software ×1

HQs:United States×4

Investments · 48 tracked

founders shown can be your intro path
Hen Technologieshentechnologies.comin𝕏✓ verified

HEN Technologies builds an integrated fire defense platform combining re-engineered suppression hardware (nozzles, monitors, pump controls), a data layer, and real-time AI incident-command software (FLUID-IQ and STAR-IQ).

AI & Machine LearningDefense TechGovTechHardwareSaaS

Sunny Sethi(Founder)

Adaption Labs
BabbleBots
BasePair
Breakout AI
Cignara
Conifer Systems
CoverSelfcoverself.comin

CoverSelf offers a healthcare payment integrity platform that helps payers detect and prevent claims inaccuracies and payment leakage while reducing administrative costs.

FintechHealthtechSaaSSan Francisco, US

Rajasekhar Maddireddy(Executive Officer, Director, Promoter)Raghavendra Pawar(Executive Officer, Director, Promoter)

Develo
DeviceThread
Dmand
Earkart
Explorex
Flashaid
FOXO
Furnishka
Gaana AI
Gimbal Space
Gloroots
Greenjets
Harness Care
Harness Insurance
Hostedhosted.aiin

hosted·ai is a turnkey platform for GPU orchestration, monetization and neocloud operations, using software-defined GPU multi-tenancy, overcommit and elastic GPUaaS to raise GPU utilization and margin.

AI & Machine LearningCloud ComputingData & InfrastructureSan Jose, US

Ditlev Bredahl(Executive Officer, Director)Narendar Shankar(Executive Officer, Director)

BoardCarl Fritjofsson(Director)James Withall(Director)Claus Zibrandtsen(Director)

Humigent
Incerto
Inito
Kidex
Kim CC
Lighthouz AIlighthouz.aiin𝕏

Lighthouz AI provides AI-powered back-office automation for freight brokers, automating freight bill audits, accounts receivable, and collections.

AI & Machine LearningEnterprise SoftwareLogistics & Supply ChainSaaSAtlanta, US

Srijan Kumar(CEO & Co-founder)inSonali Pattnaik(COO & Co-founder)in

LivSyt
Matterfact
Meomind
Mighty AI
MoneyClub
MyoLabmyolab.ai

Myolab develops MyoSapiens, an embodied AI system designed to understand and learn from human full-body movements, behaviors, and interactions by combining embodied behavior data with environmental context and world knowledge.

AI & Machine LearningDeep TechRobotics

Naïve
Optiwise
Origin
Perceptyne Robots
Rapidflare
Refold AI
Rexera
Risa Labsrisalabs.aiin
Shifu Health
The Energy Company
TrueFoundrytruefoundry.comin𝕏

TrueFoundry provides a unified platform for deploying, governing, scaling, and tracing agentic AI and LLM workloads, including an AI gateway, model hosting, fine-tuning, and observability.

AI & Machine LearningCloud ComputingDeveloper Tools

vHub
Zime

Portfolio news

latest coverage across their companies

Frequently asked questions

What stage does Z21 Ventures invest at?
Z21 Ventures invests at the Pre-Seed, Seed, Series A stages.
What is Z21 Ventures's typical check size?
Z21 Ventures typically writes checks of $500K – $1M.
What sectors does Z21 Ventures focus on?
Z21 Ventures focuses on AI & Machine Learning, Consumer, Data & Infrastructure, Deep Tech, Enterprise Software, Healthtech, SaaS.
Where is Z21 Ventures located?
Z21 Ventures is headquartered in San Francisco Bay Area, US.
Does Z21 Ventures lead rounds?
Z21 Ventures typically participates in rounds rather than leading them.

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