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Manifold

Boston, US · Founded 2019 · 76 employees on LinkedIn · 6 known investors

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Manifold Bio combines AI-guided protein design with high-throughput in vivo screening to engineer tissue-targeted biologics and deliver therapeutic payloads to specific organs. The company develops a computational and experimental platform to optimize pharmacokinetics and biodistribution directly in living systems for drug discovery and development.

Founders & leadership

Manifold was founded in 2019 by Gleb Kuznetsov and Pierce Ogden.

GKGleb Kuznetsov
Gleb KuznetsovCo-Founder & CEO
POPierce Ogden
Pierce OgdenCo-Founder & CTOPierce Ogden is co-founder and CTO of Manifold Bio, which develops AI-guided protein design and high-throughput screening methods for engineering tissue-targeted biologics. Previously, he conducted research in the Church lab on AAV variant screening using DNA synthesis and sequencing methods, work that contributed to the founding of Dyno Therapeutics.

Board

JB
Jory BellBoard director
JH
Jeff HuberBoard director
SJ
Steven J. KafkaBoard directorGeneral Partner at Third Rock Ventures
SH
Steven HoltzmanBoard director

Investors · 6

Reported raises · per SEC filings

Form D private placements

$78.2M disclosed across 3 rounds · 2020–2024

▶$32.8MraisedDec 2024 · 10 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Jory BellDirector
  • Gleb KuznetsovExecutive Officer, Director
  • Jeff HuberDirector
  • Pierce OgdenExecutive Officer, Director
  • Steven J. KafkaDirector
  • Steven HoltzmanDirector
Offering amount
$32.8M
Amount sold
$32.8M
First sale
Nov 2024
Incorporated
Corporation, Delaware
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$40MraisedJun 2022 · 13 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Jeff HuberDirector
  • Pierce OgdenExecutive Officer, Director, Promoter
  • Gleb KuznetsovExecutive Officer, Director, Promoter
  • Jory BellDirector
Offering amount
$40M
Amount sold
$40M
First sale
May 2022
Incorporated
Corporation, Delaware, 2019
Federal exemptions
06b
Full filing on SEC EDGAR ↗
▶$5.4MraisedAug 2020 · 6 investors · Biotechnology
Rule 506(b)
Officers, directors & promoters on the filing
  • Pierce OgdenExecutive Officer, Director, Promoter
  • Gleb KuznetsovExecutive Officer, Director, Promoter
  • Jory BellDirector
Offering amount
$5.4M
Amount sold
$5.4M
First sale
Jul 2020
Incorporated
Corporation, Delaware, 2019
Federal exemptions
06b
Full filing on SEC EDGAR ↗

Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.

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In the news

Frequently asked questions

What does Manifold do?
Manifold Bio combines AI-guided protein design with high-throughput in vivo screening to engineer tissue-targeted biologics and deliver therapeutic payloads to specific organs. The company develops a computational and experimental platform to optimize pharmacokinetics and biodistribution directly in living systems for drug discovery and development.
Who founded Manifold?
Manifold was founded by Gleb Kuznetsov, Pierce Ogden in 2019.
Who are Manifold's investors?
Manifold's investors include Playground Global, Fifty Years, FPV, Horizons Ventures, Triatomic Capital, Third Rock Ventures.
How much funding has Manifold raised?
Manifold has disclosed $78.2M raised across 3 rounds.
Where is Manifold headquartered?
Manifold is headquartered in Boston, US.