Manifold
Boston, US · Founded 2019 · 76 employees on LinkedIn · 6 known investors
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Manifold Bio combines AI-guided protein design with high-throughput in vivo screening to engineer tissue-targeted biologics and deliver therapeutic payloads to specific organs. The company develops a computational and experimental platform to optimize pharmacokinetics and biodistribution directly in living systems for drug discovery and development.
Founders & leadership
Manifold was founded in 2019 by Gleb Kuznetsov and Pierce Ogden.

Board
Investors · 6
How we know: Playground Global's portfolio page · the VCSheet dataset · open dataset · 5k.vc investor directory · Not right? Tell us
How we know: Fifty Years's portfolio page · the VCSheet dataset · Not right? Tell us
How we know: the VCSheet dataset · open dataset · 5k.vc investor directory · Not right? Tell us
How we know: the VCSheet dataset · Not right? Tell us
Reported raises · per SEC filings
Form D private placements$78.2M disclosed across 3 rounds · 2020–2024
▶$32.8MraisedDec 2024 · 10 investors · BiotechnologyRule 506(b)
- Jory BellDirector
- Gleb KuznetsovExecutive Officer, Director
- Jeff HuberDirector
- Pierce OgdenExecutive Officer, Director
- Steven J. KafkaDirector
- Steven HoltzmanDirector
- Offering amount
- $32.8M
- Amount sold
- $32.8M
- First sale
- Nov 2024
- Incorporated
- Corporation, Delaware
- Federal exemptions
- 06b
▶$40MraisedJun 2022 · 13 investors · BiotechnologyRule 506(b)
- Jeff HuberDirector
- Pierce OgdenExecutive Officer, Director, Promoter
- Gleb KuznetsovExecutive Officer, Director, Promoter
- Jory BellDirector
- Offering amount
- $40M
- Amount sold
- $40M
- First sale
- May 2022
- Incorporated
- Corporation, Delaware, 2019
- Federal exemptions
- 06b
▶$5.4MraisedAug 2020 · 6 investors · BiotechnologyRule 506(b)
- Pierce OgdenExecutive Officer, Director, Promoter
- Gleb KuznetsovExecutive Officer, Director, Promoter
- Jory BellDirector
- Offering amount
- $5.4M
- Amount sold
- $5.4M
- First sale
- Jul 2020
- Incorporated
- Corporation, Delaware, 2019
- Federal exemptions
- 06b
Source: SEC EDGAR Form D. Amounts as filed; amended filings shown once at their latest values.
Related companies · 4
Companies working in the same space as Manifold.
In the news
Frequently asked questions
- What does Manifold do?
- Manifold Bio combines AI-guided protein design with high-throughput in vivo screening to engineer tissue-targeted biologics and deliver therapeutic payloads to specific organs. The company develops a computational and experimental platform to optimize pharmacokinetics and biodistribution directly in living systems for drug discovery and development.
- Who founded Manifold?
- Manifold was founded by Gleb Kuznetsov, Pierce Ogden in 2019.
- Who are Manifold's investors?
- Manifold's investors include Playground Global, Fifty Years, FPV, Horizons Ventures, Triatomic Capital, Third Rock Ventures.
- How much funding has Manifold raised?
- Manifold has disclosed $78.2M raised across 3 rounds.
- Where is Manifold headquartered?
- Manifold is headquartered in Boston, US.










